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Aminoacid dehydrogenase-like, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Aminoacid dehydrogenase-like, N-terminal domain [ 53222]
Superfamily:   Aminoacid dehydrogenase-like, N-terminal domain [ 53223] (5)
Families:   Aminoacid dehydrogenases [ 53224] (3)
  Tetrahydrofolate dehydrogenase/cyclohydrolase [ 53235]
  Methylene-tetrahydromethanopterin dehydrogenase [ 82333]
  Shikimate dehydrogenase-like [ 82336] (3)
  Malic enzyme N-domain [ 53240] (2)


Superfamily statistics
Genomes (3,222) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 18,575 100,553 42
Proteins 18,519 100,395 42


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5375 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.7135 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0001886 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.4607 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.8247 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8871 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.8276 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.007724 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3752 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.000000000004727 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000777 Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.3814 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.3023 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0.0000000000006402 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0002644 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000002586 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.000000003847 Highly Informative Direct
Biological Process (BP) dicarboxylic acid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) aging 0.001138 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.05618 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000004823 Moderately Informative Direct
Molecular Function (MF) anion binding 0.139 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.04668 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.8218 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.2975 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0000000000001502 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.0006551 Informative Direct
Molecular Function (MF) coenzyme binding 0.0009825 Informative Direct
Molecular Function (MF) purine nucleotide binding 1 Informative Inherited
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.1074 Informative Inherited
Molecular Function (MF) ligase activity 0.04021 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.0000000001119 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.0000229 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0.000005634 Highly Informative Direct
Molecular Function (MF) NADP binding 0.00000001749 Highly Informative Direct
Molecular Function (MF) NAD binding 0.00004395 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.000008948 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9109 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.06111 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.08885Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.07272Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on phosphates0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)limb0.0008292InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.07044Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.9245Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors0.0000225InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Other carbon--nitrogen ligases1InformativeInherited
Enzyme Commission (EC)Shikimate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processAromatic amino acid biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
DomainTransit peptide0.0002709Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000001313InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)energy metabolism1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.00000000683InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)carbon fixation0.000000001964Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis0.00005486Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aminoacid dehydrogenase-like, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Aminoacid dehydrogenase-like, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]