SUPERFAMILY 1.73 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Cysteine proteinases [ 54000]
  consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
Superfamily:   Cysteine proteinases [ 54001] (16)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  fold similar to that of the factor XIII catalytic domain
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (4)
  Pfam 00443
  Adenain-like [ 54054] (5)
  Pfam 02902; Ulp1 protease family
  Microbial transglutaminase [ 75336]
  inverted positions of the catalytic triad Asp and His residues
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Pfam 07313, DUF1460; contains new PDB entry 2p1g, annotated as putative xylanase
  Phytochelatin synthase [ 142867]
  Pfam 05023; assosiated Pfam 09328 (DUF1984) is a part of the same functional unit
  CHAP domain [ 142870]
  Pfam 05257
  NlpC/P60 [ 142873]
  Pfam 00877


Superfamily statistics
Genomes (1,149) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 26,387 19,544 112
Proteins 26,247 19,448 112


Functional annotation
General category Processes_IC
Detailed category Proteases

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 65 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 65 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]