SUPERFAMILY 1.75 HMM library and genome assignments server


Actin-like ATPase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   Actin-like ATPase domain [ 53067] (14)
Families:   Actin/HSP70 [ 53068] (7)
  BadF/BadG/BcrA/BcrD-like [ 64089] (5)
  Acetokinase-like [ 53080] (3)
  ATPase domain of dehydratase reactivase alpha subunit [ 82440] (2)
  Hexokinase [ 53083] (3)
  Glycerol kinase [ 53089]
  Glucokinase [ 110627]
  Ppx/GppA phosphatase [ 110630]
  YeaZ-like [ 110633] (2)
  ROK [ 110636] (8)
  Cyto-EpsL domain [ 117644]
  Ta0583-like [ 142481]
  CoaX-like [ 142484]
  Fumble-like [ 159623] (3)


Superfamily statistics
Genomes (2,490) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 101,976 289,856 220
Proteins 58,654 175,185 111


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.54260.08084Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.69741Least InformativeInherited
Biological Process (BP)single-organism cellular process0.65911Least InformativeInherited
Biological Process (BP)developmental process0.55041Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.20560.0006008Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00031470Moderately InformativeDirect
Biological Process (BP)cell differentiation0.06961Moderately InformativeInherited
Biological Process (BP)organelle organization0.010731.402e-13Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.56861Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.13490.7787Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.35276.22e-05Moderately InformativeInherited
Biological Process (BP)muscle structure development0.00046460.03569InformativeInherited
Biological Process (BP)actin filament-based process0.0027846.533e-10InformativeInherited
Biological Process (BP)cytoskeleton organization0.220.004139InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.005360.5052InformativeInherited
Biological Process (BP)cellular component morphogenesis0.010720.002683InformativeInherited
Biological Process (BP)hexose metabolic process2.162e-061InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0029378.66e-09InformativeInherited
Biological Process (BP)actomyosin structure organization2.687e-060.0002541Highly InformativeDirect
Biological Process (BP)glycolysis2.752e-064.55e-11Highly InformativeDirect
Biological Process (BP)protein folding5.335e-060Highly InformativeDirect
Biological Process (BP)cellular component assembly involved in morphogenesis4.002e-051.292e-05Highly InformativeDirect
Molecular Function (MF)binding0.013030.9564Least InformativeInherited
Molecular Function (MF)transferase activity0.0013840Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups9.744e-050Moderately InformativeDirect
Molecular Function (MF)protein binding7.659e-050.03243Moderately InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor2.725e-080.0001689InformativeDirect
Molecular Function (MF)kinase activity2.826e-070InformativeDirect
Molecular Function (MF)carbohydrate kinase activity1.034e-100Highly InformativeDirect
Molecular Function (MF)unfolded protein binding3.823e-050Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.0060630Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0050557.925e-12Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00057692.687e-11Moderately InformativeDirect
Cellular Component (CC)vesicle0.15050.03668Moderately InformativeInherited
Cellular Component (CC)extracellular region0.4520.06621Moderately InformativeInherited
Cellular Component (CC)cell cortex3.98e-073.509e-10InformativeDirect
Cellular Component (CC)contractile fiber part0.00015952.117e-05InformativeDirect
Cellular Component (CC)extracellular membrane-bounded organelle2.586e-070Highly InformativeDirect
Cellular Component (CC)membrane raft6.564e-070.0001146Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton9.487e-069.065e-09Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0006008 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.08084 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1.402e-13 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 6.22e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 6.263e-10 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0001231 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001645 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.9341 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.02212 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2344 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2438 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3998 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.03916 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7787 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3864 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.5414 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.001189 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.8409 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1893 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 6.533e-10 Informative Direct
Biological Process (BP) carbohydrate catabolic process 8.66e-09 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 2.659e-05 Informative Direct
Biological Process (BP) purine nucleoside metabolic process 1.567e-08 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 7.28e-08 Informative Direct
Biological Process (BP) positive regulation of transport 0.5591 Informative Inherited
Biological Process (BP) regulation of secretion 0.5325 Informative Inherited
Biological Process (BP) protein localization to organelle 0.004161 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.2392 Informative Inherited
Biological Process (BP) transmembrane transport 0.02962 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.5109 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) locomotion 0.9957 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.198 Informative Inherited
Biological Process (BP) muscle structure development 0.03569 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2487 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.01696 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.03678 Informative Inherited
Biological Process (BP) growth 0.2211 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6954 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.2226 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.6066 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.2882 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9404 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9507 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5052 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.002683 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.004139 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.08904 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.4291 Informative Inherited
Biological Process (BP) chromosome organization 0.3046 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.1134 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.1434 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.07292 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.001306 Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.0972 Informative Inherited
Biological Process (BP) protein transport 0.0248 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.5767 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.004528 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.05994 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.01541 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.0351 Informative Inherited
Biological Process (BP) hexose metabolic process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.009102 Informative Inherited
Biological Process (BP) actomyosin structure organization 0.0002541 Highly Informative Direct
Biological Process (BP) glycolysis 4.55e-11 Highly Informative Direct
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 1.292e-05 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 7.964e-09 Highly Informative Direct
Biological Process (BP) cell division 3.273e-07 Highly Informative Direct
Biological Process (BP) polyol metabolic process 4.475e-07 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 7.617e-07 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 9.119e-07 Highly Informative Direct
Biological Process (BP) purine nucleoside bisphosphate biosynthetic process 2.258e-06 Highly Informative Direct
Biological Process (BP) ribonucleoside bisphosphate biosynthetic process 2.258e-06 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 4.492e-06 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 4.538e-06 Highly Informative Direct
Biological Process (BP) response to cadmium ion 5.304e-06 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 1.111e-05 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 1.573e-05 Highly Informative Direct
Biological Process (BP) protein complex localization 2.345e-05 Highly Informative Direct
Biological Process (BP) carbohydrate transport 6.287e-05 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0002053 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.0003035 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0003308 Highly Informative Direct
Biological Process (BP) regulation of insulin secretion 0.0003804 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0004599 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.000464 Highly Informative Direct
Biological Process (BP) meiosis 0.0007479 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 0.02795 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 0.06238 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1555 Highly Informative Inherited
Biological Process (BP) cardiocyte differentiation 0.01878 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism 0.01153 Highly Informative Inherited
Biological Process (BP) organelle localization 0.006367 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.2381 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01105 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.0206 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.01185 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.01649 Highly Informative Inherited
Biological Process (BP) regulation of cellular component size 0.0314 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.8925 Highly Informative Inherited
Biological Process (BP) histone modification 0.1069 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.02236 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.01438 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.8545 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.0925 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.9564 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 0.03243 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.02702 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001689 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 7.117e-06 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.2887 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.889 Informative Inherited
Molecular Function (MF) carbohydrate kinase activity 0 Highly Informative Direct
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Molecular Function (MF) ATP binding 2.573e-13 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 7.269e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 7.925e-12 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0.1805 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2115 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 2.687e-11 Moderately Informative Direct
Cellular Component (CC) cytosol 1.378e-09 Moderately Informative Direct
Cellular Component (CC) extracellular region 0.06621 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.03668 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.1214 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.6574 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.7512 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2713 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cell cortex 3.509e-10 Informative Direct
Cellular Component (CC) contractile fiber part 2.117e-05 Informative Direct
Cellular Component (CC) actin cytoskeleton 1.118e-12 Informative Direct
Cellular Component (CC) cell surface 0.0002148 Informative Direct
Cellular Component (CC) integral to membrane 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.001404 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8452 Informative Inherited
Cellular Component (CC) extracellular membrane-bounded organelle 0 Highly Informative Direct
Cellular Component (CC) membrane raft 0.0001146 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 9.065e-09 Highly Informative Direct
Cellular Component (CC) actin filament 0 Highly Informative Direct
Cellular Component (CC) Arp2/3 protein complex 1.554e-10 Highly Informative Direct
Cellular Component (CC) cell wall 4.679e-06 Highly Informative Direct
Cellular Component (CC) chromatin 4.739e-06 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 8.611e-06 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 1.035e-05 Highly Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0001349 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.001621 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides2.262e-07Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect
Enzyme Commission (EC)Glucokinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cognitive disorder0.07893Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.1405Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.15Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.08708Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2398Moderately InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.4572Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the systemic arterial tree0.0209InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.05754InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.004376Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cranial sutures0.00845Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01925Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3818Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5409Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid level0.0575Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.7011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fatty acid level0.0003543InformativeDirect
Mammalian Phenotype (MP)neurofibrillary tangles1.152e-07Highly InformativeDirect
Mammalian Phenotype (MP)tau protein deposits2.71e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant1.016e-05Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant2.324e-05Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.1135Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant4.551e-09Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect2.562e-05Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0005372Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.418Moderately InformativeInherited
Worm Phenotype (WP)brood size variant3.722e-05InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0002352InformativeDirect
Worm Phenotype (WP)cell division variant0.004155InformativeInherited
Worm Phenotype (WP)body wall muscle morphology variant0.005805InformativeInherited
Worm Phenotype (WP)metal response variant0.005973InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.01516InformativeInherited
Worm Phenotype (WP)egg laying variant0.3424InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased6.163e-05Highly InformativeDirect
Worm Phenotype (WP)body wall muscle myosin organization defective0.0001294Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)vegetative growth0.3834InformativeInherited

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk musculature0.0009022Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell3.459e-07Least InformativeDirect
Plant ANatomical entity (PAN)guard cell4.492e-09Moderately InformativeDirect
Plant ANatomical entity (PAN)fruit1.606e-05InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage4.374e-07InformativeDirect
Plant structure DEvelopment stage (PDE)seedling development stage1.193e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides9.199e-08InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processStress response0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Biological processRhamnose metabolism0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMitochondrion1Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentMitochondrion outer membrane4.059e-05InformativeDirect
Cellular componentChromosome0.1361InformativeInherited
Cellular componentTelomere2.308e-11Highly InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionActin-binding0.0006053InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationChromatin regulator2.582e-06InformativeDirect
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation1.716e-05Moderately InformativeDirect
Post-translational modificationOxidation0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism1.982e-10Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.9025Least InformativeInherited
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation4.458e-07Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0001176Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.906Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)glycerol metabolism0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis1InformativeInherited
UniPathway (UP)L-rhamnose metabolism0Highly InformativeDirect
UniPathway (UP)L-arabinose degradation via L-ribulose0Highly InformativeDirect
UniPathway (UP)coenzyme A biosynthesis0Highly InformativeDirect
UniPathway (UP)acetyl-CoA biosynthesis0Highly InformativeDirect
UniPathway (UP)peptidoglycan recycling0Highly InformativeDirect
UniPathway (UP)glycerol degradation via glycerol kinase pathway0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)amino-sugar biosynthesis2.916e-07Highly InformativeDirect
UniPathway (UP)butanoate metabolism6.712e-07Highly InformativeDirect
UniPathway (UP)L-threonine degradation2.705e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Actin-like ATPase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the Actin-like ATPase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]