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Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]

Superfamily statistics
Genomes (3,255) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 135,619 0 301
Proteins 123,030 0 292

Functional annotation
General category Metabolism
Detailed category Redox

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000000004463Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.00000000009784InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000000001562InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000731InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases0.000000001046Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000004643Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.03827Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04125Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4654Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.6008Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.7877InformativeInherited
Disease Ontology (DO)congenital hemolytic anemia0.00002783Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Mitochondrial inheritance0.0001681Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7027Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal CSF lactate level0.000003887Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal CNS myelination0.0006097Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2253Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6208Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.03245Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3386Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.5979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.233InformativeInherited
Mammalian Phenotype (MP)abnormal redox activity0.000000005457Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid hormone level0.03374Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.2561Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0003649Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.1525Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00000000307Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.7758Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.001005InformativeInherited
Worm Phenotype (WP)metal response variant0.003531InformativeInherited
Worm Phenotype (WP)cell stress response variant0.0273InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.00005623Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.9046Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.01078Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.5054Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8465Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.001214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.9805Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.0002524InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0006967InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.001355InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.001628InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.3238InformativeInherited
Xenopus ANatomical entity (XAN)bone tissue0.00001713Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.009846Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.0003Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.0001711Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660.0005335InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000006127Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0002126Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0009113Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001676Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006756Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02101Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05805Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09794Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1697Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6217Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.1444InformativeInherited
Plant ANatomical entity (PAN)phloem0.0005449Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.0000000005945Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)NADH dehydrogenase0.0000000000003118Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000001421Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.000001703Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000006917Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0004748Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.001717Highly InformativeInherited
Enzyme Commission (EC)Acting on hydrogen as donors0.1671Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.008002Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response0.00000001443InformativeDirect
Biological processSensory transduction0.03591InformativeInherited
Biological processFatty acid metabolism0.4211InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis0.00000000003985Highly InformativeDirect
Biological processPhenylalanine catabolism0.00000000006467Highly InformativeDirect
Biological processTwo-component regulatory system0.0000000005871Highly InformativeDirect
Biological processUnfolded protein response0.00000002458Highly InformativeDirect
Biological processSodium transport0.00000006387Highly InformativeDirect
Biological processNitrate assimilation0.0000001225Highly InformativeDirect
Biological processAuxin signaling pathway0.0000002671Highly InformativeDirect
Biological processHearing0.000000978Highly InformativeDirect
Biological processVision0.00004997Highly InformativeDirect
Biological processAntiport0.0002023Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion6.626e-16Moderately InformativeDirect
Cellular componentPlastid0.000001074Moderately InformativeDirect
Cellular componentCell projection1Moderately InformativeInherited
Cellular componentPeriplasm0.0000000000001517InformativeDirect
Cellular componentChloroplast0.0000000009115InformativeDirect
Cellular componentPeroxisome0.00008464InformativeDirect
Cellular componentCilium0.0002878InformativeDirect
Cellular componentSarcoplasmic reticulum0.000000000002201Highly InformativeDirect
Cellular componentLipid droplet0.00001778Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.00008728Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron-sulfur0.000000000006876Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionSodium0.0003982InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.00000000008138Moderately InformativeDirect
Post-translational modificationIon channel0.00002309InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.00000000000001351Highly InformativeDirect
Post-translational modificationMuscle protein0.000008711Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]