SUPERFAMILY 1.75 HMM library and genome assignments server

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S-adenosyl-L-methionine-dependent methyltransferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   S-adenosyl-L-methionine-dependent methyltransferases [ 53334]
Superfamily:   S-adenosyl-L-methionine-dependent methyltransferases [ 53335] (57)
Families:   COMT-like [ 53336] (3)
  Plant O-methyltransferase, C-terminal domain [ 64111] (5)
  RNA methyltransferase FtsJ [ 53339]
  Fibrillarin homologue [ 53342]
  rRNA methyltransferase RlmA [ 102557]
  rRNA methyltransferase AviRa [ 89738]
  rRNA adenine dimethylase-like [ 88784] (4)
  mRNA cap methylase [ 88785] (2)
  mRNA cap (Guanine N-7) methyltransferase [ 102560]
  Hypothetical protein MJ0882 [ 53345]
  Hypothetical protein HI0319 (YecO) [ 69544]
  Glycine N-methyltransferase [ 53348]
  Arylamine N-methyltransferase [ 69547] (2)
  Histamine methyltransferase [ 75261]
  Hypothetical Protein YjhP [ 82469]
  Salicylic acid carboxyl methyltransferase (SAMT) [ 102563]
  Thiopurine S-methyltransferase [ 102566]
  Leucine carboxy methyltransferase Ppm1 [ 102569]
  Precorrin-6Y methyltransferase (CbiT) [ 82472]
  MraW-like putative methyltransferases [ 82475]
  N5-glutamine methyltransferase, HemK [ 89743]
  Catalytic, N-terminal domain of histone methyltransferase Dot1l [ 89746]
  Guanidinoacetate methyltransferase [ 69550]
  Arginine methyltransferase [ 53351] (3)
  Protein-L-isoaspartyl O-methyltransferase [ 53354]
  Glucose-inhibited division protein B (GidB) [ 75264]
  tRNA(1-methyladenosine) methyltransferase-like [ 64117] (4)
  NOL1/NOP2/sun [ 102575] (3)
  Ribosomal protein L11 methyltransferase PrmA [ 102578]
  (Uracil-5-)-methyltransferase [ 102581]
  Chemotaxis receptor methyltransferase CheR, C-terminal domain [ 53357]
  C5 cytosine-specific DNA methylase, DCM [ 88786] (3)
  DNA methylase TaqI, N-terminal domain [ 88787]
  N6 adenine-specific DNA methylase, DAM [ 88788] (2)
  Type II DNA methylase [ 53377] (3)
  Spermidine synthase [ 69557] (2)
  Mycolic acid cyclopropane synthase [ 69560] (6)
  Ta1320-like [ 89751] (2)
  UbiE/COQ5-like [ 110671] (5)
  AD-003 protein-like [ 117685] (2)
  CAC2371-like [ 117688] (3)
  TehB-like [ 142603]
  N-6 DNA Methylase-like [ 142606] (3)
  YhhF-like [ 142611] (5)
  Met-10+ protein-like [ 142622]
  Nsp15 N-terminal domain-like [ 142625]
  BC2162-like [ 142629]
  CmcI-like [ 142632]
  hypothetical RNA methyltransferase [ 142635] (4)
  RPA4359-like [ 142644]
  TrmB-like [ 142647]
  Methyltransferase 10 domain [ 142651]
  YhiQ-like [ 159686]
  FkbM-like [ 159691]
  ML2640-like [ 159694]
  TRM1-like [ 159697]
  LPG1296-like [ 159700]


Superfamily statistics
Genomes (3,259) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 194,581 1,005,458 166
Proteins 189,179 989,001 166


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000000069540.0000007959Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process0.50120.0000000000003449Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.62780.0000000000000109Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.6998Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.41970.00000000000002124Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0032020Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.79411Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular protein modification process0.0000059380.000000000002191Moderately InformativeDirect
Biological Process (BP)gene expression0.000002470Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.00000012320Moderately InformativeDirect
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.0021820.00003026Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process11Moderately InformativeInherited
Biological Process (BP)purine-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.90631Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)lipid metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process11Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization11Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)organelle organization0.85220.2287Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.19610.1552Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.67960.843Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.85890.9034Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process0.17030.3378Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00069090.0004796InformativeDirect
Biological Process (BP)amine metabolic process0.000000000047280InformativeDirect
Biological Process (BP)RNA modification00InformativeDirect
Biological Process (BP)peptidyl-amino acid modification00InformativeDirect
Biological Process (BP)ncRNA processing00InformativeDirect
Biological Process (BP)chromosome organization0.0000024850InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0002640.0005457InformativeDirect
Biological Process (BP)ammonium ion metabolic process0.0000000000000031190.000000000000005614InformativeDirect
Biological Process (BP)negative regulation of molecular function0.66861InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.012990.00004533InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.0012310.0000000009051InformativeInherited
Biological Process (BP)DNA metabolic process11InformativeInherited
Biological Process (BP)embryo development0.98921InformativeInherited
Biological Process (BP)fatty acid metabolic process0.31570.8559InformativeInherited
Biological Process (BP)glycosyl compound metabolic process0.027520.00001148InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.37461InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.006750.2952InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.0022310.0566InformativeInherited
Biological Process (BP)cellular protein complex assembly0.36850.171InformativeInherited
Biological Process (BP)mitochondrion organization0.32760.001714InformativeInherited
Biological Process (BP)regulation of catabolic process0.38351InformativeInherited
Biological Process (BP)drug metabolic process0.025660.0000001495InformativeInherited
Biological Process (BP)secondary metabolic process0.0047940InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.25310.4232InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.66030.3754InformativeInherited
Biological Process (BP)transcription, DNA-templated11InformativeInherited
Biological Process (BP)polyamine metabolic process0.0000020110.0000003975Highly InformativeDirect
Biological Process (BP)protein alkylation00Highly InformativeDirect
Biological Process (BP)histone modification0.000072110Highly InformativeDirect
Biological Process (BP)antibiotic biosynthetic process0.00018570.00000000000008994Highly InformativeDirect
Biological Process (BP)mitochondrial respiratory chain complex assembly0.000035680.000000000000028Highly InformativeDirect
Biological Process (BP)ketone biosynthetic process0.00000000022130Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00000058360.0000001692Highly InformativeDirect
Biological Process (BP)cellular biogenic amine biosynthetic process0.0000030550.00000899Highly InformativeDirect
Biological Process (BP)macromolecule methylation00Highly InformativeDirect
Biological Process (BP)DNA methylation or demethylation0.00000082620.00001896Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.0000024810.000000006017Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.0000015420.0003014Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.00000000042530Highly InformativeDirect
Biological Process (BP)negative regulation of catabolic process0.12480.4477Highly InformativeInherited
Biological Process (BP)purine ribonucleoside metabolic process0.05250.01191Highly InformativeInherited
Biological Process (BP)negative regulation of lipid metabolic process0.017650.2118Highly InformativeInherited
Biological Process (BP)cell wall biogenesis0.000060770.01688Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.095760.4714Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.36630.2865Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0000034120.243Highly InformativeInherited
Biological Process (BP)regulation of lipid catabolic process0.00045770.02735Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.017640.3656Highly InformativeInherited
Biological Process (BP)phenylpropanoid metabolic process0.0033560.000003401Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.035130.0000007888Highly InformativeInherited
Biological Process (BP)biotin metabolic process0.002580.0002387Highly InformativeInherited
Biological Process (BP)serine family amino acid metabolic process0.014190.02555Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process11Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.93661Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring one-carbon groups00InformativeDirect
Molecular Function (MF)sulfur compound binding0.38470.1929InformativeInherited
Molecular Function (MF)transferase activity, transferring alkyl or aryl (other than methyl) groups0.4911InformativeInherited
Molecular Function (MF)RNA binding0.34490.1308InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)nuclear part0.78961Moderately InformativeInherited
Cellular Component (CC)organelle envelope11Moderately InformativeInherited
Cellular Component (CC)mitochondrial part0.57540.3086Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.26810.3415Moderately InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.20160.9779InformativeInherited
Cellular Component (CC)nucleolar part0.0007870.000008432Highly InformativeDirect
Cellular Component (CC)extrinsic component of organelle membrane0.0059770.01136Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000000000003449 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000007959 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000000000002124 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000000000000109 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6998 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.000000000002191 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00003026 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2287 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.1552 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.843 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.9034 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.3378 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.0004796 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00004533 Informative Direct
Biological Process (BP) amine metabolic process 0 Informative Direct
Biological Process (BP) RNA modification 0 Informative Direct
Biological Process (BP) drug metabolic process 0.0000001495 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0.000658 Informative Direct
Biological Process (BP) ncRNA processing 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000000009051 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0005457 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.000000000000005614 Informative Direct
Biological Process (BP) glycosyl compound metabolic process 0.00001148 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.004709 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.8559 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.2952 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.0566 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.171 Informative Inherited
Biological Process (BP) mitochondrion organization 0.001714 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.03555 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.7989 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.4232 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.3754 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.00347 Informative Inherited
Biological Process (BP) ribosome biogenesis 0.07406 Informative Inherited
Biological Process (BP) polyamine metabolic process 0.0000003975 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.0002387 Highly Informative Direct
Biological Process (BP) protein alkylation 0 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000003401 Highly Informative Direct
Biological Process (BP) gene silencing 0.00000635 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.00000000000008994 Highly Informative Direct
Biological Process (BP) protein repair 0.0001498 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.0000002687 Highly Informative Direct
Biological Process (BP) mitochondrial respiratory chain complex assembly 0.000000000000028 Highly Informative Direct
Biological Process (BP) regulation of gene expression, epigenetic 0.00000004107 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.0000001692 Highly Informative Direct
Biological Process (BP) cellular biogenic amine biosynthetic process 0.00000899 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.0000004787 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.00008739 Highly Informative Direct
Biological Process (BP) macromolecule methylation 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000007888 Highly Informative Direct
Biological Process (BP) DNA methylation or demethylation 0.00001896 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.000000006017 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0.0003014 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.2865 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.37 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular amide metabolic process 0.004459 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.4477 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.01191 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.2118 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 1 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.01688 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.4714 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.243 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.02735 Highly Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0.3656 Highly Informative Inherited
Biological Process (BP) tRNA modification 0.4748 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.04744 Highly Informative Inherited
Biological Process (BP) glycoside metabolic process 0.02978 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.02555 Highly Informative Inherited
Biological Process (BP) mRNA processing 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.8845 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 1 Highly Informative Inherited
Biological Process (BP) RNA splicing 1 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) rRNA metabolic process 0.9629 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.1929 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.1308 Informative Inherited
Molecular Function (MF) iron-sulfur cluster binding 0.0007446 Highly Informative Direct
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 0.0145 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.8742 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.3086 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.3415 Moderately Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) extrinsic component of membrane 0.9779 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) methylosome 0.0000000005115 Highly Informative Direct
Cellular Component (CC) nucleolar part 0.000008432 Highly Informative Direct
Cellular Component (CC) chromatin 0.6998 Highly Informative Inherited
Cellular Component (CC) extrinsic component of organelle membrane 0.01136 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.05372 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0.03493Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Flavivirin0InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphatase0InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000000809InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000002852InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000002852InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000004862InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0.00002048InformativeDirect
Enzyme Commission (EC)mRNA (nucleoside-2'-O-)-methyltransferase0.0002104InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)mRNA guanylyltransferase0.000000000000004166Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)DNA (cytosine-5-)-methyltransferase0.00001852Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.9648Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.5792Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.6588Moderately InformativeInherited
Worm Phenotype (WP)cell stress response variant0.1627InformativeInherited
Worm Phenotype (WP)cell gamma ray response variant0.000009225Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.003523Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.2026Least InformativeInherited
Yeast Phenotype (YP)RNA modification0.0000009663Highly InformativeDirect

Document: YP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)RNA-directed RNA polymerase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.0000326InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0.02597InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases1InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Polynucleotide 5'-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Flavivirin0Highly InformativeDirect
Enzyme Commission (EC)SARS coronavirus main proteinase0Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.0000003672Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0000007838Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000004703Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.000006944Highly InformativeDirect
Enzyme Commission (EC)mRNA (guanine-N(7)-)-methyltransferase0.00001147Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.00009281Highly InformativeDirect
Enzyme Commission (EC)Methyltransferase cap10.0001749Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.2967Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processViral RNA replication0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processViral immunoevasion0InformativeDirect
Biological processmRNA processing0.000000000273InformativeDirect
Biological processEukaryotic host gene expression shutoff by virus0.00000009549InformativeDirect
Biological processSteroid metabolism0.07074InformativeInherited
Biological processVirus entry into host cell0.379InformativeInherited
Biological processLipid biosynthesis1InformativeInherited
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processmRNA capping0Highly InformativeDirect
Biological processPolyamine biosynthesis0Highly InformativeDirect
Biological processActivation of host autophagy by virus0Highly InformativeDirect
Biological processInhibition of host NF-kappa-B by virus0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processDecay of host mRNAs by virus0Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0Highly InformativeDirect
Biological processFusion of virus membrane with host endosomal membrane0.000000000000004038Highly InformativeDirect
Biological processAlkaloid metabolism0.00000000000003639Highly InformativeDirect
Biological processAntibiotic biosynthesis0.0000002586Highly InformativeDirect
Biological processInhibition of host IRF3 by virus0.000007209Highly InformativeDirect
Biological processSterol biosynthesis0.00001109Highly InformativeDirect
Biological processInhibition of host ISG15 by virus0.00001675Highly InformativeDirect
Biological processSteroid biosynthesis0.000614Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentVirion1Moderately InformativeInherited
Cellular componentHost membrane0.000000000002829InformativeDirect
Cellular componentHost endoplasmic reticulum0Highly InformativeDirect
Cellular componentViral envelope protein0.0000006763Highly InformativeDirect
Coding sequence diversityRibosomal frameshifting0.00000000006388Moderately InformativeDirect
DiseaseWilliams-Beuren syndrome0.00004173Highly InformativeDirect
Molecular functionMetal-binding1Least InformativeInherited
Molecular functionIron-sulfur0.000000000000133Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationMethyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0.0000000001307InformativeDirect
Post-translational modificationIon channel1InformativeInherited
Post-translational modificationRNA-directed RNA polymerase0Highly InformativeDirect
Post-translational modificationViral ion channel0.00000000002782Highly InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0000000000003578Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0000001722Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.001239Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.1731Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism1Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)energy metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0InformativeDirect
UniPathway (UP)putrescine metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0.00000000006354InformativeDirect
UniPathway (UP)hormone biosynthesis0.00000001393InformativeDirect
UniPathway (UP)alkaloid metabolism0.00000001599InformativeDirect
UniPathway (UP)terpene biosynthesis0.0000001671InformativeDirect
UniPathway (UP)steroid metabolism0.0000002468InformativeDirect
UniPathway (UP)polyketide biosynthesis0.00001316InformativeDirect
UniPathway (UP)toxin biosynthesis0.00003621InformativeDirect
UniPathway (UP)organosulfur metabolism0.008102InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)nonprotein amino-acid biosynthesis1InformativeInherited
UniPathway (UP)isoprenoid biosynthesis1InformativeInherited
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)flavonoid metabolism1InformativeInherited
UniPathway (UP)phenylpropanoid degradation1InformativeInherited
UniPathway (UP)ubiquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect
UniPathway (UP)sterol biosynthesis4.598e-16Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis0.0000000000005638Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0.0000005803Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification0.000002474Highly InformativeDirect
UniPathway (UP)glycerophospholipid biosynthesis0.00001046Highly InformativeDirect
UniPathway (UP)plant chemical defense0.00003397Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.0001573Highly InformativeDirect
UniPathway (UP)mRNA processing0.0001787Highly InformativeDirect
UniPathway (UP)flavonoid degradation0.000454Highly InformativeDirect
UniPathway (UP)organosulfur biosynthesis0.002482Highly InformativeInherited
UniPathway (UP)catecholamine biosynthesis0.01811Highly InformativeInherited
UniPathway (UP)carotenoid biosynthesis0.1773Highly InformativeInherited
UniPathway (UP)flavonoid biosynthesis1Highly InformativeInherited
UniPathway (UP)betaine biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a S-adenosyl-L-methionine-dependent methyltransferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 127 hidden Markov models representing the S-adenosyl-L-methionine-dependent methyltransferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]