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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,588) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,819 74,967 53
Proteins 29,862 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.000002715 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.5498 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.1942 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5168 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.04251 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.6948 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.224 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2329 Least Informative Inherited
Biological Process (BP) immune system process 0.0003552 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0005298 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0006336 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.09978 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.4348 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4898 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.683 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09503 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004804 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.451 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.6435 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7624 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4923 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2191 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1686 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.02367 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4016 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.01268 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.000000000000184 Informative Direct
Biological Process (BP) response to radiation 0.00000000000255 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.0000000000443 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000002266 Informative Direct
Biological Process (BP) cell activation 0.000001842 Informative Direct
Biological Process (BP) secretion by cell 0.0001073 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0002256 Informative Direct
Biological Process (BP) response to nitrogen compound 0.08725 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.0122 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002086 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.03276 Informative Inherited
Biological Process (BP) membrane organization 0.06568 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.06929 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6803 Informative Inherited
Biological Process (BP) intracellular protein transport 0.6254 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.05398 Informative Inherited
Biological Process (BP) proteolysis 0.3084 Informative Inherited
Biological Process (BP) cell development 0.5237 Informative Inherited
Biological Process (BP) regulation of system process 0.4873 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.3386 Informative Inherited
Biological Process (BP) tissue development 0.3074 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03079 Informative Inherited
Biological Process (BP) response to metal ion 0.5303 Informative Inherited
Biological Process (BP) embryo development 0.006614 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7747 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.0181 Informative Inherited
Biological Process (BP) organelle localization 0.8456 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.143 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2299 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) locomotion 0.04427 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.04582 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.04307 Informative Inherited
Biological Process (BP) circulatory system development 0.1179 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.5702 Informative Inherited
Biological Process (BP) central nervous system development 0.63 Informative Inherited
Biological Process (BP) anion transport 0.4416 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.9278 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1805 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.08641 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.1351 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.8868 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1134 Informative Inherited
Biological Process (BP) regulation of secretion 0.9631 Informative Inherited
Biological Process (BP) immune response 0.1127 Informative Inherited
Biological Process (BP) immune effector process 0.08838 Informative Inherited
Biological Process (BP) chromosome organization 0.2552 Informative Inherited
Biological Process (BP) biological adhesion 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000000003012 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.0000001145 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0.000002032 Highly Informative Direct
Biological Process (BP) hemostasis 0.000002801 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000003083 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.000007303 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00001217 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00004149 Highly Informative Direct
Biological Process (BP) muscle structure development 0.0001049 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0001061 Highly Informative Direct
Biological Process (BP) coagulation 0.0002616 Highly Informative Direct
Biological Process (BP) neutrophil activation 0.00033 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003399 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.0003411 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0006503 Highly Informative Direct
Biological Process (BP) positive regulation of cell development 0.0007368 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.0008558 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1864 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.6843 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.305 Highly Informative Inherited
Biological Process (BP) myeloid cell differentiation 0.1513 Highly Informative Inherited
Biological Process (BP) neuron development 0.06389 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.7276 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.206 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.002235 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.001169 Highly Informative Inherited
Biological Process (BP) leukocyte degranulation 0.1072 Highly Informative Inherited
Biological Process (BP) inner ear development 0.122 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.6454 Highly Informative Inherited
Biological Process (BP) gastrulation 0.1808 Highly Informative Inherited
Biological Process (BP) appendage development 0.1997 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.002933 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04687 Highly Informative Inherited
Biological Process (BP) brain development 0.423 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.01706 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.005037 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.003453 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.03626 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.01731 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8963 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02501 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.02024 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3192 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0.01499 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.05199 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.7683 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.8398 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.00000000001922 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.0000000374 Informative Direct
Molecular Function (MF) protein dimerization activity 0.03603 Informative Inherited
Molecular Function (MF) DNA binding 0.9965 Informative Inherited
Molecular Function (MF) ATPase activity 0.5438 Informative Inherited
Molecular Function (MF) phospholipid binding 0.004011 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.006166 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.0255 Informative Inherited
Molecular Function (MF) receptor binding 0.1392 Informative Inherited
Molecular Function (MF) enzyme binding 0.7019 Informative Inherited
Molecular Function (MF) cell adhesion molecule binding 0.000000000004023 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000000002968 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000000507 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.0000003373 Highly Informative Direct
Molecular Function (MF) protease binding 0.00001422 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.01542 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.001617 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000000004171 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.00000001221 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0009026 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0000000000002112 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000000223 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000001079 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00003689 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.0008707 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2576 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.3416 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.004007 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.7489 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00276 Moderately Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular organelle 0.00000000008186 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000000009646 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0001684 Informative Direct
Cellular Component (CC) secretory granule 0.0003258 Informative Direct
Cellular Component (CC) transporter complex 0.1125 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.1737 Informative Inherited
Cellular Component (CC) plasma membrane region 0.2831 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.03596 Informative Inherited
Cellular Component (CC) side of membrane 0.001137 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000002395 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000002221 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0.0000004198 Highly Informative Direct
Cellular Component (CC) extracellular matrix component 0.0000005593 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.000006946 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0004445 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.001782 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.01448 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.6576 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.04055Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.205Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4837Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.000851InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01411InformativeInherited
Disease Ontology (DO)bullous skin disease0.01515InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0003173Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.293Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3738Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.7666Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.9218Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9705Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.01658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1788Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.3347Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.6576Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.713Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.8098Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.9048Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9401Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.9686Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.003211InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0228InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.1021InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.1047InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1283InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.1283InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.1374InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.2284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2286InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.238InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.2395InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.407InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.6384InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation0.0000001294Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0001853Highly InformativeDirect
Phenotypic Abnormality (PA)Protruding ear0.0003998Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.006185Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb joint0.04494Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.101Highly InformativeInherited
Phenotypic Abnormality (PA)Dystonia0.1446Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1568Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3438Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4495Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.3898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002928InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001595Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0003785Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)muscle attachment variant0.00008233Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0007018Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1117Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1204Least InformativeInherited
Fly Anatomy (FA)integumentary system0.312Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0751Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1379Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.004333InformativeInherited
Fly Anatomy (FA)tracheal system0.01191InformativeInherited
Fly Anatomy (FA)epithelial tube0.01347InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.01657InformativeInherited
Fly Anatomy (FA)muscle system0.01859InformativeInherited
Fly Anatomy (FA)prepupa0.02545InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.04904InformativeInherited
Fly Anatomy (FA)muscle attachment site0.00001381Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0005841Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)NF stage0.0006664Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000000000629Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000005219Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.01206Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.03567Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.08009Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000002406InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000002729InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage9.633e-16Moderately InformativeDirect
Biological processImmunity0.0000114Moderately InformativeDirect
Biological processDifferentiation0.0001238Moderately InformativeDirect
Biological processUbl conjugation pathway0.0001302Moderately InformativeDirect
Biological processCell cycle0.7236Moderately InformativeInherited
Biological processIon transport0.9751Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination0.000000000000001678InformativeDirect
Biological processInnate immunity0.00000001243InformativeDirect
Biological processHemostasis0.000003612InformativeDirect
Biological processMitosis0.00004575InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPhagocytosis0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis0.000000001694Highly InformativeDirect
Biological processComplement alternate pathway0.00000164Highly InformativeDirect
Biological processBlood coagulation0.000002646Highly InformativeDirect
Biological processComplement pathway0.000533Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0000000172Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000000009237Moderately InformativeDirect
Cellular componentEndosome0.00007703Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere0Highly InformativeDirect
Cellular componentProteasome0.00000248Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.234e-16Highly InformativeDirect
Molecular functionZinc0.000000000006749Least InformativeDirect
Molecular functionMetal-binding0.0003227Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0.00000000005606InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel0.00000001262InformativeDirect
Post-translational modificationChromatin regulator0.0003801InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationSerine protease inhibitor0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000001748Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.0000000000009627Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.00000000000004898InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis0.00000000001356Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.00000269Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]