SUPERFAMILY 1.75 HMM library and genome assignments server

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Interleukin 8-like chemokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   IL8-like [ 54116] (2)
Superfamily:   Interleukin 8-like chemokines [ 54117]
Families:   Interleukin 8-like chemokines [ 54118] (24)

Superfamily statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,033 5,645 51
Proteins 2,029 5,588 51

Functional annotation
General category Processes_EC
Detailed category Immune response

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02682Least InformativeInherited
Disease Ontology (DO)nervous system disease1Least InformativeInherited
Disease Ontology (DO)skin disease0.00000000002098Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.00000000006673Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0000003857Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000871Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.001761Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0275Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1606Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.3208Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3593Moderately InformativeInherited
Disease Ontology (DO)arthritis0.000000006338InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0000000219InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000003214InformativeDirect
Disease Ontology (DO)asthma0.0001134InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0008382InformativeDirect
Disease Ontology (DO)lymphoma0.02043InformativeInherited
Disease Ontology (DO)collagen disease0.1408InformativeInherited
Disease Ontology (DO)rheumatic disease0.1496InformativeInherited
Disease Ontology (DO)viral infectious disease0.867InformativeInherited
Disease Ontology (DO)aggressive systemic mastocytosis0.0005566Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00005887Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0003687Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.7824Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0001249Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2958Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.00009041Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

InterPro annotation
Cross references IPR001811 SSF54117 Protein matches
Abstract Synonym(s): cytokine, intecrine

Many low-molecular weight factors secreted by cells including fibroblasts, macrophages and endothelial cells, in response to a variety of stimuli such as growth factors, interferons, viral transformation and bacterial products, are structurally related [PubMed1910690, PubMed2149646, PubMed2687068]. Most members of this family of proteins seem to have mitogenic, chemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds, as shown in the following schematic representation:

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'C': conserved cysteine involved in a disulphide bond.

These proteins can be sorted into two groups based on the spacing of the two amino-terminal cysteines. In the first group (see ), the two cysteines are separated by a single residue (C-x-C), while in the second group (see ), they are adjacent (C-C).

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Interleukin 8-like chemokines domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 44 hidden Markov models representing the Interleukin 8-like chemokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Internal database links ]