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Periplasmic binding protein-like II superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Periplasmic binding protein-like II [ 53849]
Superfamily:   Periplasmic binding protein-like II [ 53850] (3)
Families:   Phosphate binding protein-like [ 53851] (40)
  Transferrin [ 53888] (3)
  PG0945 N-terminal domain-like [ 159818]


Superfamily statistics
Genomes (3,235) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 155,552 947,354 216
Proteins 153,426 934,715 192


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process10.6901Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process10.05009Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)ion transport00Moderately InformativeDirect
Biological Process (BP)sulfur compound metabolic process0.016180.302Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.7350.09631Moderately InformativeInherited
Biological Process (BP)organic substance transport0.017460.01317Moderately InformativeInherited
Biological Process (BP)single-organism transport0.47161Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.79870.004448Moderately InformativeInherited
Biological Process (BP)organic acid transport0.0000000061080.00000003546InformativeDirect
Biological Process (BP)nitrogen compound transport0.000000010220InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process0.016810.2641InformativeInherited
Biological Process (BP)pyrimidine-containing compound metabolic process0.0036970.0162InformativeInherited
Biological Process (BP)water-soluble vitamin biosynthetic process0.0016580.003701InformativeInherited
Biological Process (BP)anion transport0.029160.6862InformativeInherited
Biological Process (BP)metal ion transport0.83350.756InformativeInherited
Biological Process (BP)transition metal ion transport0.0000000001750.00005751Highly InformativeDirect
Biological Process (BP)thiamine biosynthetic process0.00000017730.0000005764Highly InformativeDirect
Biological Process (BP)amino acid transport0.000061160.0009205Highly InformativeDirect
Biological Process (BP)modified amino acid transport0.00061730.0001248Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0000000000000027030.00000008742Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides00Moderately InformativeDirect
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.020760.01296Moderately InformativeInherited
Molecular Function (MF)anion binding0.011050.3227Moderately InformativeInherited
Molecular Function (MF)ATPase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding0.000010940InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.000053141InformativeInherited
Molecular Function (MF)active transmembrane transporter activity00.01069InformativeInherited
Molecular Function (MF)amino acid binding0.000000000000001370.00000000005447Highly InformativeDirect
Molecular Function (MF)amine transmembrane transporter activity0.000023950.0001745Highly InformativeDirect
Molecular Function (MF)ATPase coupled ion transmembrane transporter activity0.56131Highly InformativeInherited
Molecular Function (MF)amino acid transmembrane transporter activity0.031950.008987Highly InformativeInherited
Cellular Component (CC)membrane10.000000153Least InformativeInherited
Cellular Component (CC)protein complex0.72031Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.023350Moderately InformativeInherited
Cellular Component (CC)membrane protein complex0.0030210.2834Moderately InformativeInherited
Cellular Component (CC)plasma membrane0.81970Moderately InformativeInherited
Cellular Component (CC)transporter complex0.000000000097540InformativeDirect
Cellular Component (CC)plasma membrane protein complex0.00000000034350.008803InformativeInherited
Cellular Component (CC)periplasmic space00Highly InformativeDirect
Cellular Component (CC)ATP-binding cassette (ABC) transporter complex0.0000000000000054410.000000000001024Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.6415 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.05009 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07603 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6901 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000007778 Moderately Informative Direct
Biological Process (BP) signaling 0.000006916 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.00008811 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0001312 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.000176 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.04702 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8578 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9453 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.9863 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.2605 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.7309 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.1309 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.302 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.8759 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.06226 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9704 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8579 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.01317 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.004448 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.09631 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic acid transport 0.00000003546 Informative Direct
Biological Process (BP) nitrogen compound transport 0 Informative Direct
Biological Process (BP) system process 0.000000000000003692 Informative Direct
Biological Process (BP) behavior 0.000000000000003692 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.00000001044 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000002878 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00002095 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.00002196 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0000288 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0001412 Informative Direct
Biological Process (BP) ion homeostasis 0.0004068 Informative Direct
Biological Process (BP) response to acid chemical 0.0004287 Informative Direct
Biological Process (BP) regulation of cytokine production 0.479 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.9978 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5885 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5964 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) defense response to other organism 0.9917 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.2641 Informative Inherited
Biological Process (BP) pyrimidine-containing compound metabolic process 0.0162 Informative Inherited
Biological Process (BP) pigment metabolic process 0.005373 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.207 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3723 Informative Inherited
Biological Process (BP) response to bacterium 0.02541 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.04252 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) response to radiation 0.477 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.003701 Informative Inherited
Biological Process (BP) anion transport 0.6862 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9582 Informative Inherited
Biological Process (BP) immune response 0.9662 Informative Inherited
Biological Process (BP) metal ion transport 0.756 Informative Inherited
Biological Process (BP) transition metal ion transport 0.00005751 Highly Informative Direct
Biological Process (BP) thiamine biosynthetic process 0.0000005764 Highly Informative Direct
Biological Process (BP) amino acid transport 0.0009205 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.0001248 Highly Informative Direct
Biological Process (BP) detection of stimulus 0 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) response to amino acid 0 Highly Informative Direct
Biological Process (BP) synaptic signaling 0 Highly Informative Direct
Biological Process (BP) calcium-mediated signaling 0 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.00000000000002413 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000000001607 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.0000001496 Highly Informative Direct
Biological Process (BP) heme biosynthetic process 0.000003055 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00002027 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.00002394 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.00007721 Highly Informative Direct
Biological Process (BP) humoral immune response 0.000314 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.01359 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.001929 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.09965 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.7883 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.1563 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.0118 Highly Informative Inherited
Biological Process (BP) ammonium transport 0.1708 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.01072 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.09259 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) response to fungus 0.006421 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.5274 Highly Informative Inherited
Biological Process (BP) amide transport 0.001186 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.002616 Highly Informative Inherited
Biological Process (BP) innate immune response 0.07144 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00000008742 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.01296 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3227 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.02187 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00000000000513 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.0000000002692 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000002281 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.01069 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.1874 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.2466 Informative Inherited
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.002024 Informative Inherited
Molecular Function (MF) DNA binding 0.9851 Informative Inherited
Molecular Function (MF) amino acid binding 0.00000000005447 Highly Informative Direct
Molecular Function (MF) amine transmembrane transporter activity 0.0001745 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.0001445 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) sodium ion transmembrane transporter activity 0.00000000000006786 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.00000007359 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0.000009468 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00007954 Highly Informative Direct
Molecular Function (MF) ATPase coupled ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) amino acid transmembrane transporter activity 0.008987 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.4409 Highly Informative Inherited
Cellular Component (CC) membrane 0.000000153 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00008119 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.2834 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.7812 Moderately Informative Inherited
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.00000000005898 Informative Direct
Cellular Component (CC) neuron projection 0.00000001955 Informative Direct
Cellular Component (CC) secretory vesicle 0.0000004071 Informative Direct
Cellular Component (CC) cell projection part 0.000152 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.008803 Informative Inherited
Cellular Component (CC) periplasmic space 0 Highly Informative Direct
Cellular Component (CC) ATP-binding cassette (ABC) transporter complex 0.000000000001024 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) dendrite 0.000001278 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.00008606Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Transferring other groups0.258InformativeInherited
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0001289Least InformativeDirect
Disease Ontology (DO)immune system disease0.1082Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000000002757Moderately InformativeDirect
Disease Ontology (DO)bone marrow disease0.0001511Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.09509Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.000000000003522InformativeDirect
Disease Ontology (DO)focal epilepsy0.04307InformativeInherited
Disease Ontology (DO)motor neuron disease0.04395InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.519InformativeInherited
Disease Ontology (DO)temporal lobe epilepsy0.000004237Highly InformativeDirect
Disease Ontology (DO)lateral sclerosis0.000005386Highly InformativeDirect
Disease Ontology (DO)bipolar disorder0.00003352Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0.00003468Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4055Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5385Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6069Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.0148Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.04011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa0.1348Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.2182Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.4231Moderately InformativeInherited
Phenotypic Abnormality (PA)Seizures0.02521InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.05244InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyebrow0.05595InformativeInherited
Phenotypic Abnormality (PA)Abnormal nasal morphology0.1425InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.3099InformativeInherited
Phenotypic Abnormality (PA)Short chin0.0001449Highly InformativeDirect
Phenotypic Abnormality (PA)Prominent nose0.0002555Highly InformativeDirect
Phenotypic Abnormality (PA)Aggressive behavior0.0003575Highly InformativeDirect
Phenotypic Abnormality (PA)Babinski sign0.0007031Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of mouth shape0.008335Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of globe location0.04968Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00014Least InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system physiology0.01533Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.000000000000828InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.00002428InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.0008013InformativeDirect
Mammalian Phenotype (MP)seizures0.0008347InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.002408InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.1782InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.0000003098Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.000006564Highly InformativeDirect
Mammalian Phenotype (MP)abnormal exploration in a new environment0.0000263Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic plasticity0.0001908Highly InformativeDirect
Mammalian Phenotype (MP)tonic-clonic seizures0.0007351Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic depression0.09541Highly InformativeInherited
Mammalian Phenotype (MP)abnormal aggression-related behavior0.1701Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0105Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.08649Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6626Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.00007163Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.05984Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.08418Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0000008023InformativeDirect
Worm Phenotype (WP)fat content variant0.0002895InformativeDirect
Worm Phenotype (WP)pharyngeal pumping variant0.0004402InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.00000006622Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0000002038Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.00002255Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping rate variant0.0001325Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.00002231InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0.00009408Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.0000007633Least InformativeDirect
Drugbank ATC_code (DB)alimentary tract and metabolism0.03304Least InformativeInherited
Drugbank ATC_code (DB)sensory organs0.07262Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.1473Least InformativeInherited
Drugbank ATC_code (DB)psychostimulants, agents used for adhd and nootropics0.0000000007706Moderately InformativeDirect
Drugbank ATC_code (DB)other ophthalmologicals0.0001029Moderately InformativeDirect
Drugbank ATC_code (DB)psycholeptics0.0001482Moderately InformativeDirect
Drugbank ATC_code (DB)analgesics0.002449Moderately InformativeInherited
Drugbank ATC_code (DB)other nervous system drugs0.01602Moderately InformativeInherited
Drugbank ATC_code (DB)anesthetics0.05263Moderately InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.05945Moderately InformativeInherited
Drugbank ATC_code (DB)antidepressants0.1339Moderately InformativeInherited
Drugbank ATC_code (DB)all other therapeutic products1Moderately InformativeInherited
Drugbank ATC_code (DB)pentobarbital0.0000000000003057InformativeDirect
Drugbank ATC_code (DB)acamprosate0.0000000004977InformativeDirect
Drugbank ATC_code (DB)prasterone0.000000005425InformativeDirect
Drugbank ATC_code (DB)other antidepressants0.0000000749InformativeDirect
Drugbank ATC_code (DB)anesthetics, general0.000008723InformativeDirect
Drugbank ATC_code (DB)other antiseptics and disinfectants0.00003251InformativeDirect
Drugbank ATC_code (DB)opioids0.0001291InformativeDirect
Drugbank ATC_code (DB)barbiturates and derivatives0.0002873InformativeDirect
Drugbank ATC_code (DB)irrigating solutions0.001177InformativeInherited
Drugbank ATC_code (DB)centrally acting sympathomimetics0.01242InformativeInherited
Drugbank ATC_code (DB)anti-dementia drugs0.04839InformativeInherited
Drugbank ATC_code (DB)other antiepileptics0.4569InformativeInherited
Drugbank ATC_code (DB)phenobarbital0Highly InformativeDirect
Drugbank ATC_code (DB)secobarbital0.000000000000003309Highly InformativeDirect
Drugbank ATC_code (DB)milnacipran0.0000000000002555Highly InformativeDirect
Drugbank ATC_code (DB)ketobemidone0.0000000000005585Highly InformativeDirect
Drugbank ATC_code (DB)acetylcysteine0.000000003177Highly InformativeDirect
Drugbank ATC_code (DB)acetylcysteine0.000000003177Highly InformativeDirect
Drugbank ATC_code (DB)memantine0.00000006941Highly InformativeDirect
Drugbank ATC_code (DB)gabapentin0.00001474Highly InformativeDirect
Drugbank ATC_code (DB)acetylcysteine0.00004114Highly InformativeDirect
Drugbank ATC_code (DB)other irrigating solutions0.0005984Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processIon transport0.0000001384Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processCell wall biogenesis/degradation0.0000000000003727InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0009423InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processNodulation0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processOsteogenesis0.0000007019Highly InformativeDirect
Biological processSugar transport0.0001323Highly InformativeDirect
Biological processHeme biosynthesis0.0003961Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentMembrane0.00008947Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0.0000122Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
Coding sequence diversityRNA editing0.00002097Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.02353Least InformativeInherited
Molecular functionATP-binding0.0000000007705Moderately InformativeDirect
Molecular functionMagnesium0.0000004349Moderately InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionMolybdenum0.00001756InformativeDirect
Molecular functionIron transport0Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationLyase0.000001483Moderately InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.1605Moderately InformativeInherited
UniPathway (UP)antibiotic biosynthesis0.475Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)pigment biosynthesis0.000000000000001364InformativeDirect
UniPathway (UP)heterocycle biosynthesis0.000001198InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)L-phenylalanine biosynthesis0Highly InformativeDirect
UniPathway (UP)prephenate biosynthesis0.00000000000005265Highly InformativeDirect
UniPathway (UP)bacilysin biosynthesis0.00001842Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Periplasmic binding protein-like II domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 83 hidden Markov models representing the Periplasmic binding protein-like II superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]