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vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,582) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,700 74,967 53
Proteins 29,726 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.079311Least InformativeInherited
Biological Process (BP)developmental process0.24320.9967Least InformativeInherited
Biological Process (BP)multicellular organismal process0.35181Least InformativeInherited
Biological Process (BP)response to stimulus0.26980.00001161Least InformativeInherited
Biological Process (BP)single-organism cellular process0.29060.00000005364Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.14750.008087Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.2140.829Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.14970.00676Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.19690.265Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.28670.2593Least InformativeInherited
Biological Process (BP)nervous system development0.0035510.02774Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0062340.3613Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.016030.2765Moderately InformativeInherited
Biological Process (BP)cell differentiation0.017281Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10941Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.010680.4279Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010670.02353Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00039080.0000000000003598InformativeDirect
Biological Process (BP)DNA metabolic process0.00052060.000000000000005594InformativeDirect
Biological Process (BP)regulation of nervous system development0.00003020.04035InformativeInherited
Biological Process (BP)regulation of cell development0.000063290.2269InformativeInherited
Biological Process (BP)positive regulation of developmental process0.00014070.3719InformativeInherited
Biological Process (BP)generation of neurons0.00058521InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.00000020810.0001417Highly InformativeDirect
Biological Process (BP)double-strand break repair0.00000026040.000000001057Highly InformativeDirect
Biological Process (BP)response to ionizing radiation0.00000032120.000000000002854Highly InformativeDirect
Cellular Component (CC)extracellular matrix0.00000016280InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00001161 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000005364 Least Informative Direct
Biological Process (BP) localization 0.000007154 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0009346 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9967 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.265 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.00676 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2593 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.829 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.008087 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001953 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004623 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3613 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1868 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4279 Moderately Informative Inherited
Biological Process (BP) organ development 0.4494 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002392 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4309 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02774 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5095 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2765 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8914 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.915 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1891 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02353 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.0000000000003598 Informative Direct
Biological Process (BP) DNA metabolic process 0.000000000000005594 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) response to wounding 0.0000000007022 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000000001404 Informative Direct
Biological Process (BP) locomotion 0.000000002611 Informative Direct
Biological Process (BP) localization of cell 0.00000007625 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000001338 Informative Direct
Biological Process (BP) leukocyte activation 0.000002865 Informative Direct
Biological Process (BP) cellular component movement 0.00001151 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.343 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04035 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2111 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1912 Informative Inherited
Biological Process (BP) regulation of protein localization 0.4501 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1097 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1283 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2477 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.03054 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9141 Informative Inherited
Biological Process (BP) tube development 0.1487 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 0.06477 Informative Inherited
Biological Process (BP) embryonic organ development 0.4216 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07322 Informative Inherited
Biological Process (BP) regulation of cell activation 0.00291 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8325 Informative Inherited
Biological Process (BP) regulation of cell development 0.2269 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3719 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04031 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02837 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2546 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3269 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.06077 Informative Inherited
Biological Process (BP) central nervous system development 0.0152 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle structure development 0.01415 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.8717 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.667 Informative Inherited
Biological Process (BP) immune response 0.08701 Informative Inherited
Biological Process (BP) regulation of immune response 0.0236 Informative Inherited
Biological Process (BP) immune effector process 0.5414 Informative Inherited
Biological Process (BP) defense response 0.03283 Informative Inherited
Biological Process (BP) organelle localization 0.6525 Informative Inherited
Biological Process (BP) cellular membrane organization 0.3008 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01466 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06708 Informative Inherited
Biological Process (BP) anion transport 0.1751 Informative Inherited
Biological Process (BP) metal ion transport 0.2236 Informative Inherited
Biological Process (BP) regulation of secretion 0.6468 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2196 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.03736 Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.0001417 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000000001057 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 0.000000000002854 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.0000000000003998 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.00000000002881 Highly Informative Direct
Biological Process (BP) hemostasis 0.0000000002019 Highly Informative Direct
Biological Process (BP) coagulation 0.000000001005 Highly Informative Direct
Biological Process (BP) protein activation cascade 0.000000001352 Highly Informative Direct
Biological Process (BP) chemotaxis 0.000000001681 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000000004481 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000007584 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0.0000001503 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.000001578 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000001754 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.000002348 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00001387 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.00002959 Highly Informative Direct
Biological Process (BP) vesicle organization 0.00003085 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.00003451 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.00003801 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000215 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0002281 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0007198 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0009018 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.172 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.09533 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2626 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01438 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.001181 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.1157 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003788 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6871 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.1384 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.09746 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.137 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03471 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.3999 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.3579 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.6986 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.3829 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01769 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6943 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.6947 Highly Informative Inherited
Biological Process (BP) ear development 0.2863 Highly Informative Inherited
Molecular Function (MF) binding 0.1326 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0.9451 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.001218 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.05151 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.00000005343 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000008708 Informative Direct
Molecular Function (MF) receptor binding 0.00006084 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1747 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.01762 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.002787 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02643 Informative Inherited
Molecular Function (MF) lipid binding 0.02416 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.6722 Informative Inherited
Molecular Function (MF) enzyme binding 0.7958 Informative Inherited
Molecular Function (MF) protein complex binding 0.0000000000001177 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.00000001689 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000005468 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000003935 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.00002095 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.00003943 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.37 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0.000009978 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.321 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.00003599 Moderately Informative Direct
Cellular Component (CC) cell projection 0.8204 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01056 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9581 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.3754 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8528 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.000000000001683 Informative Direct
Cellular Component (CC) integral to membrane 0.000000000001935 Informative Direct
Cellular Component (CC) cell junction 0.00000001054 Informative Direct
Cellular Component (CC) coated vesicle 0.000000341 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 0.0000005175 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7611 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000001044 Highly Informative Direct
Cellular Component (CC) transport vesicle 0.0000000000001071 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0000000000003158 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000001072 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0001546 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0008138 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.01831 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.1076 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.05995 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3305 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.000000001101Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001551Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.098Least InformativeInherited
Disease Ontology (DO)skin disease0.06889Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4763Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5341Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.000008829InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0007542InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01812InformativeInherited
Disease Ontology (DO)thrombocytopenia0.00085Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4786Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5942Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8661Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9339Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05158Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1435Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1435Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.2201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2547Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3392Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.7279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9156Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03391InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03449InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.1633InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.1965InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.2937InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.441InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5087InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5209InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5707InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation0.0000006557Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers0.0000006557Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles0.0000006557Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis0.000001942Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis0.000008971Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperextensibility at wrists0.00001286Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance0.0000394Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter0.00005826Highly InformativeDirect
Phenotypic Abnormality (PA)Torticollis0.0001106Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001464Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.0002387Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0002387Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0002387Highly InformativeDirect
Phenotypic Abnormality (PA)Joint laxity0.000944Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased body weight0.2884Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.3626Highly InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.4242Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1685Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4586Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4797Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.2137Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8121Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.8356Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002806InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00001361Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002257Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0001246Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.08528Least InformativeInherited
Fly Anatomy (FA)organ system0.3509Least InformativeInherited
Fly Anatomy (FA)larva0.3583Least InformativeInherited
Fly Anatomy (FA)late embryo0.04168Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.09609Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1411Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007895InformativeInherited
Fly Anatomy (FA)tracheal system0.01528InformativeInherited
Fly Anatomy (FA)epithelial tube0.01571InformativeInherited
Fly Anatomy (FA)muscle system0.02001InformativeInherited
Fly Anatomy (FA)prepupa0.03108InformativeInherited
Fly Anatomy (FA)muscle attachment site0.0000191Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0005999Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.0009433Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.0000000008795Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01459Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02808Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001122InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage0.000000000000001629Moderately InformativeDirect
Biological processIon transport0.9768Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination0.000000000000005966InformativeDirect
Biological processInnate immunity0.000000001618InformativeDirect
Biological processHemostasis0.000002816InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis0.000000001058Highly InformativeDirect
Biological processBlood coagulation0.000002325Highly InformativeDirect
Biological processComplement alternate pathway0.000004592Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0006014Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection0.0000001218Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere6.436e-16Highly InformativeDirect
Cellular componentProteasome0.000009919Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.161e-16Highly InformativeDirect
Molecular functionZinc0.0000000215Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0.00000000004118Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.535Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel0.000000006694InformativeDirect
Post-translational modificationSerine protease0.0000939InformativeDirect
Post-translational modificationChromatin regulator0.0002752InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000001548Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0.000000000007683Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan0.0000000001423InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis0.00000000001364Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.000002816Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]