SUPERFAMILY 1.75 HMM library and genome assignments server

Zn-dependent exopeptidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Zn-dependent exopeptidases [ 53187] (9)
Families:   Pancreatic carboxypeptidases [ 53188] (4)
  Carboxypeptidase T [ 53198]
  Leucine aminopeptidase, C-terminal domain [ 53201]
  Bacterial dinuclear zinc exopeptidases [ 53204] (17)
  FolH catalytic domain-like [ 53210] (2)
  N-acetylmuramoyl-L-alanine amidase-like [ 102517] (2)
  AstE/AspA-like [ 142526] (2)
  Glutaminyl-peptide cyclotransferase-like [ 142532]
  FGase-like [ 159652] (2)


Superfamily statistics
Genomes (3,239) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,651 245,511 71
Proteins 47,036 244,982 71


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.066350Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.85681Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.52981Least InformativeInherited
Biological Process (BP)single-organism cellular process0.94041Least InformativeInherited
Biological Process (BP)cellular protein modification process0.040850.3414Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.013641Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0043880InformativeInherited
Molecular Function (MF)hydrolase activity0.000002630Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.00000000010880.00000000000008561InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.0014560.000001653InformativeInherited
Molecular Function (MF)peptidase activity0.090970InformativeInherited
Molecular Function (MF)transferase activity, transferring amino-acyl groups0.000000019690Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00024530Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.00172 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.8729 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3414 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6086 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.03741 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0001301 Informative Direct
Biological Process (BP) protein maturation 0.0001598 Informative Direct
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.005612 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.008335 Informative Inherited
Biological Process (BP) growth 0.969 Informative Inherited
Biological Process (BP) synaptic transmission 0.6779 Informative Inherited
Biological Process (BP) leukocyte activation 0.4166 Informative Inherited
Biological Process (BP) cell proliferation 0.8494 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 0.8695 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.5957 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.307 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1504 Informative Inherited
Biological Process (BP) sensory organ development 0.6481 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) post-translational protein modification 0.000000005586 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0009415 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.001006 Highly Informative Inherited
Biological Process (BP) wound healing 0.4316 Highly Informative Inherited
Biological Process (BP) developmental growth 0.519 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.00374 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.01036 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.03474 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.02764 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0.001123 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00000000000008561 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000001653 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0000602 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000823 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) metallopeptidase activity 0.00000000000001506 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.0000000003458 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2514 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000000156 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000007194 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01079 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.9745 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000001837 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.00003098 Informative Direct
Cellular Component (CC) endosome 0.5384 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.09446 Informative Inherited
Cellular Component (CC) lytic vacuole 0.08538 Informative Inherited
Cellular Component (CC) midbody 0.00004444 Highly Informative Direct
Cellular Component (CC) spindle 0.02719 Highly Informative Inherited
Cellular Component (CC) ciliary part 0.002702 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.08521 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0006016InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0004204Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)blood and blood forming organs0.03578Least InformativeInherited
Drugbank ATC_code (DB)iron preparations0.0002808InformativeDirect
Drugbank ATC_code (DB)ferrous aspartate0.00001327Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processVirulence9.345e-16InformativeDirect
Biological processCell wall biogenesis/degradation0.00003016InformativeDirect
Biological processEndocytosis0.0003736InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processNotch signaling pathway0.000003783Highly InformativeDirect
Biological processPurine metabolism0.0001178Highly InformativeDirect
Cellular componentCytoplasm0.00000003564Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000005642InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0002446Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0001099Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)ureide metabolism0.004898InformativeInherited
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0.0009151Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn-dependent exopeptidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Zn-dependent exopeptidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]