SUPERFAMILY 1.75 HMM library and genome assignments server


vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,581) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,678 74,967 53
Proteins 29,707 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.076881Least InformativeInherited
Biological Process (BP)developmental process0.24170.9901Least InformativeInherited
Biological Process (BP)multicellular organismal process0.35071Least InformativeInherited
Biological Process (BP)response to stimulus0.26768.901e-06Least InformativeInherited
Biological Process (BP)single-organism cellular process0.28994.549e-08Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.14560.007874Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.21340.8238Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.14790.006553Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.19470.2614Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.28410.255Least InformativeInherited
Biological Process (BP)nervous system development0.0034490.02673Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0059550.3361Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.015370.2541Moderately InformativeInherited
Biological Process (BP)cell differentiation0.017261Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10561Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.010630.5025Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010680.02116Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00039154.646e-13InformativeDirect
Biological Process (BP)DNA metabolic process0.0005225.576e-15InformativeDirect
Biological Process (BP)regulation of nervous system development2.897e-050.04122InformativeInherited
Biological Process (BP)regulation of cell development5.299e-050.2043InformativeInherited
Biological Process (BP)positive regulation of developmental process0.00013340.3537InformativeInherited
Biological Process (BP)generation of neurons0.00058331InformativeInherited
Biological Process (BP)positive regulation of neurogenesis2.083e-070.0001174Highly InformativeDirect
Biological Process (BP)double-strand break repair2.605e-078.472e-10Highly InformativeDirect
Biological Process (BP)response to ionizing radiation3.055e-077.372e-13Highly InformativeDirect
Cellular Component (CC)extracellular matrix1.643e-070InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 8.901e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.549e-08 Least Informative Direct
Biological Process (BP) localization 8.282e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000715 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9901 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2614 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.006553 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.255 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8238 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.007874 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001585 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003927 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3361 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1742 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.5025 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.4497 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001593 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4267 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02673 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5049 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2541 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8909 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9064 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1926 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02116 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 4.646e-13 Informative Direct
Biological Process (BP) DNA metabolic process 5.576e-15 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) response to wounding 7.602e-10 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.277e-09 Informative Direct
Biological Process (BP) locomotion 2.578e-09 Informative Direct
Biological Process (BP) localization of cell 6.576e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.407e-06 Informative Direct
Biological Process (BP) leukocyte activation 2.891e-06 Informative Direct
Biological Process (BP) cellular component movement 1.261e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.3366 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04122 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2147 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1787 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.003772 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1044 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1268 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2497 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.02842 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9249 Informative Inherited
Biological Process (BP) tube development 0.1495 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 0.06465 Informative Inherited
Biological Process (BP) embryonic organ development 0.4242 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07484 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7918 Informative Inherited
Biological Process (BP) regulation of cell development 0.2043 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3537 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04211 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02899 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2451 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3224 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.06078 Informative Inherited
Biological Process (BP) central nervous system development 0.01457 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle structure development 0.01371 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.8726 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.7092 Informative Inherited
Biological Process (BP) immune response 0.08902 Informative Inherited
Biological Process (BP) regulation of immune response 0.02055 Informative Inherited
Biological Process (BP) immune effector process 0.541 Informative Inherited
Biological Process (BP) defense response 0.03469 Informative Inherited
Biological Process (BP) organelle localization 0.6556 Informative Inherited
Biological Process (BP) cellular membrane organization 0.2982 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01239 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.0657 Informative Inherited
Biological Process (BP) anion transport 0.1735 Informative Inherited
Biological Process (BP) metal ion transport 0.2246 Informative Inherited
Biological Process (BP) regulation of secretion 0.6261 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2064 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.03691 Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.0001174 Highly Informative Direct
Biological Process (BP) double-strand break repair 8.472e-10 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 7.372e-13 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 3.752e-13 Highly Informative Direct
Biological Process (BP) leukocyte migration 2.62e-11 Highly Informative Direct
Biological Process (BP) hemostasis 2.072e-10 Highly Informative Direct
Biological Process (BP) coagulation 1.031e-09 Highly Informative Direct
Biological Process (BP) protein activation cascade 1.394e-09 Highly Informative Direct
Biological Process (BP) chemotaxis 1.852e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 3.85e-09 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 7.962e-08 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.523e-07 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 1.604e-06 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.716e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 2.39e-06 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 1.216e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 2.706e-05 Highly Informative Direct
Biological Process (BP) glial cell differentiation 3.036e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 3.511e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 3.659e-05 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0002177 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0002502 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000646 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000923 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1631 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.09559 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2718 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01069 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.001179 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.1166 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003781 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6818 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.1391 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.0961 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1454 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03482 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.4015 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.3453 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7102 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3812 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01684 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.7009 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.6971 Highly Informative Inherited
Biological Process (BP) ear development 0.2848 Highly Informative Inherited
Molecular Function (MF) binding 0.1203 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8027 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.9454 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.001257 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.04874 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 5.494e-08 Informative Direct
Molecular Function (MF) sulfur compound binding 8.634e-07 Informative Direct
Molecular Function (MF) receptor binding 6.194e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1756 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.01798 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.002762 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02661 Informative Inherited
Molecular Function (MF) lipid binding 0.02366 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.6744 Informative Inherited
Molecular Function (MF) enzyme binding 0.7925 Informative Inherited
Molecular Function (MF) protein complex binding 1.149e-13 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.701e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 5.624e-08 Highly Informative Direct
Molecular Function (MF) heparin binding 4.252e-07 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 2.092e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 3.293e-05 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.37 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 9.22e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3181 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 3.45e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.7924 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9504 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3766 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8585 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.004726 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.749e-12 Informative Direct
Cellular Component (CC) integral to membrane 2.004e-12 Informative Direct
Cellular Component (CC) cell junction 1.189e-08 Informative Direct
Cellular Component (CC) coated vesicle 2.982e-07 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 5.27e-07 Informative Direct
Cellular Component (CC) Golgi apparatus 0.3405 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7629 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) transport vesicle 1.057e-13 Highly Informative Direct
Cellular Component (CC) receptor complex 1.07e-13 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 8.386e-08 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.087e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000143 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0008262 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.01774 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.1078 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.05947 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3208 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1.101e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.551e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09388Least InformativeInherited
Disease Ontology (DO)skin disease0.06846Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4748Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5348Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis8.824e-06InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0007571InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01806InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0008513Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4792Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8661Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9338Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03754Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1423Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1436Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.2201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2549Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3394Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.917Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03401InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0347InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.1628InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.1965InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.2939InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4409InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.509InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5215InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.569InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation6.682e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers6.682e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles6.682e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis1.977e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis9.106e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance3.997e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter5.908e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Torticollis0.0001121Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001484Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.0002415Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0002415Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0002415Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.1593Highly InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.2887Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.3641Highly InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.4243Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1653Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4407Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4756Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.2162Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8137Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.8375Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002936InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation1.354e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002147Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0001248Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.08523Least InformativeInherited
Fly Anatomy (FA)organ system0.3505Least InformativeInherited
Fly Anatomy (FA)larva0.3587Least InformativeInherited
Fly Anatomy (FA)late embryo0.04177Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.09618Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1413Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007904InformativeInherited
Fly Anatomy (FA)tracheal system0.01531InformativeInherited
Fly Anatomy (FA)epithelial tube0.01574InformativeInherited
Fly Anatomy (FA)muscle system0.02004InformativeInherited
Fly Anatomy (FA)prepupa0.03113InformativeInherited
Fly Anatomy (FA)muscle attachment site1.912e-05Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.000601Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.0009449Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides9.095e-10Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01471Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02846Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.144e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage1.631e-15Moderately InformativeDirect
Biological processIon transport0.976Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination5.968e-15InformativeDirect
Biological processInnate immunity1.636e-09InformativeDirect
Biological processHemostasis2.575e-06InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis1.062e-09Highly InformativeDirect
Biological processBlood coagulation2.129e-06Highly InformativeDirect
Biological processComplement alternate pathway4.592e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0005787Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection1.12e-07Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere6.428e-16Highly InformativeDirect
Cellular componentProteasome9.99e-06Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.186e-16Highly InformativeDirect
Molecular functionZinc1.624e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride3.848e-11Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.5359Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel6.668e-09InformativeDirect
Post-translational modificationSerine protease9.43e-05InformativeDirect
Post-translational modificationChromatin regulator0.0002589InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.546e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond7.915e-12Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan1.498e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)heterocycle biosynthesis8.315e-11InformativeDirect
UniPathway (UP)chlorophyll biosynthesis1.148e-08Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]