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ALDH-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   ALDH-like [ 53719]
Superfamily:   ALDH-like [ 53720] (2)
Families:   ALDH-like [ 53721] (5)
  L-histidinol dehydrogenase HisD [ 69602]


Superfamily statistics
Genomes (3,026) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 35,075 206,965 20
Proteins 34,615 205,385 20


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000000000091030Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.84721Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)response to stimulus0.92441Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.6853Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.000330.00000000004404Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.00034140.00003858Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000085430.000000000000007296Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.0084640.01227Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.092150.3792Moderately InformativeInherited
Biological Process (BP)animal organ development0.02261Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.41691Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.9231Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.92361Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.73861Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.051171Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.30960.8928Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.12740.6039Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.23040.5255Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.049350.05361Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.4880.1834Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.47680.1161Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.0041690.000000001274Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.40220.1754Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.0010420.000765Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.57950.3469Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular aldehyde metabolic process00InformativeDirect
Biological Process (BP)isoprenoid metabolic process0.000000000000006150InformativeDirect
Biological Process (BP)regulation of hormone levels0.0000000012330.0000003677InformativeDirect
Biological Process (BP)protein oligomerization0.00000065550.000000001332InformativeDirect
Biological Process (BP)ammonium ion metabolic process0.000013040.00001168InformativeDirect
Biological Process (BP)embryo development0.002070.5423InformativeInherited
Biological Process (BP)animal organ morphogenesis0.00052730.6391InformativeInherited
Biological Process (BP)alcohol metabolic process0.0067620.1327InformativeInherited
Biological Process (BP)response to acid chemical0.038140.02747InformativeInherited
Biological Process (BP)amine metabolic process0.0095290.0002417InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.017250.00000003568InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process11InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.0037460.0000001692InformativeInherited
Biological Process (BP)dicarboxylic acid metabolic process10.07179InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.51550.9373InformativeInherited
Biological Process (BP)fermentation0.00000028770.00000001935Highly InformativeDirect
Biological Process (BP)isoprenoid biosynthetic process0.00063040.0003231Highly InformativeDirect
Biological Process (BP)nucleobase metabolic process0.00010030.0001042Highly InformativeDirect
Biological Process (BP)response to water deprivation0.00062230.00005857Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.0000011920.00000009334Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.000006760.00000001383Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.0000000019880.0000000008593Highly InformativeDirect
Biological Process (BP)cellular biogenic amine catabolic process0.000081290.00000003681Highly InformativeDirect
Biological Process (BP)camera-type eye development0.000000088420.0003347Highly InformativeDirect
Biological Process (BP)imidazole-containing compound metabolic process0.000099220.00000002157Highly InformativeDirect
Biological Process (BP)embryonic organ development0.0000026660.005846Highly InformativeInherited
Biological Process (BP)appendage development0.0000012140.02413Highly InformativeInherited
Biological Process (BP)polyamine metabolic process0.0038670.02748Highly InformativeInherited
Biological Process (BP)branched-chain amino acid metabolic process0.00000880.02925Highly InformativeInherited
Biological Process (BP)glutamate metabolic process0.50170.07106Highly InformativeInherited
Biological Process (BP)glutamine family amino acid catabolic process0.027480.000002114Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.00000017380.0000001249Moderately InformativeDirect
Molecular Function (MF)anion binding0.21190.3286Moderately InformativeInherited
Molecular Function (MF)coenzyme binding00InformativeDirect
Molecular Function (MF)sulfur compound binding0.000059260.001508InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors00Highly InformativeDirect
Molecular Function (MF)NAD binding00Highly InformativeDirect
Molecular Function (MF)fatty acid derivative binding0.000000012170.000000001007Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.65920.07119Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.014520.0002537Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.94471Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6853 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000004404 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000001274 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000765 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.00003858 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01227 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3792 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.8928 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6039 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5255 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.05361 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.1834 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1161 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.1754 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3469 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00000003568 Informative Direct
Biological Process (BP) amine metabolic process 0.0002417 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000003677 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.0000001692 Informative Direct
Biological Process (BP) protein oligomerization 0.000000001332 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.00001168 Informative Direct
Biological Process (BP) embryo development 0.5423 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.6391 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1327 Informative Inherited
Biological Process (BP) response to acid chemical 0.02747 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.07179 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.9373 Informative Inherited
Biological Process (BP) fermentation 0.00000001935 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0003231 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 0.000002114 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0.0001042 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.00005857 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.00000009334 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.00000001383 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0000000008593 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.00000003681 Highly Informative Direct
Biological Process (BP) camera-type eye development 0.0003347 Highly Informative Direct
Biological Process (BP) aldehyde catabolic process 0.00003027 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.00000006342 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00000002157 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.005846 Highly Informative Inherited
Biological Process (BP) appendage development 0.02413 Highly Informative Inherited
Biological Process (BP) polyamine metabolic process 0.02748 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.02925 Highly Informative Inherited
Biological Process (BP) glutamate metabolic process 0.07106 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000001249 Moderately Informative Direct
Molecular Function (MF) anion binding 0.3286 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) sulfur compound binding 0.001508 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) fatty acid derivative binding 0.000000001007 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.07119 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.001687 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0002537 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.9278InformativeInherited
Enzyme Commission (EC)Histidinol dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0.0000000001588Highly InformativeDirect
Enzyme Commission (EC)Glutamate 5-kinase0.00004896Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0.000957InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis0.0000000000333Highly InformativeDirect
Biological processLuminescence0.00000000636Highly InformativeDirect
Cellular componentCytoplasm0.00000000000004322Least InformativeDirect
Cellular componentMitochondrion0.0006283Moderately InformativeDirect
DomainTransit peptide0.00000000001957Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationOxidation0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ALDH-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the ALDH-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]