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Thioredoxin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thioredoxin fold [ 52832] (2)
Superfamily:   Thioredoxin-like [ 52833] (23)
Families:   Thioltransferase [ 52834] (15)
  PDI-like [ 52849] (2)
  Calsequestrin [ 52855]
  DsbA-like [ 100953] (3)
  Glutathione S-transferase (GST), N-terminal domain [ 52862] (18)
  Phosducin [ 52888]
  ERP29 N domain-like [ 52892] (2)
  spliceosomal protein U5-15Kd [ 52895]
  SH3BGR (SH3-binding, glutamic acid-rich protein-like) [ 102446]
  KaiB-like [ 102449] (2)
  DsbC/DsbG C-terminal domain-like [ 52898] (2)
  Glutathione peroxidase-like [ 52901] (28)
  Thioredoxin-like 2Fe-2S ferredoxin [ 52918]
  ArsC-like [ 69518] (3)
  Txnl5-like [ 110612]
  YuzD-like [ 117605]
  YKR049C-like [ 142395]
  Atu2684-like [ 142398]
  HyaE-like [ 142401]
  NQO2-like [ 142405]
  Mitochondrial ribosomal protein L51/S25/CI-B8 domain [ 142408]
  Selenoprotein W-related [ 142411] (3)
  UAS domain [ 159589]


Superfamily statistics
Genomes (3,253) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 134,938 617,273 301
Proteins 122,565 580,796 292


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000023860.0001186Least InformativeDirect
Biological Process (BP)biological regulation0.6041Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.1477Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.2394Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process10.8686Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)peptide metabolic process0.00028520Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.00000036490.0000005561Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.000000000014130.0000000000001043Moderately InformativeDirect
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.00035861Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.83381Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00046190.8065Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.33980.0000000000006724Moderately InformativeInherited
Biological Process (BP)regulation of localization0.029751Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.00092430.07801Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.77481Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.024550Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.59891Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.97321Moderately InformativeInherited
Biological Process (BP)gene expression0.63061Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.19551Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.97611Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process0.9491Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00032550InformativeDirect
Biological Process (BP)response to oxidative stress00InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process0.000000024790.00000003814InformativeDirect
Biological Process (BP)regulation of peptide transport0.000020110.1237InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0083690.04617InformativeInherited
Biological Process (BP)regulation of cellular localization0.000076750.05345InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.000015420.4731InformativeInherited
Biological Process (BP)fatty acid metabolic process0.004480.04662InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)electron transport chain0.098420.04478InformativeInherited
Biological Process (BP)cellular respiration0.47310.4015InformativeInherited
Biological Process (BP)ATP metabolic process0.45390.7493InformativeInherited
Biological Process (BP)mitochondrial electron transport, NADH to ubiquinone0.00044520.000002913Highly InformativeDirect
Biological Process (BP)protein folding0.000010680Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid biosynthetic process0.00000000031090.0000005509Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process0.0000000018040.0000000001809Highly InformativeDirect
Biological Process (BP)glutathione metabolic process0.0000000058140Highly InformativeDirect
Biological Process (BP)regulation of protein import into nucleus0.0000000000005930.0000007446Highly InformativeDirect
Biological Process (BP)hydrogen peroxide metabolic process0.000030460.00000000000004787Highly InformativeDirect
Biological Process (BP)regulation of binding0.0000000077550.0005324Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process0.00000001280.00000001355Highly InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000070350Moderately InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity0.0000000000046520InformativeDirect
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.10810InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on a sulfur group of donors00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on hydrogen as donor0.00091830.00008167Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.031850.6316Highly InformativeInherited
Molecular Function (MF)peroxidase activity0.0038360.01213Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000022910.0009753Least InformativeDirect
Cellular Component (CC)macromolecular complex11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0017750Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane protein complex0.90451Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.37230.0005525Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.025650.004609Moderately InformativeInherited
Cellular Component (CC)oxidoreductase complex0.00000018970.00000000002252InformativeDirect
Cellular Component (CC)respiratory chain complex0.088380.02948InformativeInherited
Cellular Component (CC)plastid0.18990.000000000009308InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain0.0036080.0003565InformativeInherited
Cellular Component (CC)inner mitochondrial membrane protein complex0.037470.004425InformativeInherited
Cellular Component (CC)mitochondrial respiratory chain complex I0.000016870.00000001116Highly InformativeDirect
Cellular Component (CC)ferredoxin hydrogenase complex0.000018680.0000004149Highly InformativeDirect
Cellular Component (CC)chloroplast stroma0.000054950.00000007271Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0001186 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.2394 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1477 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8686 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000005561 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000006724 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0003037 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000000001043 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8065 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.05113 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9284 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07801 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to oxidative stress 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00004714 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.00000003814 Informative Direct
Biological Process (BP) negative regulation of transport 0.66 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.1237 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.007624 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.9413 Informative Inherited
Biological Process (BP) cell activation 0.9832 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.4024 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.2105 Informative Inherited
Biological Process (BP) regulation of system process 0.7367 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6961 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) response to metal ion 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.04617 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.2331 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.9289 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.05345 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) secretion by cell 0.7885 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5918 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.4731 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.8144 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.1375 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.1425 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.04662 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) electron transport chain 0.04478 Informative Inherited
Biological Process (BP) cellular respiration 0.4015 Informative Inherited
Biological Process (BP) ATP metabolic process 0.7493 Informative Inherited
Biological Process (BP) mitochondrion organization 0.4656 Informative Inherited
Biological Process (BP) mitochondrial electron transport, NADH to ubiquinone 0.000002913 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.0000005509 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0000000001809 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0000000000000109 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0005027 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0.0001839 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0006019 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000000007778 Highly Informative Direct
Biological Process (BP) regulation of protein import into nucleus 0.0000007446 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.00000000000004787 Highly Informative Direct
Biological Process (BP) regulation of binding 0.0005324 Highly Informative Direct
Biological Process (BP) detoxification 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.00000001355 Highly Informative Direct
Biological Process (BP) negative regulation of ion transmembrane transport 0.001734 Highly Informative Inherited
Biological Process (BP) protein maturation 0.1894 Highly Informative Inherited
Biological Process (BP) hemostasis 0.5275 Highly Informative Inherited
Biological Process (BP) biological adhesion 1 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.5074 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.371 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.66 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.03582 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.7993 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.7975 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.1685 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.1377 Highly Informative Inherited
Biological Process (BP) regulation of calcium-mediated signaling 0.008197 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.126 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.1843 Highly Informative Inherited
Biological Process (BP) protein secretion 0.4553 Highly Informative Inherited
Biological Process (BP) signal release 0.4397 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6769 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.3339 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.1966 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.3461 Highly Informative Inherited
Biological Process (BP) macromolecule glycosylation 0.4416 Highly Informative Inherited
Biological Process (BP) divalent metal ion transport 0.7069 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.02091 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01349 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.7273 Highly Informative Inherited
Biological Process (BP) response to heat 0.9848 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) amide binding 0.0000000002739 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000000000002024 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.7015 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 1 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on hydrogen as donor 0.00008167 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00000000000572 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.6316 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 1 Highly Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.02435 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) peroxidase activity 0.01213 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009753 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0005525 Moderately Informative Direct
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.004609 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 0.0779 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain 0.0003565 Informative Direct
Cellular Component (CC) plastid 0.000000000009308 Informative Direct
Cellular Component (CC) extracellular organelle 0.0001084 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00000000002252 Informative Direct
Cellular Component (CC) respiratory chain complex 0.02948 Informative Inherited
Cellular Component (CC) microbody 0.04402 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.001145 Informative Inherited
Cellular Component (CC) inner mitochondrial membrane protein complex 0.004425 Informative Inherited
Cellular Component (CC) mitochondrial respiratory chain complex I 0.00000001116 Highly Informative Direct
Cellular Component (CC) ferredoxin hydrogenase complex 0.0000004149 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.00000007271 Highly Informative Direct
Cellular Component (CC) thylakoid 0.000000006027 Highly Informative Direct
Cellular Component (CC) sarcoplasm 0.000001452 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 0.000105 Highly Informative Direct
Cellular Component (CC) peroxisomal part 0.3082 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000000004463Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH0.7939Moderately InformativeInherited
Enzyme Commission (EC)Peroxidases0InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.00000000009784InformativeDirect
Enzyme Commission (EC)With other acceptors0.0000000001562InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000731InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002113InformativeDirect
Enzyme Commission (EC)Protein-disulfide reductase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione transferase0Highly InformativeDirect
Enzyme Commission (EC)Other oxidoreductases0.000000001046Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.000004643Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.03812Least InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04103Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4649Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.5967Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.7806InformativeInherited
Disease Ontology (DO)congenital hemolytic anemia0.00002783Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Mitochondrial inheritance0.00003943Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0.9624Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5304Moderately InformativeInherited
Phenotypic Abnormality (PA)Hepatic necrosis0.0006448Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2258Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6228Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.03348Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.3384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.5975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.2383InformativeInherited
Mammalian Phenotype (MP)abnormal redox activity0.000000005329Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid hormone level0.03356Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.2581Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0004942Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.1184Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0000000003609Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.6982Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.0008474InformativeDirect
Worm Phenotype (WP)metal response variant0.002928InformativeInherited
Worm Phenotype (WP)cell stress response variant0.02354InformativeInherited
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.00004799Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.9043Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.01441Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.03334Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.1536Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.002791Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2249Moderately InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.006176InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.007017InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.007568InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.1753InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.3754InformativeInherited
Xenopus ANatomical entity (XAN)pronephric tubule0.004343Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000006127Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.0002126Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0009113Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.001676Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.006756Least InformativeInherited
Plant ANatomical entity (PAN)flower0.02101Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.05805Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.09794Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.1697Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.6217Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.1444InformativeInherited
Plant ANatomical entity (PAN)phloem0.0005449Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0.00000000004061Moderately InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.9942InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)NADH dehydrogenase0.0000000000001556Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000001242Highly InformativeDirect
Enzyme Commission (EC)NADH:ubiquinone reductase (H(+)-translocating)0.000001765Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0.00000934Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0.0002932Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0008705Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donors0.1306Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processDifferentiation0.006212Moderately InformativeInherited
Biological processIon transport1Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processStress response0.00000004865InformativeDirect
Biological processSensory transduction0.03551InformativeInherited
Biological processFatty acid metabolism0.5127InformativeInherited
Biological processDetoxification0Highly InformativeDirect
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processSpermatogenesis0.00000000002751Highly InformativeDirect
Biological processPhenylalanine catabolism0.00000000005542Highly InformativeDirect
Biological processTwo-component regulatory system0.0000000005346Highly InformativeDirect
Biological processUnfolded protein response0.00000001322Highly InformativeDirect
Biological processSodium transport0.00000006438Highly InformativeDirect
Biological processNitrate assimilation0.0000001188Highly InformativeDirect
Biological processAuxin signaling pathway0.0000002451Highly InformativeDirect
Biological processVision0.00005427Highly InformativeDirect
Biological processAntiport0.00016Highly InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentMitochondrion0.000000000000001947Moderately InformativeDirect
Cellular componentPlastid0.000002577Moderately InformativeDirect
Cellular componentCell projection1Moderately InformativeInherited
Cellular componentPeriplasm0.00000000000003846InformativeDirect
Cellular componentChloroplast0.000000002541InformativeDirect
Cellular componentPeroxisome0.000001707InformativeDirect
Cellular componentCilium0.0002529InformativeDirect
Cellular componentSarcoplasmic reticulum0.000000000001452Highly InformativeDirect
Cellular componentLipid droplet0.00001165Highly InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DiseaseAllergen0.00006315Moderately InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainTransit peptide0Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
DomainSH3-binding0.000001665InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron-sulfur0.000000000001251Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionSodium0.0002998InformativeDirect
Molecular functionChloride channel0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.0000000001407Moderately InformativeDirect
Post-translational modificationIon channel0.00002129InformativeDirect
Post-translational modificationPeroxidase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.00000000000001373Highly InformativeDirect
Post-translational modificationMuscle protein0.000007509Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000000004323Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.4544Least InformativeInherited
UniPathway (UP)lipid metabolism0.7785Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation0.00000002422Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0.0002795Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.04145Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis0.4412Moderately InformativeInherited
UniPathway (UP)protein glycosylation0.00002968InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.009889InformativeInherited
UniPathway (UP)L-phenylalanine degradation0Highly InformativeDirect
UniPathway (UP)methylamine degradation0.0000000000000598Highly InformativeDirect
UniPathway (UP)prostaglandin biosynthesis0.00000000002519Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR012336 SSF52833 Protein matches
Abstract

Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2), where a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system, the NADP/thioredoxin system, and the glutathione/glutaredoxin system [PubMed15862094]. Several of these disulphide proteins share a common structure, consisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin, thioltransferase, phosducin, glutathione peroxidase-like enzymes, arsenate reductase, disulphide bond isomerase DsbC (C-terminal domain), disulphide bond facilitator DsbA (contains an alpha-helical insertion), glutathione S-transferase (N-terminal domain), Endoplasmic reticulum protein ERP29 (N-terminal domain), spliceosomal protein U5-15Kd, circadian oscillation regulator KaiB, protein disulphide isomerase PDI (contains two tandem repeats of this fold), and calsequestrin (contains three tandem repeats of this fold).

This entry differs from the thioredoxin fold protein, the classification of this fold is in the glutathione S-transferase enzymes, where this entry defines two regions containing this fold, and the thioredoxin fold protein defines only the N-terminal as containing this fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioredoxin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 171 hidden Markov models representing the Thioredoxin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]