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Zn-dependent exopeptidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Zn-dependent exopeptidases [ 53187] (9)
Families:   Pancreatic carboxypeptidases [ 53188] (4)
  Carboxypeptidase T [ 53198]
  Leucine aminopeptidase, C-terminal domain [ 53201]
  Bacterial dinuclear zinc exopeptidases [ 53204] (17)
  FolH catalytic domain-like [ 53210] (2)
  N-acetylmuramoyl-L-alanine amidase-like [ 102517] (2)
  AstE/AspA-like [ 142526] (2)
  Glutaminyl-peptide cyclotransferase-like [ 142532]
  FGase-like [ 159652] (2)


Superfamily statistics
Genomes (3,247) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,057 268,937 71
Proteins 47,413 267,315 71


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.28180.00000005898Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.070610Least InformativeInherited
Biological Process (BP)primary metabolic process0.87290.246Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.74591Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular protein modification process0.076630.45Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.017920.003234Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.012020InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.0044270.0001682InformativeInherited
Biological Process (BP)arginine metabolic process0.000012260.000000000003954Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000018210Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000000023440InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.0066090.00004045InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.00014070.5719InformativeInherited
Molecular Function (MF)metallopeptidase activity0.000054420Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00035330Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000005898 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.246 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.000005268 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.8701 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7092 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) defense response 0.5888 Moderately Informative Inherited
Biological Process (BP) immune system process 0.93 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.2987 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.361 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7912 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8599 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.45 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.439 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6489 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.003234 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.05789 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.0001682 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.02206 Informative Inherited
Biological Process (BP) immune effector process 0.0128 Informative Inherited
Biological Process (BP) defense response to other organism 0.1202 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.02224 Informative Inherited
Biological Process (BP) regulation of immune response 0.02958 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6824 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8506 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.002003 Informative Inherited
Biological Process (BP) protein transport 0.05158 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.146 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8613 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.925 Informative Inherited
Biological Process (BP) metal ion transport 0.03777 Informative Inherited
Biological Process (BP) regulation of ion transport 0.08102 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.7831 Informative Inherited
Biological Process (BP) cation homeostasis 0.05127 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.05668 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.001341 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.03098 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1824 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) arginine metabolic process 0.000000000003954 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000003299 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000000007012 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0000001678 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000037 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000001839 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000003194 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.000003585 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.000008087 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00006335 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.00006984 Highly Informative Direct
Biological Process (BP) protein maturation 0.0001117 Highly Informative Direct
Biological Process (BP) response to virus 0.0004162 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.0009801 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.001905 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.001306 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.02798 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.006186 Highly Informative Inherited
Biological Process (BP) nervous system process 0.6698 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.001841 Highly Informative Inherited
Biological Process (BP) forebrain development 0.05948 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.2489 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01019 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1634 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00000008932 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0004436 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00004045 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0.003785 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.001281 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.03228 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.5719 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.000000000003669 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0000000001372 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.000000009748 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.00000004339 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0.00001142 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.000763 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01054 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.00000002199 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000007271 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000002793 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7963 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000009269 Informative Direct
Cellular Component (CC) extracellular organelle 0.0003146 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.05239 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.08523 Informative Inherited
Cellular Component (CC) cilium 0.1349 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.8412 Informative Inherited
Cellular Component (CC) lytic vacuole 0.1725 Informative Inherited
Cellular Component (CC) midbody 0.00001115 Highly Informative Direct
Cellular Component (CC) outer membrane-bounded periplasmic space 0.0005136 Highly Informative Direct
Cellular Component (CC) spindle 0.01118 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.1334 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0006016InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processVirulence0.00000000000004467Moderately InformativeDirect
Biological processCell wall biogenesis/degradation0.00001158InformativeDirect
Biological processEndocytosis0.0004819InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0.000002249Highly InformativeDirect
Biological processNotch signaling pathway0.000003771Highly InformativeDirect
Cellular componentCytoplasm0.00000009922Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000003705InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000097Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn-dependent exopeptidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Zn-dependent exopeptidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]