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DNA repair protein MutS, domain II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Ribonuclease H-like motif [ 53066] (7)
Superfamily:   DNA repair protein MutS, domain II [ 53150]
Families:   DNA repair protein MutS, domain II [ 53151]


Superfamily statistics
Genomes (2,559) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,467 16,369 8
Proteins 3,465 16,366 8


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000000009815 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000008373 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00003906 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0007065 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0001988 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000006856 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.04211 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.000005398 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002487 Informative Direct
Biological Process (BP) chromosome organization 0.07373 Informative Inherited
Biological Process (BP) nuclear division 0.00000001045 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000005068 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.00001429 Highly Informative Direct
Molecular Function (MF) binding 0.0001478 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.01272 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00001912 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000437 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.001314 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.005693 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.01046 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.000001034 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000004875 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000005589 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000002166 Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.0001865 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000002788 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.008807 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.04175 Least Informative Inherited
Cellular Component (CC) protein complex 0.001058 Least Informative Inherited
Cellular Component (CC) nuclear part 0.00004811 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA repair0.0000000584InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007860 SSF53150 Protein matches
Abstract This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with several other domains, , , and . The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [PubMed8036718]. This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [PubMed11048710], and has similarity to RNAse-H-like domains (see ).

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]