SUPERFAMILY 1.75 HMM library and genome assignments server


Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (623) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 47,637 52,964 156
Proteins 40,135 45,363 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process6.873e-100Least InformativeDirect
Biological Process (BP)regulation of cellular process0.12952.651e-05Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.016910.7117Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.095024.924e-06Least InformativeInherited
Biological Process (BP)multicellular organismal process0.62350.0003888Least InformativeInherited
Biological Process (BP)developmental process0.10221.587e-06Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)localization0.35013.37e-05Least InformativeInherited
Biological Process (BP)single-organism cellular process0.79098.477e-11Least InformativeInherited
Biological Process (BP)response to endogenous stimulus0.66010.7368Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.52830.9982Moderately InformativeInherited
Biological Process (BP)response to organic substance0.48750.05374Moderately InformativeInherited
Biological Process (BP)regulation of localization0.46260.205Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.96830.08402Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0030071Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.049191Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.023450Moderately InformativeInherited
Biological Process (BP)cellular protein modification process7.56e-080.09194Moderately InformativeInherited
Biological Process (BP)ion transport0.64571Moderately InformativeInherited
Biological Process (BP)organic substance transport0.43011Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0026211.253e-11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.049360.01038Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.048946.064e-12Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.78641Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.64753.392e-06Moderately InformativeInherited
Biological Process (BP)system process0.70780.5529Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.0051240InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.072891.855e-05InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.20760.1659InformativeInherited
Biological Process (BP)nitrogen compound transport0.32471InformativeInherited
Biological Process (BP)dephosphorylation0.096780.2406InformativeInherited
Biological Process (BP)single-organism behavior0.0220.1416InformativeInherited
Biological Process (BP)synaptic transmission0.023520.1672InformativeInherited
Biological Process (BP)autophagy01.086e-14Highly InformativeDirect
Biological Process (BP)monoamine transport6.141e-058.725e-05Highly InformativeDirect
Biological Process (BP)regulation of proteolysis3.043e-050Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination6.34e-081.938e-15Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.00045250Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.0028490.05648Highly InformativeInherited
Biological Process (BP)cellular response to growth factor stimulus0.0069146.219e-05Highly InformativeInherited
Biological Process (BP)protein dephosphorylation0.4850.1559Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.0019080.0627Highly InformativeInherited
Biological Process (BP)locomotory behavior0.0015230.5163Highly InformativeInherited
Biological Process (BP)adult behavior0.00016170.08932Highly InformativeInherited
Biological Process (BP)neuromuscular process0.00024260.183Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0021760.6433Highly InformativeInherited
Biological Process (BP)neurotransmitter transport0.0018460.05761Highly InformativeInherited
Molecular Function (MF)binding0.0019280Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.65090.8431Moderately InformativeInherited
Molecular Function (MF)ligase activity6.943e-136.24e-05InformativeDirect
Molecular Function (MF)enzyme binding0.013672.057e-09InformativeInherited
Molecular Function (MF)phosphoric ester hydrolase activity0.14830.11InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.00075871.351e-05Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity7.645e-151.078e-10Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0023581Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.094781Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.4975Least InformativeInherited
Cellular Component (CC)nuclear part0.019530.5318Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen1.985e-050.6004Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.0024311InformativeInherited
Cellular Component (CC)nuclear body5.979e-070.0003153Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0003888 Least Informative Direct
Biological Process (BP) developmental process 1.587e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.477e-11 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.651e-05 Least Informative Direct
Biological Process (BP) response to stimulus 4.924e-06 Least Informative Direct
Biological Process (BP) localization 3.37e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.7117 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 7.376e-09 Moderately Informative Direct
Biological Process (BP) signal transduction 7.159e-07 Moderately Informative Direct
Biological Process (BP) nervous system development 5.642e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.253e-11 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 5.695e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 6.064e-12 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0009647 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 8.833e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 4.964e-05 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 3.392e-06 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001927 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.6037 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.205 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.09194 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.7368 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05374 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9982 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05864 Moderately Informative Inherited
Biological Process (BP) system process 0.5529 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.00754 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4907 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.07204 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01038 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1573 Moderately Informative Inherited
Biological Process (BP) reproduction 0.06461 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.08402 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9054 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1967 Moderately Informative Inherited
Biological Process (BP) proteolysis 5.14e-09 Informative Direct
Biological Process (BP) phospholipid metabolic process 7.534e-07 Informative Direct
Biological Process (BP) cytoskeleton organization 8.13e-10 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0003583 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0006837 Informative Direct
Biological Process (BP) cellular membrane organization 0.0003152 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 7.376e-09 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000113 Informative Direct
Biological Process (BP) actin filament-based process 3.305e-10 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) intracellular signal transduction 6.794e-07 Informative Direct
Biological Process (BP) locomotion 0.0002447 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.44e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 5.028e-10 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0007624 Informative Direct
Biological Process (BP) embryonic morphogenesis 1.223e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0002384 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 1.855e-05 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 1.436e-08 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0001532 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of locomotion 0.1212 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3522 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.009039 Informative Inherited
Biological Process (BP) generation of neurons 0.7816 Informative Inherited
Biological Process (BP) regulation of cell development 0.08967 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.004629 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.006307 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6086 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.3169 Informative Inherited
Biological Process (BP) embryonic organ development 0.6599 Informative Inherited
Biological Process (BP) cell projection organization 0.006412 Informative Inherited
Biological Process (BP) apoptotic process 0.7291 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.7475 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1659 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2986 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9448 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.69 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.8012 Informative Inherited
Biological Process (BP) phosphorylation 0.001105 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03887 Informative Inherited
Biological Process (BP) regulation of system process 0.5897 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.7998 Informative Inherited
Biological Process (BP) cation homeostasis 0.5487 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.06149 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.2104 Informative Inherited
Biological Process (BP) synaptic transmission 0.1672 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.283 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.7088 Informative Inherited
Biological Process (BP) cell cycle process 0.6058 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.003499 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.459 Informative Inherited
Biological Process (BP) sexual reproduction 0.01312 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3732 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4194 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1213 Informative Inherited
Biological Process (BP) cellular component movement 0.04814 Informative Inherited
Biological Process (BP) localization of cell 0.005758 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.004892 Informative Inherited
Biological Process (BP) protein localization to organelle 0.07568 Informative Inherited
Biological Process (BP) organ morphogenesis 0.04022 Informative Inherited
Biological Process (BP) leukocyte activation 0.009064 Informative Inherited
Biological Process (BP) regulation of protein localization 0.1137 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.424 Informative Inherited
Biological Process (BP) dephosphorylation 0.2406 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.09853 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.5108 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) central nervous system development 0.2885 Informative Inherited
Biological Process (BP) sensory organ development 0.009254 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.7707 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) regulation of growth 0.9698 Informative Inherited
Biological Process (BP) single-organism behavior 0.1416 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2396 Informative Inherited
Biological Process (BP) response to wounding 1 Informative Inherited
Biological Process (BP) growth 0.9576 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8796 Informative Inherited
Biological Process (BP) epithelium development 0.04367 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6678 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01108 Informative Inherited
Biological Process (BP) organelle assembly 0.7938 Informative Inherited
Biological Process (BP) leukocyte homeostasis 4.484e-06 Highly Informative Direct
Biological Process (BP) autophagy 1.086e-14 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 1.938e-15 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 6.956e-06 Highly Informative Direct
Biological Process (BP) hemostasis 0.0005258 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 8.759e-06 Highly Informative Direct
Biological Process (BP) monoamine transport 8.725e-05 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.000874 Highly Informative Direct
Biological Process (BP) regulation of proteolysis 0 Highly Informative Direct
Biological Process (BP) lipid modification 0.0005198 Highly Informative Direct
Biological Process (BP) stress-activated protein kinase signaling cascade 0.0003074 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 2.514e-05 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 1.938e-15 Highly Informative Direct
Biological Process (BP) regulation of protein stability 1.189e-07 Highly Informative Direct
Biological Process (BP) cell junction organization 1.116e-05 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 1.994e-06 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 1.083e-05 Highly Informative Direct
Biological Process (BP) B cell activation 0.0001134 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 1.467e-09 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 7.746e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 2.059e-05 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0007197 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0004652 Highly Informative Direct
Biological Process (BP) protein polymerization 0.0001977 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 6.219e-05 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001582 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.07275 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.8779 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02377 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.08739 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.05648 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.03604 Highly Informative Inherited
Biological Process (BP) ear development 0.9188 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7305 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2271 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.3914 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) meiosis 0.1129 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.022 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.489 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.06427 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.05733 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.006252 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.9355 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3341 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.2024 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1678 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.006436 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001333 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.005595 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.003568 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.1559 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.1195 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.9779 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.9481 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.5128 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.001312 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.005587 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.005424 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.02209 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.03177 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1739 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.0537 Highly Informative Inherited
Biological Process (BP) DNA modification 0.7049 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.6762 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.04637 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0627 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.1026 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6462 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.02503 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.5163 Highly Informative Inherited
Biological Process (BP) adult behavior 0.08932 Highly Informative Inherited
Biological Process (BP) wound healing 0.05466 Highly Informative Inherited
Biological Process (BP) coagulation 0.003693 Highly Informative Inherited
Biological Process (BP) cell growth 0.1626 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3122 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.04502 Highly Informative Inherited
Biological Process (BP) protein folding 0.817 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.183 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.6433 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.05761 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.3391 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 6.655e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 4.577e-15 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.466 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8431 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 4.262e-08 Informative Direct
Molecular Function (MF) ligase activity 6.24e-05 Informative Direct
Molecular Function (MF) enzyme binding 2.057e-09 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) kinase activity 0.09682 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01334 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.9725 Informative Inherited
Molecular Function (MF) peptidase activity 0.1386 Informative Inherited
Molecular Function (MF) lipid binding 0.4507 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.11 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.8886 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 1.351e-05 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.000241 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0003886 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 1.078e-10 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 3.539e-12 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.144e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1297 Highly Informative Inherited
Molecular Function (MF) ribonucleoprotein complex binding 0.002427 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0.01961 Highly Informative Inherited
Molecular Function (MF) adenylyltransferase activity 0.002211 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 5.142e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4975 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01544 Least Informative Inherited
Cellular Component (CC) protein complex 0.0119 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 4.233e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.2623 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.6004 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5725 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.007104 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.7368 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5318 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00017 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001518 Informative Direct
Cellular Component (CC) cell cortex 2.602e-14 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0002296 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) synapse part 0.05627 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0003153 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0005751 Highly Informative Direct
Cellular Component (CC) cell division site part 0.001043 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.2923 Highly Informative Inherited
Cellular Component (CC) chromatin 0.6622 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)5.609e-14Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases4.359e-12Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases4.443e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep3.067e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase1.949e-13InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase3.66e-06InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase6.12e-10Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.01416Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6624Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.892InformativeInherited
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0001422Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.02064InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006354Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant1.573e-05Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.05939InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.0009859InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2677Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9239Least InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.02314Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.0007472InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.0003734Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.001382Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2239Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.009178Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.0001293InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell1.031e-06InformativeDirect
Plant ANatomical entity (PAN)gamete0.0003164InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage4.841e-06Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases5.358e-12Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.33e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases6.717e-10Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor2.115e-06Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase2.853e-06InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases6.003e-06InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.526e-05InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.06029InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase4.025e-13Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C4.119e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport9.356e-07Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis2.372e-16InformativeDirect
Biological processEndocytosis9.14e-08InformativeDirect
Biological processNeurogenesis0.0002287InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport1.641e-13Highly InformativeDirect
Biological processCilium biogenesis/degradation1.822e-07Highly InformativeDirect
Biological processExocytosis9.969e-06Highly InformativeDirect
Biological processAntiviral defense3.307e-05Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane5.386e-15Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentGolgi apparatus3.441e-06Moderately InformativeDirect
Cellular componentEndosome0.0003656Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentProteasome1.902e-09Highly InformativeDirect
Cellular componentLipid droplet2.557e-09Highly InformativeDirect
Coding sequence diversityAlternative splicing1.203e-05Least InformativeDirect
DiseaseTumor suppressor5.683e-09Moderately InformativeDirect
DiseaseProto-oncogene6.118e-06Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain5.622e-10InformativeDirect
DomainSH3 domain4.538e-05InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding9.133e-08InformativeDirect
Molecular functionLipid-binding7.419e-06InformativeDirect
Molecular functioncAMP-binding2.77e-06Highly InformativeDirect
Molecular functioncAMP0.0001101Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.001344Moderately InformativeInherited
Post-translational modificationKinase0.04505Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase2.623e-12InformativeDirect
Post-translational modificationChromatin regulator4.544e-07InformativeDirect
Post-translational modificationSerine/threonine-protein kinase2.218e-05InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationActin capping6.296e-06Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor9.6e-06Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0006933Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.03047Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism2.453e-10InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation3.13e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]