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Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,041) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 65,580 230,055 132
Proteins 64,550 227,325 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.0000000000081090Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000000061580Least InformativeDirect
Biological Process (BP)primary metabolic process0.0029270Least InformativeInherited
Biological Process (BP)response to stimulus0.011840.8876Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.2589Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biological regulation0.28520.0001313Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000000075340.3436Least InformativeInherited
Biological Process (BP)cellular protein modification process0.00087070Moderately InformativeDirect
Biological Process (BP)cellular catabolic process0.0000038360.0000414Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00011670.00006494Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.000021010.00004135Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.013861Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.92670.2405Moderately InformativeInherited
Biological Process (BP)single organism signaling0.0027881Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.021430.07552Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00072330.02413Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.026771Moderately InformativeInherited
Biological Process (BP)tissue development0.0012251Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.090911Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.066131Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.000032261Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0000023551Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.0012761Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0000035340.6106Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0000025591Moderately InformativeInherited
Biological Process (BP)gene expression0.61561Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.4730.468Moderately InformativeInherited
Biological Process (BP)animal organ development0.0034331Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.000057390.001433Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.000045280.663Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00085321Moderately InformativeInherited
Biological Process (BP)cell differentiation0.00046640.2913Moderately InformativeInherited
Biological Process (BP)cell communication0.0010061Moderately InformativeInherited
Biological Process (BP)immune system process0.0000024690.7027Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)cell death0.00000020760.000004527InformativeDirect
Biological Process (BP)regulation of proteolysis0.0000049910InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0000019080.0007099InformativeDirect
Biological Process (BP)negative regulation of cell death0.000092450.0006999InformativeDirect
Biological Process (BP)cellular response to hormone stimulus0.028030.9912InformativeInherited
Biological Process (BP)phosphorylation0.00007861InformativeInherited
Biological Process (BP)intracellular signal transduction0.0034930.2604InformativeInherited
Biological Process (BP)animal organ morphogenesis0.0000074870.956InformativeInherited
Biological Process (BP)epithelium development0.062450.3352InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.00069610.001367InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.019320.8399InformativeInherited
Biological Process (BP)response to acid chemical0.00000061110.01233InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.00055211InformativeInherited
Biological Process (BP)regulation of locomotion0.00000024980.8379InformativeInherited
Biological Process (BP)regulation of cellular component movement0.00000027330.9298InformativeInherited
Biological Process (BP)cell development0.90810.2213InformativeInherited
Biological Process (BP)regulation of immune response0.00000036070.001881InformativeInherited
Biological Process (BP)immune effector process0.000047230.007343InformativeInherited
Biological Process (BP)immune response0.000000021340.01189InformativeInherited
Biological Process (BP)programmed cell death involved in cell development0.000000048640.000000000002812Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration0.00000000000031540.00003235Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00031660.0000239Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000000000006150Highly InformativeDirect
Biological Process (BP)response to retinoic acid0.00000000000010460.000000007146Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.000000000000034650.0000007808Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.0000000012650Highly InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.00000000051780.0009647Highly InformativeDirect
Biological Process (BP)MAPK cascade0.00000000000012540.001277Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.0020490.177Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.0000000045230.593Highly InformativeInherited
Biological Process (BP)multicellular organism metabolic process0.00000056520.002187Highly InformativeInherited
Biological Process (BP)protein maturation0.0000000011270.04213Highly InformativeInherited
Biological Process (BP)extracellular matrix organization0.0000041810.3561Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.000000000016810.01794Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.0000000000022380.003962Highly InformativeInherited
Biological Process (BP)kidney development0.00000000057420.01399Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)molecular function regulator0.000054070.001322Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.00068590.00000000000996InformativeDirect
Molecular Function (MF)peptidase regulator activity0.000000000048140.0003741InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.000037720.00000000002092InformativeDirect
Molecular Function (MF)signal transducer activity0.000064981InformativeInherited
Molecular Function (MF)molecular transducer activity0.000025411InformativeInherited
Molecular Function (MF)enzyme activator activity0.000011531InformativeInherited
Molecular Function (MF)cysteine-type endopeptidase activity0.0000000000065940.000000000000001615Highly InformativeDirect
Molecular Function (MF)hormone binding00.0000007102Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.00000000000023980.00000002553Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.0000034321Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.085351Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity0.0000028660.01093Highly InformativeInherited
Cellular Component (CC)intracellular organelle part0.99651Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0082481Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00047220.0201Least InformativeInherited
Cellular Component (CC)vacuole00Moderately InformativeDirect
Cellular Component (CC)vesicle0.000013390.2307Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.00024880.6572Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0026320.01356Moderately InformativeInherited
Cellular Component (CC)lytic vacuole0.000034070.00003047InformativeDirect
Cellular Component (CC)secretory granule0.00000000001060.0000001986InformativeDirect
Cellular Component (CC)endosome0.094430.01529InformativeInherited
Cellular Component (CC)cytoplasmic vesicle part0.0058110.7716InformativeInherited
Cellular Component (CC)vacuolar part0.051151InformativeInherited
Cellular Component (CC)vacuolar lumen0.0001120.0002198Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0001313 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.8876 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2589 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3436 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0001574 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00001077 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0001301 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000414 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00006494 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00004135 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.000379 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02413 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8131 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2405 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07552 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001433 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.4824 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.532 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.663 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.468 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6106 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5796 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6985 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2913 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4084 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.879 Moderately Informative Inherited
Biological Process (BP) immune system process 0.7027 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.5498 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06279 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell death 0.000004527 Informative Direct
Biological Process (BP) regulation of catabolic process 0.00000004087 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000003682 Informative Direct
Biological Process (BP) regulation of growth 0.0003256 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00002286 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.000004369 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0007099 Informative Direct
Biological Process (BP) chromosome organization 0.00006305 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0006999 Informative Direct
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.02121 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06733 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.9912 Informative Inherited
Biological Process (BP) response to metal ion 0.482 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.08796 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2604 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.956 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.3122 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01753 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.05129 Informative Inherited
Biological Process (BP) epithelium development 0.3352 Informative Inherited
Biological Process (BP) secondary metabolic process 0.7494 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.002092 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.001367 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.8399 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.007415 Informative Inherited
Biological Process (BP) organelle assembly 0.0345 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.01408 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.01786 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.4692 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.9501 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9948 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.9477 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9802 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9085 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.7848 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.6457 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.6068 Informative Inherited
Biological Process (BP) response to acid chemical 0.01233 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3275 Informative Inherited
Biological Process (BP) central nervous system development 0.1398 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4526 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.8379 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.9298 Informative Inherited
Biological Process (BP) cell development 0.2213 Informative Inherited
Biological Process (BP) cation homeostasis 0.5287 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.5594 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9841 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1065 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.02319 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1476 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.001881 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.0013 Informative Inherited
Biological Process (BP) immune effector process 0.007343 Informative Inherited
Biological Process (BP) immune response 0.01189 Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.8263 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.7736 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.001483 Informative Inherited
Biological Process (BP) autophagy 0.00000008013 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00004816 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.000000000002812 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.00003235 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000005701 Highly Informative Direct
Biological Process (BP) viral process 0.00004299 Highly Informative Direct
Biological Process (BP) gene silencing 0.0002229 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000239 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00000007214 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00000000000005058 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.000000007146 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00008284 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000007808 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00000003117 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0009647 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000000006735 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0004541 Highly Informative Direct
Biological Process (BP) cellular response to calcium ion 0.00001542 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00001691 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.1896 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.001776 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.003528 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.3002 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.1848 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 1 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.05195 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.0348 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.00369 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.4492 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.5169 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.001277 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.593 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.177 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.0211 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.893 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02079 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.001652 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.1667 Highly Informative Inherited
Biological Process (BP) regulation of microtubule-based process 0.01866 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.004348 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.6361 Highly Informative Inherited
Biological Process (BP) cellular response to extracellular stimulus 0.04039 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.002187 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.003962 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.03921 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.006518 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.04362 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.9106 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.3393 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.1721 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.2407 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.009056 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.004375 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01771 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.39 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.004382 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.08706 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.2564 Highly Informative Inherited
Biological Process (BP) protein maturation 0.04213 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.9323 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.03324 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.3561 Highly Informative Inherited
Biological Process (BP) histone modification 0.6608 Highly Informative Inherited
Biological Process (BP) cell maturation 0.3328 Highly Informative Inherited
Biological Process (BP) anatomical structure maturation 0.2702 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.6719 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.01794 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.02692 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.01339 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.0837 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.03228 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.05592 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.2464 Highly Informative Inherited
Biological Process (BP) killing of cells of other organism 1 Highly Informative Inherited
Biological Process (BP) kidney development 0.01399 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1559 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 0.8495 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.3366 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0.0000004479 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.001322 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) structural molecule activity 0.002176 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.00000000000996 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0003741 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.00000000002092 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.7085 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.002705 Informative Inherited
Molecular Function (MF) nuclease activity 0.1723 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) chromatin binding 0.000004973 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase activity 0.000000000000001615 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000001858 Highly Informative Direct
Molecular Function (MF) hormone binding 0.0000007102 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.00000002553 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.01093 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1193 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0201 Least Informative Inherited
Cellular Component (CC) protein complex 0.02301 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.03132 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.2307 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.6572 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.00121 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01356 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00003047 Informative Direct
Cellular Component (CC) secretory granule 0.0000001986 Informative Direct
Cellular Component (CC) supramolecular polymer 0.00002434 Informative Direct
Cellular Component (CC) cilium 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) endosome 0.01529 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.7716 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.00914 Informative Inherited
Cellular Component (CC) vacuolar part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.0002198 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.000001718 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0006582 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0005509 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.000007602 Highly Informative Direct
Cellular Component (CC) chromatin 0.01165 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.4685 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000001738Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000006359Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processVirulence0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processProtein transport4.848e-16Moderately InformativeDirect
Biological processHost-virus interaction0.000000004066Moderately InformativeDirect
Biological processCell cycle0.000000593Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processmRNA processing0.0000000000131InformativeDirect
Biological processMitosis0.00000000003035InformativeDirect
Biological processViral RNA replication0.00000003688InformativeDirect
Biological processEndocytosis0.00000008534InformativeDirect
Biological processWnt signaling pathway0.0000007245InformativeDirect
Biological processVirus entry into host cell0.05319InformativeInherited
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response0.00000005471Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0.000001412Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentVirion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000004832Moderately InformativeDirect
Cellular componentSecreted0.00000001057Moderately InformativeDirect
Cellular componentCytoskeleton0.00000009144Moderately InformativeDirect
Cellular componentEndosome0.00001099Moderately InformativeDirect
Cellular componentCell projection0.02325Moderately InformativeInherited
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentVacuole0.00000000001109InformativeDirect
Cellular componentHost membrane0.0005953InformativeDirect
Cellular componentCilium0.007714InformativeInherited
Cellular componentHost cytoplasmic vesicle0.000000000007385Highly InformativeDirect
Cellular componentFlagellum0.000000001009Highly InformativeDirect
Cellular componentProteasome0.00000066Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger0.000005937Moderately InformativeDirect
DomainWD repeat0.00009395InformativeDirect
Molecular functionZinc0.00000006865Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0.0001648InformativeDirect
Molecular functionCadmium0.000000001805Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase0.000000000000006495InformativeDirect
Post-translational modificationExonuclease0.0000000000007714InformativeDirect
Post-translational modificationAntimicrobial0.04109InformativeInherited
Post-translational modificationIon channel0.1567InformativeInherited
Post-translational modificationViral ion channel0.00000000008815Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0.00000001325Highly InformativeDirect
Post-translational modificationDisulfide bond0.000009523Least InformativeDirect
Post-translational modificationUbl conjugation0.0009729Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.0000000000005876InformativeDirect
Post-translational modificationMyristate0.0002276InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0.000001356Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]