SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,031) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,958 208,755 132
Proteins 62,952 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.88290Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90920.9482Least InformativeInherited
Biological Process (BP)regulation of cellular process10.06911Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process8.618e-081Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.197Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.84561Least InformativeInherited
Biological Process (BP)response to stimulus0.2980.4211Least InformativeInherited
Biological Process (BP)developmental process1.66e-090.2323Least InformativeInherited
Biological Process (BP)negative regulation of cellular process8.248e-050.0005439Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.44451Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.645Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.062871Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.14011Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.03181Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.049121Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0029830.871Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.81940.2864Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.050470Moderately InformativeInherited
Biological Process (BP)signal transduction0.39211Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0060570.0007627Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0052350.4555Moderately InformativeInherited
Biological Process (BP)tissue development1.73e-060.631Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.01470.7728Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.12131Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.37731Moderately InformativeInherited
Biological Process (BP)organ development0.0007621Moderately InformativeInherited
Biological Process (BP)single-organism developmental process1.191e-120.3218Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0022120.5869Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.12920.05901Moderately InformativeInherited
Biological Process (BP)gene expression0.14151Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00072010.0189Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.064011Moderately InformativeInherited
Biological Process (BP)regulation of localization0.22921Moderately InformativeInherited
Biological Process (BP)cell differentiation0.36170.8095Moderately InformativeInherited
Biological Process (BP)reproduction8.701e-051Moderately InformativeInherited
Biological Process (BP)multi-organism process0.029930.06002Moderately InformativeInherited
Biological Process (BP)immune system process0.0002320.954Moderately InformativeInherited
Biological Process (BP)proteolysis8.443e-091.046e-12InformativeDirect
Biological Process (BP)peptide metabolic process1.216e-101.799e-06InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression6.276e-091.736e-11InformativeDirect
Biological Process (BP)positive regulation of developmental process8.708e-050.0002524InformativeDirect
Biological Process (BP)regulation of peptidase activity2.947e-091.728e-05InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal2.518e-130InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.90371InformativeInherited
Biological Process (BP)regulation of organelle organization0.00013330.08194InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity5.123e-050.5437InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.52250.226InformativeInherited
Biological Process (BP)response to hormone stimulus0.14051InformativeInherited
Biological Process (BP)intracellular signal transduction0.0018150.1869InformativeInherited
Biological Process (BP)tissue morphogenesis4.488e-090.1897InformativeInherited
Biological Process (BP)epithelium development0.84610.9156InformativeInherited
Biological Process (BP)tube development0.00019640.8975InformativeInherited
Biological Process (BP)multi-multicellular organism process1.336e-080.004872InformativeInherited
Biological Process (BP)single organism reproductive process6.356e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process5.314e-060.7284InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0031430.003741InformativeInherited
Biological Process (BP)organ morphogenesis3.825e-060.9999InformativeInherited
Biological Process (BP)response to lipid0.00022640.1657InformativeInherited
Biological Process (BP)regulation of cell proliferation1.547e-081InformativeInherited
Biological Process (BP)regulation of locomotion1.192e-050.7578InformativeInherited
Biological Process (BP)regulation of cellular component movement1.13e-060.816InformativeInherited
Biological Process (BP)regulation of apoptotic process4.048e-070.2787InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)regulation of immune response0.0044220.04723InformativeInherited
Biological Process (BP)immune response1.866e-070.4117InformativeInherited
Biological Process (BP)immune effector process0.0023870.2637InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.013840.9511InformativeInherited
Biological Process (BP)placenta development3.258e-153.904e-07Highly InformativeDirect
Biological Process (BP)hair follicle development6.098e-070.0007038Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity5.667e-080.000513Highly InformativeDirect
Biological Process (BP)female pregnancy3.258e-153.513e-05Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)regulation of protein stability9.304e-140Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue6.381e-151.604e-14Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00020594.671e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.373e-071Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity2.279e-060.01929Highly InformativeInherited
Biological Process (BP)developmental maturation0.00025690.3571Highly InformativeInherited
Biological Process (BP)MAPK cascade4.533e-090.09027Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube1.746e-130.00148Highly InformativeInherited
Biological Process (BP)respiratory system development5.605e-070.0374Highly InformativeInherited
Biological Process (BP)respiratory tube development4.108e-080.001068Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis2.342e-110.02302Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process4.117e-070.002759Highly InformativeInherited
Biological Process (BP)cellular component disassembly6.058e-050.03219Highly InformativeInherited
Biological Process (BP)extracellular matrix organization6.149e-060.4106Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0036591Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration2.165e-100.006444Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process1.143e-060.008219Highly InformativeInherited
Biological Process (BP)renal system development4.005e-080.04795Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity1.943e-067.207e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00013048.959e-12InformativeDirect
Molecular Function (MF)peptidase regulator activity1.155e-125.583e-10InformativeDirect
Molecular Function (MF)receptor activity0.00041841InformativeInherited
Molecular Function (MF)molecular transducer activity0.00099171InformativeInherited
Molecular Function (MF)enzyme activator activity2.491e-070.06695InformativeInherited
Molecular Function (MF)thiolester hydrolase activity9.518e-060Highly InformativeDirect
Molecular Function (MF)hormone binding1.14e-144.574e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process4.589e-111.686e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00027821Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity2.421e-070.001985Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00089460.5234Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.020981Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)extracellular region part1.725e-110.0002457Moderately InformativeDirect
Cellular Component (CC)vesicle8.328e-080.02523Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0032060.0005006Moderately InformativeInherited
Cellular Component (CC)lytic vacuole6.393e-082.02e-06InformativeDirect
Cellular Component (CC)extracellular space1.538e-050.00062InformativeDirect
Cellular Component (CC)secretory granule3.679e-102.099e-08InformativeDirect
Cellular Component (CC)endosome0.075260.03957InformativeInherited
Cellular Component (CC)vacuolar part0.029340.9552InformativeInherited
Cellular Component (CC)endosomal part0.000590.005359Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4211 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9482 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06911 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.197 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.2323 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0005706 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0007627 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.835e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0008793 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005439 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5668 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.871 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8198 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2864 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.209 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008962 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4555 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8345 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5282 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.05901 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1785 Moderately Informative Inherited
Biological Process (BP) tissue development 0.631 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7728 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.3218 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.645 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5869 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8095 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06002 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0189 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.954 Moderately Informative Inherited
Biological Process (BP) proteolysis 1.046e-12 Informative Direct
Biological Process (BP) peptide metabolic process 1.799e-06 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.736e-11 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0008345 Informative Direct
Biological Process (BP) actin filament-based process 0.0008123 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 2.58e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0008179 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0002524 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0002213 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 6.49e-09 Informative Direct
Biological Process (BP) regulation of peptidase activity 1.728e-05 Informative Direct
Biological Process (BP) muscle structure development 1.832e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 2.51e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5437 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.226 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.979 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1869 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8442 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8724 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1897 Informative Inherited
Biological Process (BP) cell cycle process 0.3649 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.7517 Informative Inherited
Biological Process (BP) epithelium development 0.9156 Informative Inherited
Biological Process (BP) tube development 0.8975 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.004872 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.04723 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.08194 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02207 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8482 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6445 Informative Inherited
Biological Process (BP) protein oligomerization 1 Informative Inherited
Biological Process (BP) regulation of growth 0.005866 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) amide biosynthetic process 0.03759 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7284 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4333 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003613 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9388 Informative Inherited
Biological Process (BP) organ morphogenesis 0.9999 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.003741 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6616 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002057 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9615 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9432 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8483 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) response to lipid 0.1657 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01921 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.554 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1893 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.7578 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.816 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01483 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.2787 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.002237 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2952 Informative Inherited
Biological Process (BP) chromosome organization 0.003019 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1588 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4117 Informative Inherited
Biological Process (BP) immune effector process 0.2637 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9511 Informative Inherited
Biological Process (BP) placenta development 3.904e-07 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0007038 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.000513 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 4.988e-09 Highly Informative Direct
Biological Process (BP) female pregnancy 3.513e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 4.196e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 7.109e-12 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.513e-08 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 7.318e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0002367 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 1.26e-14 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0006077 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0009682 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 2.434e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 3.07e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 7.788e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 1.604e-14 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.556e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 8.524e-09 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.0009274 Highly Informative Direct
Biological Process (BP) regulation of wound healing 2.429e-09 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 4.671e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.01929 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3571 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3574 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.005333 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002709 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006546 Highly Informative Inherited
Biological Process (BP) response to amino acid stimulus 0.001721 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.09027 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.004847 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.7988 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.5282 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.5103 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.03084 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9516 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.00148 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.0374 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001068 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.009349 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.002861 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002126 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.09275 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.006587 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3159 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02302 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.01553 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.3618 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.6317 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.9991 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5234 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002759 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.008837 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.5513 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03078 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.183 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09714 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3802 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6808 Highly Informative Inherited
Biological Process (BP) stem cell development 0.258 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6341 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.002242 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.03219 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4106 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.2092 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2422 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.006444 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.002705 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01683 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1859 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1049 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008219 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004311 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1308 Highly Informative Inherited
Biological Process (BP) renal system development 0.04795 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0006485 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 7.207e-09 Moderately Informative Direct
Molecular Function (MF) cation binding 3.641e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0006566 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0.0009482 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 8.959e-12 Informative Direct
Molecular Function (MF) peptidase regulator activity 5.583e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00441 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06695 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 2.375e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 4.574e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.686e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.001985 Highly Informative Inherited
Molecular Function (MF) protein binding transcription factor activity 0.2981 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000878 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5234 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.9952 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0003718 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0002457 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0005006 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1347 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02523 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 2.02e-06 Informative Direct
Cellular Component (CC) extracellular space 0.00062 Informative Direct
Cellular Component (CC) secretory granule 2.099e-08 Informative Direct
Cellular Component (CC) contractile fiber part 1.11e-06 Informative Direct
Cellular Component (CC) endosome 0.03957 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.04074 Informative Inherited
Cellular Component (CC) vacuolar part 0.9552 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0005736 Highly Informative Direct
Cellular Component (CC) centrosome 0.0003288 Highly Informative Direct
Cellular Component (CC) midbody 6.098e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.228e-13 Highly Informative Direct
Cellular Component (CC) endosomal part 0.005359 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.008931 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1485Least InformativeInherited
Disease Ontology (DO)skin disease0.01531Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5762Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis1.032e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.179Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0226InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001429Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2764Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0002887InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.689e-09Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase2.86e-06InformativeDirect
Enzyme Commission (EC)In linear amides1.025e-05InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.8413InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase3.425e-08Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase6.439e-06Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction1.592e-09Moderately InformativeDirect
Biological processCell cycle3.804e-07Moderately InformativeDirect
Biological processDifferentiation0.006123Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis8.138e-12InformativeDirect
Biological processViral RNA replication2.734e-08InformativeDirect
Biological processEndocytosis4.674e-08InformativeDirect
Biological processWnt signaling pathway5.209e-07InformativeDirect
Biological processVirus entry into host cell0.042InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response2.7e-08Highly InformativeDirect
Biological processSpermatogenesis1.982e-07Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host1.235e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum2.059e-11Moderately InformativeDirect
Cellular componentSecreted6.773e-11Moderately InformativeDirect
Cellular componentEndosome5.375e-07Moderately InformativeDirect
Cellular componentCytoskeleton3.829e-05Moderately InformativeDirect
Cellular componentCell projection0.1955Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole2.422e-05InformativeDirect
Cellular componentHost membrane0.0004452InformativeDirect
Cellular componentHost cytoplasmic vesicle4.256e-12Highly InformativeDirect
Cellular componentProteasome4.886e-07Highly InformativeDirect
Cellular componentCilium0.0001353Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger1.212e-05Moderately InformativeDirect
DomainWD repeat6.122e-05InformativeDirect
Molecular functionZinc1.767e-06Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium5.449e-10Highly InformativeDirect
Molecular functionChloride0.0001002Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase8.845e-16InformativeDirect
Post-translational modificationExonuclease3.602e-13InformativeDirect
Post-translational modificationAntimicrobial0.03743InformativeInherited
Post-translational modificationIon channel0.1696InformativeInherited
Post-translational modificationViral ion channel1.893e-11Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase1.227e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0.0002441Least InformativeDirect
Post-translational modificationUbl conjugation1.547e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage2.579e-13InformativeDirect
Post-translational modificationMyristate0.0001336InformativeDirect
Post-translational modificationCovalent protein-RNA linkage1.687e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]