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Nucleotide-diphospho-sugar transferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleotide-diphospho-sugar transferases [ 53447]
Superfamily:   Nucleotide-diphospho-sugar transferases [ 53448] (19)
Families:   Spore coat polysaccharide biosynthesis protein SpsA [ 53449]
  beta 1,4 galactosyltransferase (b4GalT1) [ 53452]
  Galactosyltransferase LgtC [ 53458]
  Glycogenin [ 75273]
  alpha-1,3-galactosyltransferase-like [ 64131] (3)
  UDP-glucose pyrophosphorylase [ 53461] (3)
  glucose-1-phosphate thymidylyltransferase [ 53464] (3)
  1,3-glucuronyltransferase [ 53467] (2)
  N-acetylglucosaminyltransferase I [ 64136]
  Exostosin [ 89760]
  Molybdenum cofactor biosynthesis protein MobA [ 53470]
  Cytidylytransferase [ 68901] (6)
  Glycolipid 2-alpha-mannosyltransferase [ 102609]
  Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain [ 117702]
  MGS-like [ 142691]
  TTHA0179-like [ 159717]
  mannose-1-phosphate guanylyl transferase [ 159720]
  MM2497-like [ 159723]
  Glycosylating toxin catalytic domain-like [ 159726] (3)


Superfamily statistics
Genomes (3,212) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 93,415 665,300 97
Proteins 91,776 652,409 97


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000000007521Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.8741Moderately InformativeInherited
Enzyme Commission (EC)Transferring other groups1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.00000001082Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.3125Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5048Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.1499Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.04567InformativeInherited
Disease Ontology (DO)bone remodeling disease0.00309Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.00007089Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.002994Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.01555Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2056Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3198Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.3777Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5867Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.02285Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.05876Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.08402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.1878Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4605Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.5073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.05956InformativeInherited
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.1131InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.1225InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.2373InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.4503InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.7067InformativeInherited
Phenotypic Abnormality (PA)Macrocephaly0.00006812Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of corneal size0.0004113Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar cyst0.0004632Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle fiber protein expression0.001032Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.007448Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.03155Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.07906Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enzyme/coenzyme activity0.1017Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal choroid morphology0.1133Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.05554Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.05575Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.6432Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.424Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.5303Moderately InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.03786InformativeInherited
Worm Phenotype (WP)vulva development variant0.1239InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.0005641Highly InformativeDirect
Worm Phenotype (WP)cell cycle progression variant0.003205Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.2241Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.2443InformativeInherited
Yeast Phenotype (YP)chitin deposition0.000008906Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.9446Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.002168Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.01892InformativeInherited
Fly Anatomy (FA)denticle belt0.0004276Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.08579Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.5349Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.877Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.009002InformativeInherited
Zebrafish Anatomy (ZA)stromal cell0.0008175Highly InformativeDirect
Zebrafish Anatomy (ZA)pectoral fin0.002279Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.2743Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.3275Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.7036Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.000000000007852InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00000000154InformativeDirect
Plant ANatomical entity (PAN)trichome0.00000000002195Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.000003388Highly InformativeDirect
Plant ANatomical entity (PAN)phloem0.0001899Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.0000003888Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 74 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotide-diphospho-sugar transferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 74 hidden Markov models representing the Nucleotide-diphospho-sugar transferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]