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Ribosomal protein S5 domain 2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ribosomal protein S5 domain 2-like [ 54210]
Superfamily:   Ribosomal protein S5 domain 2-like [ 54211] (12)
Families:   Translational machinery components [ 54212] (4)
  RNase P protein [ 54220]
  DNA gyrase/MutL, second domain [ 54224] (6)
  Hsp90 middle domain [ 102755]
  Ribonuclease PH domain 1-like [ 54229] (10)
  GHMP Kinase, N-terminal domain [ 54232] (6)
  Early switch protein XOL-1, N-terminal domain [ 89824]
  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC [ 89827]
  Imidazole glycerol phosphate dehydratase [ 102766]
  ATP-dependent protease Lon (La), catalytic domain [ 102769]
  YigZ N-terminal domain-like [ 102772] (2)
  Formaldehyde-activating enzyme, FAE [ 117795]


Superfamily statistics
Genomes (3,261) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 73,356 396,693 102
Proteins 66,488 358,007 93


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular nitrogen compound metabolic process0.00011510Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.00050030.0000000931Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.071890.00005365Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.60091Least InformativeInherited
Biological Process (BP)biosynthetic process0.12990.00003014Least InformativeInherited
Biological Process (BP)primary metabolic process0.069840Least InformativeInherited
Biological Process (BP)gene expression0.00000000012930Moderately InformativeDirect
Biological Process (BP)peptide metabolic process0.000000094080Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.00000026290Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.0006720.00000002024Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.0063080.000007392Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.070861Moderately InformativeInherited
Biological Process (BP)ribonucleoprotein complex subunit organization0.000013990InformativeDirect
Molecular Function (MF)structural molecule activity0.000000000000014450.0000000001746Moderately InformativeDirect
Cellular Component (CC)macromolecular complex0.00000870.00000000004805Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.72581Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.00031621Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.000000031530.0921Least InformativeInherited
Cellular Component (CC)cytosolic part0.00000000038650.0009044Moderately InformativeDirect
Cellular Component (CC)ribosome0.00000000040930Moderately InformativeDirect
Cellular Component (CC)small ribosomal subunit0.0000000000000077670InformativeDirect
Cellular Component (CC)cytosolic ribosome0.025410.5206InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit0.000094230.00001649Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0000000931 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00005365 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00003014 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.00001648 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.000007604 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.00006466 Least Informative Direct
Biological Process (BP) response to stimulus 0.0000000000002605 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.9783 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000002024 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000007392 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000005228 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000006174 Moderately Informative Direct
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01103 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.005701 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.804 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.857 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2261 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1893 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.814 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5221 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.6541 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) ribonucleoprotein complex subunit organization 0 Informative Direct
Biological Process (BP) ncRNA processing 0.0001381 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000000000463 Informative Direct
Biological Process (BP) DNA metabolic process 0.000000005473 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.00000002265 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000006073 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.00000007757 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000009919 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00001369 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0002745 Informative Direct
Biological Process (BP) growth 0.1972 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6452 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1082 Informative Inherited
Biological Process (BP) cell cycle process 0.2114 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.02458 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.003848 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.8579 Informative Inherited
Biological Process (BP) transmembrane transport 0.9156 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.588 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.7356 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.007709 Informative Inherited
Biological Process (BP) response to oxidative stress 0.7315 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.5906 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.1822 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.03054 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.9445 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.6652 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.7816 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9202 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) organelle assembly 0.3751 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.03175 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.4325 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0.001819 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5262 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5625 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) chromosome organization 0.08719 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.1423 Informative Inherited
Biological Process (BP) tRNA metabolic process 0.893 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1114 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.229 Informative Inherited
Biological Process (BP) ribosome biogenesis 0.02676 Informative Inherited
Biological Process (BP) ribosome assembly 0.0009271 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to antibiotic 0 Highly Informative Direct
Biological Process (BP) response to estrogen 0 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000000000003119 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0000000003048 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000002444 Highly Informative Direct
Biological Process (BP) protein folding 0.00000005269 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.0000002298 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0000004992 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0000005419 Highly Informative Direct
Biological Process (BP) rRNA metabolic process 0.0000005771 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.000002447 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.00000296 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.000005034 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000006765 Highly Informative Direct
Biological Process (BP) secondary alcohol metabolic process 0.000008316 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000009557 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.00002257 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.00004383 Highly Informative Direct
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.00005481 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.00005501 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0.00006676 Highly Informative Direct
Biological Process (BP) nuclear division 0.0001766 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.06677 Highly Informative Inherited
Biological Process (BP) cell growth 0.1143 Highly Informative Inherited
Biological Process (BP) neuron development 0.8861 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.9211 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.06196 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.02461 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1449 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2553 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.1974 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.003438 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.04186 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.2163 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.001052 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.07518 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.1072 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.02341 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.03211 Highly Informative Inherited
Biological Process (BP) response to UV 0.002995 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.6997 Highly Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.2585 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.6626 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.0000000001746 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000001309 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000000001435 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000008709 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000004142 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000002878 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.9577 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.175 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.1612 Moderately Informative Inherited
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) nuclease activity 0.000000000000001646 Informative Direct
Molecular Function (MF) RNA binding 0.000000000001945 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.0001841 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.1156 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.02099 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.008293 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.8108 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000007365 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.000003039 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.02752 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0.00000000004805 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000002922 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0921 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.0009044 Moderately Informative Direct
Cellular Component (CC) ribosome 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.001362 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.009915 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0 Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.00001383 Informative Direct
Cellular Component (CC) cytosolic ribosome 0.5206 Informative Inherited
Cellular Component (CC) chromosome 0.1552 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 0.00001649 Highly Informative Direct
Cellular Component (CC) mitochondrial small ribosomal subunit 0.00000000001896 Highly Informative Direct
Cellular Component (CC) symplast 0.0003779 Highly Informative Direct
Cellular Component (CC) germ cell nucleus 0.0004694 Highly Informative Direct
Cellular Component (CC) chromatin 0.9542 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.312 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.2271 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.8974 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.03273Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.3584InformativeInherited
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.03384Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2542Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4524Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.6342Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0176Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.08226Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.08415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.134Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1764Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1903Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1973Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.2981Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5281Moderately InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.0006503InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002719InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the biliary system0.004856InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.007359InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.03905InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.06013InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.1413InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.1826InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.2575InformativeInherited
Phenotypic Abnormality (PA)Endometrial carcinoma0.0000008408Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the small intestine0.000001355Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.000005228Highly InformativeDirect
Phenotypic Abnormality (PA)Hereditary nonpolyposis colorectal carcinoma0.000006245Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000007305Highly InformativeDirect
Phenotypic Abnormality (PA)Biliary tract neoplasm0.00003662Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00005979Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.00008403Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent urinary tract infections0.0003989Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the stomach0.0004464Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the pancreas0.0004662Highly InformativeDirect
Phenotypic Abnormality (PA)Renal neoplasm0.0006952Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal obstruction0.0007068Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0007209Highly InformativeDirect
Phenotypic Abnormality (PA)Primitive neuroectodermal tumor0.0007209Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.003769Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02613Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.09167Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.1211Least InformativeInherited
Worm Phenotype (WP)larval development variant0.2436Least InformativeInherited
Worm Phenotype (WP)cell development variant0.5291Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0349Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.07281Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.118Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1265Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.0000002258InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.0004731InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0004916InformativeDirect
Worm Phenotype (WP)diplotene progression during oogenesis variant0.0005522InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0004148Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0.0008318Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.0002765Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.003504Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.000000000104Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.2934Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)In linear amides0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.4926Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processLipid metabolism0.000000000001012Moderately InformativeDirect
Biological processCarbohydrate metabolism0.002687Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processSteroid metabolism0.03665InformativeInherited
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.00000000001157Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.00004688InformativeDirect
Cellular componentExosome0Highly InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationLyase0.000000000002619Moderately InformativeDirect
Post-translational modificationProtease0.0001577Moderately InformativeDirect
Post-translational modificationIsomerase1Moderately InformativeInherited
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.00000000001979Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0000000000002864Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)protein biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0.04611InformativeInherited
UniPathway (UP)terpene biosynthesis0.5023InformativeInherited
UniPathway (UP)steroid metabolism1InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)galactose metabolism0Highly InformativeDirect
UniPathway (UP)lipid IV(A) biosynthesis0Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.001332Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ribosomal protein S5 domain 2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the Ribosomal protein S5 domain 2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]