SUPERFAMILY 1.75 HMM library and genome assignments server

Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,895) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,441 84,926 28
Proteins 22,139 84,605 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.29130.0003621Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.99421Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.36831Least InformativeInherited
Biological Process (BP)single-organism cellular process0.97171Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.9861Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.0000000018170.494Least InformativeInherited
Biological Process (BP)regulation of cellular process0.0014711Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.00022390Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.0000000017230.00000000002211Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.00041070.0000008309Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0000000025870.00009147Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000035240.00000000254Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction0.000015570.05533Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.000013470.00411Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0000000030250.07792Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000000012140.2352Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.099330.01375Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.85910.3753Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process00InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000027570.000000000489InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)hexose metabolic process0.0000055130.0000000002106InformativeDirect
Biological Process (BP)regulation of system process00.000000000000003707InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process00.000000002619InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process00InformativeDirect
Biological Process (BP)glycolytic process0.00000000000001550Highly InformativeDirect
Biological Process (BP)lysosome organization0.00000051720.000007736Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of neurological system process00Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process00Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000000000032930Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.0000000000039750.0000000002718Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0016070.06399Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity0.00000019210.000531InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)GTPase activator activity0.0000040140.0008466Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Cellular Component (CC)membrane0.060691Least InformativeInherited
Cellular Component (CC)vesicle0.0000000000000081390.0000001419Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.000000000071030.00002546Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0003621 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.494 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000000002211 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000008309 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00009147 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000000254 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.05533 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.00411 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.07792 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.5165 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2352 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01375 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3753 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.8414 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.001967 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000000489 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) hexose metabolic process 0.0000000002106 Informative Direct
Biological Process (BP) regulation of system process 0.000000000000003707 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.00000001355 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000000002619 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.04851 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.03687 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0002404 Highly Informative Direct
Biological Process (BP) glycolytic process 0 Highly Informative Direct
Biological Process (BP) lysosome organization 0.000007736 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0006279 Highly Informative Direct
Biological Process (BP) regulation of neurological system process 0 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0.000006221 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0.00000000000004226 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.001468 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000002718 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.06399 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.001544 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.000531 Informative Direct
Molecular Function (MF) kinase activity 0.0001256 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) GTPase activator activity 0.0008466 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 0.000000000000009169 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5063 Least Informative Inherited
Cellular Component (CC) cytosol 0.0004592 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000001419 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00002546 Moderately Informative Direct
Cellular Component (CC) extracellular space 0.0005379 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.3591Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.001441InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.000001744Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000002178Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.01214Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.06641InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Cellular componentMitochondrion0.006779Moderately InformativeInherited
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentLysosome0.0000000974InformativeDirect
DomainSignal0.00000002069Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.5817Moderately InformativeInherited
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)opine metabolism0.00000009114Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]