SUPERFAMILY 1.75 HMM library and genome assignments server

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Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (625) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,033 52,964 156
Proteins 40,521 45,363 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process00Least InformativeDirect
Biological Process (BP)primary metabolic process0.000000000014810.0000000000006235Least InformativeDirect
Biological Process (BP)biological regulation0.21860.0000000000006647Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.72560Least InformativeInherited
Biological Process (BP)single-organism cellular process10.6699Least InformativeInherited
Biological Process (BP)response to stimulus0.19950.00000000002377Least InformativeInherited
Biological Process (BP)regulation of molecular function0.1180.00000004936Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.62761Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.11890Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.064851Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process10.000000002287Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.19770.03648Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.032630.00264Moderately InformativeInherited
Biological Process (BP)regulation of localization0.25130.04436Moderately InformativeInherited
Biological Process (BP)response to stress0.001960.2515Moderately InformativeInherited
Biological Process (BP)cellular catabolic process10.000000000005958Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.00000000000069330.08055Moderately InformativeInherited
Biological Process (BP)organelle organization0.094430.00005055Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.15210.0314Moderately InformativeInherited
Biological Process (BP)peptidyl-amino acid modification00.0002522InformativeDirect
Biological Process (BP)negative regulation of molecular function0.21690.4975InformativeInherited
Biological Process (BP)regulation of ion transport0.13490.4714InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.037520.02541InformativeInherited
Biological Process (BP)regulation of protein modification process0.00042780.2508InformativeInherited
Biological Process (BP)response to inorganic substance0.019011InformativeInherited
Biological Process (BP)mitochondrion organization0.28921InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.78580InformativeInherited
Biological Process (BP)cell death0.00024960.00228InformativeInherited
Biological Process (BP)post-embryonic development0.00032410.08318InformativeInherited
Biological Process (BP)cell development0.4220.2723InformativeInherited
Biological Process (BP)negative regulation of transport0.044190.04504InformativeInherited
Biological Process (BP)proteolysis10.000000001963InformativeInherited
Biological Process (BP)organelle assembly0.00020480.1962InformativeInherited
Biological Process (BP)autophagy00Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification00.00000000000004534Highly InformativeDirect
Biological Process (BP)modification-dependent protein catabolic process0.000083010.0002902Highly InformativeDirect
Biological Process (BP)cellular component disassembly0.00069670.0000046Highly InformativeDirect
Biological Process (BP)negative regulation of ion transmembrane transport0.00016080.0007765Highly InformativeDirect
Biological Process (BP)regulation of protein modification by small protein conjugation or removal0.00004530.00000002581Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.0019140.0001546Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.00075810.01855Highly InformativeInherited
Biological Process (BP)protein modification by small protein conjugation00.02166Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.0000017440.007585Highly InformativeInherited
Biological Process (BP)metamorphosis0.000023110.001065Highly InformativeInherited
Biological Process (BP)instar larval or pupal morphogenesis0.4680.3382Highly InformativeInherited
Molecular Function (MF)binding00Least InformativeDirect
Molecular Function (MF)protein binding00Moderately InformativeDirect
Molecular Function (MF)transcription factor binding00.0000000033Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.12620.008247Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00020261Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.2235Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.0038491Least InformativeInherited
Cellular Component (CC)membrane0.4930.002214Least InformativeInherited
Cellular Component (CC)nuclear part0.069050.1397Moderately InformativeInherited
Cellular Component (CC)vacuole0.0000000000040930.003151Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.037541Moderately InformativeInherited
Cellular Component (CC)whole membrane0.000046140.5659Moderately InformativeInherited
Cellular Component (CC)transferase complex0.0072190.0000708Moderately InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.00029060.000002895InformativeDirect
Cellular Component (CC)ribonucleoprotein granule0.0000062750.2252InformativeInherited
Cellular Component (CC)lytic vacuole11InformativeInherited
Cellular Component (CC)vacuolar part0.00000000089080.1234InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000000006235 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000002377 Least Informative Direct
Biological Process (BP) biological regulation 0.0000000000006647 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.6699 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00005055 Moderately Informative Direct
Biological Process (BP) cell communication 0.000000000449 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000000009315 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000005958 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000000005783 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0000000000209 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000004936 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000002287 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8162 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6584 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.00264 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1443 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.161 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01204 Moderately Informative Inherited
Biological Process (BP) response to stress 0.2515 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.08055 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04436 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6423 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008887 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.006916 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.004861 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.03648 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3692 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5966 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2238 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.0314 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.000000001963 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.0003366 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00006298 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0005695 Informative Direct
Biological Process (BP) microtubule-based process 0.0009465 Informative Direct
Biological Process (BP) regulation of catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00004648 Informative Direct
Biological Process (BP) phosphorylation 0.00000001266 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0002522 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000004136 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00001372 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000001459 Informative Direct
Biological Process (BP) regulation of proteolysis 0.0000003187 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.000001031 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00004651 Informative Direct
Biological Process (BP) locomotion 0.00006344 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0001128 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.000000000008057 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0001218 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000000002275 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000004245 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0005038 Informative Direct
Biological Process (BP) epithelium development 0.0000005234 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.0001632 Informative Direct
Biological Process (BP) negative regulation of molecular function 0.4975 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.4736 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01399 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.004126 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9952 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.03972 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.2508 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.7768 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.001706 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.003798 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4714 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00124 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.2194 Informative Inherited
Biological Process (BP) cell death 0.00228 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.9744 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1864 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) growth 0.4006 Informative Inherited
Biological Process (BP) ion homeostasis 0.6549 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.8723 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.06686 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6668 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.006181 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.368 Informative Inherited
Biological Process (BP) organelle fission 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.9921 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.04933 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.06489 Informative Inherited
Biological Process (BP) post-embryonic development 0.08318 Informative Inherited
Biological Process (BP) negative regulation of transport 0.04504 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.02541 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to cytokine 0.7998 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3135 Informative Inherited
Biological Process (BP) central nervous system development 0.124 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) embryo development 0.001708 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1643 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) cell development 0.2723 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5995 Informative Inherited
Biological Process (BP) cell cycle process 0.5657 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.08635 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3687 Informative Inherited
Biological Process (BP) organelle assembly 0.1962 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.0008356 Highly Informative Direct
Biological Process (BP) autophagy 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000000000000207 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000007026 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.0000000000006619 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0000003498 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000001579 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000003235 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000004733 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000000000004534 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.0002902 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.0000046 Highly Informative Direct
Biological Process (BP) lipid modification 0.0001 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.0001092 Highly Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00000001328 Highly Informative Direct
Biological Process (BP) negative regulation of ion transmembrane transport 0.0007765 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.00000002005 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.000000000001081 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0001043 Highly Informative Direct
Biological Process (BP) maintenance of location in cell 0.000000396 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0007929 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.000001784 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.0000000007532 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.00009436 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00000002581 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0001546 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.01855 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.2332 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.01257 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.3207 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.2704 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3797 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.02166 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.04647 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.03097 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.3129 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.02787 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.09046 Highly Informative Inherited
Biological Process (BP) apoptotic process 1 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0.8676 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.1328 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.007585 Highly Informative Inherited
Biological Process (BP) camera-type eye development 1 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.8478 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle process 0.0595 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.1249 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.1003 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.7356 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.5427 Highly Informative Inherited
Biological Process (BP) germ cell development 0.3171 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.08903 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.001065 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.3382 Highly Informative Inherited
Biological Process (BP) innate immune response 0.09937 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.001378 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.1153 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) brain development 0.03503 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.207 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.1683 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.5089 Highly Informative Inherited
Biological Process (BP) cell division 0.447 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.02414 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.08055 Highly Informative Inherited
Biological Process (BP) cell growth 0.1334 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1335 Highly Informative Inherited
Biological Process (BP) cell maturation 0.2212 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.03215 Highly Informative Inherited
Biological Process (BP) protein folding 0.02391 Highly Informative Inherited
Biological Process (BP) cell migration 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.1526 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1431 Highly Informative Inherited
Biological Process (BP) chromosome organization 1 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1958 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.09751 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.9008 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.0000000000003147 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.005853 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3033 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1 Moderately Informative Inherited
Molecular Function (MF) phospholipid binding 0.0000006832 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0001335 Informative Direct
Molecular Function (MF) enzyme binding 0.0000000000001513 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.09097 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.004892 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) ATPase activity 1 Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.4153 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.5637 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.01568 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.4002 Informative Inherited
Molecular Function (MF) kinase activity 0.01119 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000000000007196 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.0000000033 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.0003965 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.007192 Highly Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.001258 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.008247 Least Informative Inherited
Cellular Component (CC) membrane 0.002214 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2235 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.549 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0001759 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000000000005322 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.000000001214 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.0000708 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1397 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.06504 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.003151 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.5659 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.000002895 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000000001774 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell projection part 0.000005632 Informative Direct
Cellular Component (CC) apical part of cell 0.00006139 Informative Direct
Cellular Component (CC) synapse 0.000000001808 Informative Direct
Cellular Component (CC) cytoplasmic region 0.000000002133 Informative Direct
Cellular Component (CC) side of membrane 0.2419 Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.2252 Informative Inherited
Cellular Component (CC) neuron projection 0.2275 Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.01973 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.03264 Informative Inherited
Cellular Component (CC) lytic vacuole 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) vacuolar part 0.1234 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0001691 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.134 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.006631 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.7127 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.1867 Highly Informative Inherited
Cellular Component (CC) chromatin 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000005609Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000004359Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000004443Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00003067Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000001949InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000366InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0.000000000612Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.5921Moderately InformativeInherited
Disease Ontology (DO)malignant glioma0.5347InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.0476Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.2883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.02144InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.04835InformativeInherited
Phenotypic Abnormality (PA)Sarcoma0.0005384Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the lung0.001444Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)embryo phenotype0.2444Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.511Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.02148InformativeInherited
Mammalian Phenotype (MP)increased hamartoma incidence0.0008013Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0005309Least InformativeDirect
Worm Phenotype (WP)cell development variant0.03246Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.4941Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.00000003413Moderately InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.184InformativeInherited
Worm Phenotype (WP)body muscle dystrophy0.00000005968Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0001367Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.003371Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.2124Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.1727Least InformativeInherited
Yeast Phenotype (YP)protein/peptide accumulation0.0001337Highly InformativeDirect
Yeast Phenotype (YP)sexual cycle0.02107Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.0003134InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.1507Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2068Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01762Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.5776Moderately InformativeInherited
Fly Anatomy (FA)nerve0.4813InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.001519Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.008757Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.3636Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.0003296Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.002189Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.00008401InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000007526InformativeDirect
Plant ANatomical entity (PAN)gamete0.0005252InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.000003303Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000000000006253Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000003422Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000001867Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000002232Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000003001InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000006831InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00001961InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.01572InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000005088Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000004751Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.02779Least InformativeInherited
Drugbank ATC_code (DB)psychostimulants, agents used for adhd and nootropics0.0007076Moderately InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001516Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis4.822e-16Moderately InformativeDirect
Biological processImmunity0.000000001211Moderately InformativeDirect
Biological processDifferentiation0.00009363Moderately InformativeDirect
Biological processAutophagy0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis4.822e-16InformativeDirect
Biological processEndocytosis0.0000001422InformativeDirect
Biological processNeurogenesis0.00003074InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport0.0000000000009898Highly InformativeDirect
Biological processCilium biogenesis/degradation0.000001334Highly InformativeDirect
Biological processExocytosis0.00001634Highly InformativeDirect
Biological processAntiviral defense0.00002764Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome0.00002379Moderately InformativeDirect
Cellular componentGolgi apparatus0.0003394Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentProteasome0.000000001778Highly InformativeDirect
Cellular componentLipid droplet0.00000003695Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00001707Least InformativeDirect
DiseaseTumor suppressor0.00000001507Moderately InformativeDirect
DiseaseProto-oncogene0.00001073Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain0.0000000007066InformativeDirect
DomainSH3 domain0.0000534InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionLipid-binding0.00002021Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.0000001311InformativeDirect
Molecular functioncAMP-binding0.000005909Highly InformativeDirect
Molecular functioncAMP0.0001799Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.002455Moderately InformativeInherited
Post-translational modificationKinase0.06471Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase0.00000000000436InformativeDirect
Post-translational modificationChromatin regulator0.0000006964InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00003375InformativeDirect
Post-translational modificationMyosin2.271e-16Highly InformativeDirect
Post-translational modificationActin capping0.00000894Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.00001153Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0007576Highly InformativeDirect
Post-translational modificationPhosphoprotein9.502e-16Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0.0000003914InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.000945Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.1521Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)phospholipid metabolism0.00000007513InformativeDirect
UniPathway (UP)fatty acid biosynthesis0.0007764InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0.000002489Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]