SUPERFAMILY 1.75 HMM library and genome assignments server


Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,893) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,334 84,926 28
Proteins 22,034 84,605 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.00067461Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.27291Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.95591Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.6893Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.94551Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process2.3e-104.774e-10Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process1.499e-105.888e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process8.685e-074.319e-06Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.0012510Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process1.107e-080.09872Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus3.014e-090.001012Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process4.489e-060.955Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction1.149e-050.0385Moderately InformativeInherited
Biological Process (BP)organelle organization0.9181Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process00InformativeDirect
Biological Process (BP)positive regulation of signal transduction01.857e-06InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.00016060.0006019InformativeDirect
Biological Process (BP)carbohydrate catabolic process1.567e-071.167e-09InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)hexose metabolic process1.103e-100InformativeDirect
Biological Process (BP)regulation of system process06.048e-11InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process03.189e-10InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process00InformativeDirect
Biological Process (BP)glycolysis9.864e-090Highly InformativeDirect
Biological Process (BP)lysosome organization4.953e-076.941e-06Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process00Highly InformativeDirect
Molecular Function (MF)hydrolase activity1.334e-150Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity2.493e-112.973e-09Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0034370.1585Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity1.428e-070.0003717InformativeDirect
Molecular Function (MF)phosphoric ester hydrolase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity1.245e-070.003515InformativeInherited
Molecular Function (MF)GTPase activator activity3.316e-073.338e-05Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Cellular Component (CC)membrane0.10471Least InformativeInherited
Cellular Component (CC)organelle membrane3.083e-090.0004155Moderately InformativeDirect
Cellular Component (CC)vesicle1.107e-141.932e-07Moderately InformativeDirect
Cellular Component (CC)extracellular region part1.043e-104.683e-05Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6893 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 4.774e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 5.888e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 4.319e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0005925 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.09872 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.001012 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.955 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0385 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.3578 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1.857e-06 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0006019 Informative Direct
Biological Process (BP) carbohydrate catabolic process 1.167e-09 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) regulation of system process 6.048e-11 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 5.397e-09 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 3.189e-10 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.001925 Informative Inherited
Biological Process (BP) glycolysis 0 Highly Informative Direct
Biological Process (BP) lysosome organization 6.941e-06 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0005355 Highly Informative Direct
Biological Process (BP) polyol metabolic process 1.027e-10 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 1.607e-13 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 2.973e-09 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001115 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.1585 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0003717 Informative Direct
Molecular Function (MF) kinase activity 9.033e-05 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.003515 Informative Inherited
Molecular Function (MF) GTPase activator activity 3.338e-05 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 8.96e-15 Highly Informative Direct
Molecular Function (MF) sugar-phosphatase activity 8.96e-15 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7499 Least Informative Inherited
Cellular Component (CC) cytosol 0.000236 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0004155 Moderately Informative Direct
Cellular Component (CC) vesicle 1.932e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 4.683e-05 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.0002072 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.3575Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.001444InformativeInherited
Xenopus ANatomical entity (XAN)animal pole1.544e-06Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases2.253e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.01224Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.06715InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Cellular componentMitochondrion0.006561Moderately InformativeInherited
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentLysosome9.393e-08InformativeDirect
DomainSignal1.898e-08Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)nucleoside biosynthesis5.719e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]