SUPERFAMILY 1.75 HMM library and genome assignments server


S-adenosyl-L-methionine-dependent methyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   S-adenosyl-L-methionine-dependent methyltransferases [ 53334]
Superfamily:   S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (57)
Families:   COMT-like [ 53336] (3)
  Plant O-methyltransferase, C-terminal domain [ 64111] (5)
  RNA methyltransferase FtsJ [ 53339]
  Fibrillarin homologue [ 53342]
  rRNA methyltransferase RlmA [ 102557]
  rRNA methyltransferase AviRa [ 89738]
  rRNA adenine dimethylase-like [ 88784] (4)
  mRNA cap methylase [ 88785] (2)
  mRNA cap (Guanine N-7) methyltransferase [ 102560]
  Hypothetical protein MJ0882 [ 53345]
  Hypothetical protein HI0319 (YecO) [ 69544]
  Glycine N-methyltransferase [ 53348]
  Arylamine N-methyltransferase [ 69547] (2)
  Histamine methyltransferase [ 75261]
  Hypothetical Protein YjhP [ 82469]
  Salicylic acid carboxyl methyltransferase (SAMT) [ 102563]
  Thiopurine S-methyltransferase [ 102566]
  Leucine carboxy methyltransferase Ppm1 [ 102569]
  Precorrin-6Y methyltransferase (CbiT) [ 82472]
  MraW-like putative methyltransferases [ 82475]
  N5-glutamine methyltransferase, HemK [ 89743]
  Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746]
  Guanidinoacetate methyltransferase [ 69550]
  Arginine methyltransferase [ 53351] (3)
  Protein-L-isoaspartyl O-methyltransferase [ 53354]
  Glucose-inhibited division protein B (GidB) [ 75264]
  tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4)
  NOL1/NOP2/sun [ 102575] (3)
  Ribosomal protein L11 methyltransferase PrmA [ 102578]
  (Uracil-5-)-methyltransferase [ 102581]
  Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357]
  C5 cytosine-specific DNA methylase, DCM [ 88786] (3)
  DNA methylase TaqI, N-terminal domain [ 88787]
  N6 adenine-specific DNA methylase, DAM [ 88788] (2)
  Type II DNA methylase [ 53377] (3)
  Spermidine synthase [ 69557] (2)
  Mycolic acid cyclopropane synthase [ 69560] (6)
  Ta1320-like [ 89751] (2)
  UbiE/COQ5-like [ 110671] (5)
  AD-003 protein-like [ 117685] (2)
  CAC2371-like [ 117688] (3)
  TehB-like [ 142603]
  N-6 DNA Methylase-like [ 142606] (3)
  YhhF-like [ 142611] (5)
  Met-10+ protein-like [ 142622]
  Nsp15 N-terminal domain-like [ 142625]
  BC2162-like [ 142629]
  CmcI-like [ 142632]
  hypothetical RNA methyltransferase [ 142635] (4)
  RPA4359-like [ 142644]
  TrmB-like [ 142647]
  Methyltransferase 10 domain [ 142651]
  YhiQ-like [ 159686]
  FkbM-like [ 159691]
  ML2640-like [ 159694]
  TRM1-like [ 159697]
  LPG1296-like [ 159700]


Superfamily statistics
Genomes (2,487) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 155,399 378,028 166
Proteins 151,392 371,734 166


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular macromolecule metabolic process1.992e-096.458e-14Least InformativeDirect
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.41020.9173Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.8491Least InformativeInherited
Biological Process (BP)protein metabolic process0.85571Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.23281.065e-11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.022491.333e-09Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.29162.506e-10Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.3064.89e-10Least InformativeInherited
Biological Process (BP)cellular protein modification process1.554e-056.836e-09Moderately InformativeDirect
Biological Process (BP)gene expression1.153e-055.286e-13Moderately InformativeDirect
Biological Process (BP)RNA metabolic process6.471e-070Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00039263.888e-06Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process0.26440.1323Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.52840.4307Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.49551Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.018080.0004067Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.56571Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0021710.0003493Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of nitrogen compound metabolic process11Moderately InformativeInherited
Biological Process (BP)single-organism developmental process11Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.78971Moderately InformativeInherited
Biological Process (BP)organelle organization0.49030.02243Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.7641Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.51550.9863Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.27880.004029Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.97111Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.90451Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process8.977e-078.023e-09InformativeDirect
Biological Process (BP)amine biosynthetic process0.00068560.0001361InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)peptidyl-amino acid modification4.037e-090InformativeDirect
Biological Process (BP)ribonucleoprotein complex biogenesis1.895e-080InformativeDirect
Biological Process (BP)ncRNA processing5.751e-126.802e-14InformativeDirect
Biological Process (BP)chromosome organization0.00074684.008e-15InformativeDirect
Biological Process (BP)fatty acid metabolic process0.40551InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.02940.07258InformativeInherited
Biological Process (BP)ribonucleoside metabolic process0.38910.1492InformativeInherited
Biological Process (BP)purine nucleoside metabolic process0.26560.08332InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.61190.1268InformativeInherited
Biological Process (BP)isoprenoid metabolic process3.899e-060.001145InformativeInherited
Biological Process (BP)tRNA metabolic process0.17560.2903InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.85620.04209InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.027273.657e-06InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.49810.4717InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.022580.000507InformativeInherited
Biological Process (BP)mitochondrion organization0.16680.01002InformativeInherited
Biological Process (BP)transcription, DNA-dependent11InformativeInherited
Biological Process (BP)DNA metabolic process11InformativeInherited
Biological Process (BP)amino-acid betaine metabolic process3.754e-057.642e-06Highly InformativeDirect
Biological Process (BP)polyamine metabolic process1.769e-058.127e-07Highly InformativeDirect
Biological Process (BP)diol metabolic process0.00094140.0008787Highly InformativeDirect
Biological Process (BP)regulation of gene expression, epigenetic2.587e-050Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process7.274e-068.416e-12Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process5.881e-075.217e-07Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process2.989e-072.439e-07Highly InformativeDirect
Biological Process (BP)quinone biosynthetic process0.00028734.139e-05Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process0.01070.3144Highly InformativeInherited
Biological Process (BP)cellular component macromolecule biosynthetic process5.459e-060.001026Highly InformativeInherited
Biological Process (BP)cell wall biogenesis3.454e-050.02974Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.13530.777Highly InformativeInherited
Biological Process (BP)DNA methylation or demethylation2.506e-070.009885Highly InformativeInherited
Biological Process (BP)peptidyl-serine modification0.15031Highly InformativeInherited
Biological Process (BP)protein methylation0.44431Highly InformativeInherited
Biological Process (BP)peptidyl-proline modification0.41661Highly InformativeInherited
Biological Process (BP)histone modification0.018530Highly InformativeInherited
Biological Process (BP)RNA methylation0.0046510Highly InformativeInherited
Biological Process (BP)tRNA modification0.017870.8341Highly InformativeInherited
Biological Process (BP)drug metabolic process0.02280.0007136Highly InformativeInherited
Biological Process (BP)negative regulation of gene expression0.060580.3709Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.011940.2571Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.044540.1246Highly InformativeInherited
Biological Process (BP)rRNA processing0.71590.7304Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)anion binding11Moderately InformativeInherited
Molecular Function (MF)cation binding11Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring one-carbon groups00InformativeDirect
Molecular Function (MF)carboxylic acid binding0.26710.6515InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.61181InformativeInherited
Molecular Function (MF)methyltransferase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 2.506e-10 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1.333e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.458e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.065e-11 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.89e-10 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9173 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 6.836e-09 Moderately Informative Direct
Biological Process (BP) gene expression 5.286e-13 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.0004067 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 3.888e-06 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0003493 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.1323 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.4307 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.004029 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02243 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9863 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 8.023e-09 Informative Direct
Biological Process (BP) cellular biogenic amine metabolic process 0.000507 Informative Direct
Biological Process (BP) amine biosynthetic process 0.0001361 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0 Informative Direct
Biological Process (BP) ncRNA processing 6.802e-14 Informative Direct
Biological Process (BP) cellular ketone metabolic process 3.657e-06 Informative Direct
Biological Process (BP) chromosome organization 4.008e-15 Informative Direct
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) response to organic nitrogen 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.4675 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) ribonucleoside metabolic process 0.1492 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.08332 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.1268 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.001145 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.006244 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.07258 Informative Inherited
Biological Process (BP) cellular amide metabolic process 0.4163 Informative Inherited
Biological Process (BP) vitamin metabolic process 0.0365 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.8893 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.2903 Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.4717 Informative Inherited
Biological Process (BP) mitochondrion organization 0.01002 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.04209 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.3771 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.9884 Informative Inherited
Biological Process (BP) RNA methylation 0 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 7.642e-06 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 8.127e-07 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) drug metabolic process 0.0007136 Highly Informative Direct
Biological Process (BP) diol metabolic process 0.0008787 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 8.416e-12 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 5.217e-07 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 2.439e-07 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.000796 Highly Informative Direct
Biological Process (BP) quinone biosynthetic process 4.139e-05 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.3144 Highly Informative Inherited
Biological Process (BP) cellular component macromolecule biosynthetic process 0.001026 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.02974 Highly Informative Inherited
Biological Process (BP) response to acid 0.001642 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.3709 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.273 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.777 Highly Informative Inherited
Biological Process (BP) DNA methylation or demethylation 0.009885 Highly Informative Inherited
Biological Process (BP) peptidyl-serine modification 1 Highly Informative Inherited
Biological Process (BP) protein methylation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-proline modification 1 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.04021 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.8341 Highly Informative Inherited
Biological Process (BP) indole-containing compound biosynthetic process 0.01509 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.002285 Highly Informative Inherited
Biological Process (BP) protein processing 0.1444 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.2571 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.1246 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.2626 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) RNA splicing, via transesterification reactions 0.167 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 0.7927 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.7304 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.6515 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Informative Inherited
Molecular Function (MF) methyltransferase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.7901 Informative Inherited
Cellular Component (CC) trans-Golgi network 5.401e-10 Highly Informative Direct
Cellular Component (CC) RNA cap binding complex 5.378e-06 Highly Informative Direct
Cellular Component (CC) chromatin 0.01617 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.03493Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase8.09e-07InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase2.852e-06InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.852e-06InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s4.862e-06InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase2.048e-05InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0.0002104InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)mRNA guanylyltransferase4.166e-15Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase1.852e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.5343Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4832Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the philtrum0.04444Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.7216Least InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.002705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.9199InformativeInherited
Mammalian Phenotype (MP)abnormal DNA methylation0.000214Highly InformativeDirect
Mammalian Phenotype (MP)impaired somite development0.006241Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pigmentation variant0.1618InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)RNA helicase2.222e-05InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.04167InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases1InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)mRNA guanylyltransferase5.157e-15Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase8.86e-07Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase3.117e-06Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)5.304e-06Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase1.658e-05Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase5.762e-05Highly InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O)-methyltransferase0.00026Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.7248Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processViral attachment to host cell6.191e-05InformativeDirect
Biological processSteroid metabolism0.02143InformativeInherited
Biological processVirus entry into host cell0.3614InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processPolyamine biosynthesis0Highly InformativeDirect
Biological processUbiquinone biosynthesis0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processInhibition of host TYK2 by virus4.966e-15Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane1.118e-14Highly InformativeDirect
Biological processSterol biosynthesis4.027e-05Highly InformativeDirect
Biological processInhibition of host IRF3 by virus5.945e-05Highly InformativeDirect
Biological processInhibition of host ISG15 by virus9.223e-05Highly InformativeDirect
Biological processSteroid biosynthesis0.0003397Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentHost membrane7.053e-12InformativeDirect
Cellular componentVirion1InformativeInherited
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein1.161e-06Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting1.551e-10Moderately InformativeDirect
DiseaseWilliams-Beuren syndrome3.577e-05Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionRNA-binding5.334e-08Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular function4Fe-4S0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Molecular functionIron-sulfur3.593e-12InformativeDirect
Molecular functionPhosphopantetheine2.179e-09Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationChromatin regulator3.608e-08InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.005002Moderately InformativeInherited
UniPathway (UP)secondary metabolite metabolism0.005506Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.1068Moderately InformativeInherited
UniPathway (UP)aromatic compound degradation0.534Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0InformativeDirect
UniPathway (UP)putrescine metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis3.615e-11InformativeDirect
UniPathway (UP)toxin biosynthesis2.018e-06InformativeDirect
UniPathway (UP)terpene metabolism2.958e-06InformativeDirect
UniPathway (UP)alkaloid metabolism4.573e-06InformativeDirect
UniPathway (UP)polyketide biosynthesis2.866e-05InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0002069InformativeDirect
UniPathway (UP)hormone metabolism0.01218InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)isoprenoid biosynthesis1InformativeInherited
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)sterol biosynthesis2.243e-16Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis5.492e-09Highly InformativeDirect
UniPathway (UP)phosphatidylcholine biosynthesis1.386e-06Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification2.3e-06Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis5.206e-06Highly InformativeDirect
UniPathway (UP)plant chemical defense3.08e-05Highly InformativeDirect
UniPathway (UP)flavonoid degradation3.298e-05Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.0001426Highly InformativeDirect
UniPathway (UP)mRNA processing0.0001718Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.01805Highly InformativeInherited
UniPathway (UP)carotenoid biosynthesis0.1416Highly InformativeInherited
UniPathway (UP)mycotoxin biosynthesis0.9733Highly InformativeInherited
UniPathway (UP)betaine biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]