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Alkaline phosphatase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Alkaline phosphatase-like [ 53648]
Superfamily:   Alkaline phosphatase-like [ 53649] (5)
Families:   2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, catalytic domain [ 64162]
  Alkaline phosphatase [ 53650]
  Arylsulfatase [ 53653] (3)
  Phosphonoacetate hydrolase [ 102651]
  DeoB catalytic domain-like [ 142735]


Superfamily statistics
Genomes (3,036) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 24,514 136,105 33
Proteins 24,075 134,991 33


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.25840.0002941Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.19160.6387Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0080140Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.7750.005528Least InformativeInherited
Biological Process (BP)response to stimulus0.40430.9043Least InformativeInherited
Biological Process (BP)lipid metabolic process0.0000046520.000000000000212Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.00000050430Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.000000050210Moderately InformativeDirect
Biological Process (BP)single-organism transport0.67971Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0029950.5076Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.0033670.6579Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.16480.5739Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.097930.02447Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.021190.07384Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.54140.1212Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.20920.03931Moderately InformativeInherited
Biological Process (BP)immune system process0.52311Moderately InformativeInherited
Biological Process (BP)membrane lipid metabolic process0.00004330.000000000002InformativeDirect
Biological Process (BP)ammonium ion metabolic process0.0000017060.0000008442InformativeDirect
Biological Process (BP)vesicle-mediated transport0.18681InformativeInherited
Biological Process (BP)secretion by cell0.0082110.278InformativeInherited
Biological Process (BP)cell activation0.023520.4932InformativeInherited
Biological Process (BP)phospholipid metabolic process0.045010.00001179InformativeInherited
Biological Process (BP)lipid catabolic process0.20330.1362InformativeInherited
Biological Process (BP)organophosphate catabolic process0.0017380.000004789InformativeInherited
Biological Process (BP)liposaccharide metabolic process0.0043330.00000000000005703InformativeInherited
Biological Process (BP)carbohydrate derivative catabolic process0.0017750.08124InformativeInherited
Biological Process (BP)immune effector process0.020710.2025InformativeInherited
Biological Process (BP)immune response0.11260.7267InformativeInherited
Biological Process (BP)neutrophil mediated immunity0.00017180.0008637Highly InformativeDirect
Biological Process (BP)aminoglycan catabolic process0.00000008740.0000001585Highly InformativeDirect
Biological Process (BP)protein lipidation0.00026620Highly InformativeDirect
Biological Process (BP)glycoprotein metabolic process0.00000000091990Highly InformativeDirect
Biological Process (BP)phospholipid catabolic process0.00014830.0003776Highly InformativeDirect
Biological Process (BP)response to mechanical stimulus0.0000000078860.00006449Highly InformativeDirect
Biological Process (BP)glycosaminoglycan metabolic process0.0000086010.0000005152Highly InformativeDirect
Biological Process (BP)post-translational protein modification0.00000000000039450.0000000000001341Highly InformativeDirect
Biological Process (BP)myeloid cell activation involved in immune response0.0003790.001839Highly InformativeInherited
Biological Process (BP)leukocyte degranulation0.0003680.001289Highly InformativeInherited
Biological Process (BP)granulocyte activation0.00026060.001084Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds00Moderately InformativeDirect
Molecular Function (MF)phosphatase activity11InformativeInherited
Molecular Function (MF)phosphoric diester hydrolase activity0.00090360.01354Highly InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.081450.004059Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.61760.64Least InformativeInherited
Cellular Component (CC)vacuole00Moderately InformativeDirect
Cellular Component (CC)extracellular region part0.0035530.0000000000001288Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.042690.0000000000005165Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.13951Moderately InformativeInherited
Cellular Component (CC)cell surface00InformativeDirect
Cellular Component (CC)extracellular organelle0.00022240.0001912InformativeDirect
Cellular Component (CC)vacuolar part0.002180.001212InformativeInherited
Cellular Component (CC)vacuolar lumen0.00000033110.0000003683Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0002941 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.6387 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005528 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9043 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4487 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.000000000000212 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000179 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000008312 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0002237 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) tissue development 0.001133 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2245 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.6494 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.02839 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.03813 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.0398 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.04912 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9161 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3085 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1886 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5076 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5739 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.02447 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6579 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.7883 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.006214 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.6427 Moderately Informative Inherited
Biological Process (BP) cell communication 0.735 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.5023 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.07384 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.1212 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.02103 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.03931 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.23 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.07183 Moderately Informative Inherited
Biological Process (BP) system process 0.000001501 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000000000002 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00001179 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00002437 Informative Direct
Biological Process (BP) embryo development 0.000003099 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.0004147 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00003253 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000001407 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0004145 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000139 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003671 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00004103 Informative Direct
Biological Process (BP) ATP metabolic process 0.00003863 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.000004789 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0000003226 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001449 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000000000341 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.0000008442 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.00000000000005703 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.001856 Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0.001388 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.278 Informative Inherited
Biological Process (BP) cell activation 0.4932 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02498 Informative Inherited
Biological Process (BP) lipid catabolic process 0.1362 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.001898 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.2865 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.08124 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.008848 Informative Inherited
Biological Process (BP) immune effector process 0.2025 Informative Inherited
Biological Process (BP) immune response 0.7267 Informative Inherited
Biological Process (BP) cell development 0.151 Informative Inherited
Biological Process (BP) kidney development 0.000000000000007296 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.0008637 Highly Informative Direct
Biological Process (BP) muscle system process 0.00000000000006022 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0000001585 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0008899 Highly Informative Direct
Biological Process (BP) protein lipidation 0 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0000245 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000000002382 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) glycolipid biosynthetic process 0.0000003569 Highly Informative Direct
Biological Process (BP) phospholipid catabolic process 0.0003776 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0.00006449 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000005547 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.0000005152 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.0000000000001341 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0 Highly Informative Direct
Biological Process (BP) appendage development 0.0000000005769 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell proliferation 0.00000000002071 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.000000000001583 Highly Informative Direct
Biological Process (BP) myeloid cell activation involved in immune response 0.001839 Highly Informative Inherited
Biological Process (BP) leukocyte degranulation 0.001289 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.03791 Highly Informative Inherited
Biological Process (BP) phosphatidylinositol metabolic process 0.2016 Highly Informative Inherited
Biological Process (BP) granulocyte activation 0.001084 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.00005031 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00000008125 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4589 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.08891 Moderately Informative Inherited
Molecular Function (MF) carboxylic ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) intramolecular transferase activity 0 Highly Informative Direct
Molecular Function (MF) lipase activity 1 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.01354 Highly Informative Inherited
Cellular Component (CC) membrane 0.007713 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.004059 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.64 Least Informative Inherited
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000000000005165 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0000000000001288 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000497 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00007324 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000000002738 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular organelle 0.0001912 Informative Direct
Cellular Component (CC) membrane region 0.00000000001731 Informative Direct
Cellular Component (CC) vacuolar part 0.001212 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.0000003683 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.000000006922Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.000001316Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.3205Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.1016Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases (phosphomutases)0InformativeDirect
Enzyme Commission (EC)Nucleotide diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate mutase0Highly InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate group0Highly InformativeDirect
Enzyme Commission (EC)Phosphodiesterase I4.713e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.2659Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processSporulation0.0000000000003554InformativeDirect
Biological processHemostasis0.0000001205InformativeDirect
Biological processLipid degradation0.00009024InformativeDirect
Biological processCell wall biogenesis/degradation0.0003947InformativeDirect
Biological processBlood coagulation0.0000001136Highly InformativeDirect
Cellular componentMembrane0.0007495Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.0003377Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
DiseaseObesity0.000002427InformativeDirect
DiseaseMucopolysaccharidosis0Highly InformativeDirect
DomainSignal0.00000000000008657Least InformativeDirect
DomainTransmembrane0.00000000000316Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Alkaline phosphatase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Alkaline phosphatase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]