SUPERFAMILY 1.75 HMM library and genome assignments server


vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,051) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 29,612 46,348 53
Proteins 25,237 41,419 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.27090.006455Least InformativeInherited
Biological Process (BP)single-organism cellular process0.31960.0007763Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.15130.03376Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.25691Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.15720.03303Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.20370.5285Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.29850.434Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0098640.5733Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0093490.02029Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.0004953.728e-09InformativeDirect
Biological Process (BP)DNA metabolic process0.00083577.567e-11InformativeDirect
Biological Process (BP)response to ionizing radiation3.828e-076.635e-14Highly InformativeDirect
Biological Process (BP)DNA repair4.433e-051.261e-08Highly InformativeDirect
Cellular Component (CC)extracellular matrix2.432e-070InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0007763 Least Informative Direct
Biological Process (BP) localization 7.362e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.006455 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.03303 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.434 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5285 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.03376 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.08836 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7413 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5733 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8993 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.593 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.07121 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.108 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1783 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02029 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2965 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.6318 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 3.728e-09 Informative Direct
Biological Process (BP) DNA metabolic process 7.567e-11 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) cell proliferation 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 8.676e-14 Informative Direct
Biological Process (BP) positive regulation of immune system process 4.525e-08 Informative Direct
Biological Process (BP) locomotion 1.055e-07 Informative Direct
Biological Process (BP) localization of cell 3.76e-07 Informative Direct
Biological Process (BP) response to wounding 6e-07 Informative Direct
Biological Process (BP) cellular component movement 2.221e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 8.338e-06 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.08005 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1202 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.4164 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1024 Informative Inherited
Biological Process (BP) regulation of response to stress 0.218 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04781 Informative Inherited
Biological Process (BP) tube development 0.9675 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2755 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell projection organization 0.1398 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2466 Informative Inherited
Biological Process (BP) response to external stimulus 0.01196 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.009752 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9608 Informative Inherited
Biological Process (BP) muscle structure development 0.01783 Informative Inherited
Biological Process (BP) central nervous system development 0.142 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.7557 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) immune response 0.3523 Informative Inherited
Biological Process (BP) regulation of immune response 0.06956 Informative Inherited
Biological Process (BP) immune effector process 0.6457 Informative Inherited
Biological Process (BP) defense response 0.3552 Informative Inherited
Biological Process (BP) cellular membrane organization 0.9179 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.107 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.6137 Informative Inherited
Biological Process (BP) anion transport 0.07017 Informative Inherited
Biological Process (BP) regulation of secretion 0.714 Informative Inherited
Biological Process (BP) positive regulation of transport 0.6509 Informative Inherited
Biological Process (BP) chromosome organization 0.07029 Informative Inherited
Biological Process (BP) response to ionizing radiation 6.635e-14 Highly Informative Direct
Biological Process (BP) DNA repair 1.261e-08 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 5.776e-13 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.417e-11 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.5e-09 Highly Informative Direct
Biological Process (BP) chemotaxis 1.147e-08 Highly Informative Direct
Biological Process (BP) hemostasis 1.148e-08 Highly Informative Direct
Biological Process (BP) protein activation cascade 1.345e-08 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 4.146e-08 Highly Informative Direct
Biological Process (BP) coagulation 4.899e-08 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 8.722e-08 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 5.987e-07 Highly Informative Direct
Biological Process (BP) inorganic anion transport 1.623e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 8.13e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 2.382e-05 Highly Informative Direct
Biological Process (BP) humoral immune response 4.525e-05 Highly Informative Direct
Biological Process (BP) T cell activation 4.831e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 7.574e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte activation 0.0003019 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.08781 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.3061 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.0489 Highly Informative Inherited
Biological Process (BP) organelle localization 0.2665 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.004483 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.02641 Highly Informative Inherited
Biological Process (BP) tube formation 0.03588 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.4183 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.02106 Highly Informative Inherited
Biological Process (BP) wound healing 0.8968 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.4678 Highly Informative Inherited
Biological Process (BP) innate immune response 0.4637 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.1379 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.6305 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0006962 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.8575 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.07827 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.7104 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.1559 Moderately Informative Inherited
Molecular Function (MF) receptor binding 2.874e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.09126 Informative Inherited
Molecular Function (MF) carbon-oxygen lyase activity 0.1197 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.06374 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.003892 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02729 Informative Inherited
Molecular Function (MF) lipid binding 0.01925 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.8331 Informative Inherited
Molecular Function (MF) enzyme binding 0.7958 Informative Inherited
Molecular Function (MF) protein complex binding 0 Highly Informative Direct
Molecular Function (MF) glycosaminoglycan binding 2.592e-09 Highly Informative Direct
Molecular Function (MF) ion channel activity 7.255e-09 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 5.619e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.556e-06 Highly Informative Direct
Molecular Function (MF) sulfur compound binding 8.203e-06 Highly Informative Direct
Cellular Component (CC) membrane 1.58e-11 Least Informative Direct
Cellular Component (CC) protein complex 9.495e-07 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8929 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region 2.556e-13 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0002643 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0005318 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.9944 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.244 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4031 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.7008 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 1.15e-10 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 3.473e-06 Informative Direct
Cellular Component (CC) coated vesicle 0.001542 Informative Inherited
Cellular Component (CC) cell junction 0.01808 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.5679 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8957 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 3.48e-14 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.328e-08 Highly Informative Direct
Cellular Component (CC) transport vesicle 4e-06 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 4.538e-06 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 1.669e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 2.084e-05 Highly Informative Direct
Cellular Component (CC) vesicle membrane 4.949e-05 Highly Informative Direct
Cellular Component (CC) proteasome complex 0.001115 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.02293 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.07983 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.3064 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1.101e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.551e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1738Least InformativeInherited
Disease Ontology (DO)skin disease0.121Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.4421Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5542Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.74e-05InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0007475InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.02291InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0009735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4794Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5957Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8719Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.9614Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03682Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0507Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1291Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2472Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3335Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5628Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7196Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9362Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03494InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.1432InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.1784InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.2299InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.2735InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.366InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4321InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5049InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.6908InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.8803InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation7.507e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers7.507e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles7.507e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis2.253e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis1.023e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Ankle contracture1.798e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Slender build2.93e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance4.45e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter6.389e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Spasmodic torticollis0.0001215Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001604Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0002054Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.0002588Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0002588Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.1644Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.5002Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.08248Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2047Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.7667Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.7775Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.7997Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.07443InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.5077InformativeInherited
Mammalian Phenotype (MP)dermal-epidermal separation6.205e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002646Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0006924Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)surface structure0Moderately InformativeDirect
Zebrafish Anatomy (ZA)skeletal element0Moderately InformativeDirect
Zebrafish Anatomy (ZA)paired fin0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0.0001865Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001742Least InformativeInherited
Plant ANatomical entity (PAN)gynoecium0.02233Least InformativeInherited
Plant ANatomical entity (PAN)microgametophyte0.03569Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.1871Least InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.043e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0157Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02588Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.568e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage2.278e-15Moderately InformativeDirect
Biological processIon transport0.9755Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination2.955e-15InformativeDirect
Biological processInnate immunity5.281e-10InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processVoltage-gated channel3.484e-13Highly InformativeDirect
Biological processChlorophyll biosynthesis7.035e-10Highly InformativeDirect
Biological processBlood coagulation1.889e-06Highly InformativeDirect
Biological processComplement alternate pathway1.537e-05Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0005037Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere3.226e-16Highly InformativeDirect
Cellular componentProteasome1.092e-05Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain1.274e-15InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.413e-16Highly InformativeDirect
Molecular functionZinc9.732e-09Least InformativeDirect
Molecular functionMetal-binding0.000628Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionHelicase0InformativeDirect
Molecular functionCalcium transport3.652e-15Highly InformativeDirect
Molecular functionChloride3.846e-11Highly InformativeDirect
Molecular functionCalcium channel1.328e-10Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.5207Moderately InformativeInherited
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel5.122e-09InformativeDirect
Post-translational modificationSerine protease0.0001001InformativeDirect
Post-translational modificationChromatin regulator0.0002271InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond2.738e-11Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan1.3e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis1.441e-11Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis1.849e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]