SUPERFAMILY 1.75 HMM library and genome assignments server

Ribosomal protein S5 domain 2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ribosomal protein S5 domain 2-like [ 54210]
Superfamily:   Ribosomal protein S5 domain 2-like [ 54211] (12)
Families:   Translational machinery components [ 54212] (4)
  RNase P protein [ 54220]
  DNA gyrase/MutL, second domain [ 54224] (6)
  Hsp90 middle domain [ 102755]
  Ribonuclease PH domain 1-like [ 54229] (10)
  GHMP Kinase, N-terminal domain [ 54232] (6)
  Early switch protein XOL-1, N-terminal domain [ 89824]
  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase LpxC [ 89827]
  Imidazole glycerol phosphate dehydratase [ 102766]
  ATP-dependent protease Lon (La), catalytic domain [ 102769]
  YigZ N-terminal domain-like [ 102772] (2)
  Formaldehyde-activating enzyme, FAE [ 117795]


Superfamily statistics
Genomes (3,255) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 73,153 363,446 102
Proteins 66,289 325,948 93


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.11580.0000006229Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.019020.00000000000006308Least InformativeInherited
Biological Process (BP)protein metabolic process0.048580.4283Least InformativeInherited
Biological Process (BP)gene expression0.000015070Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00050220.00000000001184Moderately InformativeDirect
Molecular Function (MF)structural molecule activity0.00000089870.000003712Moderately InformativeDirect
Molecular Function (MF)structural constituent of ribosome0.000000054640.0000000000000676InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.00030790.0001936Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.062510.4517Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.35270.177Least InformativeInherited
Cellular Component (CC)ribonucleoprotein complex0.0000000028220.00000000000007324Moderately InformativeDirect
Cellular Component (CC)cytosol0.031130.01793Moderately InformativeInherited
Cellular Component (CC)small ribosomal subunit0.0000000000012180InformativeDirect
Cellular Component (CC)cytosolic ribosome0.17720.229InformativeInherited
Cellular Component (CC)cytosolic small ribosomal subunit0.00042490.000004801Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0.00000000000006308 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0000006229 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00002779 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.4283 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000000001184 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0002737 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.6294 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04142 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.03558 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.6499 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.9576 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8058 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0 Informative Direct
Biological Process (BP) organophosphate catabolic process 0 Informative Direct
Biological Process (BP) mitochondrion organization 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0 Informative Direct
Biological Process (BP) DNA repair 0.0000000001099 Informative Direct
Biological Process (BP) ribonucleoprotein complex biogenesis 0.00000004813 Informative Direct
Biological Process (BP) isoprenoid metabolic process 0.0000001709 Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000004969 Informative Direct
Biological Process (BP) cell division 0.0002274 Informative Direct
Biological Process (BP) response to cytokine 0.623 Informative Inherited
Biological Process (BP) organelle localization 0.6465 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.8093 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.9304 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.582 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.9664 Informative Inherited
Biological Process (BP) immune effector process 0.3546 Informative Inherited
Biological Process (BP) immune response 0.7555 Informative Inherited
Biological Process (BP) leukocyte activation 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.3516 Informative Inherited
Biological Process (BP) RNA processing 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) hexose metabolic process 0.04549 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 1 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.8916 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.001339 Informative Inherited
Biological Process (BP) cell cycle process 0.01564 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.07749 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001481 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.001168 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.2618 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.001727 Informative Inherited
Biological Process (BP) organelle fission 0.03777 Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0 Highly Informative Direct
Biological Process (BP) galactose metabolic process 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0.000000000000007248 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000000000002478 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.000000000006048 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0000000000191 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.00000001487 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.00000002538 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.00000007436 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.000002703 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000009197 Highly Informative Direct
Biological Process (BP) response to heat 0.00001708 Highly Informative Direct
Biological Process (BP) carbohydrate phosphorylation 0.00002446 Highly Informative Direct
Biological Process (BP) imidazole-containing compound metabolic process 0.00009891 Highly Informative Direct
Biological Process (BP) isoprenoid biosynthetic process 0.0001787 Highly Informative Direct
Biological Process (BP) nuclear division 0.0004037 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0009616 Highly Informative Direct
Biological Process (BP) B cell activation 0.01668 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.2406 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.04642 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.3508 Highly Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.0856 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.1158 Highly Informative Inherited
Biological Process (BP) nucleoside monophosphate catabolic process 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.01004 Highly Informative Inherited
Biological Process (BP) rRNA processing 0.02968 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.002664 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.000003712 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.000000001531 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000003047 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0001313 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0007122 Moderately Informative Direct
Molecular Function (MF) anion binding 0.01131 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.201 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.2214 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.001153 Moderately Informative Inherited
Molecular Function (MF) structural constituent of ribosome 0.0000000000000676 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) nuclease activity 0.000000000000146 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000003011 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000001028 Informative Direct
Molecular Function (MF) RNA binding 0.000000001874 Informative Direct
Molecular Function (MF) nucleotide binding 0.0000008178 Informative Direct
Molecular Function (MF) kinase activity 0.7826 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.1623 Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.004008 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.7744 Informative Inherited
Molecular Function (MF) peptidase activity 1 Informative Inherited
Molecular Function (MF) carbon-carbon lyase activity 0.02899 Informative Inherited
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) carbohydrate kinase activity 8.141e-16 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.00001542 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.00003111 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0003228 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00474 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0001936 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.177 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4517 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.04101 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.00000000000007324 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.000003862 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.00007052 Moderately Informative Direct
Cellular Component (CC) cytosol 0.01793 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.9922 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.04465 Moderately Informative Inherited
Cellular Component (CC) small ribosomal subunit 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0.229 Informative Inherited
Cellular Component (CC) plastid 0.002955 Informative Inherited
Cellular Component (CC) cell junction 0.5563 Informative Inherited
Cellular Component (CC) mitochondrial matrix 0.002193 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.0237 Informative Inherited
Cellular Component (CC) chromosome 0.07039 Informative Inherited
Cellular Component (CC) cytosolic small ribosomal subunit 0.000004801 Highly Informative Direct
Cellular Component (CC) symplast 0.0003314 Highly Informative Direct
Cellular Component (CC) mitochondrial ribosome 0.001564 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.5483 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.03273Least InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited
Enzyme Commission (EC)Aldehyde-lyases0.3584InformativeInherited
Enzyme Commission (EC)Endopeptidase La0Highly InformativeDirect
Enzyme Commission (EC)Homoserine kinase0Highly InformativeDirect
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)Histidinol-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.01203Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.1996Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02958Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.1736Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2516Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3171Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bleeding0.01122InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.02231InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.02254InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.02532InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1294InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.3039InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm0.00001894Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine0.00004248Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0003352Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0003866Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.0003866Highly InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.04227Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.09001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gametes0.009064InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.009064InformativeInherited
Mammalian Phenotype (MP)abnormal male germ cell morphology0.01345InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01878InformativeInherited
Mammalian Phenotype (MP)azoospermia0.0004397Highly InformativeDirect
Mammalian Phenotype (MP)abnormal meiosis0.0005355Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.3432Least InformativeInherited
Worm Phenotype (WP)growth variant0.3714Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.01511Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.03872Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.07052Moderately InformativeInherited
Worm Phenotype (WP)germ cell compartment expansion variant0.0001344InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0001353InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.0001518InformativeDirect
Worm Phenotype (WP)diplotene progression during oogenesis variant0.0001846InformativeDirect
Worm Phenotype (WP)early larval arrest0.00006174Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0001192Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.023Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.001274InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.000278Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.01931Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Endoribonucleases producing 5'-phosphomonoesters0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acceptor1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Polyribonucleotide nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ribonuclease P0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Aldehyde-lyases0.4395Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antiinfectives for systemic use0.0000007456Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.001075Least InformativeInherited
Drugbank ATC_code (DB)antibacterials for systemic use0.1439Moderately InformativeInherited
Drugbank ATC_code (DB)quinolone antibacterials0.0001039InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processLipid metabolism0.000000000001903Moderately InformativeDirect
Biological processCarbohydrate metabolism0.001145Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processSteroid metabolism0.09547InformativeInherited
Biological processHistidine biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Biological processSterol biosynthesis0.000000006012Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.0002721InformativeDirect
DomainTransit peptide0.000005698Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRibonucleoprotein0Moderately InformativeDirect
Post-translational modificationLyase0.00000000006791Moderately InformativeDirect
Post-translational modificationProtease0.00004527Moderately InformativeDirect
Post-translational modificationIsomerase1Moderately InformativeInherited
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationRibosomal protein0InformativeDirect
Post-translational modificationSerine protease0InformativeDirect
Post-translational modificationElongation factor0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)biopolymer metabolism0.00000000001003Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)biopolymer biosynthesis0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)cellular component biogenesis0.0000000000003468Moderately InformativeDirect
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)lipopolysaccharide biosynthesis0InformativeDirect
UniPathway (UP)L-histidine biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)protein biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0.04563InformativeInherited
UniPathway (UP)terpene metabolism0.6096InformativeInherited
UniPathway (UP)glycolipid biosynthesis1InformativeInherited
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)galactose metabolism0Highly InformativeDirect
UniPathway (UP)lipid IV(A) biosynthesis0Highly InformativeDirect
UniPathway (UP)cholesterol metabolism0.000005139Highly InformativeDirect
UniPathway (UP)sterol biosynthesis0.001224Highly InformativeInherited

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ribosomal protein S5 domain 2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 58 hidden Markov models representing the Ribosomal protein S5 domain 2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]