SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Lysozyme-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Lysozyme-like [ 53954]
Superfamily:   Lysozyme-like [ 53955] (11)
Families:   Family 19 glycosidase [ 53956]
  C-type lysozyme [ 53960] (2)
  Phage lysozyme [ 53981] (3)
  Lambda lysozyme [ 53984]
  G-type lysozyme [ 53987]
  Bacterial muramidase, catalytic domain [ 53991] (2)
  Chitosanase [ 53996]
  RPF-like [ 159824]
  NMB1012-like [ 159827] (2)
  PBP transglycosylase domain-like [ 159832] (2)
  PA2222-like [ 159837]


Superfamily statistics
Genomes (2,682) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 23,957 161,054 590
Proteins 23,746 160,856 590


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000044210.0000746Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process10.008243Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.84780.001971Least InformativeInherited
Biological Process (BP)response to external stimulus00Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.11010.0319Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.60920.9549Moderately InformativeInherited
Biological Process (BP)reproduction0.0053190.2974Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.54970.00001666Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.30140Moderately InformativeInherited
Biological Process (BP)defense response to other organism0.0000000017120.000000000004803InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00026160InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.024030.1512InformativeInherited
Biological Process (BP)cell wall organization or biogenesis0.002390InformativeInherited
Biological Process (BP)response to bacterium0.00000021830.0015InformativeInherited
Biological Process (BP)regulation of growth0.019520.1683InformativeInherited
Biological Process (BP)locomotion0.14610.8344InformativeInherited
Biological Process (BP)single organism reproductive process0.00066910.08698InformativeInherited
Biological Process (BP)multi-organism reproductive process0.87471InformativeInherited
Biological Process (BP)interspecies interaction between organisms0.87690.1291InformativeInherited
Biological Process (BP)aminoglycan catabolic process0.00000036220Highly InformativeDirect
Biological Process (BP)fertilization0.0000000000033010.000000003483Highly InformativeDirect
Biological Process (BP)killing of cells of other organism0.0000022820.00000001021Highly InformativeDirect
Biological Process (BP)cell wall macromolecule metabolic process0.00031230Highly InformativeDirect
Biological Process (BP)glycosaminoglycan metabolic process0.000016210.02061Highly InformativeInherited
Biological Process (BP)viral process0.0081020.4376Highly InformativeInherited
Biological Process (BP)positive regulation of growth0.00048330.005816Highly InformativeInherited
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.35620.9275Highly InformativeInherited
Molecular Function (MF)hydrolase activity00.0000000000004138Least InformativeDirect
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds00InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds00.00001237Highly InformativeDirect
Molecular Function (MF)peptidoglycan muralytic activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)extracellular region part00.00000000002009Moderately InformativeDirect
Cellular Component (CC)cell projection0.00020420.2947Moderately InformativeInherited
Cellular Component (CC)vesicle0.048420.4591Moderately InformativeInherited
Cellular Component (CC)extracellular space00.0000000000005726InformativeDirect
Cellular Component (CC)cilium0.0000010410.000858InformativeDirect
Cellular Component (CC)secretory granule0.000099020.00001343InformativeDirect
Cellular Component (CC)motile cilium0.00000000011530.00000001448Highly InformativeDirect
Cellular Component (CC)sperm part0.000000000076650.0000000002844Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0000746 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.9797 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.008243 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001971 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4558 Least Informative Inherited
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00001666 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0.0319 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.001337 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.9549 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2974 Moderately Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0 Informative Direct
Biological Process (BP) defense response to other organism 0.000000000004803 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) response to bacterium 0.0015 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.1512 Informative Inherited
Biological Process (BP) regulation of growth 0.1683 Informative Inherited
Biological Process (BP) locomotion 0.8344 Informative Inherited
Biological Process (BP) single organism reproductive process 0.08698 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1291 Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.0000000000001122 Highly Informative Direct
Biological Process (BP) aminoglycan catabolic process 0 Highly Informative Direct
Biological Process (BP) fertilization 0.000000003483 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0.00000001021 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component macromolecule biosynthetic process 0 Highly Informative Direct
Biological Process (BP) glycosaminoglycan metabolic process 0.02061 Highly Informative Inherited
Biological Process (BP) viral process 0.4376 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.005816 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.9275 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0000000000004138 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) small molecule binding 0.01982 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.05626 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.000000001032 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.0000000006954 Informative Direct
Molecular Function (MF) amide binding 0.00000004555 Informative Direct
Molecular Function (MF) sulfur compound binding 0.000000001898 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.00001237 Highly Informative Direct
Molecular Function (MF) drug binding 0.00000000001952 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0.0000000000002871 Highly Informative Direct
Molecular Function (MF) peptidoglycan muralytic activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0.00000000002009 Moderately Informative Direct
Cellular Component (CC) vesicle 0.4591 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.2947 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.0000000000005726 Informative Direct
Cellular Component (CC) cilium 0.000858 Informative Direct
Cellular Component (CC) secretory granule 0.00001343 Informative Direct
Cellular Component (CC) external encapsulating structure 0.00007008 Informative Direct
Cellular Component (CC) motile cilium 0.00000001448 Highly Informative Direct
Cellular Component (CC) sperm part 0.0000000002844 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on polysaccharides0InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Peptidoglycan glycosyltransferase0.000000000001544Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.7285Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Chitinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on polysaccharides0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processVirulence0.00005641Moderately InformativeDirect
Biological processAntibiotic resistance0InformativeDirect
Biological processCell shape0InformativeDirect
Biological processPlant defense0InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCytolysis0.0000000238InformativeDirect
Biological processVirus entry into host cell0.02586InformativeInherited
Biological processPeptidoglycan synthesis0Highly InformativeDirect
Biological processVirus exit from host cell0.000000000007641Highly InformativeDirect
Biological processFertilization0.000000001404Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell membrane0.286Moderately InformativeInherited
Cellular componentCell inner membrane0InformativeDirect
Cellular componentCell outer membrane0InformativeDirect
Cellular componentVacuole0.0000001668InformativeDirect
Developmental stageLate protein0.000001281Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.0000000002386InformativeDirect
Molecular functionCalcium0.000034Moderately InformativeDirect
Molecular functionChitin-binding0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.0164Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtease1Moderately InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationAntimicrobial0InformativeDirect
Post-translational modificationCarboxypeptidase0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cell wall metabolism0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0Moderately InformativeDirect
UniPathway (UP)peptidoglycan biosynthesis0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lysozyme-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the Lysozyme-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]