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Class II aaRS ABD-related superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Anticodon-binding domain-like [ 52953] (6)
Superfamily:   Class II aaRS ABD-related [ 52954] (2)
Families:   Anticodon-binding domain of Class II aaRS [ 52955] (6)
  Brix domain [ 142420]


Superfamily statistics
Genomes (3,250) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 15,652 76,905 19
Proteins 15,637 76,836 19


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000008422 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000003225 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000002161 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4335 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.002827 Least Informative Inherited
Biological Process (BP) amide biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8636 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.001636 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.3221 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2462 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 0.000000000005436 Informative Direct
Biological Process (BP) ribosome biogenesis 0.00000000233 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000005277 Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.00001941 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2194 Informative Inherited
Biological Process (BP) epithelium development 0.7491 Informative Inherited
Biological Process (BP) circulatory system development 0.2339 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4902 Informative Inherited
Biological Process (BP) organelle assembly 0.01215 Informative Inherited
Biological Process (BP) ribosome assembly 0.000006409 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0002027 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.1603 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.04602 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000001615 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.02419 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.04385 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.0000000004667 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0.000000005947 Informative Direct
Cellular Component (CC) intracellular organelle part 0.5445 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02427 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.65 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.001394 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00007451 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0003874 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Proline--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Histidine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationAminoacyl-tRNA synthetase0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004154 SSF52954 Protein matches
Abstract tRNA synthetases, or tRNA ligases are involved in protein synthesis. This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases [PubMed10447505] it is probably the anticodon binding domain [PubMed9115984].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class II aaRS ABD-related domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Class II aaRS ABD-related superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]