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Class II aaRS ABD-related superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Anticodon-binding domain-like [ 52953] (6)
Superfamily:   Class II aaRS ABD-related [ 52954] (2)
Families:   Anticodon-binding domain of Class II aaRS [ 52955] (6)
  Brix domain [ 142420]


Superfamily statistics
Genomes (3,250) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,652 100,980 19
Proteins 15,637 100,901 19


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Threonine--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Proline--tRNA ligase0Highly InformativeDirect
Enzyme Commission (EC)Histidine--tRNA ligase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0008845Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.001716Least InformativeInherited
Worm Phenotype (WP)cell development variant0.003996Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.006485Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.0182Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.04933Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00002611Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.000087Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0002468Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.002215Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.07503Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.3028Moderately InformativeInherited
Worm Phenotype (WP)oxygen response variant0.000000002032InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.00000002837InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.0000005332InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000008207InformativeDirect
Worm Phenotype (WP)transgene expression increased0.00001957InformativeDirect
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.07722InformativeInherited
Worm Phenotype (WP)hypoxia resistant0.0000000000001389Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic processing body variant0.00003442Highly InformativeDirect
Worm Phenotype (WP)cell differentiation variant0.00005181Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.03835Moderately InformativeInherited
Yeast Phenotype (YP)colony sectoring0.0004619Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0000006424InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compounds0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR004154 SSF52954 Protein matches
Abstract tRNA synthetases, or tRNA ligases are involved in protein synthesis. This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases [PubMed10447505] it is probably the anticodon binding domain [PubMed9115984].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Class II aaRS ABD-related domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Class II aaRS ABD-related superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]