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Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,253) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 134,938 617,273 301
Proteins 122,565 580,796 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)biological regulation0.64651Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.000050890.001233Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.1635Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.2188Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process10.8892Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)peptide metabolic process0.00031110Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.00000012980.00000009077Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.000000000023420.0000000000001294Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.41940.01058Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.99911Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.00045731Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.9261Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00063760.8909Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.35190.0000000000009139Moderately InformativeInherited
Biological Process (BP)regulation of localization0.033871Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00052270.05511Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.7271Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.82891Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.9941Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.67730.7368Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.025120Moderately InformativeInherited
Biological Process (BP)gene expression0.57271Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.19951Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.98381Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.95841Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00032890InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)regulation of peptide transport0.000022590.1241InformativeInherited
Biological Process (BP)fatty acid metabolic process0.011040.04565InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.019540.04378InformativeInherited
Biological Process (BP)regulation of cellular localization0.000082370.06733InformativeInherited
Biological Process (BP)regulation of protein localization0.000440.9275InformativeInherited
Biological Process (BP)mitochondrion organization0.094610.067InformativeInherited
Biological Process (BP)cellular protein complex assembly0.020350.0000007747InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)electron transport chain0.10070.04314InformativeInherited
Biological Process (BP)cellular respiration0.48040.3942InformativeInherited
Biological Process (BP)ATP metabolic process0.46420.7426InformativeInherited
Biological Process (BP)mitochondrial electron transport, NADH to ubiquinone0.00044590.000002757Highly InformativeDirect
Biological Process (BP)protein folding0.0000075450Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid biosynthetic process0.000000003110.0000005287Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.000000014710.000000000156Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.0000000056180Highly InformativeDirect
Biological Process (BP)mitochondrial respiratory chain complex assembly0.0000074110.00008413Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.0000001430.0007152Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.000030220.00000000000004411Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport0.0000000000080080.000009041Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000000072960.0006723Highly InformativeDirect
Biological Process (BP)mitochondrial respiratory chain complex I biogenesis0.00000046440.0001949Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus0.0000066370.000003753Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.00000010120.00000001294Highly InformativeDirect
Biological Process (BP)regulation of protein import0.00000000034930.0000005038Highly InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000085450Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000048380InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.11730InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on hydrogen as donor0.00098280.00007821Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.07820.6517Highly InformativeInherited
Molecular Function (MF)peroxidase activity0.0036680.01223Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000011180.0008923Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00044470Least InformativeDirect
Cellular Component (CC)protein complex11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)membrane protein complex0.51611Moderately InformativeInherited
Cellular Component (CC)mitochondrial protein complex0.0033860.001222Moderately InformativeInherited
Cellular Component (CC)mitochondrial envelope0.67690.5274Moderately InformativeInherited
Cellular Component (CC)organelle inner membrane0.077810.03101Moderately InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain0.00013930.00003368InformativeDirect
Cellular Component (CC)oxidoreductase complex0.0000000013380.0000000000005142InformativeDirect
Cellular Component (CC)plastid0.21040.00000000001094InformativeInherited
Cellular Component (CC)respiratory chain complex0.0076270.003882InformativeInherited
Cellular Component (CC)inner mitochondrial membrane protein complex0.0016030.0003164InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain complex I0.00000048610.000000001085Highly InformativeDirect
Cellular Component (CC)ferredoxin hydrogenase complex0.000019980.0000003894Highly InformativeDirect
Cellular Component (CC)chloroplast stroma0.000055570.00000008725Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2188 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1635 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001233 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8892 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000009077 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000009139 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0002269 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000000001294 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8909 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.05511 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7368 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.01058 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.0000007747 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.147 Informative Inherited
Biological Process (BP) regulation of ion transport 0.7129 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.006945 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1241 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2437 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of system process 0.7903 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.04565 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.04378 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.226 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.06733 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.7729 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9481 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.63 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9275 Informative Inherited
Biological Process (BP) mitochondrion organization 0.067 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.3911 Informative Inherited
Biological Process (BP) negative regulation of transport 0.706 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.9507 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.8137 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.2239 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) electron transport chain 0.04314 Informative Inherited
Biological Process (BP) cellular respiration 0.3942 Informative Inherited
Biological Process (BP) ATP metabolic process 0.7426 Informative Inherited
Biological Process (BP) mitochondrial electron transport, NADH to ubiquinone 0.000002757 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.0000005287 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000000000156 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00000000000001079 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0004635 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.00008413 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0007152 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0007218 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000003505 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.00000000000004411 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0.000009041 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0006723 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex I biogenesis 0.0001949 Highly Informative Direct
Biological Process (BP) detoxification 0 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.000003753 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000001294 Highly Informative Direct
Biological Process (BP) regulation of protein import 0.0000005038 Highly Informative Direct
Biological Process (BP) protein maturation 0.1748 Highly Informative Inherited
Biological Process (BP) response to arsenic-containing substance 0.001683 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.4005 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.01119 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.6708 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.04008 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.347 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.8389 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.8193 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 1 Highly Informative Inherited
Biological Process (BP) negative regulation of ion transmembrane transport 0.001867 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1299 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.4943 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.001317 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 1 Highly Informative Inherited
Biological Process (BP) protein secretion 0.4778 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2054 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.2884 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.6891 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.2999 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.1307 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.4294 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.4663 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.5876 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 0.08579 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01493 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.0217 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.1653 Highly Informative Inherited
Biological Process (BP) response to heat 1 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) amide binding 0.0000000003991 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00000000000004592 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.7204 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on hydrogen as donor 0.00007821 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00000000001002 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.6517 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 1 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.024 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 0.01223 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0008923 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.001222 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.5274 Moderately Informative Inherited
Cellular Component (CC) organelle inner membrane 0.03101 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.1029 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain 0.00003368 Informative Direct
Cellular Component (CC) plastid 0.00000000001094 Informative Direct
Cellular Component (CC) extracellular organelle 0.00009501 Informative Direct
Cellular Component (CC) inner mitochondrial membrane protein complex 0.0003164 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.0000000000005142 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.8342 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001075 Informative Inherited
Cellular Component (CC) respiratory chain complex 0.003882 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0.000000001085 Highly Informative Direct
Cellular Component (CC) ferredoxin hydrogenase complex 0.0000003894 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.00000008725 Highly Informative Direct
Cellular Component (CC) thylakoid 0.000000006178 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.0000003971 Highly Informative Direct
Cellular Component (CC) dendrite 0.8193 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.5367 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000000004463Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.00000000009784InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000000001562InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000731InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases0.000000001046Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000004643Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.006389Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response0.00000005444InformativeDirect
Biological processSensory transduction0.03637InformativeInherited
Biological processFatty acid metabolism0.4139InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis0.000000000027Highly InformativeDirect
Biological processPhenylalanine catabolism0.00000000005517Highly InformativeDirect
Biological processTwo-component regulatory system0.0000000005647Highly InformativeDirect
Biological processUnfolded protein response0.00000001315Highly InformativeDirect
Biological processSodium transport0.00000006402Highly InformativeDirect
Biological processNitrate assimilation0.0000001226Highly InformativeDirect
Biological processAuxin signaling pathway0.000000267Highly InformativeDirect
Biological processVision0.00005335Highly InformativeDirect
Biological processAntiport0.0002007Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0.000000000000001952Moderately InformativeDirect
Cellular componentPlastid0.000002542Moderately InformativeDirect
Cellular componentCell projection1Moderately InformativeInherited
Cellular componentPeriplasm0.0000000000000364InformativeDirect
Cellular componentChloroplast0.000000002695InformativeDirect
Cellular componentPeroxisome0.000001686InformativeDirect
Cellular componentCilium0.0002671InformativeDirect
Cellular componentSarcoplasmic reticulum0.000000000001418Highly InformativeDirect
Cellular componentLipid droplet0.00001151Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.00006766Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding0.00000166InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron-sulfur0.000000000001239Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionSodium0.0003799InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.00000000007476Moderately InformativeDirect
Post-translational modificationIon channel0.00002146InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.00000000000001417Highly InformativeDirect
Post-translational modificationMuscle protein0.000007754Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]