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Zn-dependent exopeptidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Zn-dependent exopeptidases [ 53187] (9)
Families:   Pancreatic carboxypeptidases [ 53188] (4)
  Carboxypeptidase T [ 53198]
  Leucine aminopeptidase, C-terminal domain [ 53201]
  Bacterial dinuclear zinc exopeptidases [ 53204] (17)
  FolH catalytic domain-like [ 53210] (2)
  N-acetylmuramoyl-L-alanine amidase-like [ 102517] (2)
  AstE/AspA-like [ 142526] (2)
  Glutaminyl-peptide cyclotransferase-like [ 142532]
  FGase-like [ 159652] (2)


Superfamily statistics
Genomes (3,244) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,789 245,511 71
Proteins 47,167 244,982 71


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.054490Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.27260.00000006663Least InformativeInherited
Biological Process (BP)primary metabolic process0.87460.2595Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.70991Least InformativeInherited
Biological Process (BP)single-organism cellular process0.99371Least InformativeInherited
Biological Process (BP)cellular protein modification process0.064480.241Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.016140.002868Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.011260InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.0045120.0001631InformativeInherited
Biological Process (BP)arginine metabolic process0.000011270.000000000003993Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000010080Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.0000000026370InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.0055110.00002948InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.00011590.6474InformativeInherited
Molecular Function (MF)metallopeptidase activity0.000056860.000000000000002458Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00036850Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000006663 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2595 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.00002106 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.85 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6179 Moderately Informative Inherited
Biological Process (BP) immune system process 0.8811 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5963 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.2903 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.395 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8133 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.8493 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9958 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.241 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.9783 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6352 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.05818 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.002868 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.0001631 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.07825 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.02089 Informative Inherited
Biological Process (BP) ion homeostasis 0.07471 Informative Inherited
Biological Process (BP) immune effector process 0.01046 Informative Inherited
Biological Process (BP) defense response to other organism 0.1044 Informative Inherited
Biological Process (BP) system process 0.9987 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.01849 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6319 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7983 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8097 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1286 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.8687 Informative Inherited
Biological Process (BP) metal ion transport 0.03637 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.00165 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.001411 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.0304 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.01885 Informative Inherited
Biological Process (BP) sensory organ development 0.6493 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) arginine metabolic process 0.000000000003993 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.000000004273 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000000006077 Highly Informative Direct
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.000000006323 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.00000001004 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0000001412 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0000003122 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000001298 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000003479 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.000006512 Highly Informative Direct
Biological Process (BP) protein maturation 0.00003032 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00005233 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.00006479 Highly Informative Direct
Biological Process (BP) response to virus 0.0003725 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.001727 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.02683 Highly Informative Inherited
Biological Process (BP) neurological system process 0.6035 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.006572 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.01057 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.001218 Highly Informative Inherited
Biological Process (BP) brain development 0.6232 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1331 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00000005514 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0003746 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00002948 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0008483 Informative Direct
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0.05349 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.6474 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02542 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0.000000000000002458 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.000000000004168 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00000000009777 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.00000001006 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.00000004373 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0.00001093 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.0006469 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01092 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00000001168 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000003014 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7187 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000004799 Informative Direct
Cellular Component (CC) extracellular organelle 0.0003641 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.04565 Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.0775 Informative Inherited
Cellular Component (CC) cilium 0.1219 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.7947 Informative Inherited
Cellular Component (CC) lytic vacuole 0.2035 Informative Inherited
Cellular Component (CC) midbody 0.0000104 Highly Informative Direct
Cellular Component (CC) outer membrane-bounded periplasmic space 0.0005495 Highly Informative Direct
Cellular Component (CC) spindle 0.01016 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.1273 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0006016InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2599Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.4839Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.0397InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited
Enzyme Commission (EC)In linear amidines1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processVirulence0.00000000000002823Moderately InformativeDirect
Biological processCell wall biogenesis/degradation0.00001176InformativeDirect
Biological processEndocytosis0.0004916InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0.000002295Highly InformativeDirect
Biological processNotch signaling pathway0.000003843Highly InformativeDirect
Cellular componentCytoplasm0.0000001258Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000001105InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.00006145Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0001072Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)ureide metabolism0.005414InformativeInherited
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0.0009212Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn-dependent exopeptidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Zn-dependent exopeptidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]