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Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 127,215 862,680 220
Proteins 73,626 521,206 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.001079Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.004171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.005308Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.03735Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.05003Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.06149Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.09165Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.008429Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.06425Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.08069Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.133Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.1357Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3647Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7756Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04601InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.05431InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1026InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.1492InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.2102InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.3354InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.9048InformativeInherited
Phenotypic Abnormality (PA)Transient ischemic attack0.0001898Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal gastrointestinal motility0.00682Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.1447Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.1574Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5571Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6707Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05635Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.000003369Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00005181Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00007329Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002925Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004353Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0004372Least InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000003786Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000004445Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0338Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.05516Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.09835Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1842Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.000006598InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00001135InformativeDirect
Worm Phenotype (WP)reduced brood size0.00005147InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00005702InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.004839InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01245InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.07476InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.1285InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.2342InformativeInherited
Worm Phenotype (WP)egg laying variant0.5687InformativeInherited
Worm Phenotype (WP)dead eggs laid0.00001755Highly InformativeDirect
Worm Phenotype (WP)mitochondria alignment variant0.00003993Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0001493Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.007729Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.003206Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.09715Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1448Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.008389Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.08287Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.291Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002426InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0007146InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0274InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001648InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004191InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006318InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001085InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.00002618InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationHydrolase0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]