SUPERFAMILY 1.75 HMM library and genome assignments server

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alpha/beta-Hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   alpha/beta-Hydrolases [ 53473]
Superfamily:   alpha/beta-Hydrolases [ 53474] (41)
Families:   Acetylcholinesterase-like [ 53475] (5)
  Carboxylesterase [ 53487] (6)
  Mycobacterial antigens [ 53491] (4)
  Hypothetical protein TT1662 [ 102616]
  PepX catalytic domain-like [ 69581] (3)
  Prolyl oligopeptidase, C-terminal domain [ 53496]
  DPP6 catalytic domain-like [ 82497] (2)
  Serine carboxypeptidase-like [ 53499] (3)
  Gastric lipase [ 53506]
  Proline iminopeptidase-like [ 53509] (3)
  Acetyl xylan esterase-like [ 82504] (2)
  Haloalkane dehalogenase [ 53513]
  Dienelactone hydrolase [ 53518]
  Carbon-carbon bond hydrolase [ 53522] (3)
  Biotin biosynthesis protein BioH [ 82509]
  Aclacinomycin methylesterase RdmC [ 102620]
  Carboxylesterase/lipase [ 102623]
  Epoxide hydrolase [ 53525] (2)
  Haloperoxidase [ 53531] (7)
  Thioesterases [ 53542] (3)
  Carboxylesterase/thioesterase 1 [ 53547] (4)
  Ccg1/TafII250-interacting factor B (Cib) [ 75285]
  A novel bacterial esterase [ 53552]
  Lipase [ 53555]
  Fungal lipases [ 53558] (4)
  Bacterial lipase [ 53570] (3)
  Pancreatic lipase, N-terminal domain [ 53577]
  Hydroxynitrile lyase-like [ 53585] (2)
  Thioesterase domain of polypeptide, polyketide and fatty acid synthases [ 69584] (4)
  Cutinase-like [ 52260] (2)
  YdeN-like [ 110699]
  Putative serine hydrolase Ydr428c [ 110702]
  Acylamino-acid-releasing enzyme, C-terminal donain [ 117711]
  Hypothetical esterase YJL068C [ 117714]
  Hypothetical protein VC1974 [ 117717]
  Atu1826-like [ 159742] (2)
  PHB depolymerase-like [ 159747]
  IroE-like [ 159750]
  TTHA1544-like [ 159753]
  O-acetyltransferase [ 159756] (2)
  2,6-dihydropseudooxynicotine hydrolase-like [ 159762]


Superfamily statistics
Genomes (3,191) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 174,034 845,738 251
Proteins 171,568 835,698 251


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.33910.00000000000004133Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000000000000076080Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process0.00000043590Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00025020Moderately InformativeDirect
Biological Process (BP)response to organic substance11Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of localization11Moderately InformativeInherited
Biological Process (BP)sulfur compound metabolic process0.54020.1973Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.24480.000000005864Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.8768Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.038830.0000006604Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process10.9237Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular protein modification process11Moderately InformativeInherited
Biological Process (BP)organophosphate biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.24890.02367Moderately InformativeInherited
Biological Process (BP)cellular lipid catabolic process0.00079850InformativeDirect
Biological Process (BP)glycerolipid metabolic process0.000000000050850InformativeDirect
Biological Process (BP)response to acid chemical0.56851InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.85211InformativeInherited
Biological Process (BP)cellular response to lipid0.56441InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.89331InformativeInherited
Biological Process (BP)positive regulation of transport11InformativeInherited
Biological Process (BP)sulfur compound biosynthetic process0.1650.02774InformativeInherited
Biological Process (BP)coenzyme biosynthetic process10.8157InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.27830.0000000000002998InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process0.60990.6552InformativeInherited
Biological Process (BP)ion homeostasis0.99721InformativeInherited
Biological Process (BP)fatty acid derivative metabolic process0.089720.00127InformativeInherited
Biological Process (BP)membrane organization10.6312InformativeInherited
Biological Process (BP)secondary metabolic process0.020320.00006617InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.17290.1459InformativeInherited
Biological Process (BP)pigment metabolic process0.26220.7823InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.43860.4261InformativeInherited
Biological Process (BP)regulation of catabolic process0.72221InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.19090.9403InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.35960.1816InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.58840.007312InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.92691InformativeInherited
Biological Process (BP)phospholipid metabolic process0.020180InformativeInherited
Biological Process (BP)neutral lipid metabolic process0.000000024310Highly InformativeDirect
Biological Process (BP)biotin metabolic process0.00047980.00001194Highly InformativeDirect
Biological Process (BP)polyketide metabolic process0.0005310.0000000559Highly InformativeDirect
Biological Process (BP)phosphatidylcholine metabolic process0.00033770Highly InformativeDirect
Biological Process (BP)glycerolipid catabolic process0.00000003680Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.0041470.4913Highly InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport0.072470.516Highly InformativeInherited
Biological Process (BP)acyl-CoA biosynthetic process0.037850.2076Highly InformativeInherited
Biological Process (BP)fatty acid derivative biosynthetic process0.35150.2347Highly InformativeInherited
Biological Process (BP)aldehyde catabolic process0.015920.04821Highly InformativeInherited
Biological Process (BP)detoxification0.073960.396Highly InformativeInherited
Biological Process (BP)regulation of intracellular pH0.010960.02295Highly InformativeInherited
Biological Process (BP)lysosome organization10.0224Highly InformativeInherited
Biological Process (BP)lipid modification0.53711Highly InformativeInherited
Biological Process (BP)secondary metabolite biosynthetic process0.0023290.0000000006925Highly InformativeInherited
Biological Process (BP)cell wall macromolecule metabolic process0.14440.004543Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.017661Highly InformativeInherited
Biological Process (BP)regulation of lipid catabolic process0.00004350.005262Highly InformativeInherited
Biological Process (BP)regulation of lipid localization0.026740.2968Highly InformativeInherited
Biological Process (BP)cellular response to acid chemical0.28540.982Highly InformativeInherited
Biological Process (BP)hormone-mediated signaling pathway0.051860.1641Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.019340.0003318Highly InformativeInherited
Biological Process (BP)benzene-containing compound metabolic process0.6050.1279Highly InformativeInherited
Biological Process (BP)pH reduction0.002740.001446Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.17321Highly InformativeInherited
Biological Process (BP)demethylation0.0000098750.01749Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides10.9059InformativeInherited
Molecular Function (MF)enzyme binding0.43971InformativeInherited
Molecular Function (MF)receptor binding0.98071InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.030170InformativeInherited
Molecular Function (MF)thiolester hydrolase activity0.000000011480.000001892Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity00Highly InformativeDirect
Molecular Function (MF)serine hydrolase activity10.4423Highly InformativeInherited
Molecular Function (MF)protein phosphatase binding0.000016970.1101Highly InformativeInherited
Molecular Function (MF)O-acyltransferase activity0.0020130.0000003105Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity11Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.077170Highly InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle11Moderately InformativeInherited
Cellular Component (CC)microbody0.00053220.0003774InformativeDirect
Cellular Component (CC)Golgi apparatus0.1080.7626InformativeInherited
Cellular Component (CC)lipid particle0.0000000021580Highly InformativeDirect
Cellular Component (CC)Golgi-associated vesicle0.0000029410.008463Highly InformativeInherited
Cellular Component (CC)coated vesicle0.00039220.6616Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000000004133 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0000006604 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000005864 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.1973 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8768 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.9237 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.02367 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0.00006617 Informative Direct
Biological Process (BP) cellular lipid catabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0001566 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000000000002998 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.08283 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6173 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.4612 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cellular response to lipid 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.02774 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.8157 Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.6552 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.9658 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) fatty acid derivative metabolic process 0.00127 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) membrane organization 0.6312 Informative Inherited
Biological Process (BP) lipid localization 0.06166 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) membrane lipid metabolic process 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.9754 Informative Inherited
Biological Process (BP) pigment metabolic process 0.7823 Informative Inherited
Biological Process (BP) tetrapyrrole metabolic process 0.4261 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.9403 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.5442 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.1459 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.1816 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.007312 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) neutral lipid metabolic process 0 Highly Informative Direct
Biological Process (BP) biotin metabolic process 0.00001194 Highly Informative Direct
Biological Process (BP) phospholipid catabolic process 0.000000134 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.000003338 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0003318 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0.00005601 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.0000000559 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.0000000006925 Highly Informative Direct
Biological Process (BP) phosphatidylcholine metabolic process 0 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.00000464 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.8219 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.01347 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.516 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.09808 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.5888 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.4913 Highly Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.2076 Highly Informative Inherited
Biological Process (BP) fatty acid derivative biosynthetic process 0.2347 Highly Informative Inherited
Biological Process (BP) aldehyde catabolic process 0.04821 Highly Informative Inherited
Biological Process (BP) detoxification 0.396 Highly Informative Inherited
Biological Process (BP) polysaccharide catabolic process 0.01757 Highly Informative Inherited
Biological Process (BP) digestion 0.01002 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.003919 Highly Informative Inherited
Biological Process (BP) regulation of intracellular pH 0.02295 Highly Informative Inherited
Biological Process (BP) lysosome organization 0.0224 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.03806 Highly Informative Inherited
Biological Process (BP) lipid modification 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.007143 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.4283 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of lipid catabolic process 0.005262 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 0.2968 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.982 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.1641 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule metabolic process 0.004543 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.9262 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.1279 Highly Informative Inherited
Biological Process (BP) biological adhesion 1 Highly Informative Inherited
Biological Process (BP) pH reduction 0.001446 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) demethylation 0.01749 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) trans-synaptic signaling 0.4174 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) phospholipid binding 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.9059 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) amide binding 0.6065 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.03527 Informative Inherited
Molecular Function (MF) heparin binding 0.0003388 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) O-acyltransferase activity 0.0000003105 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0.000001892 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) modified amino acid binding 0.0005002 Highly Informative Direct
Molecular Function (MF) serine hydrolase activity 0.4423 Highly Informative Inherited
Molecular Function (MF) protein phosphatase binding 0.1101 Highly Informative Inherited
Molecular Function (MF) vitamin binding 0.4025 Highly Informative Inherited
Molecular Function (MF) phospholipase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0.0003774 Informative Direct
Cellular Component (CC) plasma membrane region 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) synapse 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.7626 Informative Inherited
Cellular Component (CC) lipid particle 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) Golgi-associated vesicle 0.008463 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.6616 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)In linear amides0.9931Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000000004291InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.000000000449InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000007839InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000219InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000007623InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0.007095InformativeInherited
Enzyme Commission (EC)Peroxidases0.7098InformativeInherited
Enzyme Commission (EC)Serine-type carboxypeptidases0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0.00000000002246Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000004246Highly InformativeDirect
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.7618Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.08637Moderately InformativeInherited
Disease Ontology (DO)meningioma0.00001883InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1376Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3782Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.6755Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.7864Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.9972Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lipid metabolism0.001035InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.6818InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.8729InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the small intestine0.03885Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cholesterol metabolism0.1363Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8166Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.981Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.000405Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.06824Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.0003476InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.01259InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.1136InformativeInherited
Mammalian Phenotype (MP)abnormal phospholipid level0.0003116Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.03627Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.6027Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00000000001933Moderately InformativeDirect
Worm Phenotype (WP)movement variant1Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0.00000000000009822InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0.001091Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.5708Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.4156InformativeInherited
Yeast Phenotype (YP)lipid particle morphology0.0002579Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.00000005984Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)0 seed germination stage0.602InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.000000001511InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.7812InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9101InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)In linear amides1InformativeInherited
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)1InformativeInherited
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.00000000006985Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000002785Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000008019Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00001628Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.0003692Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000689Highly InformativeDirect
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited
Enzyme Commission (EC)In ketonic substances1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processVirulence0.00000005415Moderately InformativeDirect
Biological processAmino-acid biosynthesis0.00000889Moderately InformativeDirect
Biological processCarbohydrate metabolism0.00003216Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processLipid degradation0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processAutophagy0.000000000000003804InformativeDirect
Biological processCytolysis0.00001117InformativeDirect
Biological processCell adhesion0.0004679InformativeDirect
Biological processSteroid metabolism0.9461InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processLuminescence0Highly InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processDetoxification0.0000000000001237Highly InformativeDirect
Biological processCholesterol metabolism0.00000000002218Highly InformativeDirect
Biological processCysteine biosynthesis0.00004382Highly InformativeDirect
Cellular componentMembrane0.07091Least InformativeInherited
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0.000000002989Moderately InformativeDirect
Cellular componentEndosome0.000002396Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentGPI-anchor0.00000000000007125InformativeDirect
Cellular componentLysosome0.0000000000001314InformativeDirect
Cellular componentPeroxisome0.00007546InformativeDirect
Cellular componentSynapse0.0006628InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DiseaseAllergen0.00000003105Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0InformativeDirect
DomainCBS domain0.00072Highly InformativeDirect
Molecular functionCalcium0.000002073Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationHeparin-binding0.00000000000007088InformativeDirect
Post-translational modificationSerine protease0.00000000044InformativeDirect
Post-translational modificationAminopeptidase0Highly InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond9.536e-16Least InformativeDirect
Post-translational modificationZymogen0.00000000005475InformativeDirect
Post-translational modificationNitration0.000001155InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.00000000003647Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)antibiotic biosynthesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.0000002654Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.002152Moderately InformativeInherited
UniPathway (UP)organic acid metabolism0.07422Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism0.1167Moderately InformativeInherited
UniPathway (UP)glycan metabolism0.1991Moderately InformativeInherited
UniPathway (UP)nitrogen metabolism0.9724Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)L-methionine biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0.000000000001002InformativeDirect
UniPathway (UP)glycan degradation0.000000003431InformativeDirect
UniPathway (UP)siderophore metabolism0.000000006211InformativeDirect
UniPathway (UP)phenylpropanoid degradation0.000001729InformativeDirect
UniPathway (UP)glycerol metabolism0.000003335InformativeDirect
UniPathway (UP)toxin biosynthesis0.000005544InformativeDirect
UniPathway (UP)polyketide biosynthesis0.00005143InformativeDirect
UniPathway (UP)alkaloid metabolism0.00073InformativeDirect
UniPathway (UP)tryptophan metabolism0.9614InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)menaquinone biosynthesis0Highly InformativeDirect
UniPathway (UP)xylan degradation0Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0Highly InformativeDirect
UniPathway (UP)butanoate metabolism0.000000000004515Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation0.00000000003253Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.0000000002Highly InformativeDirect
UniPathway (UP)L-cysteine metabolism0.0000000007194Highly InformativeDirect
UniPathway (UP)mycotoxin biosynthesis0.000002161Highly InformativeDirect
UniPathway (UP)glycerolipid degradation0.00001743Highly InformativeDirect
UniPathway (UP)gramicidin S biosynthesis0.0003977Highly InformativeDirect
UniPathway (UP)alkaloid degradation0.0008169Highly InformativeDirect
UniPathway (UP)penicillin biosynthesis0.01811Highly InformativeInherited
UniPathway (UP)bacterial bioluminescence1Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 122 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha/beta-Hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 122 hidden Markov models representing the alpha/beta-Hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]