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Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,261) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 126,559 674,084 220
Proteins 73,216 406,766 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity0.086530Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00068630Moderately InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.000055530InformativeDirect
Molecular Function (MF)kinase activity0.0002290InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000001905 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000000004251 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000000000001079 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0001748 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9443 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1083 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.921 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9231 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.1039 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5834 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.00185 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.1248 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8142 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9952 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.289 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0.00005945 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.00008949 Informative Direct
Biological Process (BP) protein localization to organelle 0.0001722 Informative Direct
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.88 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5965 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.00752 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) phosphorylation 0.6897 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.07258 Informative Inherited
Biological Process (BP) response to metal ion 0.05865 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.7982 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) protein transport 0.3564 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.4879 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.9597 Informative Inherited
Biological Process (BP) supramolecular fiber organization 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.7781 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.003774 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.004542 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.3327 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.6241 Informative Inherited
Biological Process (BP) ATP metabolic process 0.6762 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.1115 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) intracellular transport 0.8918 Informative Inherited
Biological Process (BP) chromosome organization 0.1093 Informative Inherited
Biological Process (BP) RNA modification 0.2463 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.6234 Informative Inherited
Biological Process (BP) ncRNA processing 0.682 Informative Inherited
Biological Process (BP) polyol metabolic process 0 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 0.000000000000009084 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 0.000000000000009084 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.0000000000004962 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.0000000001859 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.0000001593 Highly Informative Direct
Biological Process (BP) regulation of protein polymerization 0.000001301 Highly Informative Direct
Biological Process (BP) protein targeting 0.0001337 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0001774 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0003874 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0004301 Highly Informative Direct
Biological Process (BP) fermentation 0.0006303 Highly Informative Direct
Biological Process (BP) regulation of mitotic nuclear division 0.00571 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.6137 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.003205 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6552 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.5669 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 0.6238 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.303 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.08142 Highly Informative Inherited
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.02414 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02953 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.008521 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0.01341 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.04133 Highly Informative Inherited
Biological Process (BP) regulation of actin polymerization or depolymerization 0.8275 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.6052 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.6268 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.8359 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.9634 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.006748 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.002601 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.002327 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.3723 Highly Informative Inherited
Biological Process (BP) histone modification 0.6602 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to endoplasmic reticulum 0.001342 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.3022 Highly Informative Inherited
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.06971 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.0109 Highly Informative Inherited
Biological Process (BP) response to fungus 0.3167 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.000000000000006264 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.02063 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.6345 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.001397 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.3211 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000000008622 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00000001003 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000002539 Informative Direct
Molecular Function (MF) ATPase activity 0.02848 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.935 Informative Inherited
Molecular Function (MF) racemase and epimerase activity 0.01207 Informative Inherited
Molecular Function (MF) ATP binding 0.00000000000008414 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.0003391 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.001384 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0003344 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) extracellular region part 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.7669 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) secretory granule 1 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.00196 Informative Inherited
Cellular Component (CC) transporter complex 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) microbody 0.9119 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.02454 Informative Inherited
Cellular Component (CC) lamellipodium 0 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 0.00000000001681 Highly Informative Direct
Cellular Component (CC) EKC/KEOPS complex 0.0000000002155 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0.00009694 Highly Informative Direct
Cellular Component (CC) blood microparticle 0.000323 Highly Informative Direct
Cellular Component (CC) spindle 0.9387 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.02764 Highly Informative Inherited
Cellular Component (CC) chromatin 0.05438 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processStress response0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.0001885InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0.00002653InformativeDirect
Post-translational modificationActin-binding0.0000923InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00001315Least InformativeDirect
Post-translational modificationOxidation0InformativeDirect
Post-translational modificationNitration0.0000000003141InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]