SUPERFAMILY 1.75 HMM library and genome assignments server

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NTF2-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Cystatin-like [ 54402] (7)
Superfamily:   NTF2-like [ 54427] (30)
Families:   Scytalone dehydratase [ 54428]
  NTF2-like [ 54431] (6)
  Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A [ 89851]
  Limonene-1,2-epoxide hydrolase-like [ 89854] (2)
  SnoaL-like polyketide cyclase [ 102810] (5)
  PhzA/PhzB-like [ 102813] (4)
  Ketosteroid isomerase-like [ 54434] (2)
  Ring hydroxylating beta subunit [ 54438] (6)
  Penicillin binding protein 2a (PBP2A), N-terminal domain [ 82595]
  Orange carotenoid protein, C-terminal domain [ 82598]
  Hypothetical protein egc068 from a soil-derived mobile gene cassette [ 110826]
  PA1314-like [ 110829]
  TIM44-like [ 143001]
  Sbal0622-like [ 159985]
  CHU142-like [ 159988]
  SO0125-like [ 159991] (2)
  SAV4671-like [ 159996]
  BxeB1374-like [ 159999] (2)
  Atu0744-like [ 160004]
  Rpa4348-like [ 160007] (2)
  Ava4193-like [ 160012]
  YybH-like [ 160015]
  PFL3262-like [ 160018]
  Exig0174-like [ 160021]
  Rv3472-like [ 160024] (2)
  VirB8-like [ 160029]
  ECA1476-like [ 160033]
  BaiE/LinA-like [ 160036] (5)
  Atu0742-like [ 160047]
  SEC-C associated NTF2-like domain [ 160050]


Superfamily statistics
Genomes (2,573) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,912 207,943 102
Proteins 25,394 203,200 102


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0002027Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.0006578Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000002583Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle tone0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Generalized hypotonia0Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.09936Least InformativeInherited
Worm Phenotype (WP)male mating variant0.0003397InformativeDirect
Worm Phenotype (WP)male mating defective0.00005906Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.00003039Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.0001777Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.2597Least InformativeInherited
Enzyme Commission (EC)Lyases0.9595Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000009306Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.2215Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.249Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.2943Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)RNA helicase0.0008174InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.1512InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Transposing C=C bonds0.0001227Highly InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationLyase0.0000252Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 101 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NTF2-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 101 hidden Markov models representing the NTF2-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]