SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (3,263) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 127,215 0 220
Proteins 73,626 0 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0000002262Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.0009698Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.003785Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.02956Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.03534Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.0464Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.05759Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.08887Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.008717Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.06138Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.07957Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.1207Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.1268Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.8932Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.04458InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.05294InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.1014InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.2097InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.8984InformativeInherited
Phenotypic Abnormality (PA)Transient ischemic attack0.0001673Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.1327Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.1442Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.152Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.5569Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6707Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.05634Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.000003241Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.00004621Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00006953Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002789Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000379Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004064Least InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00000003467Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000004176Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.03427Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.06031Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.09975Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1843Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.000006619InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00001139InformativeDirect
Worm Phenotype (WP)reduced brood size0.00005113InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00005523InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00466InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01231InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.07289InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.1306InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.2357InformativeInherited
Worm Phenotype (WP)egg laying variant0.5648InformativeInherited
Worm Phenotype (WP)dead eggs laid0.0000164Highly InformativeDirect
Worm Phenotype (WP)mitochondria alignment variant0.00003849Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0001464Highly InformativeDirect
Worm Phenotype (WP)body wall muscle thick filament variant0.007406Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.003155Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.09399Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1436Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.008268Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.08272Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2917Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0002386InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0007134InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02563InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.00001648InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00004191InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000006318InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage0.00001085InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.00002585InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane0.0003203InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationAllosteric enzyme0.000002597InformativeDirect
Post-translational modificationChromatin regulator0.00002955InformativeDirect
Post-translational modificationActin-binding0.00009686InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0001137Least InformativeDirect
Post-translational modificationOxidation0InformativeDirect
Post-translational modificationNitration0.00000003602InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]