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Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,034) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 64,147 208,755 132
Proteins 63,142 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.00000000021620Least InformativeDirect
Biological Process (BP)biological regulation0.39520.0002275Least InformativeInherited
Biological Process (BP)primary metabolic process0.012960Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.039820.1567Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.1388Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0002320.000001845Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.000017480.00005687Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.00029980.0004061Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0011271Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0080981Moderately InformativeInherited
Biological Process (BP)response to organic substance0.000020290.6043Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.74650.1411Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0010940Moderately InformativeInherited
Biological Process (BP)signaling0.0069321Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.095320.6085Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.00001110.2885Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00003221Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.069680.8219Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.087391Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.045470.03312Moderately InformativeInherited
Biological Process (BP)gene expression0.64861Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.49010.9015Moderately InformativeInherited
Biological Process (BP)system development0.055091Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.000056330.6646Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00016970.02072Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0027371Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.0033430.7368Moderately InformativeInherited
Biological Process (BP)cell communication0.002771Moderately InformativeInherited
Biological Process (BP)immune system process0.0000027940.4539Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0041930.01668Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)cell death0.00000025490.0000314InformativeDirect
Biological Process (BP)regulation of proteolysis0.000013260InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.00046040.0002219InformativeDirect
Biological Process (BP)regulation of immune response0.00000047850.00001118InformativeDirect
Biological Process (BP)positive regulation of developmental process0.0000046730.003114InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0011731InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.034640.9706InformativeInherited
Biological Process (BP)phosphorylation0.00044141InformativeInherited
Biological Process (BP)intracellular signal transduction0.006860.2528InformativeInherited
Biological Process (BP)epithelium development0.0032710.4336InformativeInherited
Biological Process (BP)animal organ morphogenesis0.000003570.7431InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0011720.7629InformativeInherited
Biological Process (BP)response to acid chemical0.0000029520.02654InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.00033660.4126InformativeInherited
Biological Process (BP)regulation of locomotion0.0000018360.801InformativeInherited
Biological Process (BP)regulation of cellular component movement0.00000096380.9311InformativeInherited
Biological Process (BP)cell development0.72670.1084InformativeInherited
Biological Process (BP)immune response0.000000180.03419InformativeInherited
Biological Process (BP)cell killing00Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity0.00000000024430.000002766Highly InformativeDirect
Biological Process (BP)regulation of epithelial cell migration0.000000000000011570.0001192Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00029430.00001051Highly InformativeDirect
Biological Process (BP)regulation of protein stability0.000000000000065060Highly InformativeDirect
Biological Process (BP)response to retinoic acid0.00000000000053670.00000002359Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.0000000000015510.000003583Highly InformativeDirect
Biological Process (BP)positive regulation of proteolysis0.00000000072580Highly InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.0000000012070.0004829Highly InformativeDirect
Biological Process (BP)MAPK cascade0.0000000000057060.003801Highly InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.0032510.2164Highly InformativeInherited
Biological Process (BP)tube morphogenesis0.0000000094890.5022Highly InformativeInherited
Biological Process (BP)anatomical structure homeostasis0.000000000046950.003167Highly InformativeInherited
Biological Process (BP)protein maturation0.00000000019540.04296Highly InformativeInherited
Biological Process (BP)multicellular organism metabolic process0.00000021230.002183Highly InformativeInherited
Biological Process (BP)extracellular matrix organization0.0000070210.416Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration0.00000000024430.03246Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)protein binding0.77550.381Moderately InformativeInherited
Molecular Function (MF)molecular function regulator0.00027960.001493Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups0.00082910.0000000005778InformativeDirect
Molecular Function (MF)macromolecular complex binding0.000049220.0003997InformativeDirect
Molecular Function (MF)peptidase regulator activity0.00000000077610.0009789InformativeDirect
Molecular Function (MF)signal transducer activity0.00029821InformativeInherited
Molecular Function (MF)molecular transducer activity0.00013981InformativeInherited
Molecular Function (MF)enzyme activator activity0.000022441InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.0010150.000000001585InformativeInherited
Molecular Function (MF)cysteine-type endopeptidase activity0.000000000004910Highly InformativeDirect
Molecular Function (MF)hormone binding0.0000000000000065880.000002198Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process0.0000000000016550.0000001747Highly InformativeDirect
Molecular Function (MF)transmembrane signaling receptor activity0.000019261Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity0.0000022730.006907Highly InformativeInherited
Molecular Function (MF)exopeptidase activity0.18221Highly InformativeInherited
Cellular Component (CC)intracellular organelle part0.931Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.16861Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle10.0117Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0059010.06773Least InformativeInherited
Cellular Component (CC)vacuole00Moderately InformativeDirect
Cellular Component (CC)vesicle0.000034610.1519Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0016910.02665Moderately InformativeInherited
Cellular Component (CC)nuclear part0.041390.02519Moderately InformativeInherited
Cellular Component (CC)lytic vacuole0.000015270.00001917InformativeDirect
Cellular Component (CC)secretory vesicle0.000073280.02166InformativeInherited
Cellular Component (CC)endosome0.10450.0171InformativeInherited
Cellular Component (CC)cytoplasmic vesicle part0.0027110.5617InformativeInherited
Cellular Component (CC)vacuolar part0.026221InformativeInherited
Cellular Component (CC)nucleolus0.00019510.0002815Highly InformativeDirect
Cellular Component (CC)vacuolar lumen0.00014880.0001635Highly InformativeDirect
Cellular Component (CC)alveolar lamellar body00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0002275 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1388 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1567 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000002305 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00000000001346 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000001845 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00005687 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0004061 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00578 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1411 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.6043 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.927 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.2885 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.03312 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8219 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6085 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.09572 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1833 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5537 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5569 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.7295 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9015 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.7368 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.6307 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.5904 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6646 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.1098 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.319 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4539 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01668 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.02072 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell death 0.0000314 Informative Direct
Biological Process (BP) regulation of proteolysis 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00001203 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0000527 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0002219 Informative Direct
Biological Process (BP) regulation of growth 0.0008037 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00005061 Informative Direct
Biological Process (BP) regulation of immune response 0.00001118 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00006058 Informative Direct
Biological Process (BP) organelle assembly 0.00004829 Informative Direct
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.9703 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.006227 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.01609 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.009752 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.9706 Informative Inherited
Biological Process (BP) response to cytokine 0.9474 Informative Inherited
Biological Process (BP) response to inorganic substance 0.9836 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1724 Informative Inherited
Biological Process (BP) epithelium development 0.4336 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7431 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.05513 Informative Inherited
Biological Process (BP) regulation of defense response 0.8334 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1086 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.07561 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.8662 Informative Inherited
Biological Process (BP) secondary metabolic process 0.7891 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.4486 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.9761 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.7629 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5052 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.003114 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.7189 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.669 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.5079 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.03824 Informative Inherited
Biological Process (BP) regulation of protein localization 0.9393 Informative Inherited
Biological Process (BP) negative regulation of transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2528 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2451 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2039 Informative Inherited
Biological Process (BP) regulation of ion transport 0.26 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01241 Informative Inherited
Biological Process (BP) response to acid chemical 0.02654 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.4671 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.02045 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4608 Informative Inherited
Biological Process (BP) cell development 0.1084 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.1998 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.09458 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.4126 Informative Inherited
Biological Process (BP) regulation of locomotion 0.801 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.9311 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.01488 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.8671 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.001255 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.1543 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.03419 Informative Inherited
Biological Process (BP) ribonucleoprotein complex biogenesis 0.9184 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.9356 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) cell killing 0 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.000002766 Highly Informative Direct
Biological Process (BP) autophagy 0.000000000351 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00008133 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0001512 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell migration 0.0001192 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000002304 Highly Informative Direct
Biological Process (BP) gene silencing 0.0001935 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) viral life cycle 0.00000001127 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00001051 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.00000001846 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00000000000008501 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) response to retinoic acid 0.00000002359 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00004331 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.00005719 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.000003583 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0000007089 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.0004219 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.0004829 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00000000174 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0001954 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.0009407 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0001672 Highly Informative Direct
Biological Process (BP) regulation of response to wounding 0.00001103 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0 Highly Informative Direct
Biological Process (BP) negative regulation of transferase activity 0.2166 Highly Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.01536 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.002967 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.009367 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.03403 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.003408 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.002164 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.4468 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.4623 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.003801 Highly Informative Inherited
Biological Process (BP) cell projection organization 1 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2164 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.5022 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.003368 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6982 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.00389 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01294 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.2058 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.003167 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.09411 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.02134 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.002958 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.8076 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular protein localization 0.04576 Highly Informative Inherited
Biological Process (BP) negative regulation of establishment of protein localization 0.2135 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.02096 Highly Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.008035 Highly Informative Inherited
Biological Process (BP) protein maturation 0.04296 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.01973 Highly Informative Inherited
Biological Process (BP) multicellular organism metabolic process 0.002183 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.7061 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.416 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.8797 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.668 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03246 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1124 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.1538 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.001617 Highly Informative Inherited
Biological Process (BP) cell junction assembly 0.02959 Highly Informative Inherited
Biological Process (BP) glycoprotein metabolic process 1 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.7541 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.5994 Highly Informative Inherited
Biological Process (BP) RNA splicing 0.1415 Highly Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0.914 Highly Informative Inherited
Biological Process (BP) mRNA metabolic process 0.2457 Highly Informative Inherited
Biological Process (BP) RNA catabolic process 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0005293 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.000007389 Moderately Informative Direct
Molecular Function (MF) protein binding 0.381 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.001493 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.0000000005778 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0003997 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0009789 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.000000001585 Informative Direct
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.001781 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 0.2928 Informative Inherited
Molecular Function (MF) enzyme activator activity 1 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.0000001109 Highly Informative Direct
Molecular Function (MF) hormone binding 0.000002198 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0000001747 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.006907 Highly Informative Inherited
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.1253 Highly Informative Inherited
Cellular Component (CC) protein complex 0.005749 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0117 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.06773 Least Informative Inherited
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.1519 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.02519 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.02665 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.00001917 Informative Direct
Cellular Component (CC) cilium 0.9135 Informative Inherited
Cellular Component (CC) cell projection part 1 Informative Inherited
Cellular Component (CC) secretory vesicle 0.02166 Informative Inherited
Cellular Component (CC) endosome 0.0171 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.5617 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.003201 Informative Inherited
Cellular Component (CC) vacuolar part 1 Informative Inherited
Cellular Component (CC) nucleolus 0.0002815 Highly Informative Direct
Cellular Component (CC) vacuolar lumen 0.0001635 Highly Informative Direct
Cellular Component (CC) centrosome 0.000003794 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0.0000002208 Highly Informative Direct
Cellular Component (CC) alveolar lamellar body 0 Highly Informative Direct
Cellular Component (CC) peptidase complex 0.000001802 Highly Informative Direct
Cellular Component (CC) myofibril 0.007931 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000001738Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000006359Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.4064Least InformativeInherited
Disease Ontology (DO)skin disease0.009471Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5283Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.0001333InformativeDirect
Disease Ontology (DO)bullous skin disease0.01483InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.3541Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.1395InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000002085Least InformativeDirect
Worm Phenotype (WP)cell development variant0.004545Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.3954Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6527Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.000000000001298Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000003316Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.09831Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1373Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant0.00000000000001621InformativeDirect
Worm Phenotype (WP)cell migration variant0.0000000000001028InformativeDirect
Worm Phenotype (WP)cell stress response variant0.1758InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.0000006994Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.01803Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000006221Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.0005634Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0.3788Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.02082Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1894Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4323Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.0000006167InformativeDirect
Zebrafish Anatomy (ZA)surface structure1InformativeInherited
Zebrafish Anatomy (ZA)pericardium0.0000009519Highly InformativeDirect
Zebrafish Anatomy (ZA)extension0.0007832Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0000008342Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase0.000002483InformativeDirect
Enzyme Commission (EC)In linear amides0.0001422InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.8482InformativeInherited
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase0.00000001098Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase0.000005825Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processVirulence0Moderately InformativeDirect
Biological processProtein transport4.822e-16Moderately InformativeDirect
Biological processHost-virus interaction0.000000005419Moderately InformativeDirect
Biological processCell cycle0.0000005285Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processmRNA processing0.00000000001034InformativeDirect
Biological processMitosis0.00000000001486InformativeDirect
Biological processViral RNA replication0.00000003806InformativeDirect
Biological processEndocytosis0.00000008184InformativeDirect
Biological processWnt signaling pathway0.0000007295InformativeDirect
Biological processVirus entry into host cell0.05355InformativeInherited
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response0.00000005571Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host0.000001412Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentVirion0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000001589Moderately InformativeDirect
Cellular componentSecreted0.00000000174Moderately InformativeDirect
Cellular componentCytoskeleton0.00000005167Moderately InformativeDirect
Cellular componentEndosome0.000006006Moderately InformativeDirect
Cellular componentCell projection0.01159Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole0.0000000002965InformativeDirect
Cellular componentHost membrane0.0005976InformativeDirect
Cellular componentCilium0.008683InformativeInherited
Cellular componentHost cytoplasmic vesicle0.000000000004899Highly InformativeDirect
Cellular componentProteasome0.0000005731Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger0.000004947Moderately InformativeDirect
DomainWD repeat0.00008899InformativeDirect
Molecular functionZinc0.000005713Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium0.000000001118Highly InformativeDirect
Molecular functionChloride0.0001149Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase0.000000000000003984InformativeDirect
Post-translational modificationExonuclease0.0000000000007771InformativeDirect
Post-translational modificationAntimicrobial0.04431InformativeInherited
Post-translational modificationIon channel0.1098InformativeInherited
Post-translational modificationViral ion channel0.00000000009222Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase0.00000001394Highly InformativeDirect
Post-translational modificationDisulfide bond0.00002103Least InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage0.0000000000005861InformativeDirect
Post-translational modificationMyristate0.0002382InformativeDirect
Post-translational modificationCovalent protein-RNA linkage0.000001409Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]