SUPERFAMILY 1.75 HMM library and genome assignments server

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S-adenosyl-L-methionine-dependent methyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   S-adenosyl-L-methionine-dependent methyltransferases [ 53334]
Superfamily:   S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (57)
Families:   COMT-like [ 53336] (3)
  Plant O-methyltransferase, C-terminal domain [ 64111] (5)
  RNA methyltransferase FtsJ [ 53339]
  Fibrillarin homologue [ 53342]
  rRNA methyltransferase RlmA [ 102557]
  rRNA methyltransferase AviRa [ 89738]
  rRNA adenine dimethylase-like [ 88784] (4)
  mRNA cap methylase [ 88785] (2)
  mRNA cap (Guanine N-7) methyltransferase [ 102560]
  Hypothetical protein MJ0882 [ 53345]
  Hypothetical protein HI0319 (YecO) [ 69544]
  Glycine N-methyltransferase [ 53348]
  Arylamine N-methyltransferase [ 69547] (2)
  Histamine methyltransferase [ 75261]
  Hypothetical Protein YjhP [ 82469]
  Salicylic acid carboxyl methyltransferase (SAMT) [ 102563]
  Thiopurine S-methyltransferase [ 102566]
  Leucine carboxy methyltransferase Ppm1 [ 102569]
  Precorrin-6Y methyltransferase (CbiT) [ 82472]
  MraW-like putative methyltransferases [ 82475]
  N5-glutamine methyltransferase, HemK [ 89743]
  Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746]
  Guanidinoacetate methyltransferase [ 69550]
  Arginine methyltransferase [ 53351] (3)
  Protein-L-isoaspartyl O-methyltransferase [ 53354]
  Glucose-inhibited division protein B (GidB) [ 75264]
  tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4)
  NOL1/NOP2/sun [ 102575] (3)
  Ribosomal protein L11 methyltransferase PrmA [ 102578]
  (Uracil-5-)-methyltransferase [ 102581]
  Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357]
  C5 cytosine-specific DNA methylase, DCM [ 88786] (3)
  DNA methylase TaqI, N-terminal domain [ 88787]
  N6 adenine-specific DNA methylase, DAM [ 88788] (2)
  Type II DNA methylase [ 53377] (3)
  Spermidine synthase [ 69557] (2)
  Mycolic acid cyclopropane synthase [ 69560] (6)
  Ta1320-like [ 89751] (2)
  UbiE/COQ5-like [ 110671] (5)
  AD-003 protein-like [ 117685] (2)
  CAC2371-like [ 117688] (3)
  TehB-like [ 142603]
  N-6 DNA Methylase-like [ 142606] (3)
  YhhF-like [ 142611] (5)
  Met-10+ protein-like [ 142622]
  Nsp15 N-terminal domain-like [ 142625]
  BC2162-like [ 142629]
  CmcI-like [ 142632]
  hypothetical RNA methyltransferase [ 142635] (4)
  RPA4359-like [ 142644]
  TrmB-like [ 142647]
  Methyltransferase 10 domain [ 142651]
  YhiQ-like [ 159686]
  FkbM-like [ 159691]
  ML2640-like [ 159694]
  TRM1-like [ 159697]
  LPG1296-like [ 159700]


Superfamily statistics
Genomes (3,252) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 193,140 759,822 166
Proteins 187,758 748,111 166


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process0.000000000059030.000000000000007347Least InformativeDirect
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.86661Least InformativeInherited
Biological Process (BP)protein metabolic process0.44461Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.44270.000000000004425Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.47530.000000000308Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.5990.00000000007024Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.1420.0000395Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000000095220.0000001697Moderately InformativeDirect
Biological Process (BP)gene expression0.00004310.000000000000007347Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.000011680Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.00077230.0000000000688Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.69490.5331Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.75981Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.090870.05811Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.061640.1177Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.67210.9706Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0070070.002239Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.97471Moderately InformativeInherited
Biological Process (BP)organelle organization0.87870.326Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.97241Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.27120.01301Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.84641Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)RNA processing0.00000000000021540InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.000040770.000001076InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.00000053610InformativeDirect
Biological Process (BP)ribonucleoprotein complex biogenesis0.00000000070990InformativeDirect
Biological Process (BP)ncRNA metabolic process00InformativeDirect
Biological Process (BP)fatty acid metabolic process0.37011InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.044110.06909InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.0014160.2077InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.62121InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.77330.2586InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.000025680.007789InformativeInherited
Biological Process (BP)chromosome organization0.0029890.00000000000003459InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly10.2236InformativeInherited
Biological Process (BP)secondary metabolic process0.0011710InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.032660.00000002253InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.5950.3224InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.022650.7502InformativeInherited
Biological Process (BP)mitochondrion organization0.29550.01717InformativeInherited
Biological Process (BP)transcription, DNA-dependent11InformativeInherited
Biological Process (BP)DNA metabolic process11InformativeInherited
Biological Process (BP)amino-acid betaine metabolic process0.00044140.0001229Highly InformativeDirect
Biological Process (BP)polyamine metabolic process0.00000018280.0000005021Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.000010040.000000000000001938Highly InformativeDirect
Biological Process (BP)regulation of gene expression, epigenetic0.000018210Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process0.000019440.00000000004799Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.000002510.000007263Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.00000048190.0000008967Highly InformativeDirect
Biological Process (BP)DNA modification0.0022060Highly InformativeInherited
Biological Process (BP)cell wall macromolecule biosynthetic process0.0020540.02651Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.35480.9642Highly InformativeInherited
Biological Process (BP)peptidyl-serine modification0.45911Highly InformativeInherited
Biological Process (BP)protein methylation0.35021Highly InformativeInherited
Biological Process (BP)peptidyl-proline modification0.00048240.05185Highly InformativeInherited
Biological Process (BP)histone modification0.039210Highly InformativeInherited
Biological Process (BP)RNA methylation0.0043890Highly InformativeInherited
Biological Process (BP)tRNA modification0.0088580.8811Highly InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process0.0048920.01822Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.023210.003317Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.010020.09206Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring one-carbon groups00InformativeDirect
Molecular Function (MF)carboxylic acid binding0.33350.8538InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.79891InformativeInherited
Molecular Function (MF)methyltransferase activity00Highly InformativeDirect
Molecular Function (MF)amino acid binding0.018740.2563Highly InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)organelle membrane11Moderately InformativeInherited
Cellular Component (CC)organelle envelope11Moderately InformativeInherited
Cellular Component (CC)mitochondrial part11Moderately InformativeInherited
Cellular Component (CC)mitochondrial membrane part0.71441InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000308 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0000395 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000000007347 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000000000004425 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000007024 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.0000001697 Moderately Informative Direct
Biological Process (BP) gene expression 0.000000000000007347 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.0000000000688 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.5331 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1177 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.9706 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.002239 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01301 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.326 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.05811 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000001076 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0 Informative Direct
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000002253 Informative Direct
Biological Process (BP) amide biosynthetic process 0.000000005825 Informative Direct
Biological Process (BP) chromosome organization 0.00000000000003459 Informative Direct
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.06909 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.2077 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.2586 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.007789 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.03116 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.1393 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.3224 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.7502 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01717 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.2236 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) RNA methylation 0 Highly Informative Direct
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0.0001229 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0000005021 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 0.0000436 Highly Informative Direct
Biological Process (BP) gene silencing 0.000004454 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000000000000001938 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 0.00000000004799 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000007263 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0.0000008967 Highly Informative Direct
Biological Process (BP) cell wall macromolecule biosynthetic process 0.02651 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.00302 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.5053 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.9642 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 0.05185 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.8811 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.02101 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.003866 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.247 Highly Informative Inherited
Biological Process (BP) protein processing 0.3172 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.003317 Highly Informative Inherited
Biological Process (BP) phenylpropanoid metabolic process 0.01822 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.008752 Highly Informative Inherited
Biological Process (BP) imidazole-containing compound metabolic process 0.004436 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.09206 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 1 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.002734 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.5715 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.8538 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Informative Inherited
Molecular Function (MF) methyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.2563 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial membrane part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.00000006246 Highly Informative Direct
Cellular Component (CC) chromatin 0.04776 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.03493Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000000809InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000002852InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000002852InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000004862InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0.00002048InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0.0002104InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)mRNA guanylyltransferase0.000000000000004166Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase0.00001852Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.5256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.2934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the philtrum0.02553Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.5876Least InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA methylation0.0004178Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.1618InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.3221Least InformativeInherited
Yeast Phenotype (YP)RNA modification0.000009951Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.00002156InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.03083InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases1InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase0.000000000000005223Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.0000004224Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000009037Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000003176Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0.00001137Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0000588Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10.0001983Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.4126Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0.00000004955InformativeDirect
Biological processSteroid metabolism0.02541InformativeInherited
Biological processVirus entry into host cell0.3636InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processPolyamine biosynthesis0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0.00000000000001002Highly InformativeDirect
Biological processSterol biosynthesis0.00002705Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.00005901Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000077Highly InformativeDirect
Biological processInhibition of host IRF3 by virus0.00008302Highly InformativeDirect
Biological processSteroid biosynthesis0.0003385Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentHost membrane0.000000000003633InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein0.00000105Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0.00000000004986Moderately InformativeDirect
DiseaseWilliams-Beuren syndrome0.00003458Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionRNA-binding0.00000000000000365Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Molecular functionIron-sulfur0.000000000000001834InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0.0000000004575InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationPhosphopantetheine0.00000000000003876Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.000003558Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.005739Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.1189Moderately InformativeInherited
UniPathway (UP)aromatic compound degradation0.5849Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0InformativeDirect
UniPathway (UP)putrescine metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0.00000000004115InformativeDirect
UniPathway (UP)polyketide biosynthesis0.00000001459InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0000002961InformativeDirect
UniPathway (UP)toxin biosynthesis0.000005603InformativeDirect
UniPathway (UP)terpene metabolism0.00000682InformativeDirect
UniPathway (UP)hormone biosynthesis0.00001423InformativeDirect
UniPathway (UP)alkaloid metabolism0.00002172InformativeDirect
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)isoprenoid biosynthesis1InformativeInherited
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)sterol biosynthesis2.278e-16Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis0.000000005438Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0.000002301Highly InformativeDirect
UniPathway (UP)glycerophospholipid biosynthesis0.000006373Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0.0000144Highly InformativeDirect
UniPathway (UP)plant chemical defense0.000032Highly InformativeDirect
UniPathway (UP)flavonoid degradation0.0000353Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.000148Highly InformativeDirect
UniPathway (UP)mRNA processing0.0001729Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.01661Highly InformativeInherited
UniPathway (UP)carotenoid biosynthesis0.1677Highly InformativeInherited
UniPathway (UP)betaine biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]