SUPERFAMILY 1.75 HMM library and genome assignments server

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Purine and uridine phosphorylases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Purine and uridine phosphorylases [ 53167]
Families:   Purine and uridine phosphorylases [ 53168] (6)


Superfamily statistics
Genomes (3,108) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,965 55,490 35
Proteins 10,925 55,372 35


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00000016830.0001755Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000012470.0009925Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0000001810.0001446Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000014430.0005879Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.063480.1301Least InformativeInherited
Biological Process (BP)primary metabolic process0.0043370.3056Least InformativeInherited
Biological Process (BP)single-organism cellular process0.019821Least InformativeInherited
Biological Process (BP)biosynthetic process0.056590.03593Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.000036460.007427Least InformativeInherited
Biological Process (BP)single-organism catabolic process0.00025540.0001741Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process0.000023860.00000161Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.00000092950.0000004948Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0063890.005251Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.061640.009952Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0014070.002598Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.020190.0009679Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.0047280.000108Moderately InformativeInherited
Biological Process (BP)aspartate family amino acid metabolic process0.0000000041320.000000002725InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.0000007820.0000000995InformativeDirect
Biological Process (BP)cellular metabolic compound salvage00InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.00011830.000002306InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0000000000025940.000000000005196InformativeDirect
Biological Process (BP)alpha-amino acid biosynthetic process0.00000007160.0000002027InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00InformativeDirect
Biological Process (BP)nucleoside catabolic process0.00000000000010850Highly InformativeDirect
Biological Process (BP)L-methionine salvage0.000000000000059280Highly InformativeDirect
Biological Process (BP)purine-containing compound catabolic process0.0000040450.000004003Highly InformativeDirect
Biological Process (BP)pyrimidine-containing compound catabolic process0.0000058810.0000008794Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000001170.000002789Least InformativeDirect
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.0000001060.00000145InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing N-glycosyl compounds0.0000000000015190.0000000000002416Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001755 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.0009925 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0001446 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0005879 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.1301 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.03593 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.3056 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.007427 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0009679 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000108 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0001741 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00000161 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000004948 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.005251 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.009952 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002598 Moderately Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.000000002725 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.0000000995 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000002306 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.000000000005196 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000002027 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0 Informative Direct
Biological Process (BP) nucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) L-methionine salvage 0 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.000004003 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound catabolic process 0.0000008794 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000002789 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0.00000145 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing N-glycosyl compounds 0.0000000000002416 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydrolyzing N-glycosyl compounds0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0.000007702Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase2.221e-16Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Purine and uridine phosphorylases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Purine and uridine phosphorylases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]