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TK C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TK C-terminal domain-like [ 52921]
Superfamily:   TK C-terminal domain-like [ 52922] (3)
Families:   Transketolase C-terminal domain-like [ 52923] (2)
  Branched-chain alpha-keto acid dehydrogenase beta-subunit, C-terminal-domain [ 52926] (4)
  Pyruvate-ferredoxin oxidoreductase, PFOR, domain II [ 52931]


Superfamily statistics
Genomes (3,211) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 16,969 97,481 18
Proteins 16,962 97,451 18


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000001768 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.05895 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.000000739 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000001408 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001123 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.001524 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6733 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9501 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.05693 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.772 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.005409 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0006133 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.9366 Informative Inherited
Biological Process (BP) cellular respiration 0.857 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.6766 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.001962 Informative Inherited
Biological Process (BP) citrate metabolic process 0.000000005018 Highly Informative Direct
Biological Process (BP) NADP metabolic process 0.0000003098 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0005229 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.00002467 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.03686 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.7337 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.09325 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0.0002144 Informative Direct
Molecular Function (MF) sulfur compound binding 0.00004742 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.000002147 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000566 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01594 Least Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.0000001982 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.01644 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.2898 Moderately Informative Inherited
Cellular Component (CC) plastid 0.0007183 Informative Direct
Cellular Component (CC) oxidoreductase complex 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.3443Least InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processNitrogen fixation0.00005678InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0.000001302Highly InformativeDirect
DomainTransit peptide0.00000006238Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionPyruvate0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationOxidoreductase0.000000002587Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009014 SSF52922 Protein matches
Abstract

Transketolase C-terminal-like domains [PubMed8176731] can be found in a number of different enzymes, including the C-terminal domain of the pyruvate dehydrogenase E1 component [PubMed11955070], the C-terminal domain of branched-chain alpha-keto acid dehydrogenases [PubMed10426958], and domain II of pyruvate-ferredoxin oxidoreductase (PFOR) [PubMed11752578]. Structural studies reveal this domain to comprise of three layers alpha/beta/alpha. The mixed beta sheet consists of five strands in the order 13245, where strand 1 is antiparallel to the others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TK C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the TK C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]