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Zn-dependent exopeptidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphorylase/hydrolase-like [ 53162] (8)
Superfamily:   Zn-dependent exopeptidases [ 53187] (9)
Families:   Pancreatic carboxypeptidases [ 53188] (4)
  Carboxypeptidase T [ 53198]
  Leucine aminopeptidase, C-terminal domain [ 53201]
  Bacterial dinuclear zinc exopeptidases [ 53204] (17)
  FolH catalytic domain-like [ 53210] (2)
  N-acetylmuramoyl-L-alanine amidase-like [ 102517] (2)
  AstE/AspA-like [ 142526] (2)
  Glutaminyl-peptide cyclotransferase-like [ 142532]
  FGase-like [ 159652] (2)


Superfamily statistics
Genomes (3,240) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,576 245,511 71
Proteins 46,976 244,982 71


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)primary metabolic process0.86120.526Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.26540.00000002739Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.24230.3831Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.68991Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)organic substance catabolic process0.019560.5955Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.058690.2464Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.015930.001317Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.000061430.0000001562InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.010760InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.0046890.00005428InformativeInherited
Biological Process (BP)arginine metabolic process0.000012470.000000000002599Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000098580Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds0.000000002210InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.005310.000007834InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.00011680.6353InformativeInherited
Molecular Function (MF)metallopeptidase activity0.000056560Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00037740Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000002739 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.526 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3831 Least Informative Inherited
Biological Process (BP) cellular catabolic process 0.000002401 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.8009 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7186 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5955 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.008194 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7562 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7922 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2464 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.08027 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.001317 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5516 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.0000001562 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00005428 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.00005492 Informative Direct
Biological Process (BP) regulation of ion transport 0.1455 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01515 Informative Inherited
Biological Process (BP) ion homeostasis 0.05156 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.05751 Informative Inherited
Biological Process (BP) defense response to other organism 0.08076 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7108 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8631 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.001537 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.8067 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1687 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) central nervous system development 0.8529 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.1395 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.01084 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.05165 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.1296 Informative Inherited
Biological Process (BP) regulation of immune response 0.0872 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) metal ion transport 0.03678 Informative Inherited
Biological Process (BP) arginine metabolic process 0.000000000002599 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.000000005187 Highly Informative Direct
Biological Process (BP) transition metal ion transport 0.0000001172 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000031 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.000001156 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0.000001694 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000002664 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.00000279 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0.000003192 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.000006711 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0000475 Highly Informative Direct
Biological Process (BP) protein maturation 0.00005179 Highly Informative Direct
Biological Process (BP) positive regulation of lymphocyte activation 0.0000592 Highly Informative Direct
Biological Process (BP) response to virus 0.0002556 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.001276 Highly Informative Inherited
Biological Process (BP) positive regulation of cell adhesion 0.001153 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.02015 Highly Informative Inherited
Biological Process (BP) brain development 0.6103 Highly Informative Inherited
Biological Process (BP) endocytosis 0.004123 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.008708 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.1247 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.005059 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0001655 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.000009627 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000007834 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0008012 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.05282 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02285 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.6353 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.000000000004851 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.00000000009466 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.00000002853 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0.000003135 Highly Informative Direct
Molecular Function (MF) deacetylase activity 0.001923 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3351 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0000000078 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000002946 Moderately Informative Direct
Cellular Component (CC) vacuole 0.0000008356 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.8138 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.03106 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.000004039 Informative Direct
Cellular Component (CC) extracellular organelle 0.0003843 Informative Direct
Cellular Component (CC) endosome 1 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.09108 Informative Inherited
Cellular Component (CC) cilium 0.09725 Informative Inherited
Cellular Component (CC) cell projection part 0.7546 Informative Inherited
Cellular Component (CC) lytic vacuole 0.1657 Informative Inherited
Cellular Component (CC) midbody 0.00005695 Highly Informative Direct
Cellular Component (CC) spindle 0.009674 Highly Informative Inherited
Cellular Component (CC) periplasmic space 0.001577 Highly Informative Inherited
Cellular Component (CC) centrosome 0.02338 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)In linear amides0Moderately InformativeDirect
Enzyme Commission (EC)Aminopeptidases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0006016InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.04906InformativeInherited
Enzyme Commission (EC)Aminopeptidases0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)Dipeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processVirulence0.00000000000002086Moderately InformativeDirect
Biological processCell wall biogenesis/degradation0.00001075InformativeDirect
Biological processEndocytosis0.0004605InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processNotch signaling pathway0.000003794Highly InformativeDirect
Biological processPurine metabolism0.0001348Highly InformativeDirect
Cellular componentCytoplasm0.00000008006Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.000006922InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCobalt0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000185Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.0001086Moderately InformativeDirect
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)ureide metabolism0.005314InformativeInherited
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)(S)-allantoin degradation0.0009243Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Zn-dependent exopeptidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Zn-dependent exopeptidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]