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PRTase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PRTase-like [ 53270]
Superfamily:   PRTase-like [ 53271] (2)
Families:   Phosphoribosyltransferases (PRTases) [ 53272] (15)
  Phosphoribosylpyrophosphate synthetase-like [ 53296] (2)


Superfamily statistics
Genomes (3,161) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 30,753 165,408 56
Proteins 29,035 158,368 54


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000000000061020Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000000072890.0007286Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000000000018290.000000003004Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.14561Least InformativeInherited
Biological Process (BP)biological regulation0.60781Least InformativeInherited
Biological Process (BP)primary metabolic process00.01568Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.0002820.0000000005208Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process00Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.0000000031990Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.0017210.4144Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00011720.04225Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0000059030.001272Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.65511Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00017270.9376Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0084551Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.36451Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.31870.9297Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.0000000055760.0000000000000109InformativeDirect
Biological Process (BP)pigment metabolic process0.0000000000000031190.000000000000003764InformativeDirect
Biological Process (BP)cellular metabolic compound salvage00InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00025720.0000000000001436InformativeDirect
Biological Process (BP)organophosphate catabolic process0.000000042280.00003122InformativeDirect
Biological Process (BP)protein oligomerization0.000000027290.000002656InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.000000026080InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00InformativeDirect
Biological Process (BP)nucleobase-containing compound catabolic process0.021240.1139InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.0000030460.002707InformativeInherited
Biological Process (BP)nucleobase metabolic process00Highly InformativeDirect
Biological Process (BP)nucleoside biosynthetic process00Highly InformativeDirect
Biological Process (BP)nucleoside catabolic process0.000000010470.0000000008643Highly InformativeDirect
Biological Process (BP)protein homotetramerization0.000000000089430.00000000001388Highly InformativeDirect
Biological Process (BP)purine-containing compound catabolic process0.000000011690.00000208Highly InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.0058440.2541Highly InformativeInherited
Biological Process (BP)nucleotide catabolic process0.000013310.002135Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.008710.01648Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.19761Least InformativeInherited
Molecular Function (MF)metal ion binding0.96220.8453Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.00000000000011510.000000000000004806InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)identical protein binding0.000000020290.00000000006571InformativeDirect
Molecular Function (MF)protein dimerization activity0.0000049360.00000005144InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0007286 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000003004 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01568 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000005208 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.4144 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04225 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001272 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9376 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.767 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9297 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.0000000000000109 Informative Direct
Biological Process (BP) pigment metabolic process 0.000000000000003764 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0000000000001436 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00003122 Informative Direct
Biological Process (BP) protein oligomerization 0.000002656 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.1139 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.01317 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.002707 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside biosynthetic process 0 Highly Informative Direct
Biological Process (BP) nucleoside catabolic process 0.0000000008643 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.000001606 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00000000001388 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00004728 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.00000208 Highly Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.2541 Highly Informative Inherited
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.6056 Highly Informative Inherited
Biological Process (BP) response to drug 0.04351 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.002135 Highly Informative Inherited
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.01291 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.01648 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.003437 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.003314 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8627 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.8453 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.000000000000004806 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0009315 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0001016 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0001269 Informative Direct
Molecular Function (MF) identical protein binding 0.00000000006571 Informative Direct
Molecular Function (MF) protein dimerization activity 0.00000005144 Informative Direct
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00002732 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.0000000021 Highly Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5678 Least Informative Inherited
Cellular Component (CC) transferase complex 0.02182 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.00002484 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.004046Moderately InformativeInherited
Disease Ontology (DO)arthritis0.000877InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nucleobase metabolism0.00001258Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.1265Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01769Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.0004994InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00005563Moderately InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Biological processTranscription termination0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainGlutamine amidotransferase0.0000133Highly InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0.00000000000001651Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)purine biosynthesis via salvage pathway0InformativeDirect
UniPathway (UP)nucleotide biosynthesis1InformativeInherited
UniPathway (UP)5-phospho-alpha-D-ribose 1-diphosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)pyrimidine salvage0Highly InformativeDirect
UniPathway (UP)AMP biosynthesis0Highly InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)CTP biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PRTase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the PRTase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]