SUPERFAMILY 1.75 HMM library and genome assignments server

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alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,191) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 174,034 845,738 251
Proteins 171,568 835,698 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.26480.000000000000003734Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000000000000031440Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.0000003460Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00022130Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.8166Moderately InformativeInherited
Biological Process (BP)animal organ development11Moderately InformativeInherited
Biological Process (BP)tissue development11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.53130.1833Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.20030.000000001882Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.23170.01967Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)immune system process11Moderately InformativeInherited
Biological Process (BP)defense response11Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)response to biotic stimulus11Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.037580.0000001218Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process10.9141Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process11Moderately InformativeInherited
Biological Process (BP)lipid catabolic process00InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.00000000014810InformativeDirect
Biological Process (BP)response to acid chemical0.57821InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.85261InformativeInherited
Biological Process (BP)cellular response to lipid0.59111InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)circulatory system development0.65221InformativeInherited
Biological Process (BP)growth0.59861InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.89831InformativeInherited
Biological Process (BP)coenzyme biosynthetic process10.7983InformativeInherited
Biological Process (BP)phospholipid metabolic process0.022090InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.3010.0000000000003084InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.61840.6483InformativeInherited
Biological Process (BP)pigment metabolic process0.28440.8062InformativeInherited
Biological Process (BP)inorganic ion homeostasis0.95781InformativeInherited
Biological Process (BP)cation homeostasis0.95381InformativeInherited
Biological Process (BP)single-organism membrane organization0.77530.04514InformativeInherited
Biological Process (BP)secondary metabolic process0.023810.00007037InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.19780.9423InformativeInherited
Biological Process (BP)regulation of catabolic process0.72661InformativeInherited
Biological Process (BP)immune response11InformativeInherited
Biological Process (BP)defense response to other organism11InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.160.02573InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.35350.183InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.5720.009993InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.93711InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.43290.4184InformativeInherited
Biological Process (BP)isoprenoid metabolic process11InformativeInherited
Biological Process (BP)biotin metabolic process0.0004150.00001031Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.0005890.00000005297Highly InformativeDirect
Biological Process (BP)phosphatidylcholine metabolic process0.00032710Highly InformativeDirect
Biological Process (BP)glycerolipid catabolic process0.000000040090Highly InformativeDirect
Biological Process (BP)lactone biosynthetic process0.00032710.000000001236Highly InformativeDirect
Biological Process (BP)heart development0.11291Highly InformativeInherited
Biological Process (BP)muscle tissue development0.0030361Highly InformativeInherited
Biological Process (BP)cell proliferation0.14641Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.0042680.446Highly InformativeInherited
Biological Process (BP)regulation of lipid catabolic process0.000034550.002493Highly InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.075740.5607Highly InformativeInherited
Biological Process (BP)acyl-CoA biosynthetic process0.037610.2083Highly InformativeInherited
Biological Process (BP)fatty acid derivative biosynthetic process0.33220.2297Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.026830.000000000001021Highly InformativeInherited
Biological Process (BP)aldehyde catabolic process0.01610.04821Highly InformativeInherited
Biological Process (BP)detoxification0.07840.3946Highly InformativeInherited
Biological Process (BP)lysosome organization10.02072Highly InformativeInherited
Biological Process (BP)lipid modification0.54561Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.002340.0000000006285Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.14580.004745Highly InformativeInherited
Biological Process (BP)positive regulation of cellular catabolic process0.0074290.9243Highly InformativeInherited
Biological Process (BP)regulation of lipid localization0.028780.3025Highly InformativeInherited
Biological Process (BP)cellular response to acid chemical0.29090.9958Highly InformativeInherited
Biological Process (BP)hormone-mediated signaling pathway0.053070.1424Highly InformativeInherited
Biological Process (BP)innate immune response0.81421Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.019550.0002825Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.60330.1206Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH0.011370.02406Highly InformativeInherited
Biological Process (BP)pH reduction0.0017580.001233Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.17991Highly InformativeInherited
Biological Process (BP)demethylation0.000010610.02066Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00InformativeDirect
Molecular Function (MF)enzyme binding0.47651InformativeInherited
Molecular Function (MF)receptor binding0.98831InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.037260InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides10.8804InformativeInherited
Molecular Function (MF)lipase activity00Highly InformativeDirect
Molecular Function (MF)thiolester hydrolase activity0.000000010350.00000154Highly InformativeDirect
Molecular Function (MF)serine hydrolase activity10.4694Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding0.000016440.1074Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.0017560.000002707Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.076030Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)endomembrane system11Moderately InformativeInherited
Cellular Component (CC)vesicle11Moderately InformativeInherited
Cellular Component (CC)microbody0.00050070.0003665InformativeDirect
Cellular Component (CC)Golgi apparatus0.14860.8658InformativeInherited
Cellular Component (CC)lipid droplet0.0000000023970Highly InformativeDirect
Cellular Component (CC)Golgi-associated vesicle0.000090830.2822Highly InformativeInherited
Cellular Component (CC)coated vesicle0.00045530.6632Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000000003734 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000001218 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000001882 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8166 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1833 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.01967 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9141 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0.00007037 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001667 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000000000003084 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.08728 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6262 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4519 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.04514 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cellular response to lipid 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 1 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.7983 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.6483 Informative Inherited
Biological Process (BP) pigment metabolic process 0.8062 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.5535 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 1 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) lipid localization 0.07286 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.9833 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.9423 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02573 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.183 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.009993 Informative Inherited
Biological Process (BP) organelle assembly 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.4184 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) acylglycerol metabolic process 0.000000000001021 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00001031 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0004751 Highly Informative Direct
Biological Process (BP) phospholipid catabolic process 0.0000001795 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.000006368 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0002825 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00005057 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000005297 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000000006285 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0 Highly Informative Direct
Biological Process (BP) lactone biosynthetic process 0.000000001236 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.000005248 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.5902 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.8394 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.01496 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.5607 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.1 Highly Informative Inherited
Biological Process (BP) heart development 1 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 1 Highly Informative Inherited
Biological Process (BP) muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) cell proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 0.02406 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.446 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.002493 Highly Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.2083 Highly Informative Inherited
Biological Process (BP) fatty acid derivative biosynthetic process 0.2297 Highly Informative Inherited
Biological Process (BP) aldehyde catabolic process 0.04821 Highly Informative Inherited
Biological Process (BP) detoxification 0.3946 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.01586 Highly Informative Inherited
Biological Process (BP) digestion 0.01173 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.02072 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.05309 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.4058 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.004745 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.007865 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.9243 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.3025 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.9958 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.1424 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9237 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.1206 Highly Informative Inherited
Biological Process (BP) biological adhesion 1 Highly Informative Inherited
Biological Process (BP) pH reduction 0.001233 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.002528 Highly Informative Inherited
Biological Process (BP) demethylation 0.02066 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.5861 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03509 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.8804 Informative Inherited
Molecular Function (MF) heparin binding 0.0003 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.000002707 Highly Informative Direct
Molecular Function (MF) lipase activity 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0.00000154 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0004863 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.4694 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1074 Highly Informative Inherited
Molecular Function (MF) vitamin binding 0.4164 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0006086 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0.0003665 Informative Direct
Cellular Component (CC) plasma membrane region 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.8658 Informative Inherited
Cellular Component (CC) lipid droplet 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) protein acetyltransferase complex 0.004151 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.2822 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.6632 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000000004291InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000449InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000007839InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000219InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000007623InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0.00000000002246Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000004246Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000009227Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.000006243Moderately InformativeDirect
Biological processCarbohydrate metabolism0.00001517Moderately InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processAutophagy0.000000000000004737InformativeDirect
Biological processCytolysis0.00001767InformativeDirect
Biological processCell adhesion0.0005441InformativeDirect
Biological processSteroid metabolism0.9626InformativeInherited
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processLuminescence2.442e-16Highly InformativeDirect
Biological processDetoxification0.0000000000001457Highly InformativeDirect
Biological processCholesterol metabolism0.00000000003389Highly InformativeDirect
Biological processCysteine biosynthesis0.00001191Highly InformativeDirect
Cellular componentMembrane0.1104Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell junction0.000000004077Moderately InformativeDirect
Cellular componentEndosome0.000003072Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor0.00000000000007426InformativeDirect
Cellular componentLysosome0.0000000000001865InformativeDirect
Cellular componentPeroxisome0.00007733InformativeDirect
Cellular componentSynapse0.0006383InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DiseaseAllergen0.00000007513Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainCBS domain0.0007552Highly InformativeDirect
Molecular functionCalcium0.0000031Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationHeparin-binding0.0000000000001515InformativeDirect
Post-translational modificationSerine protease0.0000000005631InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond9.634e-16Least InformativeDirect
Post-translational modificationZymogen0.0000000000666InformativeDirect
Post-translational modificationNitration0.000001718InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]