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Thiolase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiolase-like [ 53900]
Superfamily:   Thiolase-like [ 53901] (2)
Families:   Thiolase-related [ 53902] (8)
  Chalcone synthase-like [ 53914] (8)


Superfamily statistics
Genomes (3,132) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 59,678 357,251 101
Proteins 35,499 219,701 57


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000000000003429 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4468 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000002531 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0001391 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0002743 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.0102 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.09104 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.696 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.09306 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.7048 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000000000005784 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000000000006342 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000001833 Informative Direct
Biological Process (BP) lipid catabolic process 0.000006529 Informative Direct
Biological Process (BP) negative regulation of cell death 0.7801 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5598 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.03541 Informative Inherited
Biological Process (BP) central nervous system development 0.522 Informative Inherited
Biological Process (BP) mitochondrion organization 0.1057 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1712 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.2751 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.007771 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.2809 Informative Inherited
Biological Process (BP) pigment metabolic process 0.7249 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) flavonoid biosynthetic process 0.000000000005488 Highly Informative Direct
Biological Process (BP) lactone biosynthetic process 0.0000000001014 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.000001696 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.000003524 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000003603 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000004066 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.000007666 Highly Informative Direct
Biological Process (BP) response to cold 0.00001854 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00006106 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0006895 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.6435 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.001252 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.003505 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.0136 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.0212 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) lipid modification 0.1085 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) anion binding 0.4947 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.2426 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) amide binding 0.00156 Informative Inherited
Molecular Function (MF) modified amino acid binding 0.00000003319 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.000001471 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00005989 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0003788 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.8114 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.001326 Least Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.584 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5923 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.1555 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000006171 Informative Direct
Cellular Component (CC) outer membrane 0.0007217 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0002267 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00000000003516InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000000614InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0007723InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0154InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.0000000000002778Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid degradation0.00000004321InformativeDirect
Biological processLipid transport0.0008793InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processSteroid metabolism1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.000001695Highly InformativeDirect
Biological processNodulation0.00009278Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome6.58e-16InformativeDirect
DomainTransit peptide0.000000001348Moderately InformativeDirect
Molecular functionNADP0.0000000000008855Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiolase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Thiolase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]