SUPERFAMILY 1.75 HMM library and genome assignments server

Lysozyme-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Lysozyme-like [ 53954]
Superfamily:   Lysozyme-like [ 53955] (11)
Families:   Family 19 glycosidase [ 53956]
  C-type lysozyme [ 53960] (2)
  Phage lysozyme [ 53981] (3)
  Lambda lysozyme [ 53984]
  G-type lysozyme [ 53987]
  Bacterial muramidase, catalytic domain [ 53991] (2)
  Chitosanase [ 53996]
  RPF-like [ 159824]
  NMB1012-like [ 159827] (2)
  PBP transglycosylase domain-like [ 159832] (2)
  PA2222-like [ 159837]


Superfamily statistics
Genomes (2,678) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,906 161,054 590
Proteins 23,705 160,856 590


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.55920.6767Least InformativeInherited
Biological Process (BP)multi-organism process0.000014810.00000001045Moderately InformativeDirect
Biological Process (BP)defense response0.0000055470.0000000003856InformativeDirect
Biological Process (BP)regulation of growth0.013830.025InformativeInherited
Biological Process (BP)positive regulation of growth0.00016870.0005796Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.000077130.000009764Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.21381Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.63131Least InformativeInherited
Cellular Component (CC)chromosome0.000025490.07518InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.6767 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9434 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.113 Least Informative Inherited
Biological Process (BP) multi-organism process 0.00000001045 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000001749 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.1007 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.3147 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.08335 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.03488 Moderately Informative Inherited
Biological Process (BP) defense response 0.0000000003856 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.0000000007588 Informative Direct
Biological Process (BP) response to bacterium 0.5568 Informative Inherited
Biological Process (BP) regulation of growth 0.025 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.003035 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.005432 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.00000000009576 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0.0000000000002523 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0005796 Highly Informative Direct
Biological Process (BP) response to fungus 0.002032 Highly Informative Inherited
Biological Process (BP) defense response to bacterium 0.01154 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.1006 Highly Informative Inherited
Biological Process (BP) cell wall macromolecule biosynthetic process 0.01543 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000009764 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.00000004989 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) drug binding 0.000002016 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0000009365 Informative Direct
Cellular Component (CC) chromosome 0.07518 Informative Inherited
Cellular Component (CC) cell envelope 0.000001774 Highly Informative Direct
Cellular Component (CC) external encapsulating structure part 0.000002244 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Peptidoglycan glycosyltransferase0.000000000001544Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0.5513InformativeInherited
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.0000001152Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.1092Least InformativeInherited
Drugbank ATC_code (DB)antibacterials for systemic use0.0000000004685Moderately InformativeDirect
Drugbank ATC_code (DB)antiinfectives0.01178Moderately InformativeInherited
Drugbank ATC_code (DB)other beta-lactam antibacterials0.000000000000002293InformativeDirect
Drugbank ATC_code (DB)beta-lactamase sensitive penicillins0.000004855InformativeDirect
Drugbank ATC_code (DB)cloxacillin0.00000001293Highly InformativeDirect
Drugbank ATC_code (DB)oxacillin0.00000001293Highly InformativeDirect
Drugbank ATC_code (DB)penicillins with extended spectrum0.00000004905Highly InformativeDirect
Drugbank ATC_code (DB)ampicillin0.0000005996Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processVirulence0.00001208InformativeDirect
Biological processCytolysis0.0001047InformativeDirect
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processVirus exit from host cell0.00001037Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentVacuole0.00000004326InformativeDirect
Developmental stageLate protein0.0000006103Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.8428Least InformativeInherited
DomainSignal-anchor0.0000000002473InformativeDirect
Molecular functionCalcium0.00001335Moderately InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.07051Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationGlycosyltransferase0.0000006451InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lysozyme-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Lysozyme-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]