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PRTase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PRTase-like [ 53270]
Superfamily:   PRTase-like [ 53271] (2)
Families:   Phosphoribosyltransferases (PRTases) [ 53272] (15)
  Phosphoribosylpyrophosphate synthetase-like [ 53296] (2)


Superfamily statistics
Genomes (3,156) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 30,680 160,535 56
Proteins 28,977 155,563 54


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.000000000000019850Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process00.0158Least InformativeInherited
Biological Process (BP)biological regulation0.51251Least InformativeInherited
Biological Process (BP)single-organism cellular process0.000030950.09886Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.1081Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.00005950.00000000002719Moderately InformativeDirect
Biological Process (BP)ribose phosphate metabolic process0.0000000021680Moderately InformativeDirect
Biological Process (BP)nucleobase-containing compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.0000000018190Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative biosynthetic process0.00000000000014660Moderately InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.23310.6551Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.000092180.09317Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.00049730.207Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.60171Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0063481Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00017460.8751Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.00027811Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process0.00000091460.9041Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.23460.9573Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.000000010670.00000000000002413InformativeDirect
Biological Process (BP)pigment metabolic process0.0000000000000015570.0000000000001586InformativeDirect
Biological Process (BP)cellular metabolic compound salvage00InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00032510.0000000000001298InformativeDirect
Biological Process (BP)organophosphate catabolic process0.000000041830.00003143InformativeDirect
Biological Process (BP)protein oligomerization0.0000000075790.000482InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound metabolic process0.00000000086170InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000002590.0007115InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process00InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.10120.3539InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.00001180.1812InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.020420.08337InformativeInherited
Biological Process (BP)nucleobase metabolic process00Highly InformativeDirect
Biological Process (BP)ribonucleoside catabolic process0.00010190.0002477Highly InformativeDirect
Biological Process (BP)protein homotetramerization0.000000000021390.00000000000276Highly InformativeDirect
Biological Process (BP)purine-containing compound catabolic process0.000000064840.0000537Highly InformativeDirect
Biological Process (BP)guanosine-containing compound metabolic process0.00000001510.000000000322Highly InformativeDirect
Biological Process (BP)nucleotide catabolic process0.000010020.002073Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.013320.02292Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.11461Least InformativeInherited
Molecular Function (MF)protein binding0.12840.6347Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.9720.8487Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.000000000000044690.000000000000002458InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)identical protein binding0.000000011140.00000000001713InformativeDirect
Molecular Function (MF)protein dimerization activity0.0000042010.00000002138InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0158 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.09886 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.00000000002719 Moderately Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.6551 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.09317 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.207 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8751 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.9041 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9573 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7151 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.00000000000002413 Informative Direct
Biological Process (BP) pigment metabolic process 0.0000000000001586 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0000000000001298 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00003143 Informative Direct
Biological Process (BP) protein oligomerization 0.000482 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0007115 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.3539 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.1812 Informative Inherited
Biological Process (BP) epithelium development 0.5905 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.08337 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5003 Informative Inherited
Biological Process (BP) post-embryonic development 0.1074 Informative Inherited
Biological Process (BP) metamorphosis 0.0006472 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.000002233 Highly Informative Direct
Biological Process (BP) ribonucleoside catabolic process 0.0002477 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.0007708 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.0005323 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00000000000276 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.0003401 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.0000537 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000000322 Highly Informative Direct
Biological Process (BP) appendage development 0.002484 Highly Informative Inherited
Biological Process (BP) response to drug 0.04917 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.002073 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1165 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.03342 Highly Informative Inherited
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.01013 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.02292 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.0005818 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0009684 Moderately Informative Direct
Molecular Function (MF) protein binding 0.6347 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8186 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.8487 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.000000000000002458 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.000008802 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0008836 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0000187 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.000008557 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00002371 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0008162 Informative Direct
Molecular Function (MF) identical protein binding 0.00000000001713 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000002138 Informative Direct
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.000028 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.00000004188 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.904 Least Informative Inherited
Cellular Component (CC) transferase complex 0.02127 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.003968Moderately InformativeInherited
Disease Ontology (DO)arthritis0.0008806InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.1116Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01601Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.0004497InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00004271Moderately InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processTranscription termination0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainGlutamine amidotransferase0.00001319Highly InformativeDirect
Molecular functionNucleotide-binding0.00000000000001641Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)nucleotide biosynthesis1InformativeInherited
UniPathway (UP)5-phospho-alpha-D-ribose 1-diphosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)pyrimidine salvage0Highly InformativeDirect
UniPathway (UP)AMP biosynthesis0Highly InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PRTase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the PRTase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]