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Phosphoglycerate kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Phosphoglycerate kinase [ 53747]
Superfamily:   Phosphoglycerate kinase [ 53748]
Families:   Phosphoglycerate kinase [ 53749]


Superfamily statistics
Genomes (3,180) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,912 21,553 11
Proteins 3,885 21,501 11


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00072540.0005269Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0007610.0004333Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00000012750.00000002842Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00000045220.0000003371Least InformativeDirect
Biological Process (BP)primary metabolic process0.88151Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0047890.003103Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.091130.08855Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0017980.0000009962Least InformativeInherited
Biological Process (BP)response to stimulus0.63060.8705Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process00Moderately InformativeDirect
Biological Process (BP)generation of precursor metabolites and energy00Moderately InformativeDirect
Biological Process (BP)nucleoside phosphate metabolic process0.00079570.000002808Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process00Moderately InformativeDirect
Biological Process (BP)single-organism catabolic process00Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.000000000017190Moderately InformativeDirect
Biological Process (BP)purine-containing compound metabolic process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.0000000000000091160Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000000000011570.000000000000001925Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.31250.2699Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.00099190.003188Moderately InformativeInherited
Biological Process (BP)monosaccharide metabolic process0.00041720.0006554InformativeDirect
Biological Process (BP)oxidoreduction coenzyme metabolic process00InformativeDirect
Biological Process (BP)carbohydrate catabolic process00InformativeDirect
Biological Process (BP)phosphorylation00InformativeDirect
Biological Process (BP)ATP metabolic process00InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process00InformativeDirect
Biological Process (BP)carbohydrate biosynthetic process0.0012710.0005313InformativeInherited
Biological Process (BP)response to hypoxia0.00000045290.000002839Highly InformativeDirect
Biological Process (BP)glucose metabolic process0.00000000054590.0000000002841Highly InformativeDirect
Biological Process (BP)glycolytic process00Highly InformativeDirect
Biological Process (BP)hexose biosynthetic process0.000000000044550.000000000004502Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000000000073320.0000000000002126Least InformativeDirect
Molecular Function (MF)binding0.0000012180.00201Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.0000000000000053890Moderately InformativeDirect
Molecular Function (MF)anion binding00Moderately InformativeDirect
Molecular Function (MF)carbohydrate derivative binding00Moderately InformativeDirect
Molecular Function (MF)kinase activity00InformativeDirect
Molecular Function (MF)purine nucleotide binding00InformativeDirect
Molecular Function (MF)ribonucleotide binding00InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding0.0000000038440.0000000253InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0005269 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000009962 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0004333 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00000002842 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0000003371 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.003103 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.08855 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8705 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000002808 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.2699 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.003188 Moderately Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.0006554 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0005313 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) response to hypoxia 0.000002839 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0000000002841 Highly Informative Direct
Biological Process (BP) glycolytic process 0 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.000000000004502 Highly Informative Direct
Molecular Function (MF) transferase activity 0.0000000000002126 Least Informative Direct
Molecular Function (MF) binding 0.00201 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000253 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001576 SSF53748 Protein matches
Abstract

This entry represents the full PGK enzyme.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phosphoglycerate kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Phosphoglycerate kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]