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Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,903) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 22,679 105,770 28
Proteins 22,377 104,882 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process0.00079360.08083Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.21470.1176Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)biological regulation0.0072091Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.024120.5311Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.02270.5897Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.056320.000000000000007296Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.000038910.1537Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.099330.9109Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.00000013590.000000000252Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.000000015820.1179Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.00000011030.0272Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.71490.07192Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.058510.002715Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.12180.594Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0000000031630.1892Moderately InformativeInherited
Biological Process (BP)cell differentiation0.36581Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000040160.03903Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.58980.601Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0000000061090.04489Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.24841Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.0040060.0000002977Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.37650.0001124Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00055640.8979Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.25211Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0016210Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.0010150.000000004369Moderately InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.000000000660InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.000000033890.000004682InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.000000026660.000000000004208InformativeDirect
Biological Process (BP)regulation of system process00.00000000000001422InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process0.0000020590InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00.00000000000001079InformativeDirect
Biological Process (BP)regulation of transferase activity0.6780.549InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.15750.5257InformativeInherited
Biological Process (BP)regulation of phosphorylation0.037420.01743InformativeInherited
Biological Process (BP)cell death0.00026790.09235InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.00022270.005928InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.000013850.02156InformativeInherited
Biological Process (BP)regulation of catabolic process0.0058870.0005319InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.00025870.179InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.17610.4477InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.0035610.00006541InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process11InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.024780.00127InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.013591InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)ATP metabolic process0.0020990.000004921InformativeInherited
Biological Process (BP)glycolytic process0.0000003680.00000000000002102Highly InformativeDirect
Biological Process (BP)protein dephosphorylation0.000015430.00001731Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)cobalamin metabolic process0.000034980.0000001294Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.000000018390.0000009702Highly InformativeDirect
Biological Process (BP)regulation of GTPase activity0.0000000088130.0008696Highly InformativeDirect
Biological Process (BP)regulation of generation of precursor metabolites and energy0.00018230.0000000002068Highly InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of ATP metabolic process0.000087350.000000000008084Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.0068690.04991Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000000000081480.000000003777Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.014650.3475Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity0.00000023980.0006602InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Molecular Function (MF)GTPase regulator activity0.00000000014990.00007881Highly InformativeDirect
Molecular Function (MF)sugar-phosphatase activity0.0000000000048920Highly InformativeDirect
Cellular Component (CC)membrane0.0023651Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.29960.1176Least InformativeInherited
Cellular Component (CC)vesicle0.0000000000000051870.000000000003024Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.0000000000000013480.0000000001506Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle11Moderately InformativeInherited
Cellular Component (CC)whole membrane0.026590.1528Moderately InformativeInherited
Cellular Component (CC)mitochondrial envelope0.001940.01893Moderately InformativeInherited
Cellular Component (CC)outer membrane0.0000078520.00004472InformativeDirect
Cellular Component (CC)extracellular organelle0.00019510.0000001583InformativeDirect
Cellular Component (CC)mitochondrial outer membrane0.00000000068590.0000004855Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000000007296 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.08083 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9109 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1176 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5311 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5897 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1537 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000002977 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000000000252 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000000004369 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0001124 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1179 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1892 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.0272 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.07192 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.002715 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.594 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03903 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.601 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.04489 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8979 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00006541 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0005319 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000004682 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000000004208 Informative Direct
Biological Process (BP) regulation of system process 0.00000000000001422 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000003159 Informative Direct
Biological Process (BP) ATP metabolic process 0.000004921 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.00000000000001079 Informative Direct
Biological Process (BP) regulation of transferase activity 0.549 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5257 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.01743 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cell death 0.09235 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.04926 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.005928 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.02156 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.179 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4477 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.002871 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 1 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.00127 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0002502 Highly Informative Direct
Biological Process (BP) glycolytic process 0.00000000000002102 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.00001731 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) cobalamin metabolic process 0.0000001294 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0000009702 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000000000000007296 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0008696 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.0000000002068 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.0007613 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of ATP metabolic process 0.000000000008084 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.2687 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.002049 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.04991 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000002413 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.000000003777 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1804 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.3475 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.006153 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.06106 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0006602 Informative Direct
Molecular Function (MF) kinase activity 0.00000002395 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001845 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0002386 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00003853 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) ATP binding 0.000000552 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.00000000000006238 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00007881 Highly Informative Direct
Molecular Function (MF) sugar-phosphatase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1176 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000003024 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000000001506 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.1528 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.01893 Moderately Informative Inherited
Cellular Component (CC) outer membrane 0.00004472 Informative Direct
Cellular Component (CC) extracellular organelle 0.0000001583 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0000004855 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processAutophagy0.00004951InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentMitochondrion0.00008267Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentLysosome0.0000005978InformativeDirect
DomainSignal0.00000009718Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0.0009205Moderately InformativeDirect
Post-translational modificationGlycoprotein0.0004317Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]