SUPERFAMILY 1.75 HMM library and genome assignments server


vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,538) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 32,255 46,348 53
Proteins 27,757 41,419 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.25692.827e-05Least InformativeInherited
Biological Process (BP)single-organism cellular process0.2872.386e-09Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.14480.003105Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21560.5376Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.14820.002544Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.19370.1621Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.28250.1452Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.010220.639Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010830.006741Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00042617.498e-13InformativeDirect
Biological Process (BP)DNA metabolic process0.0005810InformativeDirect
Biological Process (BP)double-strand break repair2.921e-077.775e-10Highly InformativeDirect
Biological Process (BP)response to ionizing radiation3.252e-079.972e-12Highly InformativeDirect
Cellular Component (CC)extracellular matrix1.777e-070InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.827e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.386e-09 Least Informative Direct
Biological Process (BP) localization 4.117e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005199 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1621 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.002544 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1452 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.5376 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.003105 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.588e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.2453 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.639 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01875 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.4445 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.2524 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.008103 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.6855 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9689 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8539 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1564 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.006741 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8096 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 7.498e-13 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) response to wounding 8.276e-10 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.314e-09 Informative Direct
Biological Process (BP) locomotion 4.32e-08 Informative Direct
Biological Process (BP) localization of cell 3.872e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.074e-06 Informative Direct
Biological Process (BP) cellular component movement 7.853e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.2262 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02424 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2975 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.00699 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6557 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 0.0407 Informative Inherited
Biological Process (BP) embryonic organ development 0.3126 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.839 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1083 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.6951 Informative Inherited
Biological Process (BP) cardiovascular system development 0.3076 Informative Inherited
Biological Process (BP) protein complex assembly 0.00667 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3351 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04855 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.7017 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01687 Informative Inherited
Biological Process (BP) central nervous system development 0.00718 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle structure development 0.01155 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.7993 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.424 Informative Inherited
Biological Process (BP) immune response 0.241 Informative Inherited
Biological Process (BP) regulation of immune response 0.03417 Informative Inherited
Biological Process (BP) immune effector process 0.7416 Informative Inherited
Biological Process (BP) defense response 0.07165 Informative Inherited
Biological Process (BP) organelle localization 0.4111 Informative Inherited
Biological Process (BP) membrane organization 0.965 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01423 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1347 Informative Inherited
Biological Process (BP) anion transport 0.1293 Informative Inherited
Biological Process (BP) regulation of secretion 0.5828 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2801 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.02108 Informative Inherited
Biological Process (BP) double-strand break repair 7.775e-10 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 9.972e-12 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 1.899e-13 Highly Informative Direct
Biological Process (BP) leukocyte migration 4.679e-11 Highly Informative Direct
Biological Process (BP) hemostasis 1.027e-10 Highly Informative Direct
Biological Process (BP) coagulation 5.276e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 5.698e-10 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 5.143e-09 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 6.013e-09 Highly Informative Direct
Biological Process (BP) protein activation cascade 1.018e-08 Highly Informative Direct
Biological Process (BP) collagen metabolic process 2.233e-08 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 6.747e-08 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 9.002e-07 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 1.118e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 1.153e-06 Highly Informative Direct
Biological Process (BP) glial cell differentiation 5.362e-06 Highly Informative Direct
Biological Process (BP) vesicle organization 1.276e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 2.094e-05 Highly Informative Direct
Biological Process (BP) tube formation 2.253e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 2.453e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001179 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0001556 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0003375 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0004938 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0007554 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1093 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03261 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2474 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.07327 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.5046 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.04022 Highly Informative Inherited
Biological Process (BP) lung development 0.08763 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6572 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.104 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.07448 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1724 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.01691 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.02551 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.001219 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7146 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.527 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.02418 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.5421 Highly Informative Inherited
Biological Process (BP) innate immune response 0.8145 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion 0.002914 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.7049 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2101 Highly Informative Inherited
Molecular Function (MF) binding 0.1252 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0009241 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.8565 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.06067 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1.603e-07 Informative Direct
Molecular Function (MF) sulfur compound binding 1.31e-05 Informative Direct
Molecular Function (MF) receptor binding 9.754e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.2155 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.225 Informative Inherited
Molecular Function (MF) DNA binding 0.9002 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.001501 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.03841 Informative Inherited
Molecular Function (MF) lipid binding 0.03572 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.7116 Informative Inherited
Molecular Function (MF) enzyme binding 0.9343 Informative Inherited
Molecular Function (MF) protein complex binding 1.18e-14 Highly Informative Direct
Molecular Function (MF) ion channel activity 7.692e-09 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 3.763e-08 Highly Informative Direct
Molecular Function (MF) heparin binding 1.558e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1.46e-05 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.63e-05 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 9.627e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2124 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 1.143e-14 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.0001135 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.005132 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8049 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2058 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8127 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 1.778e-11 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 5.402e-08 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 4.539e-07 Informative Direct
Cellular Component (CC) coated vesicle 5.208e-07 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.8855 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8433 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 7.1e-14 Highly Informative Direct
Cellular Component (CC) transport vesicle 5.005e-13 Highly Informative Direct
Cellular Component (CC) sarcolemma 8.2e-08 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 9.81e-08 Highly Informative Direct
Cellular Component (CC) proteasome complex 0.0001307 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0003582 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.000379 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.1419 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.06799 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.01612 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.3039 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.7324 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1.101e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.551e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09573Least InformativeInherited
Disease Ontology (DO)skin disease0.06851Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4771Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5334Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.39e-05InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0006397InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01737InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0007542Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4854Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.6469Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8709Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9357Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03828Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05396Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1463Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1463Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.228Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.6766Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7277Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9398Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03635InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.1631InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2068InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.2378InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.3033InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3462InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.375InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4461InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5129InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5144InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5752InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation6.501e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers6.501e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles6.501e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis1.961e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis9.056e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Ankle contracture1.593e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Slender build2.596e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance3.993e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter5.83e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Torticollis0.0001111Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001476Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.0002412Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0002412Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0002412Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.1631Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1664Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3546Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4737Least InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.282Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3532Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0003241InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation8.218e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0003027Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides9.444e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01566Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02958Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.325e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage1.856e-15Moderately InformativeDirect
Biological processIon transport0.9774Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination6.192e-15InformativeDirect
Biological processInnate immunity1.286e-09InformativeDirect
Biological processHemostasis2.655e-06InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis7.794e-10Highly InformativeDirect
Biological processBlood coagulation2.162e-06Highly InformativeDirect
Biological processComplement alternate pathway5.343e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0005261Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection8.512e-08Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere3.21e-16Highly InformativeDirect
Cellular componentProteasome1.045e-05Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.18e-16Highly InformativeDirect
Molecular functionZinc1.333e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride3.833e-11Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.5279Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel5.686e-09InformativeDirect
Post-translational modificationSerine protease9.247e-05InformativeDirect
Post-translational modificationChromatin regulator0.0002426InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.762e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond5.92e-12Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan1.654e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis6.091e-12InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis7.149e-11Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis2.004e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]