SUPERFAMILY 1.75 HMM library and genome assignments server

Thiolase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiolase-like [ 53900]
Superfamily:   Thiolase-like [ 53901] (2)
Families:   Thiolase-related [ 53902] (8)
  Chalcone synthase-like [ 53914] (8)


Superfamily statistics
Genomes (3,126) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 59,552 273,095 101
Proteins 35,421 165,624 57


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.14330Least InformativeInherited
Biological Process (BP)single-organism cellular process0.55641Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.00024050Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.0044080Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0000085330InformativeDirect
Molecular Function (MF)transferase activity0.000067190Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.0000000004610InformativeDirect
Molecular Function (MF)C-acyltransferase activity0.001040.000000000000001593Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.38211Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.082490.01205Least InformativeInherited
Cellular Component (CC)microbody0.00000057210InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000001776 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000004096 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000001191 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000002884 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0000001995 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.5044 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.005748 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3274 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.01104 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9742 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.766 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.8986 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2056 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.0004548 Informative Direct
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) response to light stimulus 0.000563 Informative Direct
Biological Process (BP) lipid catabolic process 0.0007911 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00000000000001752 Informative Direct
Biological Process (BP) amide biosynthetic process 0.00000003703 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.00000000002229 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000002307 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000001009 Informative Direct
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.02738 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1281 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.963 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.9435 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1509 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.4483 Informative Inherited
Biological Process (BP) purine ribonucleoside metabolic process 0.3774 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5563 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) toxin metabolic process 0.00001808 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0001327 Highly Informative Direct
Biological Process (BP) response to cold 0.0000000008671 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.0000009235 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.0002645 Highly Informative Direct
Biological Process (BP) coenzyme A metabolic process 0.0001537 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.0004225 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0000000000322 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0006903 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.00000000002405 Highly Informative Direct
Biological Process (BP) benzene-containing compound metabolic process 0.0002144 Highly Informative Direct
Biological Process (BP) peptide biosynthetic process 0.00000002306 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.00000000000001071 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.003229 Highly Informative Inherited
Biological Process (BP) lipid modification 0.6452 Highly Informative Inherited
Biological Process (BP) polyol biosynthetic process 0.001731 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) lyase activity 0.3021 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.4076 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.000000437 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00006544 Informative Direct
Molecular Function (MF) C-acyltransferase activity 0.000000000000001593 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0000000811 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0002338 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01205 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0001185 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.04733 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.0009662 Informative Direct
Cellular Component (CC) lipid particle 0.00000001279 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00001562 Informative Direct
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) organelle outer membrane 0.0001816 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00000000003516InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000000614InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0007723InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0154InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.0000000000002778Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.02216Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.001948InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.06479Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.006654InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2518Least InformativeInherited
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0193Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.0005936InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.007038Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.568Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6061Least InformativeInherited
Plant ANatomical entity (PAN)fruit0InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000000000002566InformativeDirect
Plant ANatomical entity (PAN)anther0.0001344Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.000262Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.002499Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.3812InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.000000000004399Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0000000008047Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.0004314Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0008097Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processSteroid metabolism1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0Highly InformativeDirect
Biological processLipid degradation0.000000006786Highly InformativeDirect
Biological processNodulation0.00007792Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.000000000000001914InformativeDirect
DomainTransit peptide0.0000000001478Moderately InformativeDirect
Molecular functionPotassium0.0004117InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationAcetylation0.0001331Least InformativeDirect
Post-translational modificationPhosphoprotein0.0002262Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.01663Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)flavonoid metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.00000000000004388InformativeDirect
UniPathway (UP)fatty acid degradation0.0000000000002774InformativeDirect
UniPathway (UP)toxin biosynthesis0.00000008479InformativeDirect
UniPathway (UP)polyketide biosynthesis1InformativeInherited
UniPathway (UP)(R)-mevalonate metabolism0Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.00000001058Highly InformativeDirect
UniPathway (UP)plant chemical defense0.000003552Highly InformativeDirect
UniPathway (UP)beta-ketoadipate pathway0.0000103Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis0.0001982Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiolase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Thiolase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]