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Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (630) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,609 109,721 156
Proteins 41,024 93,386 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process0.044790.00000003788Least InformativeInherited
Biological Process (BP)response to stimulus0.18850.000000000534Least InformativeInherited
Biological Process (BP)biological regulation0.23660.0000000000009644Least InformativeInherited
Biological Process (BP)single-organism cellular process10.7957Least InformativeInherited
Biological Process (BP)multicellular organismal process0.69840.00007972Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.58060Least InformativeInherited
Biological Process (BP)cellular response to stress0.0000046350.0000004549Moderately InformativeDirect
Biological Process (BP)regulation of localization0.16060.005172Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.084370.00000004633Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.13950Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.26750.979Moderately InformativeInherited
Biological Process (BP)organelle organization0.085340.0001916Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process10.0000002002Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.21760.03019Moderately InformativeInherited
Biological Process (BP)cell differentiation0.7050.513Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.000000000000078140.06099Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.74020.000002835Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.077110Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.48120.095Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification00.00009434InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.069470.05811InformativeInherited
Biological Process (BP)regulation of ion transport0.21820.602InformativeInherited
Biological Process (BP)negative regulation of transport0.063610.04971InformativeInherited
Biological Process (BP)negative regulation of molecular function0.12610.435InformativeInherited
Biological Process (BP)regulation of protein modification process0.00067680.1047InformativeInherited
Biological Process (BP)response to metal ion0.0079710.558InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.00029670.4967InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.98960InformativeInherited
Biological Process (BP)cell death0.00036890.00584InformativeInherited
Biological Process (BP)post-embryonic development0.0002660.1336InformativeInherited
Biological Process (BP)cell development0.43360.3609InformativeInherited
Biological Process (BP)regulation of catabolic process0.0011530InformativeInherited
Biological Process (BP)mitochondrion organization0.067180.8296InformativeInherited
Biological Process (BP)organelle assembly0.0051910.1308InformativeInherited
Biological Process (BP)autophagy00Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification00.000000000000001925Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.000001120.000001594Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.00010690Highly InformativeDirect
Biological Process (BP)cellular response to cadmium ion0.00000000011750.000008202Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.000063920.0000002162Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.0030570.000688Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0010670.01812Highly InformativeInherited
Biological Process (BP)negative regulation of ion transmembrane transport0.00017480.001147Highly InformativeInherited
Biological Process (BP)post-embryonic animal morphogenesis0.000057560.002233Highly InformativeInherited
Biological Process (BP)programmed cell death involved in cell development0.000029680.02566Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00.01485Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)enzyme binding0.006370.00000000000001826InformativeInherited
Molecular Function (MF)transcription factor binding00.000000000006302Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.1350.01696Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00029331Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.022411Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.0102Least InformativeInherited
Cellular Component (CC)membrane0.71740.00592Least InformativeInherited
Cellular Component (CC)vacuole0.00000000000090170.0003579Moderately InformativeDirect
Cellular Component (CC)nuclear part0.029840.03134Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.021220.3901Moderately InformativeInherited
Cellular Component (CC)whole membrane0.000099980.5256Moderately InformativeInherited
Cellular Component (CC)transferase complex0.0084570.0000894Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.00022930.000006012InformativeDirect
Cellular Component (CC)ribonucleoprotein granule0.00000086290.2096InformativeInherited
Cellular Component (CC)lytic vacuole11InformativeInherited
Cellular Component (CC)vacuolar part0.0000016980.2037InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00007972 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000003788 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000534 Least Informative Direct
Biological Process (BP) biological regulation 0.0000000000009644 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7957 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.0001916 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000004668 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00006213 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00000000228 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000004549 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000002835 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.000000000000001925 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000001179 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000004633 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000002002 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.005172 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02434 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.003783 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.979 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.4558 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6745 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.08682 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6199 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4105 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7076 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.7496 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.513 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.06099 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.372 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.5284 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.641 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03019 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5996 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.095 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000004991 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0002851 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000265 Informative Direct
Biological Process (BP) microtubule-based process 0.0001808 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.0005134 Informative Direct
Biological Process (BP) embryo development 0.00005517 Informative Direct
Biological Process (BP) regulation of catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000008306 Informative Direct
Biological Process (BP) phosphorylation 0.00000000002224 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.00009434 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0002178 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000005517 Informative Direct
Biological Process (BP) regulation of proteolysis 0.000006443 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00000004857 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0002327 Informative Direct
Biological Process (BP) locomotion 0.0002039 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00002758 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0000000000001725 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0009914 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000001299 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000001684 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000155 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0001894 Informative Direct
Biological Process (BP) epithelium development 0.0000000001563 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0001118 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000000001951 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000166 Informative Direct
Biological Process (BP) negative regulation of transport 0.04971 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05811 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.435 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04101 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.5389 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.01702 Informative Inherited
Biological Process (BP) regulation of protein localization 0.005541 Informative Inherited
Biological Process (BP) regulation of ion transport 0.602 Informative Inherited
Biological Process (BP) intracellular transport 0.2779 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.002372 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.1493 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to metal ion 0.558 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.4967 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3711 Informative Inherited
Biological Process (BP) cation homeostasis 0.4724 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.3951 Informative Inherited
Biological Process (BP) circulatory system development 0.001433 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0134 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1723 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.9948 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.997 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.7994 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.549 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.1047 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03188 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8545 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9371 Informative Inherited
Biological Process (BP) cell cycle process 0.2967 Informative Inherited
Biological Process (BP) protein localization to organelle 0.7159 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) cell activation 0.215 Informative Inherited
Biological Process (BP) cell death 0.00584 Informative Inherited
Biological Process (BP) post-embryonic development 0.1336 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) protein transport 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9485 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.9359 Informative Inherited
Biological Process (BP) central nervous system development 0.2975 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7079 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.3391 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.00894 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.0992 Informative Inherited
Biological Process (BP) growth 0.4654 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01603 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) localization of cell 0.007271 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cell development 0.3609 Informative Inherited
Biological Process (BP) mitochondrion organization 0.8296 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1307 Informative Inherited
Biological Process (BP) organelle assembly 0.1308 Informative Inherited
Biological Process (BP) autophagy 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000000007296 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000001115 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0.00007842 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000000001292 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0000005784 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.0000001765 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000000000000001925 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.000001594 Highly Informative Direct
Biological Process (BP) lipid modification 0.00004042 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0003963 Highly Informative Direct
Biological Process (BP) positive regulation of cellular catabolic process 0.00000000006284 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0000000271 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.0000002154 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000002345 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0003443 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0002745 Highly Informative Direct
Biological Process (BP) cellular response to cadmium ion 0.000008202 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.000001457 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000003776 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0000001351 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000005745 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.0000002162 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00005293 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.000688 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.01812 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.31 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.0339 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.3307 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.6291 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.4102 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.016 Highly Informative Inherited
Biological Process (BP) negative regulation of ion transmembrane transport 0.001147 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.465 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9658 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.3466 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.9813 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.17 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.01057 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.9216 Highly Informative Inherited
Biological Process (BP) second-messenger-mediated signaling 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.9059 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.8512 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.7511 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.02583 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001591 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.01492 Highly Informative Inherited
Biological Process (BP) heart development 0.1594 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.4332 Highly Informative Inherited
Biological Process (BP) muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.01485 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.06268 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2585 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.2283 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1682 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.266 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.2188 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.09186 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.199 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.6403 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.002233 Highly Informative Inherited
Biological Process (BP) programmed cell death involved in cell development 0.02566 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1396 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.3854 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.2385 Highly Informative Inherited
Biological Process (BP) forebrain development 0.7063 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.02528 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1441 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.02289 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.1408 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.01802 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.0123 Highly Informative Inherited
Biological Process (BP) cell growth 0.06251 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3664 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1705 Highly Informative Inherited
Biological Process (BP) cell maturation 0.2965 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.2241 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.1569 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) protein folding 0.001774 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.8448 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.03672 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 0.1832 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.2747 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.08196 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.04713 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.9146 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.00000000000009544 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3821 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.004687 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0000003045 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00001751 Informative Direct
Molecular Function (MF) enzyme binding 0.00000000000001826 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000009551 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00271 Informative Inherited
Molecular Function (MF) kinase activity 0.007349 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.3218 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.6719 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.04105 Informative Inherited
Molecular Function (MF) phosphatase activity 0.3943 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000000000001775 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000006302 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0003978 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00007698 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.01942 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.001672 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) protein complex 0.2288 Least Informative Inherited
Cellular Component (CC) membrane 0.00592 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0102 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.01696 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vacuole 0.0003579 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000000002553 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.000000003427 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.0000894 Moderately Informative Direct
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.03134 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.005074 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.0695 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.3901 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5256 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000006012 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.000000000003553 Informative Direct
Cellular Component (CC) apical part of cell 0.0002118 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000000004273 Informative Direct
Cellular Component (CC) side of membrane 0.03261 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.2096 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.7668 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.01427 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.9754 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.03215 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.6245 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar part 0.2037 Informative Inherited
Cellular Component (CC) nuclear body 0.00002224 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0005691 Highly Informative Direct
Cellular Component (CC) presynapse 1 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 1 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.2724 Highly Informative Inherited
Cellular Component (CC) chromatin 0.7841 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000005609Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000004359Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000004443Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00003067Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000001949InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000366InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0.000000000612Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000008253Least InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processApoptosis4.846e-16Moderately InformativeDirect
Biological processImmunity0.000000004179Moderately InformativeDirect
Biological processDifferentiation0.0001368Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processEndocytosis0.0000001545InformativeDirect
Biological processNeurogenesis0.000008146InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport0.000000000003655Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000000002052Highly InformativeDirect
Biological processExocytosis0.00001773Highly InformativeDirect
Biological processAntiviral defense0.00003105Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.58e-16Least InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00003593Moderately InformativeDirect
Cellular componentGolgi apparatus0.0003975Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentProteasome0.000000001871Highly InformativeDirect
Cellular componentLipid droplet0.00000003728Highly InformativeDirect
Coding sequence diversityAlternative splicing0.000011Least InformativeDirect
DiseaseTumor suppressor0.00000002776Moderately InformativeDirect
DiseaseProto-oncogene0.000003987Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH2 domain0.0000000006998InformativeDirect
DomainSH3 domain0.00005719InformativeDirect
DomainLeucine-rich repeat0.0009365InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionLipid-binding0.00002571Moderately InformativeDirect
Molecular functioncAMP-binding0.000006286Highly InformativeDirect
Molecular functioncAMP0.0001992Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.003038Moderately InformativeInherited
Post-translational modificationKinase0.05287Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationProtein phosphatase0.000000000004771InformativeDirect
Post-translational modificationCalmodulin-binding0.0000001714InformativeDirect
Post-translational modificationChromatin regulator0.0000007585InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00001729InformativeDirect
Post-translational modificationMyosin2.219e-16Highly InformativeDirect
Post-translational modificationActin capping0.000008863Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00001466Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0008158Highly InformativeDirect
Post-translational modificationPhosphoprotein9.538e-16Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.0000004036InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]