SUPERFAMILY 1.75 HMM library and genome assignments server

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S-adenosyl-L-methionine-dependent methyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   S-adenosyl-L-methionine-dependent methyltransferases [ 53334]
Superfamily:   S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (57)
Families:   COMT-like [ 53336] (3)
  Plant O-methyltransferase, C-terminal domain [ 64111] (5)
  RNA methyltransferase FtsJ [ 53339]
  Fibrillarin homologue [ 53342]
  rRNA methyltransferase RlmA [ 102557]
  rRNA methyltransferase AviRa [ 89738]
  rRNA adenine dimethylase-like [ 88784] (4)
  mRNA cap methylase [ 88785] (2)
  mRNA cap (Guanine N-7) methyltransferase [ 102560]
  Hypothetical protein MJ0882 [ 53345]
  Hypothetical protein HI0319 (YecO) [ 69544]
  Glycine N-methyltransferase [ 53348]
  Arylamine N-methyltransferase [ 69547] (2)
  Histamine methyltransferase [ 75261]
  Hypothetical Protein YjhP [ 82469]
  Salicylic acid carboxyl methyltransferase (SAMT) [ 102563]
  Thiopurine S-methyltransferase [ 102566]
  Leucine carboxy methyltransferase Ppm1 [ 102569]
  Precorrin-6Y methyltransferase (CbiT) [ 82472]
  MraW-like putative methyltransferases [ 82475]
  N5-glutamine methyltransferase, HemK [ 89743]
  Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746]
  Guanidinoacetate methyltransferase [ 69550]
  Arginine methyltransferase [ 53351] (3)
  Protein-L-isoaspartyl O-methyltransferase [ 53354]
  Glucose-inhibited division protein B (GidB) [ 75264]
  tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4)
  NOL1/NOP2/sun [ 102575] (3)
  Ribosomal protein L11 methyltransferase PrmA [ 102578]
  (Uracil-5-)-methyltransferase [ 102581]
  Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357]
  C5 cytosine-specific DNA methylase, DCM [ 88786] (3)
  DNA methylase TaqI, N-terminal domain [ 88787]
  N6 adenine-specific DNA methylase, DAM [ 88788] (2)
  Type II DNA methylase [ 53377] (3)
  Spermidine synthase [ 69557] (2)
  Mycolic acid cyclopropane synthase [ 69560] (6)
  Ta1320-like [ 89751] (2)
  UbiE/COQ5-like [ 110671] (5)
  AD-003 protein-like [ 117685] (2)
  CAC2371-like [ 117688] (3)
  TehB-like [ 142603]
  N-6 DNA Methylase-like [ 142606] (3)
  YhhF-like [ 142611] (5)
  Met-10+ protein-like [ 142622]
  Nsp15 N-terminal domain-like [ 142625]
  BC2162-like [ 142629]
  CmcI-like [ 142632]
  hypothetical RNA methyltransferase [ 142635] (4)
  RPA4359-like [ 142644]
  TrmB-like [ 142647]
  Methyltransferase 10 domain [ 142651]
  YhiQ-like [ 159686]
  FkbM-like [ 159691]
  ML2640-like [ 159694]
  TRM1-like [ 159697]
  LPG1296-like [ 159700]


Superfamily statistics
Genomes (3,259) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 194,581 1,005,458 166
Proteins 189,179 989,001 166


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.00000014940.0000009444Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.6540Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.99891Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.5472Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.42860Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.50880.00000000000002102Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.81521Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0035580Least InformativeInherited
Biological Process (BP)cellular protein modification process0.0000074870.00000000000255Moderately InformativeDirect
Biological Process (BP)gene expression0.0000053140Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.00000010820Moderately InformativeDirect
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0011730.000006587Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.17560.1353Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.56580.6527Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)organelle organization0.86320.4866Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.90241Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.84730.9267Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis11Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.15930.3703Moderately InformativeInherited
Biological Process (BP)regulation of gene expression11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00062470.0005179InformativeDirect
Biological Process (BP)amine metabolic process0.000000000037880InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)peptidyl-amino acid modification00InformativeDirect
Biological Process (BP)ncRNA processing0.0000000000000016250InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.0009010.0000000002105InformativeDirect
Biological Process (BP)chromosome organization0.0000023580InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.000079870.000183InformativeDirect
Biological Process (BP)ammonium ion metabolic process0.000000000000006150.000000000000003734InformativeDirect
Biological Process (BP)negative regulation of molecular function0.65881InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.012540.00002318InformativeInherited
Biological Process (BP)embryo development11InformativeInherited
Biological Process (BP)fatty acid metabolic process0.21820.8InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.37561InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.027460.0000103InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.0035440.052InformativeInherited
Biological Process (BP)mitochondrion organization0.35440.05499InformativeInherited
Biological Process (BP)cellular protein complex assembly0.3950.1952InformativeInherited
Biological Process (BP)regulation of catabolic process0.37841InformativeInherited
Biological Process (BP)secondary metabolic process0.0047710InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.25240.4265InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.65980.3854InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.28040.4856InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0073680.0002075InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.0032310.0005475InformativeInherited
Biological Process (BP)transcription, DNA-templated11InformativeInherited
Biological Process (BP)DNA metabolic process11InformativeInherited
Biological Process (BP)polyamine metabolic process0.0000023990.0000003818Highly InformativeDirect
Biological Process (BP)protein alkylation00Highly InformativeDirect
Biological Process (BP)NADH dehydrogenase complex assembly0.000014880.000000000000001925Highly InformativeDirect
Biological Process (BP)histone modification0.000056960Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.00018610.00000000000009521Highly InformativeDirect
Biological Process (BP)protein repair0.00096220.0001324Highly InformativeDirect
Biological Process (BP)mitochondrial respiratory chain complex assembly0.0002070.000000000001246Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.00000000026470Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00000050630.0000001609Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.0000036170.000004666Highly InformativeDirect
Biological Process (BP)macromolecule methylation00Highly InformativeDirect
Biological Process (BP)DNA methylation or demethylation0.00000073790.00001094Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.0000021310.000000006633Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.0000015120.0003437Highly InformativeDirect
Biological Process (BP)mitochondrial respiratory chain complex I biogenesis0.000014880.000000000000003734Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.00000000016610Highly InformativeDirect
Biological Process (BP)negative regulation of lipid metabolic process0.01750.2001Highly InformativeInherited
Biological Process (BP)cell wall biogenesis0.00006020.01603Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.093370.5014Highly InformativeInherited
Biological Process (BP)negative regulation of catabolic process0.1160.4729Highly InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.054270.01292Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.35670.2573Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.018020.3665Highly InformativeInherited
Biological Process (BP)regulation of lipid catabolic process0.00036930.01553Highly InformativeInherited
Biological Process (BP)glycoside metabolic process0.041940.02852Highly InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process0.003530.000003448Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.036660.0000007734Highly InformativeInherited
Biological Process (BP)biotin metabolic process0.0022140.0002432Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.013580.02356Highly InformativeInherited
Biological Process (BP)mitochondrial gene expression0.95021Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0000016770.199Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process11Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.9451Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring one-carbon groups00InformativeDirect
Molecular Function (MF)sulfur compound binding0.39810.187InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.52011InformativeInherited
Molecular Function (MF)RNA binding0.34410.04822InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)mitochondrial envelope11Moderately InformativeInherited
Cellular Component (CC)organelle inner membrane11Moderately InformativeInherited
Cellular Component (CC)nuclear part0.68131Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.19880.3093Moderately InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.18961InformativeInherited
Cellular Component (CC)nucleolar part0.00085990.000009251Highly InformativeDirect
Cellular Component (CC)extrinsic component of organelle membrane0.0056670.01765Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.00000000000002102 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000009444 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5472 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00000000000255 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000006587 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6527 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9267 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4866 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1353 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3703 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.0005179 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00002318 Informative Direct
Biological Process (BP) amine metabolic process 0 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0002075 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.0005475 Informative Direct
Biological Process (BP) ncRNA processing 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000002105 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000183 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.000000000000003734 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.0000103 Informative Direct
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.8 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.8797 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.8227 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.052 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.05499 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.1952 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.08132 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.4265 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3854 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.4856 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.003479 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) ribosome biogenesis 0.06311 Informative Inherited
Biological Process (BP) polyamine metabolic process 0.0000003818 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.0002432 Highly Informative Direct
Biological Process (BP) protein alkylation 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000003448 Highly Informative Direct
Biological Process (BP) NADH dehydrogenase complex assembly 0.000000000000001925 Highly Informative Direct
Biological Process (BP) gene silencing 0.000005715 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.00000000000009521 Highly Informative Direct
Biological Process (BP) protein repair 0.0001324 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.0000003119 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.000000000001246 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.00000003353 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0000001609 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0.000004666 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000004067 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.00009495 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000007734 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.00001094 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.000000006633 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0.0003437 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex I biogenesis 0.000000000000003734 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0.2001 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.2849 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) viral process 0.3078 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.01603 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.5014 Highly Informative Inherited
Biological Process (BP) regulation of RNA stability 0.01337 Highly Informative Inherited
Biological Process (BP) negative regulation of translation 0.1338 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.3933 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.7684 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.01031 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.4729 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.01292 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.7955 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.2573 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.3665 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.01553 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.5423 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.0529 Highly Informative Inherited
Biological Process (BP) glycoside metabolic process 0.02852 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.02356 Highly Informative Inherited
Biological Process (BP) mitochondrial gene expression 1 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.855 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.199 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 1 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) rRNA metabolic process 1 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.187 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.04822 Informative Inherited
Molecular Function (MF) iron-sulfur cluster binding 0.0009124 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.01731 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3093 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.7831 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 1 Moderately Informative Inherited
Cellular Component (CC) organelle inner membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) extrinsic component of membrane 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) methylosome 0.0000000004017 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.000009251 Highly Informative Direct
Cellular Component (CC) chromatin 0.7033 Highly Informative Inherited
Cellular Component (CC) extrinsic component of organelle membrane 0.01765 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.05448 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.03493Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000000809InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000002852InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000002852InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000004862InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0.00002048InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0.0002104InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)mRNA guanylyltransferase0.000000000000004166Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase0.00001852Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.3004Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processViral RNA replication0InformativeDirect
Biological processmRNA processing0.00000000001383InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0.0000000994InformativeDirect
Biological processSteroid metabolism0.07956InformativeInherited
Biological processVirus entry into host cell0.3838InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processPolyamine biosynthesis0Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0.000000000000004737Highly InformativeDirect
Biological processAlkaloid metabolism0.00000000000006282Highly InformativeDirect
Biological processInhibition of host STAT2 by virus0.000000000002371Highly InformativeDirect
Biological processAntibiotic biosynthesis0.00000007745Highly InformativeDirect
Biological processInhibition of host IRF3 by virus0.000007331Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.00001187Highly InformativeDirect
Biological processSterol biosynthesis0.00001202Highly InformativeDirect
Biological processSteroid biosynthesis0.0006501Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentVirion1Moderately InformativeInherited
Cellular componentHost membrane0.000000000003313InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein0.0000007317Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0.0000000000769Moderately InformativeDirect
DiseaseWilliams-Beuren syndrome0.00004244Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron-sulfur0.000000000000176Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0.0000000001609InformativeDirect
Post-translational modificationIon channel1InformativeInherited
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0.00000000002874Highly InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]