SUPERFAMILY 1.75 HMM library and genome assignments server


vWA-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   vWA-like [ 53299]
Superfamily:   vWA-like [ 53300] (5)
Families:   Integrin A (or I) domain [ 53301] (10)
  Trunk domain of Sec23/24 [ 82458] (2)
  Ku70 subunit N-terminal domain [ 100959]
  Ku80 subunit N-terminal domain [ 100962]
  RoRNP C-terminal domain-like [ 142565]


Superfamily statistics
Genomes (2,582) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 34,685 74,967 53
Proteins 29,714 68,897 53


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.073681Least InformativeInherited
Biological Process (BP)developmental process0.23960.9793Least InformativeInherited
Biological Process (BP)multicellular organismal process0.34861Least InformativeInherited
Biological Process (BP)response to stimulus0.25747.416e-06Least InformativeInherited
Biological Process (BP)single-organism cellular process0.27964.257e-08Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.13820.007076Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.20820.8233Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.14080.005957Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.18450.2462Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.27120.2362Least InformativeInherited
Biological Process (BP)nervous system development0.0034090.02686Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0060940.3282Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.01550.2522Moderately InformativeInherited
Biological Process (BP)cell differentiation0.017031Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10451Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.010560.4695Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.010610.01778Moderately InformativeInherited
Biological Process (BP)response to DNA damage stimulus0.00037635.421e-13InformativeDirect
Biological Process (BP)DNA metabolic process0.00050923.77e-15InformativeDirect
Biological Process (BP)regulation of nervous system development2.765e-050.04254InformativeInherited
Biological Process (BP)regulation of cell development5.208e-050.2107InformativeInherited
Biological Process (BP)positive regulation of developmental process0.00013110.3695InformativeInherited
Biological Process (BP)generation of neurons0.00057881InformativeInherited
Biological Process (BP)positive regulation of neurogenesis2.051e-070.0001411Highly InformativeDirect
Biological Process (BP)double-strand break repair2.565e-077.565e-10Highly InformativeDirect
Biological Process (BP)response to ionizing radiation3.006e-077.708e-13Highly InformativeDirect
Cellular Component (CC)extracellular matrix1.522e-070InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 7.416e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.257e-08 Least Informative Direct
Biological Process (BP) localization 6.685e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005761 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9793 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2462 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.005957 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2362 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.8233 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.007076 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000149 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000355 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3282 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1697 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4695 Moderately Informative Inherited
Biological Process (BP) organ development 0.4465 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.5053 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4286 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.02686 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.5115 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2522 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9506 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9003 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1962 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01778 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to DNA damage stimulus 5.421e-13 Informative Direct
Biological Process (BP) DNA metabolic process 3.77e-15 Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) response to wounding 7.113e-10 Informative Direct
Biological Process (BP) positive regulation of immune system process 1.406e-09 Informative Direct
Biological Process (BP) locomotion 2.219e-09 Informative Direct
Biological Process (BP) localization of cell 6.292e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.458e-06 Informative Direct
Biological Process (BP) leukocyte activation 2.849e-06 Informative Direct
Biological Process (BP) cellular component movement 1.354e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.309 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.04254 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.2113 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.176 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.003594 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.01335 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.1267 Informative Inherited
Biological Process (BP) cardiovascular system development 0.2473 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.9178 Informative Inherited
Biological Process (BP) tube development 0.1519 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell projection organization 0.06829 Informative Inherited
Biological Process (BP) embryonic organ development 0.4223 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07746 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.8055 Informative Inherited
Biological Process (BP) regulation of cell development 0.2107 Informative Inherited
Biological Process (BP) protein complex assembly 0.005561 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3695 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.04319 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.03009 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2451 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.3219 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.06027 Informative Inherited
Biological Process (BP) central nervous system development 0.01368 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle structure development 0.01374 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.8721 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.6826 Informative Inherited
Biological Process (BP) immune response 0.09022 Informative Inherited
Biological Process (BP) regulation of immune response 0.02067 Informative Inherited
Biological Process (BP) immune effector process 0.5517 Informative Inherited
Biological Process (BP) defense response 0.04747 Informative Inherited
Biological Process (BP) organelle localization 0.6614 Informative Inherited
Biological Process (BP) cellular membrane organization 0.2983 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01126 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06314 Informative Inherited
Biological Process (BP) anion transport 0.169 Informative Inherited
Biological Process (BP) metal ion transport 0.2263 Informative Inherited
Biological Process (BP) regulation of secretion 0.6169 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2108 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.03698 Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.0001411 Highly Informative Direct
Biological Process (BP) double-strand break repair 7.565e-10 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 7.708e-13 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 3.86e-13 Highly Informative Direct
Biological Process (BP) leukocyte migration 2.623e-11 Highly Informative Direct
Biological Process (BP) hemostasis 2.034e-10 Highly Informative Direct
Biological Process (BP) coagulation 1.01e-09 Highly Informative Direct
Biological Process (BP) protein activation cascade 1.421e-09 Highly Informative Direct
Biological Process (BP) chemotaxis 2.054e-09 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 3.796e-09 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 7.696e-08 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 1.547e-07 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 1.601e-06 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 1.787e-06 Highly Informative Direct
Biological Process (BP) inorganic anion transport 2.173e-06 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 1.125e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 2.49e-05 Highly Informative Direct
Biological Process (BP) glial cell differentiation 3.262e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 3.328e-05 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 3.771e-05 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000216 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0002613 Highly Informative Direct
Biological Process (BP) inflammatory response 0.0005767 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0009733 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1549 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.09295 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.2753 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.01117 Highly Informative Inherited
Biological Process (BP) artery morphogenesis 0.001229 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.117 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.003985 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.6752 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.1429 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0428 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.09966 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.03308 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.3757 Highly Informative Inherited
Biological Process (BP) DNA damage checkpoint 0.3531 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.4011 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.01479 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6721 Highly Informative Inherited
Biological Process (BP) antigen processing and presentation 0.7024 Highly Informative Inherited
Biological Process (BP) ear development 0.286 Highly Informative Inherited
Molecular Function (MF) binding 0.1073 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.8065 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.9324 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.001381 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.04552 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 5.829e-08 Informative Direct
Molecular Function (MF) sulfur compound binding 8.249e-07 Informative Direct
Molecular Function (MF) receptor binding 6.099e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1758 Informative Inherited
Molecular Function (MF) protein dimerization activity 0.01859 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.002686 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.02654 Informative Inherited
Molecular Function (MF) lipid binding 0.02388 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.6803 Informative Inherited
Molecular Function (MF) enzyme binding 0.7775 Informative Inherited
Molecular Function (MF) protein complex binding 1.108e-13 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 1.704e-08 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 5.742e-08 Highly Informative Direct
Molecular Function (MF) heparin binding 4.716e-07 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 2.127e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 3.117e-05 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.3727 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 9.404e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3423 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 3.65e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0.765 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.005049 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.9553 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4133 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.8824 Moderately Informative Inherited
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 1.85e-12 Informative Direct
Cellular Component (CC) integral to membrane 3.818e-12 Informative Direct
Cellular Component (CC) coated vesicle 2.509e-07 Informative Direct
Cellular Component (CC) nuclear DNA-directed RNA polymerase complex 5.408e-07 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7482 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0 Highly Informative Direct
Cellular Component (CC) receptor complex 1.166e-13 Highly Informative Direct
Cellular Component (CC) transport vesicle 1.192e-13 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 8.562e-08 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.061e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.0001488 Highly Informative Direct
Cellular Component (CC) cell-substrate junction 0.0005927 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0008575 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.01341 Highly Informative Inherited
Cellular Component (CC) ion channel complex 0.1073 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.05357 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.3167 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides1.101e-09Least InformativeDirect
Enzyme Commission (EC)Ligases0.04839Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01625Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.551e-13Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1102Least InformativeInherited
Disease Ontology (DO)skin disease0.0694Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4756Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.5369Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.431e-05InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.0006529InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.01722InformativeInherited
Disease Ontology (DO)thrombocytopenia0.0007152Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4831Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5971Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8706Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9362Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03792Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.05365Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1436Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1448Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.2218Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2549Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.724Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.9189Moderately InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.03574InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.03625InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the joints of the lower limbs0.1639InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.2059InformativeInherited
Phenotypic Abnormality (PA)Abnormality of thrombocytes0.3003InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.3425InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.4461InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.5118InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5147InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5739InformativeInherited
Phenotypic Abnormality (PA)Nocturnal hypoventilation6.201e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of fingers6.201e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Increased laxity of ankles6.201e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber necrosis1.871e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital muscular torticollis8.633e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Type 1 muscle fiber predominance3.797e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Increased variability in muscle fiber diameter5.572e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Torticollis0.0001068Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal rigidity0.0001421Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding time0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Mildly elevated creatine phosphokinase0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.1606Highly InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.2935Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body height0.3728Highly InformativeInherited
Phenotypic Abnormality (PA)Limb joint contracture0.4319Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1641Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4219Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4731Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.2148Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.8031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.8142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.8385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte migration0.0002981InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation7.88e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell adhesion0.0002299Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell shape defective0.0001258Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.08709Least InformativeInherited
Fly Anatomy (FA)organ system0.355Least InformativeInherited
Fly Anatomy (FA)larva0.3601Least InformativeInherited
Fly Anatomy (FA)late embryo0.04245Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.09631Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1415Moderately InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.007959InformativeInherited
Fly Anatomy (FA)tracheal system0.0153InformativeInherited
Fly Anatomy (FA)epithelial tube0.01598InformativeInherited
Fly Anatomy (FA)muscle system0.01901InformativeInherited
Fly Anatomy (FA)prepupa0.03205InformativeInherited
Fly Anatomy (FA)muscle attachment site1.912e-05Highly InformativeDirect
Fly Anatomy (FA)primary trachea0.0005984Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0.0009387Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1.004e-09Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01521Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.02844Moderately InformativeInherited
Enzyme Commission (EC)DNA helicase0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.152e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processDNA damage1.631e-15Moderately InformativeDirect
Biological processIon transport0.976Moderately InformativeInherited
Biological processCell adhesion0InformativeDirect
Biological processDNA recombination5.968e-15InformativeDirect
Biological processInnate immunity1.636e-09InformativeDirect
Biological processHemostasis2.575e-06InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis1.062e-09Highly InformativeDirect
Biological processBlood coagulation2.129e-06Highly InformativeDirect
Biological processComplement alternate pathway4.592e-06Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.0005787Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell projection1.12e-07Moderately InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentTelomere6.428e-16Highly InformativeDirect
Cellular componentProteasome9.99e-06Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainCollagen0Highly InformativeDirect
DomainSushi6.186e-16Highly InformativeDirect
Molecular functionZinc1.624e-08Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride3.848e-11Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtease0.5359Moderately InformativeInherited
Post-translational modificationHelicase0InformativeDirect
Post-translational modificationProtease inhibitor0InformativeDirect
Post-translational modificationIon channel6.668e-09InformativeDirect
Post-translational modificationSerine protease9.43e-05InformativeDirect
Post-translational modificationChromatin regulator0.0002589InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationVoltage-gated channel1.546e-15Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond7.915e-12Least InformativeDirect
Post-translational modificationHydroxylation0InformativeDirect
Post-translational modificationProteoglycan1.498e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)pigment biosynthesis0InformativeDirect
UniPathway (UP)heterocycle biosynthesis0InformativeDirect
UniPathway (UP)bacteriochlorophyll biosynthesis1.366e-11Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis2.821e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a vWA-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the vWA-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]