SUPERFAMILY 1.75 HMM library and genome assignments server


vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,574) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 33,508 74,967 53
Proteins 28,870 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.24322.632e-06Least InformativeInherited
Biological Process (BP)single-organism cellular process0.26755.988e-09Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.13270.003919Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.20240.6706Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.13560.003221Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.17760.1806Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.2610.1685Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.010550.423Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010780.01381Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00035885.31e-13InformativeDirect
Biological Process (BP)DNA metabolic process0.00051063.722e-15InformativeDirect
Biological Process (BP)double-strand break repair2.472e-077.664e-10Highly InformativeDirect
Biological Process (BP)response to ionizing radiation2.899e-076.507e-13Highly InformativeDirect
Cellular Component (CC)extracellular matrix1.371e-070InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 2.632e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 5.988e-09 Least Informative Direct
Biological Process (BP) localization 2.846e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00029 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1806 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.003221 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.1685 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.6706 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.003919 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 3.54e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.266 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.423 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.3155 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01443 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.5042 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7165 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01728 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7815 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1963 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01381 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7217 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 5.31e-13 Informative Direct
Biological Process (BP) DNA metabolic process 3.722e-15 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 5.476e-10 Informative Direct
Biological Process (BP) response to wounding 7.396e-10 Informative Direct
Biological Process (BP) locomotion 2.096e-09 Informative Direct
Biological Process (BP) localization of cell 1.343e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.152e-06 Informative Direct
Biological Process (BP) leukocyte activation 2.056e-06 Informative Direct
Biological Process (BP) cellular component movement 2.585e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.2767 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04084 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2264 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.08501 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1089 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2228 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.7125 Informative Inherited
Biological Process (BP) tube development 0.1241 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 0.06286 Informative Inherited
Biological Process (BP) embryonic organ development 0.3494 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.7333 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1013 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.7931 Informative Inherited
Biological Process (BP) protein complex assembly 0.002244 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2708 Informative Inherited
Biological Process (BP) regulation of response to stress 0.1629 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04575 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.957 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.2893 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.03726 Informative Inherited
Biological Process (BP) central nervous system development 0.01002 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle structure development 0.008356 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.8334 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6419 Informative Inherited
Biological Process (BP) immune response 0.08116 Informative Inherited
Biological Process (BP) regulation of immune response 0.0211 Informative Inherited
Biological Process (BP) immune effector process 0.5285 Informative Inherited
Biological Process (BP) defense response 0.04494 Informative Inherited
Biological Process (BP) organelle localization 0.5353 Informative Inherited
Biological Process (BP) cellular membrane organization 0.6967 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01134 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.05491 Informative Inherited
Biological Process (BP) anion transport 0.171 Informative Inherited
Biological Process (BP) metal ion transport 0.2005 Informative Inherited
Biological Process (BP) regulation of secretion 0.5405 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1371 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.0289 Informative Inherited
Biological Process (BP) double-strand break repair 7.664e-10 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 6.507e-13 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 2.276e-13 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.094e-10 Highly Informative Direct
Biological Process (BP) hemostasis 1.16e-10 Highly Informative Direct
Biological Process (BP) coagulation 5.932e-10 Highly Informative Direct
Biological Process (BP) chemotaxis 1.204e-09 Highly Informative Direct
Biological Process (BP) protein activation cascade 1.438e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 1.602e-09 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 8.658e-08 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.307e-07 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 1.288e-06 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.42e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 1.663e-06 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 1.151e-05 Highly Informative Direct
Biological Process (BP) glial cell differentiation 1.175e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 1.828e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 2.686e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 3.003e-05 Highly Informative Direct
Biological Process (BP) humoral immune response 0.0002357 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0006313 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0007482 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000865 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1298 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.04227 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2769 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.008898 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.001202 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.09689 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003468 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.661 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.1304 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.02436 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.08814 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.02644 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.02961 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.378 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.3505 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3833 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01097 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.4151 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6665 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.6872 Highly Informative Inherited
Biological Process (BP) inner ear development 0.2263 Highly Informative Inherited
Molecular Function (MF) binding 0.1212 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0009406 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.9141 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.03553 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 4.17e-08 Informative Direct
Molecular Function (MF) sulfur compound binding 6.139e-07 Informative Direct
Molecular Function (MF) receptor binding 3.304e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1571 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.2902 Informative Inherited
Molecular Function (MF) DNA binding 0.9617 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.002639 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02267 Informative Inherited
Molecular Function (MF) lipid binding 0.0197 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.6414 Informative Inherited
Molecular Function (MF) enzyme binding 0.9959 Informative Inherited
Molecular Function (MF) protein complex binding 3.729e-14 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.707e-08 Highly Informative Direct
Molecular Function (MF) heparin binding 4.907e-07 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 1.726e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 2.273e-05 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 4.991e-05 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.3723 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 7.945e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2524 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 2.061e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.003602 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.8547 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3499 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8866 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) integral to membrane 2.516e-11 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 7.809e-10 Informative Direct
Cellular Component (CC) coated vesicle 2.438e-07 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 4.314e-07 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.9233 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7421 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) transport vesicle 1.215e-13 Highly Informative Direct
Cellular Component (CC) receptor complex 1.269e-13 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 4.06e-08 Highly Informative Direct
Cellular Component (CC) sarcolemma 5.289e-08 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 8.535e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0001475 Highly Informative Direct
Cellular Component (CC) proteasome complex 0.000165 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.08341 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.09102 Highly Informative Inherited
Cellular Component (CC) adherens junction 0.001231 Highly Informative Inherited
Cellular Component (CC) transcription factor complex 0.3146 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3127 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1.101e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.551e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.09583Least InformativeInherited
Disease Ontology (DO)skin disease0.06802Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4737Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5296Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.392e-05InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0006392InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01726InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0007534Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4857Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5984Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8712Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9357Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1449Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1459Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.2241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2543Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7273Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9166Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03474InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03644InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.163InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2066InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.3034InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3459InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.3751InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4461InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5129InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.575InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation6.498e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers6.498e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles6.498e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis1.96e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis9.05e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Slender build2.594e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance3.984e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter5.816e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Torticollis0.000111Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001474Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.000241Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.000241Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.000241Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.1631Highly InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.429Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.166Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4197Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4719Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.2193Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0003055InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation8.012e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002358Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.004e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01528Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02849Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.166e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage1.627e-15Moderately InformativeDirect
Biological processIon transport0.9776Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination5.962e-15InformativeDirect
Biological processInnate immunity1.587e-09InformativeDirect
Biological processHemostasis2.59e-06InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis1.074e-09Highly InformativeDirect
Biological processBlood coagulation2.097e-06Highly InformativeDirect
Biological processComplement alternate pathway4.583e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0005545Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection1.1e-07Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere6.421e-16Highly InformativeDirect
Cellular componentProteasome9.764e-06Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.164e-16Highly InformativeDirect
Molecular functionZinc1.402e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride3.754e-11Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.53Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel6.441e-09InformativeDirect
Post-translational modificationSerine protease9.191e-05InformativeDirect
Post-translational modificationChromatin regulator0.0002536InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.545e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond6.161e-12Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan1.496e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis1.377e-11Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis2.843e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]