SUPERFAMILY 1.73 HMM library and genome assignments server


SIS domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   SIS domain [ 53696]
  3 layers: a/b/a; parallel beta-sheet of 5 strands, order 21345
Superfamily:   SIS domain [ 53697] (3)
Families:   mono-SIS domain [ 69599] (5)
  dimer of mono-domain subunits
  double-SIS domain [ 53698] (4)
  duplication: consists of two SIS domains related by pseudo dyad
  Phosphoglucose isomerase, PGI [ 53701]
  permutation of the double-SIS domain fold


Superfamily statistics
Genomes (1,215) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 6,923 9,633 25
Proteins 6,881 9,617 25


Functional annotation
General category Metabolism
Detailed category Energy

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SIS domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the SIS domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]