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Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,248) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 134,146 496,606 301
Proteins 121,973 472,930 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.81891Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.1206Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.000049620.1345Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.0000000001498Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process10.9263Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)peptide metabolic process0.00031960Moderately InformativeDirect
Biological Process (BP)response to stress0.000049220.0000000003117Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00000000005160.0000000000001768Moderately InformativeDirect
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.00026561Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.78451Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.21110.00000000000001243Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.011860.09005Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.38930.8338Moderately InformativeInherited
Biological Process (BP)regulation of localization0.028361Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0074011Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.011040Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.96141Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.59351Moderately InformativeInherited
Biological Process (BP)gene expression0.7241Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.1981Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.96920.9667Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)ribose phosphate metabolic process0.96481Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.94091Moderately InformativeInherited
Biological Process (BP)glycosyl compound metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.0002880InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)regulation of cellular localization0.000047140.03472InformativeInherited
Biological Process (BP)regulation of protein localization0.00039810.8121InformativeInherited
Biological Process (BP)response to inorganic substance0.013330.00000001269InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0086850.09283InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0047690.09263InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)electron transport chain0.098520.04618InformativeInherited
Biological Process (BP)cellular respiration0.47450.4052InformativeInherited
Biological Process (BP)ATP metabolic process0.44150.7182InformativeInherited
Biological Process (BP)mitochondrial electron transport, NADH to ubiquinone0.00047230.000002924Highly InformativeDirect
Biological Process (BP)protein folding0.0000099310Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid biosynthetic process0.000000001380.000009647Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.000000001320.000000001136Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.000000014460Highly InformativeDirect
Biological Process (BP)regulation of protein import into nucleus0.00000000000050740.0000006741Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000000061170.0005197Highly InformativeDirect
Biological Process (BP)reactive oxygen species metabolic process00Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.0000000006230.0000000002973Highly InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.00007060Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000027640InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.045580InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.034180.6224Highly InformativeInherited
Molecular Function (MF)peroxidase activity0.0021970.003501Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.00037750Least InformativeDirect
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00010030.02089Least InformativeInherited
Cellular Component (CC)membrane protein complex0.88441Moderately InformativeInherited
Cellular Component (CC)organelle membrane10.9066Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.54190.001224Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.015420.00434Moderately InformativeInherited
Cellular Component (CC)oxidoreductase complex0.00000020480.00000000001043InformativeDirect
Cellular Component (CC)plastid0.11230.000000000001817InformativeInherited
Cellular Component (CC)respiratory chain complex0.092080.03099InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain0.0035650.0002479InformativeInherited
Cellular Component (CC)inner mitochondrial membrane protein complex0.037480.00418InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain complex I0.00076810.00000554Highly InformativeDirect
Cellular Component (CC)ferredoxin hydrogenase complex0.000018630.0000003948Highly InformativeDirect
Cellular Component (CC)chloroplast stroma0.000010180.0000001519Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0.0000000001498 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1206 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9263 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1345 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to stress 0.0000000003117 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000000001243 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.00007109 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000000001768 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.09005 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8562 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.9667 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8338 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) response to inorganic substance 0.00000001269 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.4458 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6502 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.00525 Informative Inherited
Biological Process (BP) negative regulation of transport 0.6142 Informative Inherited
Biological Process (BP) cell adhesion 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.03472 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.09606 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of system process 0.7441 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9444 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.3209 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.9027 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.5668 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.738 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8121 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.7894 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.123 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1692 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.09283 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.09263 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) electron transport chain 0.04618 Informative Inherited
Biological Process (BP) cellular respiration 0.4052 Informative Inherited
Biological Process (BP) ATP metabolic process 0.7182 Informative Inherited
Biological Process (BP) mitochondrion organization 0.1553 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) mitochondrial electron transport, NADH to ubiquinone 0.000002924 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.000009647 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000001136 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0009465 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.00007202 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00000000004744 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.0000006741 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.0004252 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0005197 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0.0000000000004711 Highly Informative Direct
Biological Process (BP) reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) detoxification 0.000000001389 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000000002973 Highly Informative Direct
Biological Process (BP) hemostasis 0.5207 Highly Informative Inherited
Biological Process (BP) wound healing 0.9958 Highly Informative Inherited
Biological Process (BP) coagulation 0.5005 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01001 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.1266 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.3502 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.008541 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.01815 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.0179 Highly Informative Inherited
Biological Process (BP) maintenance of location in cell 0.08833 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.6954 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6755 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.7965 Highly Informative Inherited
Biological Process (BP) negative regulation of ion transmembrane transport 0.001185 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.001616 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.14 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.2719 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.4931 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.625 Highly Informative Inherited
Biological Process (BP) response to heat 1 Highly Informative Inherited
Biological Process (BP) endocytosis 0.1507 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) amide binding 0.000000001589 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000000001312 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.6981 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00000000005623 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.6224 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 1 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 0.003501 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02089 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.00434 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.05016 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9066 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.001224 Moderately Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain 0.0002479 Informative Direct
Cellular Component (CC) plastid 0.000000000001817 Informative Direct
Cellular Component (CC) organelle subcompartment 0.0001534 Informative Direct
Cellular Component (CC) extracellular organelle 0.0001061 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00000000001043 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.01846 Informative Inherited
Cellular Component (CC) respiratory chain complex 0.03099 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.00418 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0.00000554 Highly Informative Direct
Cellular Component (CC) ferredoxin hydrogenase complex 0.0000003948 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.0000001519 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.000001052 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum subcompartment 0.0093 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000000004463Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.00000000009784InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000000001562InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000731InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases0.000000001046Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000004643Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04153Least InformativeInherited
Disease Ontology (DO)immune system disease1Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04039Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.5948Moderately InformativeInherited
Disease Ontology (DO)anemia0.06401InformativeInherited
Disease Ontology (DO)malignant glioma0.7824InformativeInherited
Disease Ontology (DO)congenital hemolytic anemia0.00002256Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Mitochondrial inheritance0.00003707Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9617Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5527Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis0.0005909Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2274Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6093Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.02845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2656Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6028Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.2359InformativeInherited
Mammalian Phenotype (MP)abnormal redox activity0.000000005071Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid hormone level0.03377Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.2565Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.003898Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1848Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.000000000001724Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.8243Moderately InformativeInherited
Worm Phenotype (WP)metal response variant0.003525InformativeInherited
Worm Phenotype (WP)pericellular component morphology variant0.005734InformativeInherited
Worm Phenotype (WP)cell stress response variant0.0186InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.00001598Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.00005977Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.4857Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.01283Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.02919Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.1565Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.002616Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2141Moderately InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.006214InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.007075InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.007535InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.1533InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.3059InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.00367Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000006127Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0002126Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0009113Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001676Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006756Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02101Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05805Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09794Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1697Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6217Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.1444InformativeInherited
Plant ANatomical entity (PAN)phloem0.0005449Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.00000000003888Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.9673InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)NADH dehydrogenase0.0000000000001527Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000002483Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.000001781Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000007616Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00001196Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002912Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0004422Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donors0.1252Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)glutathione0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.004543Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response0.00000003172InformativeDirect
Biological processSensory transduction0.03477InformativeInherited
Biological processFatty acid metabolism0.5101InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis0.00000000001391Highly InformativeDirect
Biological processPhenylalanine catabolism0.0000000000545Highly InformativeDirect
Biological processTwo-component regulatory system0.0000000005198Highly InformativeDirect
Biological processUnfolded protein response0.00000001306Highly InformativeDirect
Biological processSodium transport0.0000000552Highly InformativeDirect
Biological processNitrate assimilation0.00000009386Highly InformativeDirect
Biological processAuxin signaling pathway0.0000002317Highly InformativeDirect
Biological processVision0.00005303Highly InformativeDirect
Biological processAntiport0.0001211Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion9.774e-16Moderately InformativeDirect
Cellular componentPlastid0.000009444Moderately InformativeDirect
Cellular componentCell projection0.9026Moderately InformativeInherited
Cellular componentPeriplasm0.00000000000002883InformativeDirect
Cellular componentChloroplast0.00000001586InformativeDirect
Cellular componentPeroxisome0.000001336InformativeDirect
Cellular componentCilium0.0001607InformativeDirect
Cellular componentSarcoplasmic reticulum0.0000000000008566Highly InformativeDirect
Cellular componentLipid droplet0.00001127Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.00008068Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide6.217e-16Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding0.0000016InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular function2Fe-2S0InformativeDirect
Molecular functionIron-sulfur0.0000000000008902InformativeDirect
Molecular functionSodium0.0002632InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.0000000001607Moderately InformativeDirect
Post-translational modificationIon channel0.0000194InformativeDirect
Post-translational modificationAntioxidant0Highly InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.00000000000001054Highly InformativeDirect
Post-translational modificationEye lens protein0.00000004833Highly InformativeDirect
Post-translational modificationMuscle protein0.00000697Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000432Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.1852Least InformativeInherited
UniPathway (UP)lipid metabolism0.794Least InformativeInherited
UniPathway (UP)aromatic compound metabolism0.9782Least InformativeInherited
UniPathway (UP)amino-acid degradation0.00000000321Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0000009303Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0001107Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.02199Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.485Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0.004944InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)methylamine degradation0.00000000000002128Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.00000000001071Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]