SUPERFAMILY 1.75 HMM library and genome assignments server

Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,895) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,429 84,926 28
Proteins 22,129 84,605 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00096691Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.31671Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.95971Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.5168Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.94991Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00054390Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.00000000020620.0000000000003598Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000000002490.0002904Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000015080.00000009367Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.93560.4594Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000000014280.1323Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.0000000029390.001539Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0000057250.6817Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.000011790.05152Moderately InformativeInherited
Biological Process (BP)organelle organization0.92721Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process00InformativeDirect
Biological Process (BP)positive regulation of signal transduction00.00000306InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.00000017520.000000001896InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)hexose metabolic process0.00000000012650InformativeDirect
Biological Process (BP)regulation of system process00.0000000001346InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process00.0000000005317InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process00InformativeDirect
Biological Process (BP)glycolysis0.0000000096470Highly InformativeDirect
Biological Process (BP)lysosome organization0.00000052190.000007796Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process00Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000000000038990Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0000000000042460.0000000002877Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0037020.1761Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity0.00000016920.000458InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity0.00000013450.004067InformativeInherited
Molecular Function (MF)GTPase activator activity0.00000031320.00003281Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Cellular Component (CC)membrane0.060421Least InformativeInherited
Cellular Component (CC)organelle membrane0.0000000041290.0006146Moderately InformativeDirect
Cellular Component (CC)vesicle0.0000000000000095510.000000335Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000000000076540.0000586Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5168 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000000003598 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0002904 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000009367 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0009845 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.8576 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.4594 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1323 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.001539 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.05152 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6817 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.4585 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00000306 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000001896 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) regulation of system process 0.0000000001346 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000001531 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.0000000005317 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.02997 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.005159 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.7272 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0005742 Highly Informative Direct
Biological Process (BP) glycolysis 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000007796 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0006329 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000000000147 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0.0000000000001581 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.001441 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000002877 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001513 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.1761 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000458 Informative Direct
Molecular Function (MF) kinase activity 0.000126 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.004067 Informative Inherited
Molecular Function (MF) GTPase activator activity 0.00003281 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0.000000000000009712 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4971 Least Informative Inherited
Cellular Component (CC) cytosol 0.0004212 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0006146 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000000335 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000586 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.0002122 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.3591Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.001441InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.000001744Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000002178Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.01214Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.06641InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Cellular componentMitochondrion0.006779Moderately InformativeInherited
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentLysosome0.0000000974InformativeDirect
DomainSignal0.00000002069Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.5817Moderately InformativeInherited
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)opine metabolism0.00000009114Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]