SUPERFAMILY 1.75 HMM library and genome assignments server

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Dihydrofolate reductase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Dihydrofolate reductase-like [ 53596]
Superfamily:   Dihydrofolate reductase-like [ 53597] (2)
Families:   Dihydrofolate reductases [ 53598] (3)
  RibD C-terminal domain-like [ 142701] (2)


Superfamily statistics
Genomes (3,071) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,766 53,164 32
Proteins 7,756 53,082 32


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000014110.0001272Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0000000002870.000000000000003734Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000001940.0000000000002512Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000096440.0000894Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.000000000030920Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00000000020470.00000000001129Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000000097450.00000043Least InformativeDirect
Biological Process (BP)biosynthetic process0.30710.002389Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.000000000000031880Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.048090.00001111Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.031370.000002446Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.093080.04515Moderately InformativeInherited
Biological Process (BP)amide biosynthetic process11Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.51790.002452Moderately InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process00InformativeDirect
Biological Process (BP)dicarboxylic acid metabolic process0.0081460.0001455InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.89260.4157InformativeInherited
Biological Process (BP)folic acid-containing compound metabolic process00Highly InformativeDirect
Biological Process (BP)cellular modified amino acid biosynthetic process0.00052660.000003642Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000019110.00000000007754Highly InformativeDirect
Molecular Function (MF)binding0.0077720.5795Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.0052680.00006938Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding0.039440.9367Moderately InformativeInherited
Molecular Function (MF)RNA binding0.0000000014220.0000007392InformativeDirect
Molecular Function (MF)coenzyme binding0.0000000013750.000000000121InformativeDirect
Molecular Function (MF)drug binding00.000000000000004728Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors00Highly InformativeDirect
Molecular Function (MF)NADP binding0.0000000000036820.000000000000001615Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.17670.7767Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.21820.04388Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0001272 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000000000000003734 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000000002512 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000894 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000000001129 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000043 Least Informative Direct
Biological Process (BP) biosynthetic process 0.002389 Least Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.000002446 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00001111 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.04515 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.002452 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.0001455 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.4157 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.8427 Informative Inherited
Biological Process (BP) folic acid-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.000003642 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.00000000007754 Highly Informative Direct
Molecular Function (MF) binding 0.5795 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00006938 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.9367 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000007392 Informative Direct
Molecular Function (MF) coenzyme binding 0.000000000121 Informative Direct
Molecular Function (MF) drug binding 0.000000000000004728 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0000000001232 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.000000000000001615 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.7767 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.04388 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.0001523Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000000000004166Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.000001304Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0.000000006147InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAntibiotic resistance0InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationMethyltransferase0.000000001988InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dihydrofolate reductase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Dihydrofolate reductase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]