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Thiolase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Thiolase-like [ 53900]
Superfamily:   Thiolase-like [ 53901] (2)
Families:   Thiolase-related [ 53902] (8)
  Chalcone synthase-like [ 53914] (8)


Superfamily statistics
Genomes (3,131) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 59,655 273,095 101
Proteins 35,485 165,624 57


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00000000000006905 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5804 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000007481 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0001264 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000244 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.008386 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07905 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0779 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6686 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6154 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.000000000001148 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.000000000003049 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00000000002556 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0000001674 Informative Direct
Biological Process (BP) cellular lipid catabolic process 0.0000002443 Informative Direct
Biological Process (BP) drug metabolic process 0.0000009241 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.0002112 Informative Direct
Biological Process (BP) negative regulation of cell death 0.7708 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.162 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.1111 Informative Inherited
Biological Process (BP) pigment metabolic process 0.7044 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.02823 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.2624 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5371 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.005236 Informative Inherited
Biological Process (BP) membrane organization 0.2707 Informative Inherited
Biological Process (BP) polyketide metabolic process 0 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0 Highly Informative Direct
Biological Process (BP) flavonoid biosynthetic process 0.00000000000576 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.0000007636 Highly Informative Direct
Biological Process (BP) ketone biosynthetic process 0.000002938 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0.000003541 Highly Informative Direct
Biological Process (BP) antibiotic biosynthetic process 0.000003834 Highly Informative Direct
Biological Process (BP) regulation of membrane permeability 0.000008602 Highly Informative Direct
Biological Process (BP) response to cold 0.000008779 Highly Informative Direct
Biological Process (BP) mitochondrial membrane organization 0.00006453 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.0008108 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.01483 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.001277 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.003817 Highly Informative Inherited
Biological Process (BP) lipid modification 0.09196 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.2485 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.4925 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) amide binding 0.001081 Informative Inherited
Molecular Function (MF) modified amino acid binding 0.00000003504 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.000001376 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00005859 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 0.0003192 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.7742 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.005662 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.0003946 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.5833 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.1456 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.596 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000006904 Informative Direct
Cellular Component (CC) outer membrane 0.0007642 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.0002321 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00000000003516InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.0000000000614InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0007723InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0154InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.0000000000002778Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00007266Least InformativeDirect
Worm Phenotype (WP)lipid metabolism variant0.0000001128InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)morphology0.08866Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.007336InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.3704Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02684Moderately InformativeInherited
Xenopus ANatomical entity (XAN)intestine0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0.0006684InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0.007081Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.569Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6065Least InformativeInherited
Plant ANatomical entity (PAN)fruit0InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.000000000003345InformativeDirect
Plant ANatomical entity (PAN)anther0.0001348Highly InformativeDirect
Plant ANatomical entity (PAN)leaf epidermis0.0002757Highly InformativeDirect
Plant ANatomical entity (PAN)trichome0.002502Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0.01933InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.4217InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0.000000000004308Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000001508Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.0001069Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.0003796Highly InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processLipid metabolism0Moderately InformativeDirect
Biological processFatty acid metabolism0InformativeDirect
Biological processLipid degradation0.00000002954InformativeDirect
Biological processLipid transport0.0006135InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processSteroid metabolism1InformativeInherited
Biological processAntibiotic biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.000002068Highly InformativeDirect
Biological processNodulation0.00009372Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome6.562e-16InformativeDirect
Coding sequence diversityAlternative initiation0.0009943Moderately InformativeDirect
DomainTransit peptide0.0000000008677Moderately InformativeDirect
Molecular functionNADP0.00000000002093Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.0211Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis2.314e-16Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)flavonoid metabolism0InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0.0000000000002389InformativeDirect
UniPathway (UP)toxin biosynthesis0.000000003184InformativeDirect
UniPathway (UP)pigment biosynthesis0.9476InformativeInherited
UniPathway (UP)polyketide biosynthesis1InformativeInherited
UniPathway (UP)flavonoid biosynthesis0Highly InformativeDirect
UniPathway (UP)(R)-mevalonate metabolism0Highly InformativeDirect
UniPathway (UP)antifungal biosynthesis0.00000001238Highly InformativeDirect
UniPathway (UP)plant chemical defense0.000003954Highly InformativeDirect
UniPathway (UP)melanin biosynthesis0.000008707Highly InformativeDirect
UniPathway (UP)beta-ketoadipate pathway0.00001142Highly InformativeDirect
UniPathway (UP)bacillaene biosynthesis0.0004208Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thiolase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Thiolase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]