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Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 135,619 814,729 301
Proteins 123,030 771,535 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000000004463Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.00000000009784InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000000001562InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000731InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases0.000000001046Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000004643Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.03827Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04125Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4654Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.6008Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.7877InformativeInherited
Disease Ontology (DO)congenital hemolytic anemia0.00002783Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Mitochondrial inheritance0.0002035Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6466Least InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2251Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6211Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.0324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.5979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.233InformativeInherited
Mammalian Phenotype (MP)abnormal redox activity0.000000005457Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid hormone level0.03374Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.256Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0003847Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.1582Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.000000002976Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.7772Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.001038InformativeInherited
Worm Phenotype (WP)metal response variant0.003463InformativeInherited
Worm Phenotype (WP)cell stress response variant0.02769InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.00005601Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.9035Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.006023Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02503Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.3984Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7492Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0008962Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.0002026InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0006196InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.001099InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.001205InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.3184InformativeInherited
Xenopus ANatomical entity (XAN)bone tissue0.00001313Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.009785Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.0003908Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.0002354Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660.0003957InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000006127Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0002126Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0009113Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001676Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006756Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02101Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05805Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09794Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1697Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6217Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.1444InformativeInherited
Plant ANatomical entity (PAN)phloem0.0005449Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.0000000004906Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)NADH dehydrogenase0.0000000000003037Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000001428Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.000001711Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000004Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0004686Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.01483Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donors0.1663Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationTransferase0.00000000001464Moderately InformativeDirect
Post-translational modificationEye lens protein0.000000000002793InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]