SUPERFAMILY 1.75 HMM library and genome assignments server


S-adenosyl-L-methionine-dependent methyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   S-adenosyl-L-methionine-dependent methyltransferases [ 53334]
Superfamily:   S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (57)
Families:   COMT-like [ 53336] (3)
  Plant O-methyltransferase, C-terminal domain [ 64111] (5)
  RNA methyltransferase FtsJ [ 53339]
  Fibrillarin homologue [ 53342]
  rRNA methyltransferase RlmA [ 102557]
  rRNA methyltransferase AviRa [ 89738]
  rRNA adenine dimethylase-like [ 88784] (4)
  mRNA cap methylase [ 88785] (2)
  mRNA cap (Guanine N-7) methyltransferase [ 102560]
  Hypothetical protein MJ0882 [ 53345]
  Hypothetical protein HI0319 (YecO) [ 69544]
  Glycine N-methyltransferase [ 53348]
  Arylamine N-methyltransferase [ 69547] (2)
  Histamine methyltransferase [ 75261]
  Hypothetical Protein YjhP [ 82469]
  Salicylic acid carboxyl methyltransferase (SAMT) [ 102563]
  Thiopurine S-methyltransferase [ 102566]
  Leucine carboxy methyltransferase Ppm1 [ 102569]
  Precorrin-6Y methyltransferase (CbiT) [ 82472]
  MraW-like putative methyltransferases [ 82475]
  N5-glutamine methyltransferase, HemK [ 89743]
  Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746]
  Guanidinoacetate methyltransferase [ 69550]
  Arginine methyltransferase [ 53351] (3)
  Protein-L-isoaspartyl O-methyltransferase [ 53354]
  Glucose-inhibited division protein B (GidB) [ 75264]
  tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4)
  NOL1/NOP2/sun [ 102575] (3)
  Ribosomal protein L11 methyltransferase PrmA [ 102578]
  (Uracil-5-)-methyltransferase [ 102581]
  Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357]
  C5 cytosine-specific DNA methylase, DCM [ 88786] (3)
  DNA methylase TaqI, N-terminal domain [ 88787]
  N6 adenine-specific DNA methylase, DAM [ 88788] (2)
  Type II DNA methylase [ 53377] (3)
  Spermidine synthase [ 69557] (2)
  Mycolic acid cyclopropane synthase [ 69560] (6)
  Ta1320-like [ 89751] (2)
  UbiE/COQ5-like [ 110671] (5)
  AD-003 protein-like [ 117685] (2)
  CAC2371-like [ 117688] (3)
  TehB-like [ 142603]
  N-6 DNA Methylase-like [ 142606] (3)
  YhhF-like [ 142611] (5)
  Met-10+ protein-like [ 142622]
  Nsp15 N-terminal domain-like [ 142625]
  BC2162-like [ 142629]
  CmcI-like [ 142632]
  hypothetical RNA methyltransferase [ 142635] (4)
  RPA4359-like [ 142644]
  TrmB-like [ 142647]
  Methyltransferase 10 domain [ 142651]
  YhiQ-like [ 159686]
  FkbM-like [ 159691]
  ML2640-like [ 159694]
  TRM1-like [ 159697]
  LPG1296-like [ 159700]


Superfamily statistics
Genomes (3,246) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 190,974 0 166
Proteins 185,812 0 166


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process1.542e-092.604e-14Least InformativeDirect
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.97731Least InformativeInherited
Biological Process (BP)protein metabolic process0.37731Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.60636.695e-12Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.64854.574e-10Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.7562.509e-10Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.26778.936e-05Least InformativeInherited
Biological Process (BP)cellular protein modification process1.538e-071.573e-06Moderately InformativeDirect
Biological Process (BP)gene expression1.157e-051.922e-15Moderately InformativeDirect
Biological Process (BP)RNA metabolic process6.371e-060Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.4980.4578Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.96350.8058Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.74481Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.33550.1952Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.28730.3091Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.89431Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.016630.003993Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.94491Moderately InformativeInherited
Biological Process (BP)organelle organization0.87820.3871Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.97151Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)single-organism biosynthetic process0.0052451.005e-09Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.40690.02356Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.75831Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)RNA processing1.396e-120InformativeDirect
Biological Process (BP)cellular modified amino acid metabolic process0.00097223.108e-05InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)peptidyl-amino acid modification1.457e-060InformativeDirect
Biological Process (BP)ribonucleoprotein complex biogenesis9.764e-100InformativeDirect
Biological Process (BP)ncRNA metabolic process00InformativeDirect
Biological Process (BP)fatty acid metabolic process0.80291InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.24610.2641InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.96281InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.35190.07395InformativeInherited
Biological Process (BP)isoprenoid metabolic process2.421e-050.007372InformativeInherited
Biological Process (BP)chromosome organization0.0032328.856e-14InformativeInherited
Biological Process (BP)protein complex assembly11InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly10.277InformativeInherited
Biological Process (BP)secondary metabolic process0.0025240InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.014374.08e-09InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.28290.1292InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.023040.7597InformativeInherited
Biological Process (BP)mitochondrion organization0.3010.01537InformativeInherited
Biological Process (BP)transcription, DNA-dependent11InformativeInherited
Biological Process (BP)DNA metabolic process11InformativeInherited
Biological Process (BP)amino-acid betaine metabolic process0.00049570.0001286Highly InformativeDirect
Biological Process (BP)polyamine metabolic process2.393e-075.574e-07Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process9.317e-061.782e-11Highly InformativeDirect
Biological Process (BP)regulation of gene expression, epigenetic1.724e-050Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process1.215e-060Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process1.406e-061.704e-12Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process2.745e-067.18e-06Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process3.103e-076.853e-07Highly InformativeDirect
Biological Process (BP)quinone metabolic process1.098e-071.76e-07Highly InformativeDirect
Biological Process (BP)DNA modification0.0021070Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.2390.9109Highly InformativeInherited
Biological Process (BP)cellular component macromolecule biosynthetic process0.0021330.084Highly InformativeInherited
Biological Process (BP)cell wall biogenesis0.018920.2071Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.36251Highly InformativeInherited
Biological Process (BP)peptidyl-serine modification0.34671Highly InformativeInherited
Biological Process (BP)protein methylation0.27971Highly InformativeInherited
Biological Process (BP)peptidyl-proline modification0.01940.2468Highly InformativeInherited
Biological Process (BP)histone modification0.040760Highly InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process0.0042820.01529Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.024450.003653Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.0081560.0772Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring one-carbon groups00InformativeDirect
Molecular Function (MF)carboxylic acid binding0.33020.8334InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.74081InformativeInherited
Molecular Function (MF)methyltransferase activity00Highly InformativeDirect
Molecular Function (MF)amino acid binding0.01870.2434Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 4.574e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 8.936e-05 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.604e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 6.695e-12 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 2.509e-10 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 1.573e-06 Moderately Informative Direct
Biological Process (BP) gene expression 1.922e-15 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 1.005e-09 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.4578 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3091 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.003993 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.8058 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.02356 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3871 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1952 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 3.108e-05 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0 Informative Direct
Biological Process (BP) ncRNA metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 4.08e-09 Informative Direct
Biological Process (BP) chromosome organization 8.856e-14 Informative Direct
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.9943 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.07395 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.007372 Informative Inherited
Biological Process (BP) protein complex assembly 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.03305 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.1231 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.2641 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.09929 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.08406 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 1 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.1292 Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.7597 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01537 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.277 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) DNA modification 0 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0.0001286 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 5.574e-07 Highly Informative Direct
Biological Process (BP) glycoside metabolic process 2.919e-05 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 1.782e-11 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 1.704e-12 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 7.18e-06 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 6.853e-07 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 2.64e-09 Highly Informative Direct
Biological Process (BP) quinone metabolic process 1.76e-07 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.9109 Highly Informative Inherited
Biological Process (BP) cellular component macromolecule biosynthetic process 0.084 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.2071 Highly Informative Inherited
Biological Process (BP) response to acid 0.008244 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.5105 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 0.2468 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.8586 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.01955 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.00296 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.2328 Highly Informative Inherited
Biological Process (BP) protein processing 0.3105 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.003653 Highly Informative Inherited
Biological Process (BP) phenylpropanoid metabolic process 0.01529 Highly Informative Inherited
Biological Process (BP) toxin metabolic process 0.01715 Highly Informative Inherited
Biological Process (BP) imidazole-containing compound metabolic process 0.003758 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.0772 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 1 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 1 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.005066 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.7451 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.8334 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Informative Inherited
Molecular Function (MF) methyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.2434 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) trans-Golgi network 6.485e-08 Highly Informative Direct
Cellular Component (CC) RNA cap binding complex 1.193e-05 Highly Informative Direct
Cellular Component (CC) methylosome 1.211e-06 Highly Informative Direct
Cellular Component (CC) chromatin 0.04844 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.03493Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase8.09e-07InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.852e-06InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.852e-06InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s4.862e-06InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase2.048e-05InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0.0002104InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)mRNA guanylyltransferase4.166e-15Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase1.852e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.4336Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.3668Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the philtrum0.03613Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.5552Least InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA methylation0.0004256Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.1618InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.4112Least InformativeInherited

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)RNA helicase1.727e-05InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.03131InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases1InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase5.667e-15Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)4.254e-07Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase9.092e-07Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase3.197e-06Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase1.117e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase5.918e-05Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10.0001956Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.4043Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus5.007e-08InformativeDirect
Biological processSteroid metabolism0.02305InformativeInherited
Biological processVirus entry into host cell0.3529InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane1.002e-14Highly InformativeDirect
Biological processSterol biosynthesis2.827e-05Highly InformativeDirect
Biological processAntibiotic biosynthesis5.815e-05Highly InformativeDirect
Biological processInhibition of host ISG15 by virus5.896e-05Highly InformativeDirect
Biological processInhibition of host IRF3 by virus8.335e-05Highly InformativeDirect
Biological processSteroid biosynthesis0.00034Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentHost membrane3.717e-12InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein1.093e-06Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting5.007e-11Moderately InformativeDirect
DiseaseWilliams-Beuren syndrome3.396e-05Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionRNA-binding5.029e-15Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Molecular functionIron-sulfur1.383e-15InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationChromatin regulator2.49e-09InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationPhosphopantetheine9.017e-14Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism7.26e-06Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.005143Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.105Moderately InformativeInherited
UniPathway (UP)aromatic compound degradation0.5831Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0InformativeDirect
UniPathway (UP)putrescine metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis3.576e-11InformativeDirect
UniPathway (UP)polyketide biosynthesis2.062e-08InformativeDirect
UniPathway (UP)antibiotic biosynthesis1.736e-07InformativeDirect
UniPathway (UP)terpene metabolism5.015e-06InformativeDirect
UniPathway (UP)toxin biosynthesis5.506e-06InformativeDirect
UniPathway (UP)hormone biosynthesis1.401e-05InformativeDirect
UniPathway (UP)alkaloid metabolism1.927e-05InformativeDirect
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)isoprenoid biosynthesis1InformativeInherited
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)sterol biosynthesis2.274e-16Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis5.534e-09Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification2.295e-06Highly InformativeDirect
UniPathway (UP)glycerophospholipid biosynthesis6.282e-06Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis1.072e-05Highly InformativeDirect
UniPathway (UP)plant chemical defense3.169e-05Highly InformativeDirect
UniPathway (UP)flavonoid degradation3.523e-05Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.0001464Highly InformativeDirect
UniPathway (UP)mRNA processing0.0001724Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.01675Highly InformativeInherited
UniPathway (UP)carotenoid biosynthesis0.1668Highly InformativeInherited
UniPathway (UP)betaine biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]