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Lysozyme-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Lysozyme-like [ 53954]
Superfamily:   Lysozyme-like [ 53955] (11)
Families:   Family 19 glycosidase [ 53956]
  C-type lysozyme [ 53960] (2)
  Phage lysozyme [ 53981] (3)
  Lambda lysozyme [ 53984]
  G-type lysozyme [ 53987]
  Bacterial muramidase, catalytic domain [ 53991] (2)
  Chitosanase [ 53996]
  RPF-like [ 159824]
  NMB1012-like [ 159827] (2)
  PBP transglycosylase domain-like [ 159832] (2)
  PA2222-like [ 159837]


Superfamily statistics
Genomes (2,678) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,906 161,054 590
Proteins 23,705 160,856 590


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.015940.2955Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.88360.0005262Least InformativeInherited
Biological Process (BP)biological regulation0.38051Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.98280.00000000009062Least InformativeInherited
Biological Process (BP)response to external stimulus0.000056830.000002741Moderately InformativeDirect
Biological Process (BP)multi-organism process0.0000000049130.00000000000001409Moderately InformativeDirect
Biological Process (BP)response to stress0.026450.003319Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.22750.9047Moderately InformativeInherited
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.00060670.000000002364InformativeDirect
Biological Process (BP)defense response to other organism0.00045630.000005728InformativeDirect
Biological Process (BP)multi-organism cellular process0.0018010.00002281InformativeInherited
Biological Process (BP)regulation of growth0.010330.1109InformativeInherited
Biological Process (BP)locomotion0.054690.6349InformativeInherited
Biological Process (BP)cell killing0.000015110.0000001904Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.042570.526Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.0002250.003305Highly InformativeInherited
Biological Process (BP)viral life cycle0.0098670.02882Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process0.00013830.02196Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00000000000015380.0000000004914Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00.0002331Highly InformativeDirect
Molecular Function (MF)peptidoglycan muralytic activity00Highly InformativeDirect
Cellular Component (CC)extracellular region part0.000013310.01999Moderately InformativeInherited
Cellular Component (CC)extracellular space0.000000061950.0001017InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.0005262 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000000009062 Least Informative Direct
Biological Process (BP) biosynthetic process 0.1444 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8613 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2955 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to external stimulus 0.000002741 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00004255 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000000000001409 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.00009269 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0007315 Moderately Informative Direct
Biological Process (BP) response to stress 0.003319 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9047 Moderately Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.000000002364 Informative Direct
Biological Process (BP) multi-organism cellular process 0.00002281 Informative Direct
Biological Process (BP) defense response to other organism 0.000005728 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000000001375 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0000004474 Informative Direct
Biological Process (BP) response to bacterium 0.5021 Informative Inherited
Biological Process (BP) regulation of growth 0.1109 Informative Inherited
Biological Process (BP) locomotion 0.6349 Informative Inherited
Biological Process (BP) cell killing 0.0000001904 Highly Informative Direct
Biological Process (BP) aminoglycan biosynthetic process 0 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0000000000001129 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0 Highly Informative Direct
Biological Process (BP) defense response to bacterium 0.3553 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.526 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.003305 Highly Informative Inherited
Biological Process (BP) viral life cycle 0.02882 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.02196 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000004914 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.01432 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.05041 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0000001828 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000001281 Informative Direct
Molecular Function (MF) amide binding 0.0000001227 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000005856 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.0002331 Highly Informative Direct
Molecular Function (MF) drug binding 0.000000000006161 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.000000000002723 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0 Highly Informative Direct
Cellular Component (CC) extracellular region part 0.01999 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0001017 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0001219 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Peptidoglycan glycosyltransferase0.000000000001544Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.5816InformativeInherited
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.0000003997Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.03739Least InformativeInherited
Drugbank ATC_code (DB)antibacterials for systemic use0.000000003022Moderately InformativeDirect
Drugbank ATC_code (DB)antiinfectives0.003822Moderately InformativeInherited
Drugbank ATC_code (DB)other beta-lactam antibacterials0.00000000000003788InformativeDirect
Drugbank ATC_code (DB)antibiotics0.00008253InformativeDirect
Drugbank ATC_code (DB)beta-lactam antibacterials, penicillins0.04526InformativeInherited
Drugbank ATC_code (DB)oxacillin0.0000001013Highly InformativeDirect
Drugbank ATC_code (DB)penicillins with extended spectrum0.0000002548Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processVirulence0.00004573Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCytolysis0.00000001747InformativeDirect
Biological processVirus entry into host cell0.02425InformativeInherited
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processVirus exit from host cell0.000000000005917Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentVacuole0.0000001534InformativeDirect
Developmental stageLate protein0.000001222Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.9231Least InformativeInherited
DomainSignal-anchor0.0000000002116InformativeDirect
Molecular functionCalcium0.00002642Moderately InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.1238Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationGlycosyltransferase0.0000005432InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect
Post-translational modificationHydroxylation0.000945InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lysozyme-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Lysozyme-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]