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Interleukin 8-like chemokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   IL8-like [ 54116] (2)
Superfamily:   Interleukin 8-like chemokines [ 54117]
Families:   Interleukin 8-like chemokines [ 54118] (24)


Superfamily statistics
Genomes (65) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,033 4,726 51
Proteins 2,029 4,686 51


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.0000000000023310Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00000000000042520.00109Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.099681Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.00021810.1172Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.49740.9512Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)ion transport0.000000088540.0000000006926Moderately InformativeDirect
Biological Process (BP)defense response0.000000000010210Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus0.0000000065510Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.00000060570.0001233Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000000047280.00003372Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00000000000021290.00003114Moderately InformativeDirect
Biological Process (BP)regulation of localization00Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)single-organism transport0.000000016030.0000003669Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.0000025280.000000474Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00000000088390.000000000000003734Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.00000082540.000007367Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.0000000010690.00000000001582Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0000000016450.00000000000001763Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0027430.08887Moderately InformativeInherited
Biological Process (BP)response to organic substance0.3131Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.7290.1213Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.00014620.00819Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.50941Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000041060.1568Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.25981Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.80821Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.84511Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0000072360.001808Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.11670.03573Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.00050610.4556Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)organelle organization0.13750.2135Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.00016060.04295Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.000000035850.003171Moderately InformativeInherited
Biological Process (BP)cell activation00InformativeDirect
Biological Process (BP)regulation of cytokine production0.000020470.0000000000003999InformativeDirect
Biological Process (BP)positive regulation of immune system process0.00000000000032130InformativeDirect
Biological Process (BP)movement of cell or subcellular component00InformativeDirect
Biological Process (BP)immune response0.0000000000023090InformativeDirect
Biological Process (BP)behavior0.000000000000042880.0000004801InformativeDirect
Biological Process (BP)positive regulation of gene expression0.00000000001820.000002116InformativeDirect
Biological Process (BP)vesicle-mediated transport0.00000000026440.00000006803InformativeDirect
Biological Process (BP)phosphorylation0.00000000015060.000000005011InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.00000010820.000000005942InformativeDirect
Biological Process (BP)metal ion transport00InformativeDirect
Biological Process (BP)regulation of defense response0.00053480.00004794InformativeDirect
Biological Process (BP)regulation of protein modification process0.00018370.0004241InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.0000000000020410InformativeDirect
Biological Process (BP)secretion by cell0.0000000041230.00000000297InformativeDirect
Biological Process (BP)locomotion00InformativeDirect
Biological Process (BP)regulation of locomotion00InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00000001390.0000000004858InformativeDirect
Biological Process (BP)regulation of apoptotic process0.00000000000034990.00000000002564InformativeDirect
Biological Process (BP)regulation of ion transport0.0000000000038270.00000000000242InformativeDirect
Biological Process (BP)interspecies interaction between organisms0.00000000019870InformativeDirect
Biological Process (BP)regulation of cell differentiation0.00000011110.00002127InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process00InformativeDirect
Biological Process (BP)positive regulation of transport0.000000068470.0000000000115InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000000015270.00001316InformativeDirect
Biological Process (BP)regulation of cellular component movement00InformativeDirect
Biological Process (BP)localization of cell00InformativeDirect
Biological Process (BP)cation homeostasis00InformativeDirect
Biological Process (BP)cellular chemical homeostasis00.00000000000001079InformativeDirect
Biological Process (BP)transmembrane transport0.000000000014820.00000000000006343InformativeDirect
Biological Process (BP)cellular response to lipid0.000096190.000000519InformativeDirect
Biological Process (BP)inorganic ion homeostasis00InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.000000011250.0000000008395InformativeDirect
Biological Process (BP)negative regulation of cell death10.8022InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0022030.02485InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.00081120.01868InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.14160.3229InformativeInherited
Biological Process (BP)response to bacterium0.21780.6903InformativeInherited
Biological Process (BP)response to organic cyclic compound0.073270.3429InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.34490.0596InformativeInherited
Biological Process (BP)regulation of phosphorylation11InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.000027370.02745InformativeInherited
Biological Process (BP)regulation of system process0.0012930.00009564InformativeInherited
Biological Process (BP)regulation of protein localization0.36120.8225InformativeInherited
Biological Process (BP)regulation of peptide transport0.08790.03641InformativeInherited
Biological Process (BP)regulation of secretion0.044250.01765InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.074930.5984InformativeInherited
Biological Process (BP)generation of neurons11InformativeInherited
Biological Process (BP)positive regulation of developmental process0.6560.7969InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)immune effector process11InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.046540.01634InformativeInherited
Biological Process (BP)intracellular signal transduction0.68790.8021InformativeInherited
Biological Process (BP)regulation of cellular localization11InformativeInherited
Biological Process (BP)response to radiation0.0014490.003179InformativeInherited
Biological Process (BP)cell cycle process0.038840.7558InformativeInherited
Biological Process (BP)regulation of cell cycle0.80781InformativeInherited
Biological Process (BP)circulatory system development0.023060.06384InformativeInherited
Biological Process (BP)anatomical structure formation involved in morphogenesis0.000092630.006581InformativeInherited
Biological Process (BP)MAPK cascade0.0000000078280.00000000002619Highly InformativeDirect
Biological Process (BP)angiogenesis0.0000039210.0000001615Highly InformativeDirect
Biological Process (BP)positive regulation of cytokine production0.000000460.00000000002864Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.00000000000008880Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process0.00000000000071010.000000000001965Highly InformativeDirect
Biological Process (BP)regulation of leukocyte migration00Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis00Highly InformativeDirect
Biological Process (BP)inflammatory response00Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway0.000028330.000103Highly InformativeDirect
Biological Process (BP)cell-cell signaling00Highly InformativeDirect
Biological Process (BP)hemostasis0.000000014020.00000006753Highly InformativeDirect
Biological Process (BP)regulation of cell shape0.0000000025250.000000000001575Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000093670.0000000007432Highly InformativeDirect
Biological Process (BP)antimicrobial humoral response0.000000013350Highly InformativeDirect
Biological Process (BP)second-messenger-mediated signaling0.000000000000033280.000000000003243Highly InformativeDirect
Biological Process (BP)positive regulation of cell migration00.00000000000006667Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process00Highly InformativeDirect
Biological Process (BP)killing of cells of other organism00Highly InformativeDirect
Biological Process (BP)positive regulation of response to external stimulus00Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 production0.0000000026240.00000000000125Highly InformativeDirect
Biological Process (BP)negative regulation of homeostatic process0.0000000000000091160Highly InformativeDirect
Biological Process (BP)positive regulation of homeostatic process0.00000000019140.000000003899Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.00053210.00001488Highly InformativeDirect
Biological Process (BP)granulocyte activation00.0001409Highly InformativeDirect
Biological Process (BP)gliogenesis0.000000014060.000000000000148Highly InformativeDirect
Biological Process (BP)positive regulation of apoptotic process0.0000024090.0006647Highly InformativeDirect
Biological Process (BP)positive regulation of ion transport00Highly InformativeDirect
Biological Process (BP)leukocyte degranulation0.00000036720.0000000002506Highly InformativeDirect
Biological Process (BP)regulation of neuron apoptotic process0.000058130.000004207Highly InformativeDirect
Biological Process (BP)negative regulation of multi-organism process0.0000000000057150.00000000000002769Highly InformativeDirect
Biological Process (BP)positive regulation of nucleotide metabolic process0.0000000023570.00000000000001079Highly InformativeDirect
Biological Process (BP)coagulation0.00015390.000006002Highly InformativeDirect
Biological Process (BP)regulation of calcium-mediated signaling0.0000000057960.0000000000000538Highly InformativeDirect
Biological Process (BP)leukocyte migration00Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.000095010.00005492Highly InformativeDirect
Biological Process (BP)interaction with symbiont0.0000000000010370.0000000000005312Highly InformativeDirect
Biological Process (BP)regulation of calcium ion transport0.00000076760.000000002486Highly InformativeDirect
Biological Process (BP)cell chemotaxis00Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus00Highly InformativeDirect
Biological Process (BP)divalent inorganic cation transport00Highly InformativeDirect
Biological Process (BP)response to alcohol0.00031790.000002414Highly InformativeDirect
Biological Process (BP)inorganic cation transmembrane transport00Highly InformativeDirect
Biological Process (BP)positive regulation of secretion by cell0.00033690.000001553Highly InformativeDirect
Biological Process (BP)regulation of hemopoiesis0.0000000061040.0000000003527Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport00Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.000018020.00000000000007621Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process11Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.10930.1545Highly InformativeInherited
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction0.0010770.1872Highly InformativeInherited
Biological Process (BP)positive regulation of peptide secretion0.11770.1361Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.52380.5706Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.0014670.00004733Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.045120.1673Highly InformativeInherited
Biological Process (BP)regulation of fibroblast proliferation0.019950.03407Highly InformativeInherited
Biological Process (BP)positive regulation of cell development0.03480.2126Highly InformativeInherited
Biological Process (BP)positive regulation of nervous system development0.440.9689Highly InformativeInherited
Biological Process (BP)regulation of viral process0.012220.01663Highly InformativeInherited
Biological Process (BP)myeloid cell activation involved in immune response0.17520.06626Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte proliferation0.20880.0903Highly InformativeInherited
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.0024470.00002822Highly InformativeInherited
Biological Process (BP)regulation of cell killing0.030030.001312Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)transferase activity0.035930.296Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000000010950.0001887Moderately InformativeDirect
Molecular Function (MF)molecular function regulator0.000000000000032560.0000000000002491Moderately InformativeDirect
Molecular Function (MF)anion binding0.0016380.01923Moderately InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.1220.1303Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)enzyme activator activity0.000000040210.000005091InformativeDirect
Molecular Function (MF)kinase activity0.00000000025310.00001129InformativeDirect
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0000000000017930.000002006InformativeDirect
Molecular Function (MF)sulfur compound binding0.000000089770.0000001177InformativeDirect
Molecular Function (MF)G-protein coupled receptor binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.0000000000000013860.00000001631Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding00Highly InformativeDirect
Molecular Function (MF)heparin binding0.0000000000000020690.0000000000000108Highly InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00109 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1172 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.9512 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0.0000000006926 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0001233 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00003372 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00003114 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000003669 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000474 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000000003734 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000007367 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000000001582 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000000000001763 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.1213 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00819 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.03573 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08887 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1568 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001808 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.4556 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2135 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04295 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.003171 Moderately Informative Inherited
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000000000003999 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) behavior 0.0000004801 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000002116 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00000006803 Informative Direct
Biological Process (BP) phosphorylation 0.000000005011 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000005942 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) regulation of defense response 0.00004794 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0004241 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) secretion by cell 0.00000000297 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of locomotion 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000004858 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000002564 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000000000242 Informative Direct
Biological Process (BP) regulation of system process 0.00009564 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.00002127 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.0000000000115 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001316 Informative Direct
Biological Process (BP) regulation of cellular component movement 0 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.0005529 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.00000000000001079 Informative Direct
Biological Process (BP) transmembrane transport 0.00000000000006343 Informative Direct
Biological Process (BP) cellular response to lipid 0.000000519 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0000000008395 Informative Direct
Biological Process (BP) negative regulation of cell death 0.8022 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.01868 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3229 Informative Inherited
Biological Process (BP) response to bacterium 0.6903 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3429 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0596 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.02745 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.3661 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8225 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.03641 Informative Inherited
Biological Process (BP) regulation of secretion 0.01765 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.5984 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7969 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.002953 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01634 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02485 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8021 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) response to radiation 0.003179 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.9388 Informative Inherited
Biological Process (BP) cell cycle process 0.7558 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) circulatory system development 0.06384 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.006581 Informative Inherited
Biological Process (BP) MAPK cascade 0.00000000002619 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000001615 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00000000002864 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000000000001965 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000103 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000006753 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.000111 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000000001575 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000007432 Highly Informative Direct
Biological Process (BP) antimicrobial humoral response 0 Highly Informative Direct
Biological Process (BP) second-messenger-mediated signaling 0.000000000003243 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.00000000000006667 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) killing of cells of other organism 0 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 production 0.00000000000125 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000000003899 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00001488 Highly Informative Direct
Biological Process (BP) granulocyte activation 0.0001409 Highly Informative Direct
Biological Process (BP) gliogenesis 0.000000000000148 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.0006647 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0 Highly Informative Direct
Biological Process (BP) leukocyte degranulation 0.0000000002506 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.000004207 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.00000000000002769 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00001536 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.00000000000001079 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00004733 Highly Informative Direct
Biological Process (BP) coagulation 0.000006002 Highly Informative Direct
Biological Process (BP) regulation of calcium-mediated signaling 0.0000000000000538 Highly Informative Direct
Biological Process (BP) leukocyte migration 0 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000004797 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.00005492 Highly Informative Direct
Biological Process (BP) interaction with symbiont 0.0000000000005312 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000000002486 Highly Informative Direct
Biological Process (BP) cell chemotaxis 0 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000002414 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000001553 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.0000000003527 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.00000000000007621 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00002822 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.2882 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.8686 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1545 Highly Informative Inherited
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.1872 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.6767 Highly Informative Inherited
Biological Process (BP) positive regulation of peptide secretion 0.1361 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.5706 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.1673 Highly Informative Inherited
Biological Process (BP) regulation of fibroblast proliferation 0.03407 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.2126 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.9689 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.01663 Highly Informative Inherited
Biological Process (BP) regulation of GTPase activity 0.001074 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.06626 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.0903 Highly Informative Inherited
Biological Process (BP) regulation of cell killing 0.001312 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.296 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0001887 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0000000000002491 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01923 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.1303 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) enzyme activator activity 0.000005091 Informative Direct
Molecular Function (MF) kinase activity 0.00001129 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000002006 Informative Direct
Molecular Function (MF) sulfur compound binding 0.0000001177 Informative Direct
Molecular Function (MF) signal transducer activity 0.8744 Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000001631 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000000000000108 Highly Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processInflammatory response0InformativeDirect
Biological processChemotaxis0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationAntimicrobial0.0000564InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationAntibiotic0.000001297Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationCitrullination0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001811 SSF54117 Protein matches
Abstract Synonym(s): cytokine, intecrine

Many low-molecular weight factors secreted by cells including fibroblasts, macrophages and endothelial cells, in response to a variety of stimuli such as growth factors, interferons, viral transformation and bacterial products, are structurally related [PubMed1910690, PubMed2149646, PubMed2687068]. Most members of this family of proteins seem to have mitogenic, chemotactic or inflammatory activities. These small cytokines are also called intercrines or chemokines. They are cationic proteins of 70 to 100 amino acid residues that share four conserved cysteine residues involved in two disulphide bonds, as shown in the following schematic representation:

                             +------------------------------------+
                             |                                    |
     xxxxxxxxxxxxxxxxxxxxxxCxCxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxCxxxxx
                           |                         |
                           +-------------------------+

'C': conserved cysteine involved in a disulphide bond.

These proteins can be sorted into two groups based on the spacing of the two amino-terminal cysteines. In the first group (see ), the two cysteines are separated by a single residue (C-x-C), while in the second group (see ), they are adjacent (C-C).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 31 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Interleukin 8-like chemokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 31 hidden Markov models representing the Interleukin 8-like chemokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]