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Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,900) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 22,576 84,926 28
Proteins 22,274 84,605 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.12940.8855Least InformativeInherited
Biological Process (BP)biological regulation0.0052291Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.28940.1321Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.034670.5001Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.000098360.1564Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.032920.561Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.071040.000000000000007367Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0018010.07987Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.00000013650.0000000004008Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.25031Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.12650.5793Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.0000000080540.0366Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.000000019220.1082Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.00000014080.02171Moderately InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.11650.00215Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0000000025230.1373Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.51880.00006126Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.000000046240.1131Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.59340.5447Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.92081Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.21341Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.0093180.0000001029Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00049520.8779Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0017180Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.84740.0611Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.0034340.000000002362Moderately InformativeInherited
Biological Process (BP)nucleoside diphosphate metabolic process0.0000010380InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000000440.000005849InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.00000036740.000000000001913InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)regulation of system process00.000000000000007367InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process0.0000000014150InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00.00000000000001958InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.000014640.02017InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.16320.8819InformativeInherited
Biological Process (BP)regulation of phosphorylation0.036920.1665InformativeInherited
Biological Process (BP)regulation of transferase activity0.67990.5456InformativeInherited
Biological Process (BP)cell death0.00023470.1011InformativeInherited
Biological Process (BP)phosphorylation11InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.00021630.002413InformativeInherited
Biological Process (BP)regulation of catabolic process0.0061890.0288InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.00041650.1804InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.18420.4504InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.0036390.000007622InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process11InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.024970.001421InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.011591InformativeInherited
Biological Process (BP)ATP metabolic process0.0037410.000003883InformativeInherited
Biological Process (BP)glycolytic process0.0000011180.000000000000007367Highly InformativeDirect
Biological Process (BP)protein dephosphorylation0.000015950.00001777Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)cobalamin metabolic process0.00003590.0000001686Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.000000016280.000004492Highly InformativeDirect
Biological Process (BP)regulation of GTPase activity0.00000001120.0007991Highly InformativeDirect
Biological Process (BP)regulation of generation of precursor metabolites and energy0.00015650.000005362Highly InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process00Highly InformativeDirect
Biological Process (BP)monosaccharide biosynthetic process0.0000049420.000006189Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity0.0069010.05007Highly InformativeInherited
Biological Process (BP)muscle structure development0.00013010.3962Highly InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process11Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity0.000000000099930.00000000469Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.014270.321Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity0.00000025240.0005819InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Molecular Function (MF)GTPase regulator activity0.00000000019940.00006565Highly InformativeDirect
Molecular Function (MF)sugar-phosphatase activity0.0000000000033850Highly InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)membrane0.0030011Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.29540.09428Least InformativeInherited
Cellular Component (CC)vesicle0.0000000000000065060.000000000003Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.0000000000000013540.00000000007115Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle11Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.25450.3309Moderately InformativeInherited
Cellular Component (CC)whole membrane0.029030.152Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.017330.1226Moderately InformativeInherited
Cellular Component (CC)outer membrane0.0000088330.00004642InformativeDirect
Cellular Component (CC)extracellular organelle0.00024440.0000002046InformativeDirect
Cellular Component (CC)mitochondrial outer membrane0.00000000080530.0000004955Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000000007367 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1321 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5001 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1564 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.561 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.8855 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.07987 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000001029 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000004008 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000000002362 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00006126 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.5793 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.0366 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1082 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.02171 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.0611 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.00215 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.1373 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1131 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.5447 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.8779 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.000007622 Informative Direct
Biological Process (BP) nucleoside diphosphate metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.000005849 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000000000001913 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) regulation of system process 0.000000000000007367 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.000003981 Informative Direct
Biological Process (BP) ATP metabolic process 0.000003883 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.00000000000001958 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.02017 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8819 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.1665 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.5456 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) cell death 0.1011 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.05105 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.002413 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.0288 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.1804 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4504 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 1 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.001421 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.003803 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0002384 Highly Informative Direct
Biological Process (BP) glycolytic process 0.000000000000007367 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.00001777 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) cobalamin metabolic process 0.0000001686 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000004492 Highly Informative Direct
Biological Process (BP) polyol metabolic process 0.000000000000007367 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0007991 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.000005362 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000006189 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.00004444 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.002176 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.002023 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0.2405 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.05007 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.3962 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 0.7719 Highly Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000002019 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.00000000469 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.321 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.1752 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01005 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.06155 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0005819 Informative Direct
Molecular Function (MF) kinase activity 0.00000002115 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0002003 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0002579 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000431 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) ATP binding 0.0000006115 Highly Informative Direct
Molecular Function (MF) phosphotransferase activity, phosphate group as acceptor 0.00000000000006442 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00006565 Highly Informative Direct
Molecular Function (MF) sugar-phosphatase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.09428 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000003 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000000007115 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.3309 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.152 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.1226 Moderately Informative Inherited
Cellular Component (CC) outer membrane 0.00004642 Informative Direct
Cellular Component (CC) extracellular organelle 0.0000002046 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0000004955 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.09679Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7274Least InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0001261Highly InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.000426Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0002313Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.01191Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.01594InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processAutophagy0.00005089InformativeDirect
Biological processGluconeogenesis0Highly InformativeDirect
Cellular componentMitochondrion0.00008389Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentLysosome0.000000578InformativeDirect
DomainSignal0.00000007794Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0.000978Moderately InformativeDirect
Post-translational modificationGlycoprotein0.0004082Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.7091Moderately InformativeInherited
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)opine metabolism0.00000009097Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]