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ALDH-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   ALDH-like [ 53719]
Superfamily:   ALDH-like [ 53720] (2)
Families:   ALDH-like [ 53721] (5)
  L-histidinol dehydrogenase HisD [ 69602]

 Superfamily statistics
Genomes (2,354) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 27,885 76,276 20
Proteins 27,504 75,813 20

 Functional annotation
General category Metabolism
Detailed category Redox

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)developmental process0.17111Least InformativeInherited
Biological Process (BP)multicellular organismal process0.47781Least InformativeInherited
Biological Process (BP)response to stimulus0.70991Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.22870.005892Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process10.8957Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process3.672e-080Moderately InformativeDirect
Biological Process (BP)organic hydroxy compound metabolic process3.385e-071.527e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.035540.0684Moderately InformativeInherited
Biological Process (BP)response to organic substance0.76491Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.32561Moderately InformativeInherited
Biological Process (BP)organ development0.011111Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.04750.6425Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.063670.2881Moderately InformativeInherited
Biological Process (BP)nervous system development0.068240.5503Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.097150.1818Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.35480.0008157Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.46190.00153Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.98631Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.04660.01446Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.11670.3941Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.64971Moderately InformativeInherited
Biological Process (BP)tissue development0.051751Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.24660.02304Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.89540.475Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.91810.7756Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.97060.1294Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)isoprenoid metabolic process04.332e-13InformativeDirect
Biological Process (BP)central nervous system development0.00010650.0003956InformativeDirect
Biological Process (BP)regulation of hormone levels4.345e-121.104e-11InformativeDirect
Biological Process (BP)organonitrogen compound catabolic process0.00059527.502e-08InformativeDirect
Biological Process (BP)sensory organ development5.085e-050.1428InformativeInherited
Biological Process (BP)embryonic organ development6.179e-070.005818InformativeInherited
Biological Process (BP)embryonic morphogenesis2.355e-050.1496InformativeInherited
Biological Process (BP)alcohol metabolic process0.23850.7462InformativeInherited
Biological Process (BP)response to inorganic substance0.25620.03133InformativeInherited
Biological Process (BP)carboxylic acid catabolic process0.085081.736e-07InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.001370.0003338InformativeInherited
Biological Process (BP)glutamine family amino acid metabolic process0.0051078.99e-10InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.0061420.005834InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds11InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.11910.8902InformativeInherited
Biological Process (BP)organ morphogenesis0.0014330.7312InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.034690.9435InformativeInherited
Biological Process (BP)tissue morphogenesis0.00021570.2484InformativeInherited
Biological Process (BP)epithelium development0.015490.6834InformativeInherited
Biological Process (BP)alpha-amino acid biosynthetic process11InformativeInherited
Biological Process (BP)retinoid metabolic process00Highly InformativeDirect
Biological Process (BP)cellular aldehyde metabolic process00Highly InformativeDirect
Biological Process (BP)amino-acid betaine metabolic process00Highly InformativeDirect
Biological Process (BP)polyamine metabolic process8.88e-072.337e-07Highly InformativeDirect
Biological Process (BP)isoprenoid biosynthetic process1.295e-072.568e-05Highly InformativeDirect
Biological Process (BP)response to water deprivation5.301e-053.955e-06Highly InformativeDirect
Biological Process (BP)phenylpropanoid metabolic process0.00060050.0006444Highly InformativeDirect
Biological Process (BP)embryonic organ morphogenesis1.373e-060.001357Highly InformativeInherited
Biological Process (BP)eye morphogenesis3.258e-060.002117Highly InformativeInherited
Biological Process (BP)nucleobase metabolic process0.0003810.007608Highly InformativeInherited
Biological Process (BP)monocarboxylic acid catabolic process0.90630.1612Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process0.67651Highly InformativeInherited
Biological Process (BP)branched-chain amino acid metabolic process0.00026460.06285Highly InformativeInherited
Biological Process (BP)glutamine family amino acid biosynthetic process0.064870.004287Highly InformativeInherited
Biological Process (BP)arginine metabolic process0.0017420.03457Highly InformativeInherited
Biological Process (BP)glutamine family amino acid catabolic process0.0011191.883e-05Highly InformativeInherited
Biological Process (BP)morphogenesis of embryonic epithelium0.00025150.00183Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding0.093340.9884Moderately InformativeInherited
Molecular Function (MF)heterocyclic compound binding0.11731Moderately InformativeInherited
Molecular Function (MF)anion binding0.0032060.01039Moderately InformativeInherited
Molecular Function (MF)cofactor binding6.01e-140InformativeDirect
Molecular Function (MF)nucleotide binding0.52230.5911InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on CH-OH group of donors11InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the aldehyde or oxo group of donors00Highly InformativeDirect
Molecular Function (MF)hormone binding3.881e-061.307e-05Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.74990.2469Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00085210.003234Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.026413.48e-14Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.005892 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8957 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0008157 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 1.527e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0684 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.7811 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.6425 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2881 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.00153 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5503 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1818 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.01446 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.3941 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02304 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.475 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7756 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.1294 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0003338 Informative Direct
Biological Process (BP) isoprenoid metabolic process 4.332e-13 Informative Direct
Biological Process (BP) central nervous system development 0.0003956 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 8.99e-10 Informative Direct
Biological Process (BP) regulation of hormone levels 1.104e-11 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1.736e-07 Informative Direct
Biological Process (BP) protein oligomerization 0.0008603 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 7.502e-08 Informative Direct
Biological Process (BP) sensory organ development 0.1428 Informative Inherited
Biological Process (BP) embryonic organ development 0.005818 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1496 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.4836 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.7462 Informative Inherited
Biological Process (BP) response to inorganic substance 0.03133 Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.005834 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.8902 Informative Inherited
Biological Process (BP) organ morphogenesis 0.7312 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.9435 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2484 Informative Inherited
Biological Process (BP) epithelium development 0.6834 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 1 Informative Inherited
Biological Process (BP) retinoid metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Highly Informative Direct
Biological Process (BP) amino-acid betaine metabolic process 0 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 2.337e-07 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 2.568e-05 Highly Informative Direct
Biological Process (BP) glutamine family amino acid catabolic process 1.883e-05 Highly Informative Direct
Biological Process (BP) response to water deprivation 3.955e-06 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0006444 Highly Informative Direct
Biological Process (BP) protein tetramerization 8.394e-07 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.08785 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001357 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.002117 Highly Informative Inherited
Biological Process (BP) nucleobase metabolic process 0.007608 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid catabolic process 0.1612 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 1 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.06285 Highly Informative Inherited
Biological Process (BP) glutamine family amino acid biosynthetic process 0.004287 Highly Informative Inherited
Biological Process (BP) arginine metabolic process 0.03457 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.00183 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.9884 Moderately Informative Inherited
Molecular Function (MF) heterocyclic compound binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.01039 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.5911 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 1 Informative Inherited
Molecular Function (MF) kinase activity 0.8651 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) hormone binding 1.307e-05 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.2469 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.005971 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 3.48e-14 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.003234 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00874 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.0001324 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.9278InformativeInherited
Enzyme Commission (EC)Histidinol dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase1.588e-10Highly InformativeDirect
Enzyme Commission (EC)Glutamate 5-kinase4.896e-05Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye morphology0.01497Moderately InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.04477Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial development0.0005513InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic tissue morphology0.009084InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0002578Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant cell0.002992Least InformativeInherited
Plant ANatomical entity (PAN)guard cell9.287e-08Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With other acceptors0.1822Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0.9164Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)vitamins0.04905Least InformativeInherited
Drugbank ATC_code (DB)respiratory system0.008729Moderately InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.01516Moderately InformativeInherited
Drugbank ATC_code (DB)other ophthalmologicals1Moderately InformativeInherited
Drugbank ATC_code (DB)vitamin a, plain4.239e-05InformativeDirect
Drugbank ATC_code (DB)retinol4.239e-05InformativeDirect
Drugbank ATC_code (DB)retinol4.239e-05InformativeDirect
Drugbank ATC_code (DB)retinol4.239e-05InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0008915InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis6.832e-11Highly InformativeDirect
Biological processLuminescence6.34e-09Highly InformativeDirect
Cellular componentCytoplasm6.395e-16Least InformativeDirect
Cellular componentMitochondrion0.0001862Moderately InformativeDirect
DomainTransit peptide2.952e-12Moderately InformativeDirect
Molecular functionZinc1.143e-05Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0Moderately InformativeDirect
UniPathway (UP)amino-acid degradation1.109e-15Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0.0001747Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine degradation0InformativeDirect
UniPathway (UP)alcohol degradation0InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis3.165e-10InformativeDirect
UniPathway (UP)organic acid degradation1.111e-06InformativeDirect
UniPathway (UP)histidine metabolism0.001861InformativeInherited
UniPathway (UP)putrescine metabolism0.7423InformativeInherited
UniPathway (UP)amine and polyamine degradation1InformativeInherited
UniPathway (UP)myo-inositol degradation into acetyl-CoA0Highly InformativeDirect
UniPathway (UP)L-proline biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)putrescine degradation0Highly InformativeDirect
UniPathway (UP)betaine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-proline degradation1.381e-09Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ALDH-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the ALDH-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.