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Nucleotide-diphospho-sugar transferases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Nucleotide-diphospho-sugar transferases [ 53447]
Superfamily:   Nucleotide-diphospho-sugar transferases [ 53448] (19)
Families:   Spore coat polysaccharide biosynthesis protein SpsA [ 53449]
  beta 1,4 galactosyltransferase (b4GalT1) [ 53452]
  Galactosyltransferase LgtC [ 53458]
  Glycogenin [ 75273]
  alpha-1,3-galactosyltransferase-like [ 64131] (3)
  UDP-glucose pyrophosphorylase [ 53461] (3)
  glucose-1-phosphate thymidylyltransferase [ 53464] (3)
  1,3-glucuronyltransferase [ 53467] (2)
  N-acetylglucosaminyltransferase I [ 64136]
  Exostosin [ 89760]
  Molybdenum cofactor biosynthesis protein MobA [ 53470]
  Cytidylytransferase [ 68901] (6)
  Glycolipid 2-alpha-mannosyltransferase [ 102609]
  Polypeptide N-acetylgalactosaminyltransferase 1, N-terminal domain [ 117702]
  MGS-like [ 142691]
  TTHA0179-like [ 159717]
  mannose-1-phosphate guanylyl transferase [ 159720]
  MM2497-like [ 159723]
  Glycosylating toxin catalytic domain-like [ 159726] (3)


Superfamily statistics
Genomes (3,209) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 92,944 369,448 97
Proteins 91,320 363,466 97


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process00Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.00010840.00000000001024Least InformativeDirect
Biological Process (BP)primary metabolic process0.000000000024290.00000004758Least InformativeDirect
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00000040470Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.081550.3989Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.99790.000002222Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.0000000000000031190Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process00Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.16140.0002368Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.78171Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.00000000023290.00115Moderately InformativeInherited
Biological Process (BP)multi-organism process0.92031Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.3140.001109Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.97281Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.97321Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus11Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process0.22131Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy11Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process11Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.000000000050240InformativeDirect
Biological Process (BP)membrane lipid metabolic process0.000000000000013370InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0000000014960InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.00000000000002870InformativeDirect
Biological Process (BP)cell wall organization or biogenesis0.000000020550InformativeDirect
Biological Process (BP)liposaccharide metabolic process00InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.0890.001744InformativeInherited
Biological Process (BP)regulation of cell proliferation0.051811InformativeInherited
Biological Process (BP)phospholipid metabolic process0.0063920.06494InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.52831InformativeInherited
Biological Process (BP)peptidyl-amino acid modification11InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.0000062990.1383InformativeInherited
Biological Process (BP)aminoglycan biosynthetic process0.0000000000000090330Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process0.00080650.00000000004646Highly InformativeDirect
Biological Process (BP)lipopolysaccharide metabolic process0.000082990.00003614Highly InformativeDirect
Biological Process (BP)glycoprotein metabolic process00Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000000000041760Highly InformativeDirect
Biological Process (BP)glycolipid biosynthetic process0.000014610.0001536Highly InformativeDirect
Biological Process (BP)Mo-molybdopterin cofactor metabolic process0.00000013990.000001258Highly InformativeDirect
Biological Process (BP)sphingolipid biosynthetic process0.00000000048130.00000000003921Highly InformativeDirect
Biological Process (BP)extracellular matrix organization0.00000098610Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.000000077430Highly InformativeDirect
Biological Process (BP)cell wall biogenesis0.00000000000031960Highly InformativeDirect
Biological Process (BP)macromolecule glycosylation00Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process0.00096680Highly InformativeDirect
Biological Process (BP)phosphatidylinositol metabolic process0.000000000089850.0006059Highly InformativeDirect
Biological Process (BP)regulation of fibroblast proliferation0.000000094240.0007707Highly InformativeDirect
Biological Process (BP)cellular component macromolecule biosynthetic process0.00003770Highly InformativeDirect
Biological Process (BP)glycosaminoglycan metabolic process01Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0005530.9655Highly InformativeInherited
Biological Process (BP)multi-organism cellular process0.023710.05028Highly InformativeInherited
Biological Process (BP)glycosphingolipid metabolic process0.0045290.00000000001203Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0091450.04087Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.98951Moderately InformativeInherited
Molecular Function (MF)metal ion binding0.0012550.00001134Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring glycosyl groups00InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)UDP-glycosyltransferase activity0.00086920Highly InformativeDirect
Molecular Function (MF)transferase activity, transferring hexosyl groups0.0000000016970Highly InformativeDirect
Molecular Function (MF)manganese ion binding0.000011520Highly InformativeDirect
Cellular Component (CC)intracellular organelle part0.24220.1754Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0045160.0009848Least InformativeInherited
Cellular Component (CC)macromolecular complex11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.021190.00000000000001356Least InformativeInherited
Cellular Component (CC)membrane0.000045060.02481Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0000000083580Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.000000031850.00000000000003485Moderately InformativeDirect
Cellular Component (CC)transferase complex0.27911Moderately InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.059580.0293Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.0000030520.000000006955InformativeDirect
Cellular Component (CC)Golgi apparatus00InformativeDirect
Cellular Component (CC)cis-Golgi network0.000001030.00000009909Highly InformativeDirect
Cellular Component (CC)intrinsic component of organelle membrane0.00082320.000005901Highly InformativeDirect
Cellular Component (CC)Golgi subcompartment0.000013610Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000001024 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000004758 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.000002222 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.3989 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0002368 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0003479 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.118 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.00115 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001109 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6708 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0 Informative Direct
Biological Process (BP) growth 0.0002569 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3328 Informative Inherited
Biological Process (BP) tissue development 0.2427 Informative Inherited
Biological Process (BP) cell development 0.1618 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.8528 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.001744 Informative Inherited
Biological Process (BP) central nervous system development 0.5636 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.588 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.06494 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9231 Informative Inherited
Biological Process (BP) embryo development 0.6696 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.2298 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1614 Informative Inherited
Biological Process (BP) reproductive system development 0.3102 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.9168 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.1383 Informative Inherited
Biological Process (BP) system process 0.9288 Informative Inherited
Biological Process (BP) renal system process 0.000000000009724 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0000003903 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.00000000004646 Highly Informative Direct
Biological Process (BP) translational initiation 0.0000002679 Highly Informative Direct
Biological Process (BP) glycosphingolipid metabolic process 0.00000000001203 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.00003614 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.0001536 Highly Informative Direct
Biological Process (BP) Mo-molybdopterin cofactor metabolic process 0.000001258 Highly Informative Direct
Biological Process (BP) sphingolipid biosynthetic process 0.00000000003921 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.0006059 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.0007707 Highly Informative Direct
Biological Process (BP) seed development 0.0006417 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0000004235 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.719 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.6682 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3198 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.503 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.9655 Highly Informative Inherited
Biological Process (BP) pigmentation 0.2826 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.05028 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.8647 Highly Informative Inherited
Biological Process (BP) gastrulation 0.2341 Highly Informative Inherited
Biological Process (BP) appendage development 0.8771 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 1 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.003093 Highly Informative Inherited
Biological Process (BP) cell growth 0.8812 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.1637 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.009831 Highly Informative Inherited
Biological Process (BP) cell division 0.9451 Highly Informative Inherited
Biological Process (BP) ceramide metabolic process 0.001031 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.04087 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.00001134 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.8063 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 1 Informative Inherited
Molecular Function (MF) RNA binding 0.9062 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000001183 Highly Informative Direct
Molecular Function (MF) translation factor activity, RNA binding 0.0000000000007595 Highly Informative Direct
Molecular Function (MF) UDP-glycosyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0 Highly Informative Direct
Molecular Function (MF) manganese ion binding 0 Highly Informative Direct
Molecular Function (MF) monosaccharide binding 0.0008229 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.1332 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring pentosyl groups 1 Highly Informative Inherited
Molecular Function (MF) dioxygenase activity 0.006431 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009848 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000001356 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1754 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.02481 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00000000000003485 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0293 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.000000006955 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) cis-Golgi network 0.00000009909 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.000005901 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.5372 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.00000000007521Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.8741Moderately InformativeInherited
Enzyme Commission (EC)Transferring other groups1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Cellulose synthase (UDP-forming)0Highly InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.00000001082Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0.3125Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.5023Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.1453Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.04453InformativeInherited
Disease Ontology (DO)bone remodeling disease0.003058Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Death in childhood0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.0004022Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.008807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04759Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.07241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1331Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3509Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8858Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.005789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.07401Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.08549Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.08603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.135Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the posterior segment of the globe0.1364Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.1579Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.1609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.1748Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.2153Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.22Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.2365Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.2496Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2967Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.3711Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.4826Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.6536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.7412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.7495Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.0001573InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.007428InformativeInherited
Phenotypic Abnormality (PA)Decreased facial expression0.01294InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.01947InformativeInherited
Phenotypic Abnormality (PA)Abnormality of refraction0.04073InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.04247InformativeInherited
Phenotypic Abnormality (PA)Respiratory insufficiency0.04293InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral ventricles0.04799InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.05502InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.05599InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral cortex0.1345InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1516InformativeInherited
Phenotypic Abnormality (PA)Abnormality of neuronal migration0.1688InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebellum0.1726InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.1763InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.2112InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.2335InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.2681InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal muscles0.3662InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.368InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.485InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the myocardium0.6521InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the retina0.877InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calf musculature0.00008044Highly InformativeDirect
Phenotypic Abnormality (PA)Optic nerve hypoplasia0.0002792Highly InformativeDirect
Phenotypic Abnormality (PA)Myopathic facies0.0003676Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of corneal size0.00079Highly InformativeDirect
Phenotypic Abnormality (PA)Left ventricular hypertrophy0.0009344Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the retina0.002288Highly InformativeInherited
Phenotypic Abnormality (PA)Cerebellar vermis hypoplasia0.002446Highly InformativeInherited
Phenotypic Abnormality (PA)Encephalocele0.004402Highly InformativeInherited
Phenotypic Abnormality (PA)Central nervous system cyst0.008276Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vitreous humor0.0108Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.03159Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.03646Highly InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle hypertrophy0.04973Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of extrapyramidal motor function0.05855Highly InformativeInherited
Phenotypic Abnormality (PA)Incoordination0.06566Highly InformativeInherited
Phenotypic Abnormality (PA)Ventriculomegaly0.15Highly InformativeInherited
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.3506Highly InformativeInherited
Phenotypic Abnormality (PA)Myopia0.455Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.6853Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.4904Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.5783Moderately InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.04299InformativeInherited
Worm Phenotype (WP)pharyngeal development variant0.0006629Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.2578Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.2443InformativeInherited
Yeast Phenotype (YP)chitin deposition0.00001143Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.008033Least InformativeInherited
Fly Anatomy (FA)integumentary system0.06754Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1199Least InformativeInherited
Fly Anatomy (FA)adult0.1858Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3779Least InformativeInherited
Fly Anatomy (FA)larva0.6363Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.0004799Moderately InformativeDirect
Fly Anatomy (FA)adult thorax0.1211Moderately InformativeInherited
Fly Anatomy (FA)appendage0.185Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2264Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.3529Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.7197Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.7256Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.000713InformativeDirect
Fly Anatomy (FA)embryonic/larval integumentary system0.01336InformativeInherited
Fly Anatomy (FA)denticle belt0.0001935Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0.06622Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2039Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.6777Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal element0.0007939InformativeDirect
Zebrafish Anatomy (ZA)surface structure0.03902InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.001187Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0.2737Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.3276Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.7038Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.000000000007829InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.000000001535InformativeDirect
Plant ANatomical entity (PAN)trichome0.00000000002187Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.000003372Highly InformativeDirect
Plant ANatomical entity (PAN)phloem0.0001889Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.000000483Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups1Highly InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processCell shape0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processAntibiotic resistance0.000000000000001678InformativeDirect
Biological processLipid biosynthesis0.1307InformativeInherited
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processSphingolipid metabolism0.00000000000001956Highly InformativeDirect
Biological processNodulation0.0000000009256Highly InformativeDirect
Biological processLipid A biosynthesis0.000000005063Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0.0001111Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
DiseaseDystroglycanopathy0.000000001955Highly InformativeDirect
DiseaseCongenital muscular dystrophy0.000000005464Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.0000000000003496Least InformativeDirect
DomainSignal-anchor0InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionManganese0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.01631Moderately InformativeInherited
UniPathway (UP)alcohol metabolism0.3391Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)protein glycosylation0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)organic acid biosynthesis0.00000000000001031InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis0.0000000008602InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.9796InformativeInherited
UniPathway (UP)pigment biosynthesis1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)coenzyme F420 biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0Highly InformativeDirect
UniPathway (UP)LPS lipid A biosynthesis0Highly InformativeDirect
UniPathway (UP)teichoic acid biosynthesis0.000000000000462Highly InformativeDirect
UniPathway (UP)glycosaminoglycan metabolism0.00009281Highly InformativeDirect
UniPathway (UP)carotenoid biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nucleotide-diphospho-sugar transferases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Nucleotide-diphospho-sugar transferases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]