SUPERFAMILY 1.75 HMM library and genome assignments server

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Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,038) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,702 208,755 132
Proteins 63,687 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000000000008010Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00000006930Least InformativeDirect
Biological Process (BP)response to stimulus0.0091080.4525Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process0.0034450Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biological regulation0.22720.00004294Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1786Least InformativeInherited
Biological Process (BP)cellular protein modification process0.00068090Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.0000051040.00006414Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.000049570.0000007743Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000023810.0002872Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000022960.000051Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.9130.2452Moderately InformativeInherited
Biological Process (BP)cell communication0.00093471Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00040280.06572Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.01710.0202Moderately InformativeInherited
Biological Process (BP)system development0.015651Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.07481Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.049621Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.00014861Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000003190.4683Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.000002830.9871Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.037691Moderately InformativeInherited
Biological Process (BP)gene expression0.58981Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.50180.4955Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.000058010.7562Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.001441Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0013431Moderately InformativeInherited
Biological Process (BP)regulation of localization0.001371Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.0026090.2729Moderately InformativeInherited
Biological Process (BP)single organism signaling0.0028291Moderately InformativeInherited
Biological Process (BP)immune system process0.0000018420.6157Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)cell death0.00000020830.000003786InformativeDirect
Biological Process (BP)regulation of proteolysis0.0000018710InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00031390.0002339InformativeDirect
Biological Process (BP)negative regulation of cell death0.00016530.0009025InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0000020750.001764InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.032410.989InformativeInherited
Biological Process (BP)phosphorylation0.000088281InformativeInherited
Biological Process (BP)intracellular signal transduction0.003990.179InformativeInherited
Biological Process (BP)tissue development0.00086011InformativeInherited
Biological Process (BP)animal organ morphogenesis0.0000056040.824InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.001470.6165InformativeInherited
Biological Process (BP)response to acid chemical0.00000084620.01349InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.00059291InformativeInherited
Biological Process (BP)regulation of locomotion0.00000037820.8392InformativeInherited
Biological Process (BP)regulation of cellular component movement0.00000040380.931InformativeInherited
Biological Process (BP)cell development0.91310.1203InformativeInherited
Biological Process (BP)immune effector process0.000064790.005752InformativeInherited
Biological Process (BP)immune response0.000000024650.01925InformativeInherited
Biological Process (BP)regulation of epithelial cell migration0.0000000000000061020.00002562Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00021210.000009873Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.0000000000000061020Highly InformativeDirect
Biological Process (BP)response to retinoic acid0.000000000000086810.000000003422Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000000000000039690.000000692Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.00000000025020Highly InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.00000000090190.0008201Highly InformativeDirect
Biological Process (BP)MAPK cascade0.00000000000018330.001506Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.0014360.1132Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.0000000038830.4995Highly InformativeInherited
Biological Process (BP)multicellular organism metabolic process0.00000063440.002394Highly InformativeInherited
Biological Process (BP)protein maturation0.000000000032050.01464Highly InformativeInherited
Biological Process (BP)extracellular matrix organization0.0000043020.3494Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000016480.01572Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.0000000000039790.001786Highly InformativeInherited
Biological Process (BP)kidney development0.00000000051690.01077Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding0.99621Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)molecular function regulator0.000058540.0009527Moderately InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00065240.000000000005423InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00000000005350.0004562InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.00010770.00000000003743InformativeDirect
Molecular Function (MF)signal transducer activity0.00005831InformativeInherited
Molecular Function (MF)molecular transducer activity0.000023261InformativeInherited
Molecular Function (MF)enzyme activator activity0.000010691InformativeInherited
Molecular Function (MF)cysteine-type endopeptidase activity0.0000000000055790Highly InformativeDirect
Molecular Function (MF)hormone binding00.0000002849Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00000000000026780.00000003303Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.00000281Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.091691Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity0.0000021230.007464Highly InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.019721Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00051060.02887Least InformativeInherited
Cellular Component (CC)vesicle0.000014560.2176Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0025370.01176Moderately InformativeInherited
Cellular Component (CC)lytic vacuole0.000020990.0000235InformativeDirect
Cellular Component (CC)secretory granule0.0000000000061370.0000002618InformativeDirect
Cellular Component (CC)endosome0.10220.01816InformativeInherited
Cellular Component (CC)cytoplasmic vesicle part0.0053410.7462InformativeInherited
Cellular Component (CC)vacuolar part0.048931InformativeInherited
Cellular Component (CC)vacuolar lumen0.000080040.0002011Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.00004294 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.4525 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1786 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001669 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00002293 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00008784 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00006414 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.0000007743 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0002872 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000051 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0002835 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.8318 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0202 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9111 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2452 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9808 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7562 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5758 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.6838 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3722 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5847 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.7848 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.4683 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9871 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06572 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.4955 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.2729 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.9327 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6157 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5225 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05709 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell death 0.000003786 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0000000008577 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0002339 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00004002 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.000001176 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.00002208 Informative Direct
Biological Process (BP) chromosome organization 0.00006941 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0009025 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.01687 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.001764 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.989 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) response to metal ion 0.5931 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.147 Informative Inherited
Biological Process (BP) response to acid chemical 0.01349 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.824 Informative Inherited
Biological Process (BP) regulation of defense response 0.8963 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.3578 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9997 Informative Inherited
Biological Process (BP) regulation of ion transport 0.2658 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9089 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) secondary metabolic process 0.7617 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.002819 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.9438 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.6165 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.01463 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3238 Informative Inherited
Biological Process (BP) organelle assembly 0.02742 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.46 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.84 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5092 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.7938 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.7929 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.179 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1992 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.001952 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.7064 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.5551 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cell development 0.1203 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.009575 Informative Inherited
Biological Process (BP) central nervous system development 0.1832 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9376 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of growth 0.001222 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3073 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.05874 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.8392 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.931 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.0449 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.00329 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.02305 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.02886 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.02356 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune effector process 0.005752 Informative Inherited
Biological Process (BP) immune response 0.01925 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.8476 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.9285 Informative Inherited
Biological Process (BP) autophagy 0.00000004337 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00003875 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0001688 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.00002562 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000001436 Highly Informative Direct
Biological Process (BP) viral process 0.0002322 Highly Informative Direct
Biological Process (BP) gene silencing 0.0002256 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000009873 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00000002871 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00000000000005443 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000000003422 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00008063 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.000000692 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.0000254 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000008393 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0003237 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0008201 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000000008742 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.00000000000002124 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00001485 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.004382 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.003269 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.3451 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.6772 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.06069 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.03017 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.00425 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.4371 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.5445 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.001506 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1132 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.1945 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.8771 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1081 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4995 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.1765 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.01746 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.0278 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001786 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.02492 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.00718 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.987 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.2549 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01496 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.03856 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.02683 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.002394 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.1853 Highly Informative Inherited
Biological Process (BP) protein maturation 0.01464 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01885 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.008198 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.3494 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.6453 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3232 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.7018 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.01572 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01977 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.03012 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01453 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.231 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0525 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.02955 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.101 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2889 Highly Informative Inherited
Biological Process (BP) killing of cells of other organism 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.01077 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.9679 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3276 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1462 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0000002914 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0009527 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.002195 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.000000000005423 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0004562 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.00000000003743 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.2588 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00171 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) nuclease activity 0.2954 Informative Inherited
Molecular Function (MF) chromatin binding 0.0000116 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000001775 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000002849 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000003303 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.007464 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1117 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.02814 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.02887 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0006206 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.2176 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01176 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.0000235 Informative Direct
Cellular Component (CC) secretory granule 0.0000002618 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00001094 Informative Direct
Cellular Component (CC) cilium 0.9879 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) endosome 0.01816 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7462 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.007631 Informative Inherited
Cellular Component (CC) vacuolar part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.0002011 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.000001582 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00000000000004324 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000003994 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.00003096 Highly Informative Direct
Cellular Component (CC) myofibril 0.008146 Highly Informative Inherited
Cellular Component (CC) chromatin 0.01106 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.4957 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000001738Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000006359Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)skin disease0.01236Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5316Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.01636InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.3527Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.1398InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)axon degeneration0.06776Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00000002857Least InformativeDirect
Worm Phenotype (WP)cell development variant0.003939Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.37Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.711Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0000000000009995Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000001757Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.1513Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.234Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0.00000000000001298InformativeDirect
Worm Phenotype (WP)neuron migration variant0.0000005157InformativeDirect
Worm Phenotype (WP)pesticide response variant0.0371InformativeInherited
Worm Phenotype (WP)cell stress response variant0.2623InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.000001643Highly InformativeDirect
Worm Phenotype (WP)paraquat hypersensitive0.0003471Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.00001493Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.0003552Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.346Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.02068Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.2265Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4608Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.0000004935InformativeDirect
Zebrafish Anatomy (ZA)surface structure1InformativeInherited
Zebrafish Anatomy (ZA)somite0.00000004048Highly InformativeDirect
Zebrafish Anatomy (ZA)pericardium0.0000006257Highly InformativeDirect
Zebrafish Anatomy (ZA)extension0.0005758Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0000356Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0.000002218InformativeDirect
Enzyme Commission (EC)In linear amides0.0001476InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.838InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000000871Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0.00000536Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processVirulence0Moderately InformativeDirect
Biological processProtein transport4.844e-16Moderately InformativeDirect
Biological processHost-virus interaction0.000000004337Moderately InformativeDirect
Biological processCell cycle0.0000005771Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processmRNA processing0.00000000001324InformativeDirect
Biological processMitosis0.00000000001748InformativeDirect
Biological processViral RNA replication0.00000003836InformativeDirect
Biological processEndocytosis0.00000008874InformativeDirect
Biological processWnt signaling pathway0.0000007343InformativeDirect
Biological processVirus entry into host cell0.05367InformativeInherited
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response0.00000005598Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0.000001418Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentVirion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000003534Moderately InformativeDirect
Cellular componentSecreted0.000000002923Moderately InformativeDirect
Cellular componentCytoskeleton0.00000008628Moderately InformativeDirect
Cellular componentEndosome0.000009124Moderately InformativeDirect
Cellular componentCell projection0.02017Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole0.00000000000912InformativeDirect
Cellular componentHost membrane0.000608InformativeDirect
Cellular componentCilium0.00801InformativeInherited
Cellular componentHost cytoplasmic vesicle0.000000000007004Highly InformativeDirect
Cellular componentFlagellum0.0000000009664Highly InformativeDirect
Cellular componentProteasome0.0000006014Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger0.000007035Moderately InformativeDirect
DomainWD repeat0.0001014InformativeDirect
Molecular functionZinc0.00000006418Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0.0001238InformativeDirect
Molecular functionCadmium0.000000001298Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase0.00000000000000691InformativeDirect
Post-translational modificationExonuclease0.0000000000008268InformativeDirect
Post-translational modificationAntimicrobial0.03787InformativeInherited
Post-translational modificationIon channel0.08674InformativeInherited
Post-translational modificationViral ion channel0.00000000009091Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0.00000001378Highly InformativeDirect
Post-translational modificationDisulfide bond0.000006504Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.0000000000007164InformativeDirect
Post-translational modificationMyristate0.0002373InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0.00000148Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]