SUPERFAMILY 1.75 HMM library and genome assignments server

Ubiquitin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Ubiquitin-like [ 54236] (8)
Families:   Ubiquitin-related [ 54237] (38)
  UBX domain [ 54250] (5)
  GABARAP-like [ 54253] (3)
  First domain of FERM [ 54256] (6)
  Ras-binding domain, RBD [ 54263] (13)
  BM-002-like [ 75362] (3)
  APG12-like [ 142972]
  DIX domain [ 159926]


Superfamily statistics
Genomes (624) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 48,097 52,964 156
Proteins 40,563 45,363 155


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process00Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00000000094940Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.011970.4489Least InformativeInherited
Biological Process (BP)regulation of cellular process0.20610.0001254Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.046850.4743Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process10.8015Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)developmental process0.064560.0000004486Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)response to stimulus0.091430.000002494Least InformativeInherited
Biological Process (BP)multicellular organismal process0.56940.00118Least InformativeInherited
Biological Process (BP)localization0.40490.00008843Least InformativeInherited
Biological Process (BP)positive regulation of cellular process0.082990.3328Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.081950Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.22251Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.05090.01336Moderately InformativeInherited
Biological Process (BP)response to organic substance0.49350.04032Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.53630.9375Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.66940.5047Moderately InformativeInherited
Biological Process (BP)ion transport0.74151Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.62880.000001266Moderately InformativeInherited
Biological Process (BP)regulation of localization0.4810.08227Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.000000076990.1059Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.91460.05523Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0018141Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0010040.009325Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.23121Moderately InformativeInherited
Biological Process (BP)organic substance transport0.43651Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0026050.000000001073Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.075690.01391Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.052560.00000000009124Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.84241Moderately InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal00InformativeDirect
Biological Process (BP)regulation of cellular catabolic process0.0063240InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.023930.003073InformativeInherited
Biological Process (BP)positive regulation of gene expression0.023161InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.0032860InformativeInherited
Biological Process (BP)synaptic transmission0.023690.5913InformativeInherited
Biological Process (BP)organic hydroxy compound transport0.0044380.1106InformativeInherited
Biological Process (BP)regulation of secretion0.0010640.3942InformativeInherited
Biological Process (BP)dephosphorylation0.097480.5041InformativeInherited
Biological Process (BP)response to nutrient levels0.0000036620.01567InformativeInherited
Biological Process (BP)cellular response to external stimulus0.000063240.1169InformativeInherited
Biological Process (BP)nitrogen compound transport0.3331InformativeInherited
Biological Process (BP)single-organism behavior0.0087080.09545InformativeInherited
Biological Process (BP)neurological system process0.19660.1433InformativeInherited
Biological Process (BP)dopamine transport0.00000850.0000002199Highly InformativeDirect
Biological Process (BP)macroautophagy0.00000000021720.00000000003503Highly InformativeDirect
Biological Process (BP)regulation of protein ubiquitination0.000000000000090140.0006634Highly InformativeDirect
Biological Process (BP)regulation of proteolysis involved in cellular protein catabolic process0.00020580Highly InformativeDirect
Biological Process (BP)positive regulation of protein modification by small protein conjugation or removal0.00005210.00000001056Highly InformativeDirect
Biological Process (BP)cellular response to growth factor stimulus0.0077590.00001802Highly InformativeInherited
Biological Process (BP)neurotransmitter transport0.0017650.05592Highly InformativeInherited
Biological Process (BP)regulation of synaptic transmission0.010270.000712Highly InformativeInherited
Biological Process (BP)protein dephosphorylation0.4880.152Highly InformativeInherited
Biological Process (BP)phenol-containing compound metabolic process0.0061470.3032Highly InformativeInherited
Biological Process (BP)locomotory behavior0.0016560.3174Highly InformativeInherited
Biological Process (BP)adult behavior0.00016710.08596Highly InformativeInherited
Biological Process (BP)neuromuscular process0.000240.06638Highly InformativeInherited
Biological Process (BP)regulation of neurotransmitter levels0.0022390.6638Highly InformativeInherited
Molecular Function (MF)binding0.0014290Least InformativeInherited
Molecular Function (MF)transferase activity10.2939Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.65910.8732Moderately InformativeInherited
Molecular Function (MF)enzyme binding0.014380.000000001326InformativeInherited
Molecular Function (MF)ligase activity0.0000000007420.2816InformativeInherited
Molecular Function (MF)phosphatase activity0.10130.1205InformativeInherited
Molecular Function (MF)phosphoprotein phosphatase activity0.0007620.00001572Highly InformativeDirect
Molecular Function (MF)ubiquitin-protein transferase activity0.0000830.000001219Highly InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.11940.02111Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00076231Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.096391Least InformativeInherited
Cellular Component (CC)cytoplasmic part10.7076Least InformativeInherited
Cellular Component (CC)nuclear part0.010560.2906Moderately InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.000044250.5671Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.0028141InformativeInherited
Cellular Component (CC)nuclear body0.00000043050.0003266Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000004486 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0001254 Least Informative Direct
Biological Process (BP) response to stimulus 0.000002494 Least Informative Direct
Biological Process (BP) localization 0.00008843 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.4743 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4489 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8015 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00118 Least Informative Inherited
Biological Process (BP) signal transduction 0.0000009326 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00007908 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000001073 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00008887 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000000009124 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000422 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000001762 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000001266 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0001447 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000000001101 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.001127 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.04032 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.5047 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.1933 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2122 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.08227 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.3328 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.1059 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01336 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01391 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.1618 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.08739 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.84 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.05523 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2423 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.9525 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9375 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4276 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.009325 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.000000002464 Informative Direct
Biological Process (BP) phospholipid metabolic process 0.000001914 Informative Direct
Biological Process (BP) cellular component movement 0.0004045 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000003042 Informative Direct
Biological Process (BP) microtubule-based process 0.00005362 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0003839 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0004273 Informative Direct
Biological Process (BP) phosphorylation 0.0000475 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000003349 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000754 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000000009141 Informative Direct
Biological Process (BP) cell projection organization 0.0001097 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.00005374 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000003251 Informative Direct
Biological Process (BP) locomotion 0.0002465 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.00009762 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00001444 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000003625 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00001188 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0002966 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000223 Informative Direct
Biological Process (BP) epithelium development 0.0004297 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0.000000003426 Informative Direct
Biological Process (BP) regulation of locomotion 0.1282 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.3562 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.8311 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01112 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.2398 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.8615 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.0278 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.007805 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.001085 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.3722 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.003073 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.002859 Informative Inherited
Biological Process (BP) sensory organ development 0.008893 Informative Inherited
Biological Process (BP) embryonic organ development 0.6504 Informative Inherited
Biological Process (BP) apoptotic process 0.5797 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.6862 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.2062 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.08788 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.1027 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.1627 Informative Inherited
Biological Process (BP) cation homeostasis 0.5168 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.1248 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8336 Informative Inherited
Biological Process (BP) synaptic transmission 0.5913 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9376 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.1106 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.7775 Informative Inherited
Biological Process (BP) localization of cell 0.004424 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.2268 Informative Inherited
Biological Process (BP) generation of neurons 0.773 Informative Inherited
Biological Process (BP) sexual reproduction 0.03767 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.3788 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6945 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1046 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.6776 Informative Inherited
Biological Process (BP) regulation of secretion 0.3942 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 0.07018 Informative Inherited
Biological Process (BP) protein localization to organelle 0.08761 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.03645 Informative Inherited
Biological Process (BP) leukocyte activation 0.005147 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.01603 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.6247 Informative Inherited
Biological Process (BP) dephosphorylation 0.5041 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6898 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.1081 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.03812 Informative Inherited
Biological Process (BP) fatty acid metabolic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 1 Informative Inherited
Biological Process (BP) central nervous system development 0.3373 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.03812 Informative Inherited
Biological Process (BP) response to nutrient levels 0.01567 Informative Inherited
Biological Process (BP) cellular response to external stimulus 0.1169 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) cell proliferation 0.2332 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4423 Informative Inherited
Biological Process (BP) regulation of growth 0.9382 Informative Inherited
Biological Process (BP) single-organism behavior 0.09545 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.2379 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7536 Informative Inherited
Biological Process (BP) growth 0.9534 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) cell division 0.08109 Informative Inherited
Biological Process (BP) neurological system process 0.1433 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.8817 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1532 Informative Inherited
Biological Process (BP) organelle fission 0.935 Informative Inherited
Biological Process (BP) mitochondrion organization 1 Informative Inherited
Biological Process (BP) cell cycle process 0.165 Informative Inherited
Biological Process (BP) organelle assembly 0.8074 Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.000005884 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.000002304 Highly Informative Direct
Biological Process (BP) hemostasis 0.0005285 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000008969 Highly Informative Direct
Biological Process (BP) dopamine transport 0.0000002199 Highly Informative Direct
Biological Process (BP) macroautophagy 0.00000000003503 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0008496 Highly Informative Direct
Biological Process (BP) lipid modification 0.0009208 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.000771 Highly Informative Direct
Biological Process (BP) regulation of protein ubiquitination 0.0006634 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0000001744 Highly Informative Direct
Biological Process (BP) cell junction organization 0.00000103 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000002119 Highly Informative Direct
Biological Process (BP) response to topologically incorrect protein 0.00001577 Highly Informative Direct
Biological Process (BP) B cell activation 0.0003017 Highly Informative Direct
Biological Process (BP) positive regulation of GTPase activity 0.0000000005703 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.000002142 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.000712 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0008029 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0.00001802 Highly Informative Direct
Biological Process (BP) protein localization to membrane 0.0002508 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0006077 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein modification by small protein conjugation or removal 0.00000001056 Highly Informative Direct
Biological Process (BP) response to nerve growth factor 0.0001405 Highly Informative Direct
Biological Process (BP) positive regulation of cell migration 0.06995 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.415 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 0.02547 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.5839 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2033 Highly Informative Inherited
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.6357 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.001854 Highly Informative Inherited
Biological Process (BP) protein ubiquitination 1 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.03917 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4114 Highly Informative Inherited
Biological Process (BP) ear development 0.916 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.7232 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 1 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 0.3252 Highly Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.003827 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.4423 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.05592 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.003219 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.5334 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.2026 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0.9339 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.3403 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3398 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.2582 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1658 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.008802 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.01037 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.002928 Highly Informative Inherited
Biological Process (BP) regulation of protein targeting 0.2284 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.152 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.1207 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.4439 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.00134 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.005462 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 1 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.0169 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.03175 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.1228 Highly Informative Inherited
Biological Process (BP) regulation of mitochondrion organization 0.08332 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.03827 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.3032 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.6542 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.3174 Highly Informative Inherited
Biological Process (BP) adult behavior 0.08596 Highly Informative Inherited
Biological Process (BP) wound healing 0.05511 Highly Informative Inherited
Biological Process (BP) coagulation 0.003236 Highly Informative Inherited
Biological Process (BP) cell growth 0.04652 Highly Informative Inherited
Biological Process (BP) developmental growth 0.3077 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.18 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.001266 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.005474 Highly Informative Inherited
Biological Process (BP) nuclear division 1 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.07852 Highly Informative Inherited
Biological Process (BP) protein folding 0.8157 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.06638 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.6638 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.2939 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00007727 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.05323 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.4738 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8732 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00000004052 Informative Direct
Molecular Function (MF) enzyme binding 0.000000001326 Informative Direct
Molecular Function (MF) protein complex binding 0.0184 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) receptor binding 1 Informative Inherited
Molecular Function (MF) nucleotide binding 0.9761 Informative Inherited
Molecular Function (MF) peptidase activity 0.1469 Informative Inherited
Molecular Function (MF) ligase activity 0.2816 Informative Inherited
Molecular Function (MF) kinase activity 0.09185 Informative Inherited
Molecular Function (MF) lipid binding 0.4607 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.02641 Informative Inherited
Molecular Function (MF) phosphatase activity 0.1205 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.01373 Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 1 Informative Inherited
Molecular Function (MF) RNA binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.8888 Informative Inherited
Molecular Function (MF) phosphoprotein phosphatase activity 0.00001572 Highly Informative Direct
Molecular Function (MF) ubiquitin-protein transferase activity 0.000001219 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0008894 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000004221 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.133 Highly Informative Inherited
Molecular Function (MF) ribonucleoprotein complex binding 0.00257 Highly Informative Inherited
Molecular Function (MF) acid-amino acid ligase activity 0.02111 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited
Molecular Function (MF) adenylyltransferase activity 0.002257 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.0000009713 Least Informative Direct
Cellular Component (CC) membrane 0.01703 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7076 Least Informative Inherited
Cellular Component (CC) protein complex 0.163 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000004336 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.000003195 Moderately Informative Direct
Cellular Component (CC) transferase complex 0.000079 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.5671 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.7673 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.04579 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2906 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0.00003869 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0001477 Informative Direct
Cellular Component (CC) cell cortex 0.00000000000003406 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) synapse 0.000000004104 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cell surface 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 1 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0003266 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0006722 Highly Informative Direct
Cellular Component (CC) cell division site part 0.00115 Highly Informative Inherited
Cellular Component (CC) spliceosomal complex 0.34 Highly Informative Inherited
Cellular Component (CC) chromatin 0.9997 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000000005609Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0102Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Omega peptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000004359Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000004443Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.00003067Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00289Moderately InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000001949InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000366InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol 3-kinase0.000000000612Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Neoplasm0.01416Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6624Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.892InformativeInherited
Phenotypic Abnormality (PA)Alveolar cell carcinoma0.0001422Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.02064InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006354Least InformativeInherited
Worm Phenotype (WP)protein aggregation variant0.00001573Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.05939InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.0009859InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2677Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9239Least InformativeInherited
Zebrafish Anatomy (ZA)electrically signaling cell0.02314Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically responsive cell1Moderately InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.0007472InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.0003734Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0.001382Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2239Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.009178Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.0001293InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.000001031InformativeDirect
Plant ANatomical entity (PAN)gamete0.0003164InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.000004841Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.000000000005358Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000133Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000006717Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.000002115Moderately InformativeDirect
Enzyme Commission (EC)Omega peptidases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000002853InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000006003InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00001526InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.06029InformativeInherited
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.0000000000004025Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000004119Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0.02675Least InformativeInherited
Drugbank ATC_code (DB)other analgesics and antipyretics0.0001384Moderately InformativeDirect
Drugbank ATC_code (DB)psychoanaleptics0.1075Moderately InformativeInherited
Drugbank ATC_code (DB)paracetamol0.00006072InformativeDirect
Drugbank ATC_code (DB)xanthine derivatives0.00006072InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000009356Least InformativeDirect
Biological processApoptosis0Moderately InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processAngiogenesis2.372e-16InformativeDirect
Biological processEndocytosis0.0000000914InformativeDirect
Biological processNeurogenesis0.0002287InformativeDirect
Biological processAutophagy0Highly InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Biological processmRNA transport0.0000000000001641Highly InformativeDirect
Biological processCilium biogenesis/degradation0.0000001822Highly InformativeDirect
Biological processExocytosis0.000009969Highly InformativeDirect
Biological processAntiviral defense0.00003307Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane0.000000000000005386Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentGolgi apparatus0.000003441Moderately InformativeDirect
Cellular componentEndosome0.0003656Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentProteasome0.000000001902Highly InformativeDirect
Cellular componentLipid droplet0.000000002557Highly InformativeDirect
Coding sequence diversityAlternative splicing0.00001203Least InformativeDirect
DiseaseTumor suppressor0.000000005683Moderately InformativeDirect
DiseaseProto-oncogene0.000006118Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0Moderately InformativeDirect
DomainSH2 domain0.0000000005622InformativeDirect
DomainSH3 domain0.00004538InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionActin-binding0InformativeDirect
Molecular functionCalmodulin-binding0.00000009133InformativeDirect
Molecular functionLipid-binding0.000007419InformativeDirect
Molecular functioncAMP-binding0.00000277Highly InformativeDirect
Molecular functioncAMP0.0001101Highly InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationProtease0.001344Moderately InformativeInherited
Post-translational modificationKinase0.04505Moderately InformativeInherited
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationThiol protease0InformativeDirect
Post-translational modificationProtein phosphatase0.000000000002623InformativeDirect
Post-translational modificationChromatin regulator0.0000004544InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0.00002218InformativeDirect
Post-translational modificationMyosin0Highly InformativeDirect
Post-translational modificationActin capping0.000006296Highly InformativeDirect
Post-translational modificationSignal transduction inhibitor0.0000096Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0.0006933Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.03047Least InformativeInherited
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect
UniPathway (UP)phospholipid metabolism0.0000000002453InformativeDirect
UniPathway (UP)phosphatidylinositol phosphate biosynthesis0Highly InformativeDirect
UniPathway (UP)protein degradation0.00000313Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 79 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ubiquitin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 79 hidden Markov models representing the Ubiquitin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]