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PRTase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   PRTase-like [ 53270]
Superfamily:   PRTase-like [ 53271] (2)
Families:   Phosphoribosyltransferases (PRTases) [ 53272] (15)
  Phosphoribosylpyrophosphate synthetase-like [ 53296] (2)


Superfamily statistics
Genomes (3,163) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 30,799 165,408 56
Proteins 29,077 158,368 54


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000000000031440Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000000064750.0006412Least InformativeDirect
Biological Process (BP)heterocycle metabolic process00Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000000000002280.000000003436Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.14331Least InformativeInherited
Biological Process (BP)primary metabolic process00.01624Least InformativeInherited
Biological Process (BP)biological regulation0.60161Least InformativeInherited
Biological Process (BP)nucleoside phosphate metabolic process0.00027450.0000000004036Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process00Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)organophosphate biosynthetic process0.0000000032220Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process00Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.30190.9186Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00017880.04814Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.0023590.4447Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.0000089570.001414Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.63171Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.00018560.9579Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.010111Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.35151Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.0000000058660.00000000000001079InformativeDirect
Biological Process (BP)pigment metabolic process0.0000000000000031440.000000000000003734InformativeDirect
Biological Process (BP)cellular metabolic compound salvage00InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.00029030.00000000000009834InformativeDirect
Biological Process (BP)organophosphate catabolic process0.000000040130.00003112InformativeDirect
Biological Process (BP)protein oligomerization0.000000046230.000003005InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process00InformativeDirect
Biological Process (BP)pyrimidine-containing compound biosynthetic process0.000000025670InformativeDirect
Biological Process (BP)glycosyl compound metabolic process00InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.000003360.002514InformativeInherited
Biological Process (BP)nucleobase-containing compound catabolic process0.019720.1099InformativeInherited
Biological Process (BP)nucleobase metabolic process00Highly InformativeDirect
Biological Process (BP)nucleoside biosynthetic process00Highly InformativeDirect
Biological Process (BP)nucleoside catabolic process0.0000000097870.0000000006667Highly InformativeDirect
Biological Process (BP)protein homotetramerization0.000000000098920.00000000001121Highly InformativeDirect
Biological Process (BP)purine-containing compound catabolic process0.000000010610.000001895Highly InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.0052770.2722Highly InformativeInherited
Biological Process (BP)nucleotide catabolic process0.000011630.002072Highly InformativeInherited
Biological Process (BP)purine ribonucleoside monophosphate biosynthetic process0.0090380.01682Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.1821Least InformativeInherited
Molecular Function (MF)metal ion binding0.84720.7955Moderately InformativeInherited
Molecular Function (MF)magnesium ion binding0.00000000000032580.000000000000005506InformativeDirect
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)identical protein binding0.000000043490.0000000001974InformativeDirect
Molecular Function (MF)protein dimerization activity0.000008210.0000001146InformativeDirect
Molecular Function (MF)transferase activity, transferring pentosyl groups00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0006412 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000000003436 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01624 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.0000000004036 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.9186 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04814 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4447 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.001414 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.9579 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7676 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.00000000000001079 Informative Direct
Biological Process (BP) pigment metabolic process 0.000000000000003734 Informative Direct
Biological Process (BP) cellular metabolic compound salvage 0 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.00000000000009834 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00003112 Informative Direct
Biological Process (BP) protein oligomerization 0.000003005 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.002514 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.1099 Informative Inherited
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleoside biosynthetic process 0 Highly Informative Direct
Biological Process (BP) nucleoside catabolic process 0.0000000006667 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleotide metabolic process 0.000001378 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00000000001121 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00004417 Highly Informative Direct
Biological Process (BP) purine-containing compound catabolic process 0.000001895 Highly Informative Direct
Biological Process (BP) pyrimidine ribonucleoside metabolic process 0.6052 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.2722 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.002072 Highly Informative Inherited
Biological Process (BP) response to drug 0.05574 Highly Informative Inherited
Biological Process (BP) pyrimidine nucleotide biosynthetic process 0.01164 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside monophosphate biosynthetic process 0.01682 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.002079 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.003129 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8552 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.7955 Moderately Informative Inherited
Molecular Function (MF) magnesium ion binding 0.000000000000005506 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 0.0008821 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.00009004 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.0001127 Informative Direct
Molecular Function (MF) identical protein binding 0.0000000001974 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000001146 Informative Direct
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00002631 Highly Informative Direct
Molecular Function (MF) nucleobase-containing compound kinase activity 0.000000002015 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.5917 Least Informative Inherited
Cellular Component (CC) transferase complex 0.02119 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.00002387 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00006002Moderately InformativeDirect
Biological processTranscription termination0Highly InformativeDirect
Biological processPyrimidine biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainGlutamine amidotransferase0.0000127Highly InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0.00000000000003677Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PRTase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the PRTase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]