SUPERFAMILY 1.75 HMM library and genome assignments server

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Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,032) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,962 208,755 132
Proteins 62,956 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.82210Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90540.9645Least InformativeInherited
Biological Process (BP)regulation of cellular process10.07252Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000090040.879Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1039Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.77881Least InformativeInherited
Biological Process (BP)response to stimulus0.30420.4141Least InformativeInherited
Biological Process (BP)developmental process0.0000000017860.1026Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.00010240.0008009Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.062331Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.4691Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.6208Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.14771Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.027381Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.049471Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0031040.8837Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.82540.3115Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.049960Moderately InformativeInherited
Biological Process (BP)signal transduction0.37811Moderately InformativeInherited
Biological Process (BP)tissue development0.0000017260.7688Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0063550.0001025Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0047780.4216Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.016470.7971Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.13111Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.38381Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0024720.6105Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.13170.06261Moderately InformativeInherited
Biological Process (BP)gene expression0.14091Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00038090.008841Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.044381Moderately InformativeInherited
Biological Process (BP)regulation of localization0.23891Moderately InformativeInherited
Biological Process (BP)cell differentiation0.34090.7902Moderately InformativeInherited
Biological Process (BP)reproduction0.000087831Moderately InformativeInherited
Biological Process (BP)multi-organism process0.031870.06834Moderately InformativeInherited
Biological Process (BP)immune system process0.00023140.9481Moderately InformativeInherited
Biological Process (BP)organ development0.00079991Moderately InformativeInherited
Biological Process (BP)proteolysis0.0000000021750.00000000000003956InformativeDirect
Biological Process (BP)peptide metabolic process0.0000000001550.000001933InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression0.000000005950.00000000001315InformativeDirect
Biological Process (BP)positive regulation of developmental process0.000082420.0002558InformativeDirect
Biological Process (BP)regulation of peptidase activity0.0000000029120.00001836InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal0.00000000000022480InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.90761InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.08310.02606InformativeInherited
Biological Process (BP)regulation of organelle organization0.00012310.082InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.000026220.4861InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.5220.2365InformativeInherited
Biological Process (BP)response to hormone stimulus0.13921InformativeInherited
Biological Process (BP)intracellular signal transduction0.0018440.1915InformativeInherited
Biological Process (BP)tissue morphogenesis0.0000000041930.2355InformativeInherited
Biological Process (BP)epithelium development0.84840.9215InformativeInherited
Biological Process (BP)tube development0.00019030.938InformativeInherited
Biological Process (BP)multi-multicellular organism process0.000000013550.00515InformativeInherited
Biological Process (BP)regulation of defense response0.041671InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.13840.0007853InformativeInherited
Biological Process (BP)single organism reproductive process0.0000006381InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.0000050770.7386InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0033690.003564InformativeInherited
Biological Process (BP)organ morphogenesis0.0000045451InformativeInherited
Biological Process (BP)response to lipid0.00028150.1804InformativeInherited
Biological Process (BP)regulation of cell proliferation0.000000015961InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.032511InformativeInherited
Biological Process (BP)regulation of locomotion0.000011770.7533InformativeInherited
Biological Process (BP)regulation of cellular component movement0.0000011070.8066InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)regulation of immune response0.004050.0449InformativeInherited
Biological Process (BP)immune response0.00000018430.4057InformativeInherited
Biological Process (BP)immune effector process0.0023720.2642InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.013871InformativeInherited
Biological Process (BP)placenta development0.0000000000000032610.0000005204Highly InformativeDirect
Biological Process (BP)hair follicle development0.00000033170.0003548Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity0.000000056050.0005313Highly InformativeDirect
Biological Process (BP)female pregnancy0.0000000000000032610.00003686Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000000000092060Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue0.0000000000000063980.0000000000000161Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.0002860.0000005484Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization0.00000013631Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity0.0000019290.01764Highly InformativeInherited
Biological Process (BP)MAPK cascade0.0000000050470.08472Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube0.00000000000017220.001459Highly InformativeInherited
Biological Process (BP)respiratory system development0.00000054050.03748Highly InformativeInherited
Biological Process (BP)respiratory tube development0.000000039310.001396Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.000000064740.002201Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.00042110.08996Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis0.000000000023180.02139Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process0.000000260.002739Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process0.0000010780.008578Highly InformativeInherited
Biological Process (BP)cellular component disassembly0.000060220.03182Highly InformativeInherited
Biological Process (BP)extracellular matrix organization10.4087Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0033571Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.00000000025180.006487Highly InformativeInherited
Biological Process (BP)renal system development0.000000038470.04739Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity0.0000020280.000000007443Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00013190.000000000009358InformativeDirect
Molecular Function (MF)peptidase regulator activity0.0000000000011310.0000000005199InformativeDirect
Molecular Function (MF)receptor activity0.00043891InformativeInherited
Molecular Function (MF)molecular transducer activity0.0010341InformativeInherited
Molecular Function (MF)enzyme activator activity0.00000026850.06927InformativeInherited
Molecular Function (MF)thiolester hydrolase activity0.0000094370Highly InformativeDirect
Molecular Function (MF)hormone binding0.000000000000011360.00000004486Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.000000000043420.0000001629Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00024061Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity0.00000025110.002018Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00093310.4608Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.021591Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)extracellular region part0.000000000024660.0003257Moderately InformativeDirect
Cellular Component (CC)vesicle0.000000080990.03459Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0031970.0004848Moderately InformativeInherited
Cellular Component (CC)lytic vacuole0.000000063410.00000006314InformativeDirect
Cellular Component (CC)extracellular space0.000015670.0006408InformativeDirect
Cellular Component (CC)secretory granule0.00000000035860.00000002297InformativeDirect
Cellular Component (CC)endosome0.074690.04744InformativeInherited
Cellular Component (CC)vacuolar part0.029050.9691InformativeInherited
Cellular Component (CC)endosomal part0.00058150.0144Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4141 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9645 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.879 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.07252 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1039 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.1026 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0005721 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001025 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000003958 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0008009 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3034 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8837 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.824 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3115 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1002 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.009086 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7688 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4216 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8123 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.16 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5009 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06261 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7971 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6208 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.6105 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.7902 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06834 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.008841 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001074 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9481 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000000003956 Informative Direct
Biological Process (BP) peptide metabolic process 0.000001933 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000000001315 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0007445 Informative Direct
Biological Process (BP) actin filament-based process 0.0007906 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.00001969 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0007853 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0008994 Informative Direct
Biological Process (BP) regulation of cell activation 0.00002982 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002558 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0003163 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.00000000452 Informative Direct
Biological Process (BP) regulation of peptidase activity 0.00001836 Informative Direct
Biological Process (BP) muscle structure development 0.00000421 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 0.00000007848 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.02606 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.4861 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.2365 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.9751 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1915 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8492 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.881 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.2355 Informative Inherited
Biological Process (BP) cell cycle process 0.3615 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.749 Informative Inherited
Biological Process (BP) epithelium development 0.9215 Informative Inherited
Biological Process (BP) tube development 0.938 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.00515 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.0449 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.082 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02167 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8626 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.658 Informative Inherited
Biological Process (BP) protein oligomerization 1 Informative Inherited
Biological Process (BP) regulation of growth 0.006043 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03774 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7386 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4383 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003287 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.2369 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01574 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.948 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003564 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6829 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002105 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9663 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.843 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 0.4784 Informative Inherited
Biological Process (BP) response to lipid 0.1804 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.03678 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5459 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2618 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7533 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8066 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01662 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2561 Informative Inherited
Biological Process (BP) chromosome organization 0.002972 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1489 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4057 Informative Inherited
Biological Process (BP) immune effector process 0.2642 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 1 Informative Inherited
Biological Process (BP) placenta development 0.0000005204 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0003548 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0005313 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 0.000000006549 Highly Informative Direct
Biological Process (BP) female pregnancy 0.00003686 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00004903 Highly Informative Direct
Biological Process (BP) regulation of autophagy 0.00000000001992 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000006522 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.000000000000007347 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002366 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00000000000002119 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005772 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00002221 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.00000003391 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00007132 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 0.0000000000000161 Highly Informative Direct
Biological Process (BP) negative regulation of immune response 0.0008411 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000001259 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000001094 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009718 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.000000001991 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 0.0000005484 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.01764 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3596 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.005273 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002636 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006787 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.001704 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.08472 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.005016 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7947 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.522 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.5004 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.03546 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9535 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.001459 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.03748 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001396 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.01013 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.00297 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002201 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.08996 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.00689 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3212 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02139 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.2286 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.6198 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5278 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002739 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008578 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.008914 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5501 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03167 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1807 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09192 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.004092 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3953 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.7391 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2552 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6312 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.002145 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.03182 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4087 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.004774 Highly Informative Inherited
Biological Process (BP) interaction with host 0.01141 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2368 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.006487 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002673 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01802 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1825 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1002 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004455 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1254 Highly Informative Inherited
Biological Process (BP) renal system development 0.04739 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1946 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.2761 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.04351 Highly Informative Inherited
Biological Process (BP) mRNA catabolic process 0.1612 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006304 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000007443 Moderately Informative Direct
Molecular Function (MF) cation binding 0.000003868 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0008656 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0009488 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.000000000009358 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0000000005199 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.004442 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06927 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 0.00000002511 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0.00000004486 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001629 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.002018 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4608 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.9899 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001991 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.000009937 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0003257 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0004848 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1373 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.03459 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00000006314 Informative Direct
Cellular Component (CC) extracellular space 0.0006408 Informative Direct
Cellular Component (CC) secretory granule 0.00000002297 Informative Direct
Cellular Component (CC) contractile fiber part 0.000001415 Informative Direct
Cellular Component (CC) endosome 0.04744 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03859 Informative Inherited
Cellular Component (CC) vacuolar part 0.9691 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0005391 Highly Informative Direct
Cellular Component (CC) centrosome 0.0003275 Highly Informative Direct
Cellular Component (CC) midbody 0.00006976 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0000000000001187 Highly Informative Direct
Cellular Component (CC) endosomal part 0.0144 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.008934 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000001738Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000006359Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1501Least InformativeInherited
Disease Ontology (DO)skin disease0.01546Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5772Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis0.00001033InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02254InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.000141Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2699Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000002959Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.000000000000007096Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.00000002651Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0.000000002184InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.00000006743Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0004467InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.000000001626Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0.000002807InformativeDirect
Enzyme Commission (EC)In linear amides0.000009973InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.8387InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000003421Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0.00000635Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction0.000000001674Moderately InformativeDirect
Biological processCell cycle0.0000002818Moderately InformativeDirect
Biological processDifferentiation0.006641Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis0.000000000006109InformativeDirect
Biological processViral RNA replication0.00000002758InformativeDirect
Biological processEndocytosis0.00000005191InformativeDirect
Biological processWnt signaling pathway0.0000005243InformativeDirect
Biological processVirus entry into host cell0.04288InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response0.00000003222Highly InformativeDirect
Biological processSpermatogenesis0.0000001942Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0.000001242Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum0.00000000002995Moderately InformativeDirect
Cellular componentSecreted0.00000000008293Moderately InformativeDirect
Cellular componentEndosome0.0000006403Moderately InformativeDirect
Cellular componentCytoskeleton0.00004074Moderately InformativeDirect
Cellular componentCell projection0.05661Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole0.0000253InformativeDirect
Cellular componentHost membrane0.0004496InformativeDirect
Cellular componentHost cytoplasmic vesicle0.000000000004385Highly InformativeDirect
Cellular componentProteasome0.0000005069Highly InformativeDirect
Cellular componentCilium0.000372Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger0.00001339Moderately InformativeDirect
DomainWD repeat0.00006391InformativeDirect
Molecular functionZinc0.00000274Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium0.0000000006035Highly InformativeDirect
Molecular functionChloride0.0001059Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase0.000000000000001328InformativeDirect
Post-translational modificationExonuclease0.0000000000003724InformativeDirect
Post-translational modificationAntimicrobial0.03754InformativeInherited
Post-translational modificationIon channel0.1711InformativeInherited
Post-translational modificationViral ion channel0.00000000001907Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0.0000000124Highly InformativeDirect
Post-translational modificationDisulfide bond0.0003505Least InformativeDirect
Post-translational modificationUbl conjugation0.000002774Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.0000000000002935InformativeDirect
Post-translational modificationMyristate0.0001435InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0.000001746Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]