SUPERFAMILY 1.75 HMM library and genome assignments server


Cysteine proteinases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cysteine proteinases [ 54000]
Superfamily:   Cysteine proteinases [ 54001] (22)
Families:   Papain-like [ 54002] (25)
  Avirulence protein Avrpph3 [ 102723]
  FMDV leader protease [ 54037]
  Calpain large subunit, catalytic domain (domain II) [ 54040]
  Transglutaminase core [ 54044] (2)
  Arylamine N-acetyltransferase [ 54047]
  Ubiquitin carboxyl-terminal hydrolase UCH-L [ 54050] (2)
  Ubiquitin carboxyl-terminal hydrolase, UCH [ 82568] (5)
  Adenain-like [ 54054] (5)
  Microbial transglutaminase [ 75336]
  Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [ 110773]
  IgG-specific endopeptidase IdeS (Sib38) [ 117762]
  Lpg0564-like [ 142864]
  Phytochelatin synthase [ 142867]
  CHAP domain [ 142870]
  NlpC/P60 [ 142873]
  PMT C-terminal domain like [ 159843]
  MOA C-terminal domain-like [ 159846]
  Atu2299-like [ 159849]
  M48USP-like [ 159852]
  YiiX-like [ 159855]
  Autophagin-like [ 159858] (2)


Superfamily statistics
Genomes (3,032) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 63,971 208,755 132
Proteins 62,965 207,593 132


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.9021.944e-15Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.90630.9495Least InformativeInherited
Biological Process (BP)regulation of cellular process10.07477Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process1.374e-071Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis10.2186Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.85781Least InformativeInherited
Biological Process (BP)response to stimulus0.30590.4301Least InformativeInherited
Biological Process (BP)developmental process2.669e-090.2742Least InformativeInherited
Biological Process (BP)negative regulation of cellular process9.14e-050.0004503Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.43831Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.6782Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.063291Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.14731Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.031121Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.049521Moderately InformativeInherited
Biological Process (BP)response to organic substance0.0029740.861Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.82560.3146Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.049620Moderately InformativeInherited
Biological Process (BP)signal transduction0.39461Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0061120.001412Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.0055540.4301Moderately InformativeInherited
Biological Process (BP)tissue development1.791e-060.6338Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.015540.7677Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.1231Moderately InformativeInherited
Biological Process (BP)homeostatic process0.00017430.8622Moderately InformativeInherited
Biological Process (BP)organ development0.00074361Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0023640.5867Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.12850.06549Moderately InformativeInherited
Biological Process (BP)gene expression0.14581Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.00076360.01848Moderately InformativeInherited
Biological Process (BP)organonitrogen compound catabolic process0.067691Moderately InformativeInherited
Biological Process (BP)regulation of localization0.22461Moderately InformativeInherited
Biological Process (BP)cell differentiation0.36840.8127Moderately InformativeInherited
Biological Process (BP)reproduction0.00010141Moderately InformativeInherited
Biological Process (BP)multi-organism process0.02770.05216Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.52440.6448Moderately InformativeInherited
Biological Process (BP)immune system process0.00027130.9643Moderately InformativeInherited
Biological Process (BP)proteolysis9.466e-096.861e-13InformativeDirect
Biological Process (BP)posttranscriptional regulation of gene expression6.938e-091.61e-11InformativeDirect
Biological Process (BP)cellular amide metabolic process1.026e-060.0001388InformativeDirect
Biological Process (BP)positive regulation of developmental process9.321e-050.0003064InformativeDirect
Biological Process (BP)regulation of peptidase activity3.479e-092.077e-05InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal2.577e-130InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.90821InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.07570.02366InformativeInherited
Biological Process (BP)regulation of organelle organization0.00014690.07025InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity4.612e-050.5333InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.51580.231InformativeInherited
Biological Process (BP)response to hormone stimulus0.14621InformativeInherited
Biological Process (BP)intracellular signal transduction0.0022350.2575InformativeInherited
Biological Process (BP)tissue morphogenesis4.761e-090.1773InformativeInherited
Biological Process (BP)epithelium development0.8460.9155InformativeInherited
Biological Process (BP)tube development0.00019450.9024InformativeInherited
Biological Process (BP)multi-multicellular organism process1.445e-080.005628InformativeInherited
Biological Process (BP)single organism reproductive process6.796e-071InformativeInherited
Biological Process (BP)multicellular organismal reproductive process5.166e-060.7693InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0033790.00358InformativeInherited
Biological Process (BP)organ morphogenesis3.779e-061InformativeInherited
Biological Process (BP)response to lipid0.00023890.1765InformativeInherited
Biological Process (BP)regulation of locomotion1.162e-050.762InformativeInherited
Biological Process (BP)regulation of cellular component movement1.072e-060.8181InformativeInherited
Biological Process (BP)apoptotic process11InformativeInherited
Biological Process (BP)regulation of immune response0.004080.04755InformativeInherited
Biological Process (BP)immune response2.305e-070.4262InformativeInherited
Biological Process (BP)immune effector process0.0023880.2888InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.014240.9549InformativeInherited
Biological Process (BP)placenta development3.321e-153.876e-07Highly InformativeDirect
Biological Process (BP)hair follicle development7.411e-070.0006437Highly InformativeDirect
Biological Process (BP)leukocyte mediated immunity6.536e-080.0005921Highly InformativeDirect
Biological Process (BP)female pregnancy3.321e-153.509e-05Highly InformativeDirect
Biological Process (BP)protein processing00Highly InformativeDirect
Biological Process (BP)regulation of protein stability1.085e-130Highly InformativeDirect
Biological Process (BP)chemical homeostasis within a tissue9.649e-152.125e-14Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic signaling pathway0.00021725.845e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization1.341e-071Highly InformativeInherited
Biological Process (BP)positive regulation of endopeptidase activity2.707e-060.02033Highly InformativeInherited
Biological Process (BP)developmental maturation0.00025580.3622Highly InformativeInherited
Biological Process (BP)MAPK cascade5.261e-090.0917Highly InformativeInherited
Biological Process (BP)branching morphogenesis of an epithelial tube2.074e-130.001848Highly InformativeInherited
Biological Process (BP)respiratory system development5.586e-070.04371Highly InformativeInherited
Biological Process (BP)respiratory tube development4.098e-080.001078Highly InformativeInherited
Biological Process (BP)regulation of angiogenesis2.733e-110.02395Highly InformativeInherited
Biological Process (BP)multicellular organismal metabolic process4.485e-070.002963Highly InformativeInherited
Biological Process (BP)cellular component disassembly6.837e-050.03218Highly InformativeInherited
Biological Process (BP)extracellular matrix organization6.66e-060.4296Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.0037731Highly InformativeInherited
Biological Process (BP)positive regulation of cell migration2.145e-100.007193Highly InformativeInherited
Biological Process (BP)regulation of cysteine-type endopeptidase activity involved in apoptotic process1.311e-060.008846Highly InformativeInherited
Biological Process (BP)renal system development4.003e-080.0535Highly InformativeInherited
Molecular Function (MF)hydrolase activity00Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)enzyme regulator activity2.295e-069.59e-09Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds11Moderately InformativeInherited
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups0.00048523.143e-11InformativeDirect
Molecular Function (MF)peptidase regulator activity1.417e-126.049e-10InformativeDirect
Molecular Function (MF)receptor activity0.00046771InformativeInherited
Molecular Function (MF)molecular transducer activity0.0011041InformativeInherited
Molecular Function (MF)enzyme activator activity2.492e-070.06413InformativeInherited
Molecular Function (MF)thiolester hydrolase activity9.614e-060Highly InformativeDirect
Molecular Function (MF)hormone binding1.386e-145.505e-08Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase regulator activity involved in apoptotic process4.62e-111.795e-07Highly InformativeDirect
Molecular Function (MF)exopeptidase activity0.00016621Highly InformativeInherited
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Molecular Function (MF)acetyltransferase activity1.959e-060.005881Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0013310.5067Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.02031Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle10.0005013Least InformativeInherited
Cellular Component (CC)extracellular region part2.128e-110.0004023Moderately InformativeDirect
Cellular Component (CC)vesicle7.873e-080.02723Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0037210.0003793Moderately InformativeInherited
Cellular Component (CC)nuclear part0.074640.1043Moderately InformativeInherited
Cellular Component (CC)lytic vacuole6.928e-082.247e-06InformativeDirect
Cellular Component (CC)extracellular space1.553e-050.0006195InformativeDirect
Cellular Component (CC)nucleolus0.00034530.0009953InformativeDirect
Cellular Component (CC)secretory granule4.304e-102.368e-08InformativeDirect
Cellular Component (CC)endosome0.070880.0387InformativeInherited
Cellular Component (CC)vacuolar part0.02880.961InformativeInherited
Cellular Component (CC)endosomal part0.00059130.01414Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.944e-15 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4301 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.9495 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.07477 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2186 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.2742 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0007774 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.161e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0004503 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.564 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.3146 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.861 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8029 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2027 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.008335 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.4301 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8421 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.06549 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.3538 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6338 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7677 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8622 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6782 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5867 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8127 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001412 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05216 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.6448 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.01848 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001053 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9643 Moderately Informative Inherited
Biological Process (BP) protein complex assembly 0.0002082 Informative Direct
Biological Process (BP) proteolysis 6.861e-13 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.61e-11 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0007586 Informative Direct
Biological Process (BP) actin filament-based process 0.000818 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 1.748e-05 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0006585 Informative Direct
Biological Process (BP) cellular amide metabolic process 0.0001388 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.0003064 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000204 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 9.025e-09 Informative Direct
Biological Process (BP) regulation of peptidase activity 2.077e-05 Informative Direct
Biological Process (BP) muscle structure development 1.849e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) organelle assembly 2.453e-08 Informative Direct
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.02366 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.5333 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.231 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.988 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2575 Informative Inherited
Biological Process (BP) response to inorganic substance 0.8332 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.8813 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1773 Informative Inherited
Biological Process (BP) cell cycle process 0.3758 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.736 Informative Inherited
Biological Process (BP) epithelium development 0.9155 Informative Inherited
Biological Process (BP) tube development 0.9024 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.005628 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) regulation of immune response 0.04755 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.07025 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.02699 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8604 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6537 Informative Inherited
Biological Process (BP) regulation of growth 0.005678 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) secondary metabolic process 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.7693 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.4276 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.003285 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9477 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00358 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6609 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.002057 Informative Inherited
Biological Process (BP) negative regulation of transport 0.9553 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.9509 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.8539 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) gland development 1 Informative Inherited
Biological Process (BP) response to lipid 0.1765 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.02031 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.5634 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1893 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.762 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.8181 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01241 Informative Inherited
Biological Process (BP) apoptotic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.00199 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.2721 Informative Inherited
Biological Process (BP) chromosome organization 0.002993 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.1649 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) immune response 0.4262 Informative Inherited
Biological Process (BP) immune effector process 0.2888 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9549 Informative Inherited
Biological Process (BP) placenta development 3.876e-07 Highly Informative Direct
Biological Process (BP) hair follicle development 0.0006437 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0005921 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) autophagy 4.981e-09 Highly Informative Direct
Biological Process (BP) female pregnancy 3.509e-05 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 4.409e-05 Highly Informative Direct
Biological Process (BP) regulation of autophagy 1.053e-11 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 2.329e-08 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 9.182e-15 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.00024 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 2.462e-14 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0006192 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.0007723 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 1.956e-05 Highly Informative Direct
Biological Process (BP) positive regulation of growth 2.759e-08 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 8.228e-05 Highly Informative Direct
Biological Process (BP) chemical homeostasis within a tissue 2.125e-14 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 1.56e-06 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 1.058e-08 Highly Informative Direct
Biological Process (BP) protein tetramerization 0.000983 Highly Informative Direct
Biological Process (BP) regulation of wound healing 3.115e-09 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic signaling pathway 5.845e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of endopeptidase activity 0.02033 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3622 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.3409 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.004436 Highly Informative Inherited
Biological Process (BP) response to calcium ion 0.002835 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.006556 Highly Informative Inherited
Biological Process (BP) response to acid 0.004892 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.0917 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.004806 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.4611 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.874 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.5373 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.4947 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.01692 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.9524 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.001848 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.04371 Highly Informative Inherited
Biological Process (BP) respiratory tube development 0.001078 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.01008 Highly Informative Inherited
Biological Process (BP) regulation of ligase activity 0.002831 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.002385 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 0.06988 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.005863 Highly Informative Inherited
Biological Process (BP) secondary metabolite biosynthetic process 0.3159 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.02395 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.0149 Highly Informative Inherited
Biological Process (BP) negative regulation of cell activation 0.3648 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.6374 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.5431 Highly Informative Inherited
Biological Process (BP) multicellular organismal metabolic process 0.002963 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular transport 0.009267 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.564 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.03238 Highly Informative Inherited
Biological Process (BP) regulation of protein localization to nucleus 0.1903 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.09538 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3851 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.6772 Highly Informative Inherited
Biological Process (BP) stem cell development 0.2558 Highly Informative Inherited
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 0.6379 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.001232 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.03218 Highly Informative Inherited
Biological Process (BP) extracellular matrix organization 0.4296 Highly Informative Inherited
Biological Process (BP) axon development 0.2586 Highly Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.1788 Highly Informative Inherited
Biological Process (BP) multi-organism cellular process 0.2441 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.007193 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.00293 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.01566 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1677 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.1071 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.008846 Highly Informative Inherited
Biological Process (BP) gene silencing 0.004403 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.1282 Highly Informative Inherited
Biological Process (BP) renal system development 0.0535 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0007397 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 9.59e-09 Moderately Informative Direct
Molecular Function (MF) cation binding 2.686e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) chromatin binding 0.0008618 Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 3.143e-11 Informative Direct
Molecular Function (MF) peptidase regulator activity 6.049e-10 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.005445 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.06413 Informative Inherited
Molecular Function (MF) transition metal ion binding 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) nuclease activity 1 Informative Inherited
Molecular Function (MF) calcium ion binding 4.203e-08 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 0 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) hormone binding 5.505e-08 Highly Informative Direct
Molecular Function (MF) cysteine-type endopeptidase regulator activity involved in apoptotic process 1.795e-07 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Molecular Function (MF) acetyltransferase activity 0.005881 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005013 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5067 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosol 0.0005797 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0004023 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0003793 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1043 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02723 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 2.247e-06 Informative Direct
Cellular Component (CC) extracellular space 0.0006195 Informative Direct
Cellular Component (CC) nucleolus 0.0009953 Informative Direct
Cellular Component (CC) secretory granule 2.368e-08 Informative Direct
Cellular Component (CC) contractile fiber part 1.26e-06 Informative Direct
Cellular Component (CC) endosome 0.0387 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.03314 Informative Inherited
Cellular Component (CC) vacuolar part 0.961 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) chromatin 0.0007105 Highly Informative Direct
Cellular Component (CC) centrosome 0.0001777 Highly Informative Direct
Cellular Component (CC) midbody 6.514e-05 Highly Informative Direct
Cellular Component (CC) sarcolemma 1.641e-13 Highly Informative Direct
Cellular Component (CC) endosomal part 0.01414 Highly Informative Inherited
Cellular Component (CC) sarcomere 0.008954 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides1.738e-06Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1InformativeInherited
Enzyme Commission (EC)Protein-glutamine gamma-glutamyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase6.359e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.1976Least InformativeInherited
Disease Ontology (DO)skin disease0.006659Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.5752Moderately InformativeInherited
Disease Ontology (DO)dermatitis herpetiformis3.222e-07InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.1843Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02308InformativeInherited
Phenotypic Abnormality (PA)Melanoma0.0001368Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.2762Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant2.959e-07Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.9645Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant7.096e-15Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant2.651e-08Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.0803Moderately InformativeInherited
Worm Phenotype (WP)basement membrane remodeling variant2.184e-09InformativeDirect
Worm Phenotype (WP)osmotic integrity variant6.743e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0002474InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1.533e-09Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)RNA-directed RNA polymerase2.795e-06InformativeDirect
Enzyme Commission (EC)In linear amides3.13e-06InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.839InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0Highly InformativeDirect
Enzyme Commission (EC)N-acetylmuramoyl-L-alanine amidase5.693e-08Highly InformativeDirect
Enzyme Commission (EC)Nucleoside-triphosphate phosphatase6.33e-06Highly InformativeDirect
Enzyme Commission (EC)Dipeptidyl-peptidases and tripeptidyl-peptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processProtein transport0Moderately InformativeDirect
Biological processHost-virus interaction1.592e-09Moderately InformativeDirect
Biological processCell cycle3.804e-07Moderately InformativeDirect
Biological processDifferentiation0.006123Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processMitosis8.138e-12InformativeDirect
Biological processViral RNA replication2.734e-08InformativeDirect
Biological processEndocytosis4.674e-08InformativeDirect
Biological processWnt signaling pathway5.209e-07InformativeDirect
Biological processVirus entry into host cell0.042InformativeInherited
Biological processAutophagy0Highly InformativeDirect
Biological processModulation of host ubiquitin pathway by viral deubiquitinase0Highly InformativeDirect
Biological processUnfolded protein response2.7e-08Highly InformativeDirect
Biological processSpermatogenesis1.982e-07Highly InformativeDirect
Biological processClathrin-mediated endocytosis of virus by host1.235e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndoplasmic reticulum2.059e-11Moderately InformativeDirect
Cellular componentSecreted6.773e-11Moderately InformativeDirect
Cellular componentEndosome5.375e-07Moderately InformativeDirect
Cellular componentCytoskeleton3.829e-05Moderately InformativeDirect
Cellular componentCell projection0.1955Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentHost cytoplasm0InformativeDirect
Cellular componentHost nucleus0InformativeDirect
Cellular componentVacuole2.422e-05InformativeDirect
Cellular componentHost membrane0.0004452InformativeDirect
Cellular componentHost cytoplasmic vesicle4.256e-12Highly InformativeDirect
Cellular componentProteasome4.886e-07Highly InformativeDirect
Cellular componentCilium0.0001353Highly InformativeDirect
Developmental stageLate protein0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainZinc-finger1.212e-05Moderately InformativeDirect
DomainWD repeat6.122e-05InformativeDirect
Molecular functionZinc1.767e-06Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCadmium5.449e-10Highly InformativeDirect
Molecular functionChloride0.0001002Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease1Moderately InformativeInherited
Post-translational modificationNucleotidyltransferase1Moderately InformativeInherited
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationAcyltransferase8.845e-16InformativeDirect
Post-translational modificationExonuclease3.602e-13InformativeDirect
Post-translational modificationAntimicrobial0.03743InformativeInherited
Post-translational modificationIon channel0.1696InformativeInherited
Post-translational modificationViral ion channel1.893e-11Highly InformativeDirect
Post-translational modificationRNA-directed RNA polymerase1.227e-08Highly InformativeDirect
Post-translational modificationDisulfide bond0.0002441Least InformativeDirect
Post-translational modificationUbl conjugation1.547e-05Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationAutocatalytic cleavage2.579e-13InformativeDirect
Post-translational modificationMyristate0.0001336InformativeDirect
Post-translational modificationCovalent protein-RNA linkage1.687e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details) Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cysteine proteinases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Cysteine proteinases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]