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Thiolase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiolase-like [ 53900]
Superfamily:   Thiolase-like [ 53901] (2)
Families:   Thiolase-related [ 53902] (8)
  Chalcone synthase-like [ 53914] (8)


Superfamily statistics
Genomes (3,134) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 59,791 0 101
Proteins 35,571 0 57


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00000000003516InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000000614InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0007723InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0154InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.0000000000002778Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00008878Least InformativeDirect
Worm Phenotype (WP)fat content variant0.00000000001323InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.08867Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.007337InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.4374Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02364Moderately InformativeInherited
Xenopus ANatomical entity (XAN)intestine0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0.0008267InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.007081Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.569Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6065Least InformativeInherited
Plant ANatomical entity (PAN)fruit0InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000000000003345InformativeDirect
Plant ANatomical entity (PAN)anther0.0001348Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0002757Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.002502Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0.02391InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4245InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.000000000004429Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000002084Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.000025Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0003888Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processAntibiotic biosynthesis0InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid degradation0.00000004945InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processSteroid metabolism1InformativeInherited
Biological processSterol biosynthesis0.000001456Highly InformativeDirect
Biological processNodulation0.00009427Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome6.626e-16InformativeDirect
DomainTransit peptide0.000000004677Moderately InformativeDirect
Molecular functionNADP0.000000000000001236Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationMultifunctional enzyme0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiolase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Thiolase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]