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Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (630) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 48,609 109,721 156
Proteins 41,024 93,386 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0000000000000090330Least InformativeDirect
Biological Process (BP)biological regulation0.27940.000000000006821Least InformativeInherited
Biological Process (BP)single-organism cellular process10.4363Least InformativeInherited
Biological Process (BP)response to stimulus0.24990.000000001234Least InformativeInherited
Biological Process (BP)primary metabolic process0.12330.00000008797Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.35010Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular response to stress0.000052330.0000005578Moderately InformativeDirect
Biological Process (BP)regulation of localization0.10430.002967Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.054860.0000001019Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.14980Moderately InformativeInherited
Biological Process (BP)organelle organization0.020040.00007322Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.10130.8186Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.19780.01201Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.05180.003165Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process10.00000001151Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.030310Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.0000000000017410.08239Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.75390.000001655Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.56080.133Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification00.0003375InformativeDirect
Biological Process (BP)regulation of ion transport0.21020.6086InformativeInherited
Biological Process (BP)negative regulation of transport0.049620.03102InformativeInherited
Biological Process (BP)negative regulation of molecular function0.13170.3435InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.067170.05805InformativeInherited
Biological Process (BP)regulation of protein modification process0.00047170.1526InformativeInherited
Biological Process (BP)response to metal ion0.0059640.4846InformativeInherited
Biological Process (BP)cellular response to inorganic substance0.00029870.4618InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.93890InformativeInherited
Biological Process (BP)cell death0.00027060.003831InformativeInherited
Biological Process (BP)cell development0.43810.1561InformativeInherited
Biological Process (BP)proteolysis10.00000000002675InformativeInherited
Biological Process (BP)post-embryonic development0.00018680.07991InformativeInherited
Biological Process (BP)mitochondrion organization0.11110.8617InformativeInherited
Biological Process (BP)organelle assembly0.010480.147InformativeInherited
Biological Process (BP)autophagy00Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification00.0000000000001358Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.000063380.00001063Highly InformativeDirect
Biological Process (BP)modification-dependent macromolecule catabolic process0.000085990Highly InformativeDirect
Biological Process (BP)cellular response to cadmium ion0.000000000062970.000007203Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.000056840.00000004253Highly InformativeDirect
Biological Process (BP)negative regulation of ion transmembrane transport0.00015940.001149Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.0023560.0004609Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.00084630.01675Highly InformativeInherited
Biological Process (BP)post-embryonic animal morphogenesis0.000078980.001289Highly InformativeInherited
Biological Process (BP)proteolysis involved in cellular protein catabolic process0.0095350Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00.03776Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)enzyme binding0.0029920.00000000000004348InformativeInherited
Molecular Function (MF)transcription factor binding00.000000002756Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.040230.009782Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.087710.0103Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.01387Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00027431Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0030351Least InformativeInherited
Cellular Component (CC)membrane0.52460.005316Least InformativeInherited
Cellular Component (CC)nuclear part0.029830.03394Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.053330.3157Moderately InformativeInherited
Cellular Component (CC)whole membrane0.000077310.4922Moderately InformativeInherited
Cellular Component (CC)transferase complex0.0071960.00009821Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.00027860.000005515InformativeDirect
Cellular Component (CC)ribonucleoprotein granule0.0000014970.2133InformativeInherited
Cellular Component (CC)lytic vacuole11InformativeInherited
Cellular Component (CC)vacuolar part0.0000000040960.05957InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000008797 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000001234 Least Informative Direct
Biological Process (BP) biological regulation 0.000000000006821 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.4363 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00007322 Moderately Informative Direct
Biological Process (BP) cell communication 0.000008787 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0004364 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000000009953 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0000005578 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000000002801 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000001655 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000000746 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000001175 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000001019 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00000001151 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.002967 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7168 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1909 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.003165 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4143 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4374 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.002566 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2913 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8186 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08239 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6614 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02577 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3893 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.0177 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.4861 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01201 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.133 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000000002675 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.00008204 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00006778 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0004627 Informative Direct
Biological Process (BP) microtubule-based process 0.000386 Informative Direct
Biological Process (BP) cell-cell signaling 0.0001198 Informative Direct
Biological Process (BP) sensory organ development 0.00008352 Informative Direct
Biological Process (BP) embryo development 0.0001096 Informative Direct
Biological Process (BP) regulation of catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000003667 Informative Direct
Biological Process (BP) phosphorylation 0.000000009297 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0003375 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0006073 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000003335 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000006189 Informative Direct
Biological Process (BP) regulation of proteolysis 0.00000177 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000001737 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0001095 Informative Direct
Biological Process (BP) locomotion 0.00003268 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00007194 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000000000006258 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000878 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000000305 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00002436 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.00008334 Informative Direct
Biological Process (BP) regulation of transferase activity 0.000966 Informative Direct
Biological Process (BP) membrane organization 0.0005035 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0001572 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000000007983 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.00006943 Informative Direct
Biological Process (BP) negative regulation of transport 0.03102 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.3435 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01946 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3862 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.07909 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.8512 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.01844 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.01513 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05805 Informative Inherited
Biological Process (BP) regulation of ion transport 0.6086 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.1526 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.08695 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01054 Informative Inherited
Biological Process (BP) cell death 0.003831 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.888 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to metal ion 0.4846 Informative Inherited
Biological Process (BP) cellular response to inorganic substance 0.4618 Informative Inherited
Biological Process (BP) cell development 0.1561 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4089 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.001925 Informative Inherited
Biological Process (BP) tissue development 0.3339 Informative Inherited
Biological Process (BP) ion homeostasis 0.44 Informative Inherited
Biological Process (BP) positive regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.005512 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.1302 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.006024 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.6343 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7818 Informative Inherited
Biological Process (BP) protein localization to organelle 0.6845 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.1016 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) cell activation 0.1941 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to cytokine 1 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8407 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9319 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.9186 Informative Inherited
Biological Process (BP) generation of neurons 0.9004 Informative Inherited
Biological Process (BP) central nervous system development 0.1713 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.322 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7818 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.128 Informative Inherited
Biological Process (BP) growth 0.5209 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6165 Informative Inherited
Biological Process (BP) cell cycle process 0.3828 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.07991 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) mitochondrion organization 0.8617 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) organelle assembly 0.147 Informative Inherited
Biological Process (BP) autophagy 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0000000000003837 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.00001001 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000001269 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.000000245 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000000006728 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.0000001782 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0000000000001358 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00001063 Highly Informative Direct
Biological Process (BP) lipid modification 0.0001071 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0004636 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000002359 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.000000189 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000004549 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000311 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0003209 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to cadmium ion 0.000007203 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0000007732 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000002839 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.000007129 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0000000005993 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000004253 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00004818 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0004609 Highly Informative Direct
Biological Process (BP) negative regulation of ion transmembrane transport 0.001149 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.01675 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.302 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.03519 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.3181 Highly Informative Inherited
Biological Process (BP) positive regulation of protein serine/threonine kinase activity 0.5964 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.6194 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3837 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.1188 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.01531 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1183 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.2091 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.3642 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.01269 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.0119 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.9386 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.5972 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.08035 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.001044 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2504 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.01011 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2395 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.03776 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.03 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.05075 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3195 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.1045 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.136 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.05029 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.09312 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.506 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.001289 Highly Informative Inherited
Biological Process (BP) innate immune response 0.1084 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.157 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1307 Highly Informative Inherited
Biological Process (BP) brain development 0.04956 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.06776 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.3604 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.3443 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.9361 Highly Informative Inherited
Biological Process (BP) cell division 0.48 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.04157 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.03946 Highly Informative Inherited
Biological Process (BP) cell growth 0.1723 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1677 Highly Informative Inherited
Biological Process (BP) cell maturation 0.244 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.1647 Highly Informative Inherited
Biological Process (BP) protein folding 0.001567 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.1868 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.9186 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.0000000000001649 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.006139 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3553 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0000003369 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0001441 Informative Direct
Molecular Function (MF) enzyme binding 0.00000000000004348 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000003767 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.005078 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) kinase activity 0.0123 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.2871 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.6298 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.04513 Informative Inherited
Molecular Function (MF) phosphatase activity 0.3804 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000000000003651 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000002756 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0005237 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0001826 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.02209 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.001226 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0.009782 Least Informative Inherited
Cellular Component (CC) membrane 0.005316 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0103 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01387 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00000000000000914 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.000000003356 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.00009821 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9613 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.003223 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.03394 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.08583 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.3157 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.4922 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000005515 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.000000000004107 Informative Direct
Cellular Component (CC) apical part of cell 0.0001045 Informative Direct
Cellular Component (CC) synapse 0.000000008785 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0000000001581 Informative Direct
Cellular Component (CC) side of membrane 0.1194 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.2133 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.7012 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.01393 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.8705 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 1 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.02689 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.4775 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar part 0.05957 Informative Inherited
Cellular Component (CC) nuclear body 0.000003019 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0005708 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate adherens junction 0.9764 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.2471 Highly Informative Inherited
Cellular Component (CC) chromatin 0.7191 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000005609Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000004359Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000004443Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00003067Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000001949InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000366InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0.000000000612Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.601Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.5646InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.06979Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.04155InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.04859InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.0008189Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the lung0.001871Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)embryo phenotype0.2547Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.02283InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0008033Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00008821Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001967Least InformativeDirect
Worm Phenotype (WP)cell development variant0.01825Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.5132Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000003768Moderately InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.1895InformativeInherited
Worm Phenotype (WP)body muscle dystrophy0.00000006074Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0001734Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.004467Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.2331Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1844Least InformativeInherited
Yeast Phenotype (YP)protein/peptide accumulation0.0001273Highly InformativeDirect
Yeast Phenotype (YP)sexual cycle0.02103Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.0008147InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.05863Least InformativeInherited
Fly Anatomy (FA)nervous system0.1945Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03101Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.6565Moderately InformativeInherited
Fly Anatomy (FA)nerve0.5145InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.0007212Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.009425Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.3573Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.0001757Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.002013Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.00007272InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000007526InformativeDirect
Plant ANatomical entity (PAN)gamete0.0005252InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.000003303Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00000000001645Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000000002709Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000003993Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001937Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000002281Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.002777Moderately InformativeInherited
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000003007InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000006929InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00002163InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00003877InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0164InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000000001356Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000008162Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001866Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.844e-16Moderately InformativeDirect
Biological processImmunity0.000000001775Moderately InformativeDirect
Biological processDifferentiation0.0001311Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis4.844e-16InformativeDirect
Biological processEndocytosis0.000000154InformativeDirect
Biological processNeurogenesis0.000007807InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport0.00000000000161Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000000001923Highly InformativeDirect
Biological processExocytosis0.00001683Highly InformativeDirect
Biological processAntiviral defense0.00003052Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane3.305e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome0.00003513Moderately InformativeDirect
Cellular componentGolgi apparatus0.0004061Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentProteasome0.00000000188Highly InformativeDirect
Cellular componentLipid droplet0.00000003804Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00001822Least InformativeDirect
DiseaseTumor suppressor0.00000002113Moderately InformativeDirect
DiseaseProto-oncogene0.00001222Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain0.0000000007475InformativeDirect
DomainSH3 domain0.00005883InformativeDirect
DomainLeucine-rich repeat0.0009312InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionLipid-binding0.00002438Moderately InformativeDirect
Molecular functioncAMP-binding0.000006281Highly InformativeDirect
Molecular functioncAMP0.0001989Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.002905Moderately InformativeInherited
Post-translational modificationKinase0.06843Moderately InformativeInherited
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase0.000000000004588InformativeDirect
Post-translational modificationCalmodulin-binding0.0000001711InformativeDirect
Post-translational modificationChromatin regulator0.0000007499InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00003594InformativeDirect
Post-translational modificationMyosin2.216e-16Highly InformativeDirect
Post-translational modificationActin capping0.000008845Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00001414Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0007287Highly InformativeDirect
Post-translational modificationPhosphoprotein0.000000000000001892Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.0000004109InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.0009326Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.1513Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)phospholipid metabolism0.00000007426InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.0007647InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0.000002361Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]