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Nucleotide-diphospho-sugar transferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleotide-diphospho-sugar transferases [ 53447]
Superfamily:   Nucleotide-diphospho-sugar transferases [ 53448] (19)
Families:   Spore coat polysaccharide biosynthesis protein SpsA [ 53449]
  beta 1,4 galactosyltransferase (b4GalT1) [ 53452]
  Galactosyltransferase LgtC [ 53458]
  Glycogenin [ 75273]
  alpha-1,3-galactosyltransferase-like [ 64131] (3)
  UDP-glucose pyrophosphorylase [ 53461] (3)
  glucose-1-phosphate thymidylyltransferase [ 53464] (3)
  1,3-glucuronyltransferase [ 53467] (2)
  N-acetylglucosaminyltransferase I [ 64136]
  Exostosin [ 89760]
  Molybdenum cofactor biosynthesis protein MobA [ 53470]
  Cytidylytransferase [ 68901] (6)
  Glycolipid 2-alpha-mannosyltransferase [ 102609]
  Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain [ 117702]
  MGS-like [ 142691]
  TTHA0179-like [ 159717]
  mannose-1-phosphate guanylyl transferase [ 159720]
  MM2497-like [ 159723]
  Glycosylating toxin catalytic domain-like [ 159726] (3)


Superfamily statistics
Genomes (3,205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 92,577 369,448 97
Proteins 90,962 363,466 97


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.000074910.0000000000094Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000024030.0000000000007665Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.086730.5217Least InformativeInherited
Biological Process (BP)primary metabolic process0.00083450.2395Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.71360.0001369Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.000000000066970.0007464Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative biosynthetic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.75141Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)multi-organism process0.84021Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.13660.00005224Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.074460.000425Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.97331Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.97021Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.2291Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy11Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.00000000062350InformativeDirect
Biological Process (BP)membrane lipid metabolic process0.000000000000055960InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.000000011670InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.0000000000003340InformativeDirect
Biological Process (BP)liposaccharide metabolic process00InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.083620.0003202InformativeInherited
Biological Process (BP)regulation of cell proliferation0.052491InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.45861InformativeInherited
Biological Process (BP)multi-organism cellular process0.48231InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)phospholipid metabolic process0.0059630.02488InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.000011370.07338InformativeInherited
Biological Process (BP)aminoglycan biosynthetic process0.000000000000019850Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process0.00067480.0000000001808Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.00032850.00008874Highly InformativeDirect
Biological Process (BP)glycoprotein metabolic process00Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.0000000023960Highly InformativeDirect
Biological Process (BP)glycolipid biosynthetic process0.000011770.0002766Highly InformativeDirect
Biological Process (BP)Mo-molybdopterin cofactor metabolic process0.00000013590.000001225Highly InformativeDirect
Biological Process (BP)sphingolipid biosynthetic process0.000000000048740Highly InformativeDirect
Biological Process (BP)extracellular matrix organization0.000000000000015760Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.00000088480Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.00000000000027170Highly InformativeDirect
Biological Process (BP)biofilm formation0.00011770.0000009483Highly InformativeDirect
Biological Process (BP)macromolecule glycosylation00Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.000000000074930.0004312Highly InformativeDirect
Biological Process (BP)regulation of fibroblast proliferation0.0000001040.000753Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.00040670Highly InformativeDirect
Biological Process (BP)glycosaminoglycan metabolic process01Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.00062260.9658Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0041740.0000000000593Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0060520.02607Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.961Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity0.00097410Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.00000000067830Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.22670.1144Least InformativeInherited
Cellular Component (CC)membrane0.000024890.01211Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0020470.0002229Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0043560Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000000076260Moderately InformativeDirect
Cellular Component (CC)transferase complex0.48831Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.0010390.0000002674Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.038190.01941Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.000016560.00000002583InformativeDirect
Cellular Component (CC)Golgi apparatus00InformativeDirect
Cellular Component (CC)cis-Golgi network0.0000010960.0000001233Highly InformativeDirect
Cellular Component (CC)intrinsic component of organelle membrane0.00060880.000001504Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000000094 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000007665 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0001369 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2395 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5217 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000425 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.0007464 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00005224 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.06793 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.4751 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.004081 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) growth 0.0002021 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0003202 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.007787 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9326 Informative Inherited
Biological Process (BP) cell development 0.2421 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.9136 Informative Inherited
Biological Process (BP) post-embryonic development 0.6425 Informative Inherited
Biological Process (BP) reproductive system development 0.01221 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) multi-organism cellular process 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1961 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.06232 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) central nervous system development 0.5373 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8898 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.9755 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.02488 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9677 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.8378 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.07338 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) embryo development 0.8663 Informative Inherited
Biological Process (BP) renal system process 0.000000000002312 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0000003089 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0000000001808 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000007486 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.0000000000593 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.00008874 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.0002766 Highly Informative Direct
Biological Process (BP) oligosaccharide metabolic process 0.0006762 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0005174 Highly Informative Direct
Biological Process (BP) Mo-molybdopterin cofactor metabolic process 0.000001225 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) biofilm formation 0.0000009483 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0004312 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.000753 Highly Informative Direct
Biological Process (BP) seed development 0.0003829 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0000001609 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.008473 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.03902 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3031 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.002849 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.4955 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.9658 Highly Informative Inherited
Biological Process (BP) pigmentation 0.2304 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.02884 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.7432 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2344 Highly Informative Inherited
Biological Process (BP) cell migration 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.9943 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.5749 Highly Informative Inherited
Biological Process (BP) cell growth 0.6294 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.1747 Highly Informative Inherited
Biological Process (BP) cell division 0.7369 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.8156 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.7846 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.02607 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00006988 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.8026 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) RNA binding 0.8697 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000008203 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.000000000004966 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0008702 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.5668 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.1131 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002229 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1144 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01211 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000002674 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.01941 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00000002583 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) organelle subcompartment 0 Informative Direct
Cellular Component (CC) cis-Golgi network 0.0000001233 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000001504 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.5727 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000000007521Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.8741Moderately InformativeInherited
Enzyme Commission (EC)Transferring other groups1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.00000001082Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.3125Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5073Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.1436Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.04498InformativeInherited
Disease Ontology (DO)bone remodeling disease0.002934Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Death in childhood0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.0004256Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.008581Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.03966Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.07207Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1167Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3896Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5695Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8871Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.005691Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.0735Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.09545Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.134Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.1536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.158Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.1661Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.1796Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1897Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.2337Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.2366Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2525Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.358Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.4558Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6535Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.7711Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.7836Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.0001531InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.007376InformativeInherited
Phenotypic Abnormality (PA)Decreased facial expression0.01269InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.01905InformativeInherited
Phenotypic Abnormality (PA)Cerebellar malformation0.03957InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.03962InformativeInherited
Phenotypic Abnormality (PA)Abnormality of refraction0.04266InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.04303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.05042InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.05784InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.134InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1475InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.1715InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.1789InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.2103InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.2464InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.2697InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.3643InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.4834InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.653InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.8825InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.00008375Highly InformativeDirect
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0002964Highly InformativeDirect
Phenotypic Abnormality (PA)Myopathic facies0.0003773Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of corneal size0.000801Highly InformativeDirect
Phenotypic Abnormality (PA)Left ventricular hypertrophy0.0009808Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the retina0.002285Highly InformativeInherited
Phenotypic Abnormality (PA)Cerebellar vermis hypoplasia0.002557Highly InformativeInherited
Phenotypic Abnormality (PA)Encephalocele0.004614Highly InformativeInherited
Phenotypic Abnormality (PA)Central nervous system cyst0.008798Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vitreous humor0.01091Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.03379Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.03618Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle hypertrophy0.05067Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of extrapyramidal motor function0.06063Highly InformativeInherited
Phenotypic Abnormality (PA)Incoordination0.06553Highly InformativeInherited
Phenotypic Abnormality (PA)Ventriculomegaly0.1435Highly InformativeInherited
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.3536Highly InformativeInherited
Phenotypic Abnormality (PA)Myopia0.4473Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.8699Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.09609Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.4936Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.578Moderately InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.04497InformativeInherited
Worm Phenotype (WP)vulva development variant0.1416InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.0006565Highly InformativeDirect
Worm Phenotype (WP)one cell arrest early emb0.0008282Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.2572Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.2436InformativeInherited
Yeast Phenotype (YP)chitin deposition0.00001155Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.1003Least InformativeInherited
Fly Anatomy (FA)anatomical group0.4552Least InformativeInherited
Fly Anatomy (FA)larva0.52Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.001529Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval integumentary system0.008169InformativeInherited
Fly Anatomy (FA)denticle belt0.0001445Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.1091Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.728Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.07671InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.000839Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.2737Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.3276Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.7038Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.000000000007829InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.000000001535InformativeDirect
Plant ANatomical entity (PAN)trichome0.00000000002187Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.000003372Highly InformativeDirect
Plant ANatomical entity (PAN)phloem0.0001889Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.00000009712Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)sensory organs0.02396Least InformativeInherited
Drugbank ATC_code (DB)other ophthalmologicals0.0001844Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.001947Moderately InformativeInherited
Drugbank ATC_code (DB)ascorbic acid0.000002618InformativeDirect
Drugbank ATC_code (DB)ascorbic acid0.000002618InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processAntibiotic resistance0.000000000000001433InformativeDirect
Biological processLipid biosynthesis0.1289InformativeInherited
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000002785Highly InformativeDirect
Biological processNodulation0.0000000008714Highly InformativeDirect
Biological processLipid A biosynthesis0.000000005015Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0000694Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
DiseaseDystroglycanopathy0.00000000185Highly InformativeDirect
DiseaseCongenital muscular dystrophy0.000000005307Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.0000000000001404Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.02295Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.3949Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)protein glycosylation0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0.00000000000001534InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.0000000008546InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.9798InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)coenzyme F420 biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS lipid A biosynthesis0Highly InformativeDirect
UniPathway (UP)teichoic acid biosynthesis0.000000000000199Highly InformativeDirect
UniPathway (UP)glycosaminoglycan metabolism0.00009388Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotide-diphospho-sugar transferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotide-diphospho-sugar transferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]