SUPERFAMILY 1.75 HMM library and genome assignments server


PRTase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PRTase-like [ 53270]
Superfamily:   PRTase-like [ 53271] (2)
Families:   Phosphoribosyltransferases (PRTases) [ 53272] (15)
  Phosphoribosylpyrophosphate synthetase-like [ 53296] (2)


Superfamily statistics
Genomes (3,154) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30,659 160,535 56
Proteins 28,961 155,563 54


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process1.544e-090Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.040120.7764Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.0073971Least InformativeInherited
Biological Process (BP)regulation of cellular process0.33481Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process1.306e-130Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process00Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process3.461e-110Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process9.649e-150Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.0041750.4104Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00044310.07024Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.470.961Moderately InformativeInherited
Biological Process (BP)organic cyclic compound catabolic process0.40751Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.34271Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process2.275e-070.465Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.00028061Moderately InformativeInherited
Biological Process (BP)protein complex assembly1.068e-060.000742InformativeDirect
Biological Process (BP)nucleotide biosynthetic process2.596e-090InformativeDirect
Biological Process (BP)pigment metabolic process09.182e-15InformativeDirect
Biological Process (BP)cellular metabolic compound salvage00InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00074466.572e-14InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00059290InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process00InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.8131InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process7.636e-090.001736InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.69251InformativeInherited
Biological Process (BP)organophosphate catabolic process0.00038650.6545InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.0049960.6023InformativeInherited
Biological Process (BP)glycosyl compound catabolic process0.0021130.1665InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process7.194e-110.05869InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.45171InformativeInherited
Biological Process (BP)nucleobase metabolic process00Highly InformativeDirect
Biological Process (BP)regulation of cellular amine metabolic process00Highly InformativeDirect
Biological Process (BP)pigment biosynthetic process1.585e-147.377e-15Highly InformativeDirect
Biological Process (BP)protein homooligomerization1.925e-112.097e-09Highly InformativeDirect
Biological Process (BP)protein tetramerization2.036e-125.029e-12Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate catabolic process0.00054041Highly InformativeInherited
Biological Process (BP)purine ribonucleotide catabolic process11Highly InformativeInherited
Biological Process (BP)purine ribonucleoside catabolic process11Highly InformativeInherited
Biological Process (BP)guanosine-containing compound metabolic process0.54910.003128Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.078551Least InformativeInherited
Molecular Function (MF)cation binding1.148e-090.03155Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding00InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)protein dimerization activity1.435e-061.296e-09InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.7764 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.4104 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.07024 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.7998 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.961 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.465 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.3041 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.000742 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 9.182e-15 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 6.572e-14 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 1 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.6023 Informative Inherited
Biological Process (BP) glycosyl compound catabolic process 0.1665 Informative Inherited
Biological Process (BP) organophosphate catabolic process 0.6545 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.05869 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.001322 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.001736 Informative Inherited
Biological Process (BP) organ morphogenesis 0.4318 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.2211 Informative Inherited
Biological Process (BP) pyrimidine nucleotide metabolic process 6.904e-06 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 1.298e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 2.766e-07 Highly Informative Direct
Biological Process (BP) external encapsulating structure organization 0.0009535 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 5.259e-08 Highly Informative Direct
Biological Process (BP) pigment biosynthetic process 7.377e-15 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0001253 Highly Informative Direct
Biological Process (BP) protein homooligomerization 2.097e-09 Highly Informative Direct
Biological Process (BP) protein tetramerization 5.029e-12 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 2.659e-08 Highly Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 6.349e-11 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.07554 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 1 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate catabolic process 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 1 Highly Informative Inherited
Biological Process (BP) guanosine-containing compound metabolic process 0.003128 Highly Informative Inherited
Biological Process (BP) response to drug 0.05131 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.004079 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.06156 Highly Informative Inherited
Biological Process (BP) tryptophan metabolic process 0.003395 Highly Informative Inherited
Biological Process (BP) aromatic amino acid family biosynthetic process 0.06173 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.3789 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.03155 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 2.493e-05 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1.734e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 1.296e-09 Informative Direct
Molecular Function (MF) nucleotide binding 0.7639 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 5.743e-07 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 2.952e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.000217 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)bone disease0Moderately InformativeDirect
Disease Ontology (DO)arthritis0InformativeDirect
Disease Ontology (DO)gout0Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01393Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.001416Moderately InformativeInherited
Worm Phenotype (WP)drug resistant5.341e-05InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation1.326e-05Moderately InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processTranscription termination0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainGlutamine amidotransferase1.593e-05Highly InformativeDirect
Molecular functionNucleotide-binding4.299e-14Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)nucleotide biosynthesis1InformativeInherited
UniPathway (UP)5-phospho-alpha-D-ribose 1-diphosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)pyrimidine salvage0Highly InformativeDirect
UniPathway (UP)AMP biosynthesis0Highly InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PRTase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the PRTase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]