SUPERFAMILY 1.75 HMM library and genome assignments server


Phosphoglycerate mutase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate mutase-like [ 53253]
Superfamily:   Phosphoglycerate mutase-like [ 53254] (3)
Families:   Cofactor-dependent phosphoglycerate mutase [ 53255] (3)
  Histidine acid phosphatase [ 53258] (3)
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain [ 53267]


Superfamily statistics
Genomes (2,853) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 21,353 40,938 28
Proteins 21,099 40,688 28


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.0004221Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.26711Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.95791Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.6894Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.94271Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)protein metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)sulfur compound metabolic process1.636e-103.131e-10Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus3.539e-090.0006219Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process6.769e-113.269e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process6.608e-077.282e-06Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.0013370Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process9.12e-090.07542Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.11721Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.3924Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0024330.3091Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.043250.7316Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process3.935e-060.883Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction1.421e-050.02598Moderately InformativeInherited
Biological Process (BP)organelle organization0.90641Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0035930.9321Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process00InformativeDirect
Biological Process (BP)positive regulation of signal transduction09.818e-07InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.00015880.0005664InformativeDirect
Biological Process (BP)carbohydrate catabolic process1.69e-075.02e-10InformativeDirect
Biological Process (BP)dephosphorylation00InformativeDirect
Biological Process (BP)hexose metabolic process1.204e-100InformativeDirect
Biological Process (BP)regulation of system process03.103e-11InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process01.768e-10InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process00InformativeDirect
Biological Process (BP)cell death0.00026670.1391InformativeInherited
Biological Process (BP)regulation of nucleoside metabolic process2.795e-060.0184InformativeInherited
Biological Process (BP)regulation of nucleotide catabolic process0.011850.1051InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity2.524e-050.01861InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process0.95371InformativeInherited
Biological Process (BP)glycolysis9.726e-090Highly InformativeDirect
Biological Process (BP)protein dephosphorylation0.00042890.0006894Highly InformativeDirect
Biological Process (BP)lysosome organization5.413e-077.638e-06Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway00Highly InformativeDirect
Biological Process (BP)thiamine-containing compound metabolic process00Highly InformativeDirect
Biological Process (BP)positive regulation of GTPase activity4.499e-108.505e-05Highly InformativeDirect
Molecular Function (MF)hydrolase activity2.589e-150Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)isomerase activity2.207e-111.634e-09Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity0.0034880.1494Moderately InformativeInherited
Molecular Function (MF)enzyme activator activity1.542e-070.0003313InformativeDirect
Molecular Function (MF)phosphatase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity1.371e-070.003161InformativeInherited
Molecular Function (MF)GTPase activator activity2.939e-073.415e-05Highly InformativeDirect
Molecular Function (MF)intramolecular transferase activity00Highly InformativeDirect
Cellular Component (CC)membrane0.093741Least InformativeInherited
Cellular Component (CC)organelle membrane2.254e-090.0002675Moderately InformativeDirect
Cellular Component (CC)vesicle7.813e-151.806e-07Moderately InformativeDirect
Cellular Component (CC)extracellular region part1.05e-107.949e-05Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6894 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 3.131e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0006219 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 3.269e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 7.282e-06 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0004489 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.07542 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.3924 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3091 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7316 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.883 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.02598 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9321 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.424 Moderately Informative Inherited
Biological Process (BP) vitamin metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 9.818e-07 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0005664 Informative Direct
Biological Process (BP) carbohydrate catabolic process 5.02e-10 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) hexose metabolic process 0 Informative Direct
Biological Process (BP) regulation of system process 3.103e-11 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 3.92e-09 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.768e-10 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cell death 0.1391 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.0184 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 0.1051 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01861 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.001829 Informative Inherited
Biological Process (BP) glycolysis 0 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.0006894 Highly Informative Direct
Biological Process (BP) lysosome organization 7.638e-06 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) polyol metabolic process 1.055e-10 Highly Informative Direct
Biological Process (BP) thiamine-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 8.505e-05 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 1.732e-13 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0008713 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 1.634e-09 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.1494 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0.0003313 Informative Direct
Molecular Function (MF) kinase activity 7.202e-05 Informative Direct
Molecular Function (MF) phosphatase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.003161 Informative Inherited
Molecular Function (MF) GTPase activator activity 3.415e-05 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 1.109e-14 Highly Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6745 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001304 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0002675 Moderately Informative Direct
Cellular Component (CC) vesicle 1.806e-07 Moderately Informative Direct
Cellular Component (CC) extracellular region part 7.949e-05 Moderately Informative Direct
Cellular Component (CC) extracellular space 2.065e-05 Informative Direct
Cellular Component (CC) periplasmic space 2.86e-09 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02118Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.1111InformativeInherited
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Inositol-hexakisphosphate kinase0Highly InformativeDirect
Enzyme Commission (EC)Acid phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases4.26e-07Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.01288Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor0.06897InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Cellular componentMitochondrion0.006157Moderately InformativeInherited
Cellular componentPeriplasm0InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
Cellular componentLysosome9.293e-08InformativeDirect
DomainSignal1.374e-08Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.9317Least InformativeInherited
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)glycolysis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 18 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate mutase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 18 hidden Markov models representing the Phosphoglycerate mutase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]