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Lysozyme-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Lysozyme-like [ 53954]
Superfamily:   Lysozyme-like [ 53955] (11)
Families:   Family 19 glycosidase [ 53956]
  C-type lysozyme [ 53960] (2)
  Phage lysozyme [ 53981] (3)
  Lambda lysozyme [ 53984]
  G-type lysozyme [ 53987]
  Bacterial muramidase, catalytic domain [ 53991] (2)
  Chitosanase [ 53996]
  RPF-like [ 159824]
  NMB1012-like [ 159827] (2)
  PBP transglycosylase domain-like [ 159832] (2)
  PA2222-like [ 159837]


Superfamily statistics
Genomes (2,685) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 23,996 155,747 590
Proteins 23,785 155,132 590


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000053810.00008961Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process10.005585Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.83750.001267Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)defense response00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.29040Moderately InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.10260.03078Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.5870.9547Moderately InformativeInherited
Biological Process (BP)reproduction0.0052840.2879Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.52070.000009861Moderately InformativeInherited
Biological Process (BP)defense response to other organism0.0000000014810.000000000009475InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0002440InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.022460.1516InformativeInherited
Biological Process (BP)response to bacterium0.00000033270.003109InformativeInherited
Biological Process (BP)interspecies interaction between organisms0.87920.1245InformativeInherited
Biological Process (BP)locomotion0.16330.8578InformativeInherited
Biological Process (BP)regulation of growth0.018890.177InformativeInherited
Biological Process (BP)single organism reproductive process0.00065830.08011InformativeInherited
Biological Process (BP)multi-organism reproductive process0.87331InformativeInherited
Biological Process (BP)aminoglycan catabolic process0.00000038420Highly InformativeDirect
Biological Process (BP)fertilization0.000000000011150.000000003076Highly InformativeDirect
Biological Process (BP)killing of cells of other organism0.0000022670.000000008609Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process0.00028850Highly InformativeDirect
Biological Process (BP)viral process0.0078270.4077Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.00045780.006183Highly InformativeInherited
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.32190.9079Highly InformativeInherited
Biological Process (BP)glycosaminoglycan metabolic process0.000018080.01847Highly InformativeInherited
Molecular Function (MF)hydrolase activity00.0000000000004105Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00.00001341Highly InformativeDirect
Molecular Function (MF)peptidoglycan muralytic activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part00.00000000001462Moderately InformativeDirect
Cellular Component (CC)cell projection0.00023850.3101Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.025690.5353Moderately InformativeInherited
Cellular Component (CC)vesicle0.044480.4215Moderately InformativeInherited
Cellular Component (CC)extracellular space00.0000000000003582InformativeDirect
Cellular Component (CC)cilium0.0000012320.0008177InformativeDirect
Cellular Component (CC)secretory granule0.00011940.00001125InformativeDirect
Cellular Component (CC)motile cilium0.000000000090310.00000001088Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00008961 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.005585 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.9854 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4079 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001267 Least Informative Inherited
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000009861 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.03078 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.001101 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9547 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2879 Moderately Informative Inherited
Biological Process (BP) defense response to other organism 0.000000000009475 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.1516 Informative Inherited
Biological Process (BP) response to bacterium 0.003109 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1245 Informative Inherited
Biological Process (BP) locomotion 0.8578 Informative Inherited
Biological Process (BP) regulation of growth 0.177 Informative Inherited
Biological Process (BP) single organism reproductive process 0.08011 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0000000000001233 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) fertilization 0.000000003076 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0.000000008609 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0 Highly Informative Direct
Biological Process (BP) viral process 0.4077 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.006183 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.9079 Highly Informative Inherited
Biological Process (BP) glycosaminoglycan metabolic process 0.01847 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000000004105 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.01638 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.0492 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0000000008307 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000005098 Informative Direct
Molecular Function (MF) amide binding 0.00000006126 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000001424 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.00001341 Highly Informative Direct
Molecular Function (MF) drug binding 0.00000000001764 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0000000000002106 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.00000000001462 Moderately Informative Direct
Cellular Component (CC) cell projection 0.3101 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.4215 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.5353 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0000000000003582 Informative Direct
Cellular Component (CC) cilium 0.0008177 Informative Direct
Cellular Component (CC) secretory granule 0.00001125 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00005425 Informative Direct
Cellular Component (CC) motile cilium 0.00000001088 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Peptidoglycan glycosyltransferase0.000000000001544Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processVirulence0.00006601Moderately InformativeDirect
Biological processCell shape0InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processCytolysis0.00000003332InformativeDirect
Biological processVirus entry into host cell0.02572InformativeInherited
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processVirus exit from host cell0.000000000007641Highly InformativeDirect
Biological processFertilization0.000000001621Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.3128Moderately InformativeInherited
Cellular componentCell inner membrane0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentVacuole0.0000001691InformativeDirect
Developmental stageLate protein0.000001249Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000000002176InformativeDirect
Molecular functionCalcium0.00003562Moderately InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.01593Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lysozyme-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Lysozyme-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]