Thiolase-like superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Alpha and beta proteins (a/b) [ 51349] (147)
Fold:	Thiolase-like [ 53900]
Superfamily:	Thiolase-like [ 53901] (2)
Families:	Thiolase-related [ 53902] (8)
	Chalcone synthase-like [ 53914] (8)

Superfamily statistics

	Genomes (2,414)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	46,341	135,688	101
Proteins	27,670	85,334	57

Functional annotation

General category	Metabolism
Detailed category	Other enzymes

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)

	GO term	FDR (singleton)	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	0.2635	0	Least Informative	Inherited
Biological Process (BP)	monocarboxylic acid metabolic process	0.0002376	0	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	0.003159	0	Moderately Informative	Inherited
Biological Process (BP)	fatty acid metabolic process	1.554e-05	0	Informative	Direct
Molecular Function (MF)	transferase activity	5.875e-05	0	Least Informative	Direct
Molecular Function (MF)	transferase activity, transferring acyl groups	1.144e-09	0	Informative	Direct
Molecular Function (MF)	C-acyltransferase activity	0.00128	6.098e-13	Highly Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0.046	0	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	0.4358	0.0404	Least Informative	Inherited
Cellular Component (CC)	microbody	3.951e-06	0	Informative	Direct

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	single-organism metabolic process	0	Least Informative	Direct
Biological Process (BP)	biosynthetic process	0	Least Informative	Direct
Biological Process (BP)	cellular component organization or biogenesis	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	1	Least Informative	Inherited
Biological Process (BP)	multicellular organismal process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	heterocycle metabolic process	1	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	cellular aromatic compound metabolic process	1	Least Informative	Inherited
Biological Process (BP)	response to stimulus	1	Least Informative	Inherited
Biological Process (BP)	monocarboxylic acid metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	cellular lipid metabolic process	0	Moderately Informative	Direct
Biological Process (BP)	lipid biosynthetic process	3.329e-14	Moderately Informative	Direct
Biological Process (BP)	small molecule biosynthetic process	7.681e-09	Moderately Informative	Direct
Biological Process (BP)	cofactor metabolic process	6.495e-07	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	3.314e-05	Moderately Informative	Direct
Biological Process (BP)	organic cyclic compound biosynthetic process	0.0001304	Moderately Informative	Direct
Biological Process (BP)	regulation of cell communication	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of signaling	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	1	Moderately Informative	Inherited
Biological Process (BP)	regulation of localization	0.7654	Moderately Informative	Inherited
Biological Process (BP)	regulation of cellular component organization	1	Moderately Informative	Inherited
Biological Process (BP)	organophosphate metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	phosphate-containing compound metabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	cellular catabolic process	0.7234	Moderately Informative	Inherited
Biological Process (BP)	organic substance catabolic process	1	Moderately Informative	Inherited
Biological Process (BP)	cellular component biogenesis	0.02098	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	oxidation-reduction process	1	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of cellular process	1	Moderately Informative	Inherited
Biological Process (BP)	heterocycle biosynthetic process	0.6317	Moderately Informative	Inherited
Biological Process (BP)	aromatic compound biosynthetic process	0.001249	Moderately Informative	Inherited
Biological Process (BP)	response to abiotic stimulus	0.004943	Moderately Informative	Inherited
Biological Process (BP)	fatty acid metabolic process	0	Informative	Direct
Biological Process (BP)	cellular ketone metabolic process	9.858e-14	Informative	Direct
Biological Process (BP)	response to light stimulus	4.692e-06	Informative	Direct
Biological Process (BP)	organic hydroxy compound biosynthetic process	2.053e-05	Informative	Direct
Biological Process (BP)	carboxylic acid catabolic process	0.0001588	Informative	Direct
Biological Process (BP)	monocarboxylic acid biosynthetic process	0.0003768	Informative	Direct
Biological Process (BP)	lipid catabolic process	0.0005809	Informative	Direct
Biological Process (BP)	regulation of intracellular transport	0.0006952	Informative	Direct
Biological Process (BP)	regulation of apoptotic process	0.9223	Informative	Inherited
Biological Process (BP)	phospholipid metabolic process	0.9304	Informative	Inherited
Biological Process (BP)	alcohol metabolic process	0.04609	Informative	Inherited
Biological Process (BP)	steroid metabolic process	0.002137	Informative	Inherited
Biological Process (BP)	negative regulation of cellular component organization	0.1076	Informative	Inherited
Biological Process (BP)	regulation of organelle organization	0.2426	Informative	Inherited
Biological Process (BP)	phenylpropanoid metabolic process	0	Highly Informative	Direct
Biological Process (BP)	cell wall biogenesis	0	Highly Informative	Direct
Biological Process (BP)	acyl-CoA metabolic process	0	Highly Informative	Direct
Biological Process (BP)	response to cold	5.078e-12	Highly Informative	Direct
Biological Process (BP)	secondary metabolite biosynthetic process	1.714e-10	Highly Informative	Direct
Biological Process (BP)	phenol-containing compound metabolic process	3.356e-06	Highly Informative	Direct
Biological Process (BP)	regulation of mitochondrion organization	1.282e-05	Highly Informative	Direct
Biological Process (BP)	regulation of apoptotic signaling pathway	1.981e-05	Highly Informative	Direct
Biological Process (BP)	diol metabolic process	0.0002512	Highly Informative	Direct
Biological Process (BP)	polyol metabolic process	0.08516	Highly Informative	Inherited
Biological Process (BP)	alcohol biosynthetic process	0.009496	Highly Informative	Inherited
Biological Process (BP)	lipid modification	0.4065	Highly Informative	Inherited
Molecular Function (MF)	transferase activity	0	Least Informative	Direct
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	transferase activity, transferring acyl groups	0	Informative	Direct
Molecular Function (MF)	cofactor binding	0.00064	Informative	Direct
Molecular Function (MF)	C-acyltransferase activity	6.098e-13	Highly Informative	Direct
Molecular Function (MF)	acetyltransferase activity	1	Highly Informative	Inherited
Cellular Component (CC)	cytoplasmic part	0	Least Informative	Direct
Cellular Component (CC)	intracellular membrane-bounded organelle	0.0404	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	protein complex	0.8545	Least Informative	Inherited
Cellular Component (CC)	membrane	0.9561	Least Informative	Inherited
Cellular Component (CC)	mitochondrial part	0.0003148	Moderately Informative	Direct
Cellular Component (CC)	organelle envelope	0.006459	Moderately Informative	Inherited
Cellular Component (CC)	intracellular organelle lumen	0.2893	Moderately Informative	Inherited
Cellular Component (CC)	organelle membrane	0.06304	Moderately Informative	Inherited
Cellular Component (CC)	microbody	0	Informative	Direct
Cellular Component (CC)	external encapsulating structure	6.198e-07	Informative	Direct
Cellular Component (CC)	cell wall	1.002e-08	Highly Informative	Direct
Cellular Component (CC)	lipid particle	3.989e-06	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lyases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acting on ester bonds	1	Least Informative	Inherited
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0	Moderately Informative	Direct
Enzyme Commission (EC)	Hydro-lyases	1	Moderately Informative	Inherited
Enzyme Commission (EC)	Acting on the CH-CH group of donors	1	Moderately Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	Moderately Informative	Inherited
Enzyme Commission (EC)	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat	3.516e-11	Informative	Direct
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s	6.14e-11	Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	0.0007723	Informative	Direct
Enzyme Commission (EC)	Thiolester hydrolases	0.0154	Informative	Inherited
Enzyme Commission (EC)	Acyl groups converted into alkyl on transfer	1	Informative	Inherited
Enzyme Commission (EC)	Beta-ketoacyl-acyl-carrier-protein synthase I	0	Highly Informative	Direct
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	2.778e-13	Highly Informative	Direct

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details) Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism metabolism processing variant	0.02216	Least Informative	Inherited
Worm Phenotype (WP)	lipid metabolism variant	0.001948	Informative	Inherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)

	YP term	FDR (all)	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	morphology	0.05805	Moderately Informative	Inherited
Yeast Phenotype (YP)	subcellular morphology	0.004141	Informative	Inherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)

	XA term	FDR (all)	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	alimentary system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	central nervous system	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	head	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	viscus	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	gonad	0	Least Informative	Direct
Xenopus ANatomical entity (XAN)	portion of tissue	0.2458	Least Informative	Inherited
Xenopus ANatomical entity (XAN)	intestine	0	Moderately Informative	Direct
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.01833	Moderately Informative	Inherited
Xenopus ANatomical entity (XAN)	skeletal muscle	0.0005801	Informative	Direct

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)

	AP term	FDR (all)	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	vascular leaf	0.08928	Least Informative	Inherited
Plant ANatomical entity (PAN)	microsporophyll	0.5919	Least Informative	Inherited
Plant ANatomical entity (PAN)	androecium	0.8991	Least Informative	Inherited
Plant ANatomical entity (PAN)	fruit	0	Informative	Direct
Plant ANatomical entity (PAN)	rosette leaf	2.447e-12	Informative	Direct
Plant ANatomical entity (PAN)	anther	0.0002096	Highly Informative	Direct
Plant ANatomical entity (PAN)	leaf epidermis	0.000246	Highly Informative	Direct
Plant ANatomical entity (PAN)	trichome	0.003359	Highly Informative	Inherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	1	Least Informative	Inherited
Enzyme Commission (EC)	Hydrolases	1	Least Informative	Inherited
Enzyme Commission (EC)	Acyltransferases	0	Moderately Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	1	Moderately Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.3706	Informative	Inherited
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	Informative	Inherited
Enzyme Commission (EC)	3-oxoacyl-[acyl-carrier-protein] reductase	0	Highly Informative	Direct
Enzyme Commission (EC)	Beta-ketoacyl-[acyl-carrier-protein] synthase I	0	Highly Informative	Direct
Enzyme Commission (EC)	Enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific)	6.76e-11	Highly Informative	Direct
Enzyme Commission (EC)	Oleoyl-[acyl-carrier-protein] hydrolase	8.663e-10	Highly Informative	Direct
Enzyme Commission (EC)	Fatty-acyl-CoA synthase	0.0004516	Highly Informative	Direct
Enzyme Commission (EC)	Fatty-acid synthase	0.0008394	Highly Informative	Direct
Enzyme Commission (EC)	Acyl groups converted into alkyl on transfer	1	Highly Informative	Inherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	1	Least Informative	Inherited
Biological process	Lipid metabolism	0	Moderately Informative	Direct
Biological process	Fatty acid metabolism	0	Informative	Direct
Biological process	Lipid transport	0.0005228	Informative	Direct
Biological process	Lipid biosynthesis	1	Informative	Inherited
Biological process	Steroid metabolism	1	Informative	Inherited
Biological process	Antibiotic biosynthesis	0	Highly Informative	Direct
Biological process	Sterol biosynthesis	0	Highly Informative	Direct
Biological process	Cholesterol biosynthesis	4.622e-16	Highly Informative	Direct
Biological process	Lipid degradation	2.291e-09	Highly Informative	Direct
Biological process	Nodulation	7.628e-05	Highly Informative	Direct
Cellular component	Cytoplasm	0	Least Informative	Direct
Cellular component	Peroxisome	2.835e-15	Informative	Direct
Domain	Transit peptide	2.62e-11	Moderately Informative	Direct
Molecular function	Potassium	0.0001274	Informative	Direct
Molecular function	Phosphopantetheine	0	Highly Informative	Direct
Post-translational modification	Transferase	0	Least Informative	Direct
Post-translational modification	Acyltransferase	0	Informative	Direct
Post-translational modification	Acetylation	4.429e-05	Moderately Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	lipid metabolism	0	Least Informative	Direct
UniPathway (UP)	aromatic compound metabolism	0.1435	Least Informative	Inherited
UniPathway (UP)	fatty acid metabolism	0	Moderately Informative	Direct
UniPathway (UP)	secondary metabolite metabolism	0	Moderately Informative	Direct
UniPathway (UP)	aromatic compound biosynthesis	0	Moderately Informative	Direct
UniPathway (UP)	metabolic intermediate biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	lipid biosynthesis	1	Moderately Informative	Inherited
UniPathway (UP)	fatty acid biosynthesis	0	Informative	Direct
UniPathway (UP)	flavonoid metabolism	0	Informative	Direct
UniPathway (UP)	phenylpropanoid biosynthesis	0	Informative	Direct
UniPathway (UP)	antibiotic biosynthesis	2.243e-16	Informative	Direct
UniPathway (UP)	toxin biosynthesis	2.8e-08	Informative	Direct
UniPathway (UP)	polyketide biosynthesis	0.8635	Informative	Inherited
UniPathway (UP)	(R)-mevalonate biosynthesis	0	Highly Informative	Direct
UniPathway (UP)	fatty acid degradation	2.818e-13	Highly Informative	Direct
UniPathway (UP)	antifungal biosynthesis	9.694e-09	Highly Informative	Direct
UniPathway (UP)	plant chemical defense	3.341e-06	Highly Informative	Direct
UniPathway (UP)	beta-ketoadipate pathway	6.178e-06	Highly Informative	Direct
UniPathway (UP)	bacillaene biosynthesis	0.0008817	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Thiolase-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Thiolase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

SEARCH

BROWSE

TOOLS

ABOUT

HELP

Thiolase-like superfamily