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alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,193) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 174,635 1,106,958 251
Proteins 172,120 1,094,325 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000000004291InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000449InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000007839InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000219InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000007623InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0.00000000002246Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000004246Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.7626Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.08831Moderately InformativeInherited
Disease Ontology (DO)meningioma0.00002077InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1011Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2539Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.8779Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.001347InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.4291InformativeInherited
Phenotypic Abnormality (PA)Malabsorption0.04174Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality lipoprotein cholesterol concentration0.2066Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8298Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.9745Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0007705Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.1052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5372Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.0002943InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.008737InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.1681InformativeInherited
Mammalian Phenotype (MP)abnormal circulating phospholipid level0.0009186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.03365Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.5932Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000000001719Moderately InformativeDirect
Worm Phenotype (WP)movement variant1Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0.000000000000085InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.001388Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.5709Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.4157InformativeInherited
Yeast Phenotype (YP)lipid particle morphology0.0002579Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.00000003822Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.602InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases7.479e-16InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.8493InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9275InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.0000000000786Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000002862Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.00001211Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.00003344Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00004168Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationHydrolase0.00000000000006295Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]