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Nucleotide-diphospho-sugar transferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleotide-diphospho-sugar transferases [ 53447]
Superfamily:   Nucleotide-diphospho-sugar transferases [ 53448] (19)
Families:   Spore coat polysaccharide biosynthesis protein SpsA [ 53449]
  beta 1,4 galactosyltransferase (b4GalT1) [ 53452]
  Galactosyltransferase LgtC [ 53458]
  Glycogenin [ 75273]
  alpha-1,3-galactosyltransferase-like [ 64131] (3)
  UDP-glucose pyrophosphorylase [ 53461] (3)
  glucose-1-phosphate thymidylyltransferase [ 53464] (3)
  1,3-glucuronyltransferase [ 53467] (2)
  N-acetylglucosaminyltransferase I [ 64136]
  Exostosin [ 89760]
  Molybdenum cofactor biosynthesis protein MobA [ 53470]
  Cytidylytransferase [ 68901] (6)
  Glycolipid 2-alpha-mannosyltransferase [ 102609]
  Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain [ 117702]
  MGS-like [ 142691]
  TTHA0179-like [ 159717]
  mannose-1-phosphate guanylyl transferase [ 159720]
  MM2497-like [ 159723]
  Glycosylating toxin catalytic domain-like [ 159726] (3)


Superfamily statistics
Genomes (3,212) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 93,415 665,300 97
Proteins 91,776 652,409 97


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000000007521Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.8741Moderately InformativeInherited
Enzyme Commission (EC)Transferring other groups1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.00000001082Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.3125Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5049Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.1496Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.04545InformativeInherited
Disease Ontology (DO)bone remodeling disease0.003064Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.0000902Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.001038Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.06316Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.09224Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4749Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5869Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.8662Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.00001649Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal globe morphology0.005216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.03635Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.06748Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2578Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uvea0.3875InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.5575InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.8773InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the metencephalon1InformativeInherited
Phenotypic Abnormality (PA)Macrocephaly0.00001275Highly InformativeDirect
Phenotypic Abnormality (PA)Microcornea0.0006394Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal enzyme/coenzyme activity0.02317Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal chorioretinal morphology0.0523Highly InformativeInherited
Phenotypic Abnormality (PA)Anterior segment developmental abnormality0.07006Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.3018Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.7029Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.4956Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.5863Moderately InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.04661InformativeInherited
Worm Phenotype (WP)vulva development variant0.1475InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.0007026Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.2579Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.2443InformativeInherited
Yeast Phenotype (YP)chitin deposition0.00001143Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.343Least InformativeInherited
Fly Anatomy (FA)larva0.7964Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.000353Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.01906InformativeInherited
Fly Anatomy (FA)denticle belt0.0006747Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.1211Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3682Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.7885Least InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.01857InformativeInherited
Zebrafish Anatomy (ZA)stromal cell0.0008254Highly InformativeDirect
Zebrafish Anatomy (ZA)pectoral fin0.001875Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.2737Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.3276Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.7038Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.000000000007829InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.000000001535InformativeDirect
Plant ANatomical entity (PAN)trichome0.00000000002187Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.000003372Highly InformativeDirect
Plant ANatomical entity (PAN)phloem0.0001889Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.0000001256Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotide-diphospho-sugar transferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotide-diphospho-sugar transferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]