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Pyruvate-ferredoxin oxidoreductase, PFOR, domain III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [ 53322]
Superfamily:   Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [ 53323]
Families:   Pyruvate-ferredoxin oxidoreductase, PFOR, domain III [ 53324]


Superfamily statistics
Genomes (1,778) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,674 23,568 1
Proteins 3,674 23,556 1


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.0000030220.00000007466Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000062130.01729Least InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.00000089540.00000000004774Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.000061680.00000001721Moderately InformativeDirect
Biological Process (BP)fermentation00.0000002964Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000007466 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01729 Least Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.00000000004774 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000001721 Moderately Informative Direct
Biological Process (BP) fermentation 0.0000002964 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000000001436 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000005139 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00002362Least InformativeDirect
Biological processElectron transport0.0000000000002087InformativeDirect
Biological processNitrogen fixation0.0000000000002923InformativeDirect
DomainRepeat0.0004204Least InformativeDirect
Molecular functionMetal-binding0.264Least InformativeInherited
Molecular functionIron-sulfur0.0000000002948Moderately InformativeDirect
Molecular functionIron0.000001475Moderately InformativeDirect
Molecular function4Fe-4S0.00000000004905InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR002869 SSF53323 Protein matches
Abstract This domain is found in prokaryotes. It includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether the gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms [PubMed8550425]. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA [PubMed8550425]. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [PubMed8415612].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Pyruvate-ferredoxin oxidoreductase, PFOR, domain III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Pyruvate-ferredoxin oxidoreductase, PFOR, domain III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]