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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,584) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,541 74,967 53
Proteins 29,610 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000229 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.684 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02699 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.5296 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8633 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.2395 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2321 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2186 Least Informative Inherited
Biological Process (BP) regulation of localization 0.0004603 Moderately Informative Direct
Biological Process (BP) immune system process 0.0006247 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.9465 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9231 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02452 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4238 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.689 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6034 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4134 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.3866 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8484 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05055 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) system development 0.9972 Moderately Informative Inherited
Biological Process (BP) response to stress 0.01255 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1909 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2329 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1914 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.977 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04956 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.009441 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0000000000001435 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00000000002603 Informative Direct
Biological Process (BP) response to radiation 0.0000000002366 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000006083 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0009107 Informative Direct
Biological Process (BP) regulation of protein localization 0.9756 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.005005 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.682 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02105 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.4617 Informative Inherited
Biological Process (BP) proteolysis 0.2519 Informative Inherited
Biological Process (BP) regulation of system process 0.5369 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.6939 Informative Inherited
Biological Process (BP) generation of neurons 0.265 Informative Inherited
Biological Process (BP) cell development 0.3959 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) locomotion 0.02571 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2785 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3115 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.02323 Informative Inherited
Biological Process (BP) cell adhesion 0.06544 Informative Inherited
Biological Process (BP) circulatory system development 0.1065 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.03666 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.6017 Informative Inherited
Biological Process (BP) central nervous system development 0.5854 Informative Inherited
Biological Process (BP) embryo development 0.004422 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.01286 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01457 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1014 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.07094 Informative Inherited
Biological Process (BP) regulation of immune response 0.1556 Informative Inherited
Biological Process (BP) immune response 0.4558 Informative Inherited
Biological Process (BP) anion transport 0.4281 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6567 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.1407 Informative Inherited
Biological Process (BP) protein targeting 0.384 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.03941 Informative Inherited
Biological Process (BP) positive regulation of transport 0.08282 Informative Inherited
Biological Process (BP) regulation of secretion 0.9023 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02233 Informative Inherited
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00000000006367 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000001349 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00001201 Highly Informative Direct
Biological Process (BP) hemostasis 0.00001325 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.00001924 Highly Informative Direct
Biological Process (BP) muscle structure development 0.00007036 Highly Informative Direct
Biological Process (BP) antigen processing and presentation of exogenous peptide antigen 0.0002347 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0002608 Highly Informative Direct
Biological Process (BP) chromosome organization 0.000352 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.000417 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0004471 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0005086 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.000629 Highly Informative Direct
Biological Process (BP) coagulation 0.0008611 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.6747 Highly Informative Inherited
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.03482 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.01927 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.003562 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.4883 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8131 Highly Informative Inherited
Biological Process (BP) neuron development 0.04477 Highly Informative Inherited
Biological Process (BP) inner ear development 0.1101 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.02094 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.6923 Highly Informative Inherited
Biological Process (BP) cell migration 0.7101 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.6692 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.01447 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.2457 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.007386 Highly Informative Inherited
Biological Process (BP) appendage development 0.1851 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.3066 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.002619 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04042 Highly Informative Inherited
Biological Process (BP) brain development 0.3779 Highly Informative Inherited
Biological Process (BP) cell junction assembly 0.002175 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.005059 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.4139 Highly Informative Inherited
Biological Process (BP) endocytosis 1 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.006082 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.09177 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.01394 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02213 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.2593 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.02164 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) gastrulation 0.1812 Highly Informative Inherited
Molecular Function (MF) binding 0.03032 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.000003782 Moderately Informative Direct
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.04225 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.6174 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.7519 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 0.00000002565 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000006014 Informative Direct
Molecular Function (MF) protein dimerization activity 0.04533 Informative Inherited
Molecular Function (MF) DNA binding 0.8581 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.02515 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.00466 Informative Inherited
Molecular Function (MF) ATPase activity 0.4864 Informative Inherited
Molecular Function (MF) receptor binding 0.08639 Informative Inherited
Molecular Function (MF) enzyme binding 0.6619 Informative Inherited
Molecular Function (MF) phospholipid binding 0.003081 Informative Inherited
Molecular Function (MF) ion channel activity 0.000000001812 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000001482 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.007577 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.001261 Highly Informative Inherited
Cellular Component (CC) protein complex 0.0000000000003597 Least Informative Direct
Cellular Component (CC) membrane 0.000000000002971 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.06743 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000000000003546 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000000002437 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000002726 Moderately Informative Direct
Cellular Component (CC) cell projection 0.1813 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1601 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.005486 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05397 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1881 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.859 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.4159 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00000000000001039 Informative Direct
Cellular Component (CC) transport vesicle 0.00000000000005053 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000000007226 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.0000000003223 Informative Direct
Cellular Component (CC) cell junction 0.000000001565 Informative Direct
Cellular Component (CC) DNA-directed RNA polymerase complex 0.0000001896 Informative Direct
Cellular Component (CC) side of membrane 0.000479 Informative Direct
Cellular Component (CC) transporter complex 0.0839 Informative Inherited
Cellular Component (CC) cell projection part 0.1558 Informative Inherited
Cellular Component (CC) plasma membrane region 0.3142 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1658 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix 0 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.000000000001583 Highly Informative Direct
Cellular Component (CC) receptor complex 0.000000000006464 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0.000000000572 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000002279 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.000252 Highly Informative Direct
Cellular Component (CC) anchoring junction 0.002474 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.004298 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome 0.3051 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.2649Least InformativeInherited
Disease Ontology (DO)blood coagulation disease0.02991Moderately InformativeInherited
Disease Ontology (DO)skin disease0.06261Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4807Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.003153InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.01232InformativeInherited
Disease Ontology (DO)bullous skin disease0.01389InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0002526Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.04901Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2985Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4935Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7728Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.9821Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.003601Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2127Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2898Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.3872Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.5748Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.6883Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7316Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.767Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.8459Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9636Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.9807Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.002366InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0171InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.0748InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.08187InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1327InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.1603InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.1613InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1843InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.2006InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4026InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.8817InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation0.00000008528Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0001291Highly InformativeDirect
Phenotypic Abnormality (PA)Protruding ear0.0003955Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0008672Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.00379Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb joint0.02565Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.106Highly InformativeInherited
Phenotypic Abnormality (PA)Dystonia0.1129Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1739Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3493Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.5104Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3775Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0003543InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001811Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002808Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.09657Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5308Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.07437Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.2756Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.4038Moderately InformativeInherited
Worm Phenotype (WP)gonad development variant0.0009441InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0579InformativeInherited
Worm Phenotype (WP)locomotion reduced0.1653InformativeInherited
Worm Phenotype (WP)muscle attachment variant0.00007606Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.0009793Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0006093Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.1122Least InformativeInherited
Fly Anatomy (FA)integumentary system0.3231Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.07924Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.4636Moderately InformativeInherited
Fly Anatomy (FA)procuticle0.00002181InformativeDirect
Fly Anatomy (FA)integumentary specialisation0.004438InformativeInherited
Fly Anatomy (FA)tracheal system0.01301InformativeInherited
Fly Anatomy (FA)epithelial tube0.0139InformativeInherited
Fly Anatomy (FA)muscle system0.0175InformativeInherited
Fly Anatomy (FA)prepupa0.02405InformativeInherited
Fly Anatomy (FA)muscle attachment site0.00001221Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.0006506Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000005512Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.01156Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.04873Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.00000000000008736InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.0003888Least InformativeDirect
Drugbank ATC_code (DB)aldosterone antagonists0.00001125InformativeDirect
Drugbank ATC_code (DB)dihydropyridine derivatives0.00003777InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage7.223e-16Moderately InformativeDirect
Biological processImmunity0.000008961Moderately InformativeDirect
Biological processDifferentiation0.00009196Moderately InformativeDirect
Biological processCell cycle0.7129Moderately InformativeInherited
Biological processIon transport0.9757Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination0.000000000000001433InformativeDirect
Biological processInnate immunity0.000000009942InformativeDirect
Biological processHemostasis0.000003516InformativeDirect
Biological processMitosis0.00003954InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPhagocytosis0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis0.000000001601Highly InformativeDirect
Biological processComplement alternate pathway0.000001758Highly InformativeDirect
Biological processBlood coagulation0.000002516Highly InformativeDirect
Biological processComplement pathway0.0005675Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.000002729Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000000002015Moderately InformativeDirect
Cellular componentEndosome0.00004999Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere0Highly InformativeDirect
Cellular componentProteasome0.000002113Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.217e-16Highly InformativeDirect
Molecular functionZinc0.00000000004545Least InformativeDirect
Molecular functionMetal-binding0.0003985Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0.00000000004708Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel0.00000001058InformativeDirect
Post-translational modificationChromatin regulator0.0003462InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000001344Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.0000000006432Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000000000001151Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.0000000001054InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis0.00000000001359Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.000002711Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]