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MHC antigen-recognition domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MHC antigen-recognition domain [ 54451]
Superfamily:   MHC antigen-recognition domain [ 54452]
Families:   MHC antigen-recognition domain [ 54453] (12)


Superfamily statistics
Genomes (93) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,661 62,409 190
Proteins 3,650 62,349 190


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.1710Least InformativeInherited
Biological Process (BP)immune system process0.000069450Moderately InformativeDirect
Biological Process (BP)immune response0.00028950InformativeDirect
Cellular Component (CC)membrane0.00096480Least InformativeDirect
Cellular Component (CC)plasma membrane0.032530Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0000000845 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0001405 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0001721 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.03156 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001254 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.004844 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) cell activation 0.000000000001404 Informative Direct
Biological Process (BP) regulation of cytokine production 0.000000000004814 Informative Direct
Biological Process (BP) positive regulation of immune response 0.0000003579 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000004057 Informative Direct
Biological Process (BP) response to bacterium 0.0000006214 Informative Direct
Biological Process (BP) regulation of secretion 0.000003083 Informative Direct
Biological Process (BP) regulation of peptide transport 0.000004383 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001728 Informative Direct
Biological Process (BP) regulation of cellular localization 0.00003714 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.006846 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7791 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2121 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1486 Informative Inherited
Biological Process (BP) protein oligomerization 0.0764 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.08911 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1162 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.2317 Informative Inherited
Biological Process (BP) sensory organ development 0.2198 Informative Inherited
Biological Process (BP) secretion by cell 0.1886 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.6246 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.002902 Informative Inherited
Biological Process (BP) immune effector process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.7208 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.9422 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.5344 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) innate immune response 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.000000000000003764 Highly Informative Direct
Biological Process (BP) protein folding 0.00000000000001615 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.000000000000668 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.000000000002996 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00000000003732 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00000000004913 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.00000008584 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000001031 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.0000003633 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000001129 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.000003767 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000004095 Highly Informative Direct
Biological Process (BP) inner ear development 0.00009828 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.0001215 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0002196 Highly Informative Direct
Biological Process (BP) neutrophil activation 0.0005191 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.0005315 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0007263 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.006088 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.001005 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.009887 Highly Informative Inherited
Biological Process (BP) leukocyte degranulation 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.004496 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.147 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.02619 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.6126 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 0.01113 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.000004516 Informative Direct
Molecular Function (MF) molecular transducer activity 0.002157 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.3677 Informative Inherited
Molecular Function (MF) signal transducer activity 0.01685 Informative Inherited
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.0000186 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000004551 Least Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00556 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) lytic vacuole 0 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) extracellular space 0.00003016 Informative Direct
Cellular Component (CC) extracellular organelle 0.0006061 Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) endosome membrane 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0 Highly Informative Direct
Cellular Component (CC) lysosomal membrane 0.000000000000006155 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 0.00000000000003201 Highly Informative Direct
Cellular Component (CC) late endosome 0.00004283 Highly Informative Direct
Cellular Component (CC) extracellular vesicle 1 Highly Informative Inherited
Cellular Component (CC) anchored component of membrane 0.06081 Highly Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01621Least InformativeInherited
Disease Ontology (DO)organ system cancer0.07718Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001939Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000003687Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000001273Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00001492Moderately InformativeDirect
Disease Ontology (DO)skin disease0.00002237Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.00002366Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0001701Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.003256Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.007086Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03787Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04103Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2864Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.7104Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006075InformativeDirect
Disease Ontology (DO)liver disease0.00000002012InformativeDirect
Disease Ontology (DO)alopecia0.00003396InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.00007686InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003258InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0005197InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0007408InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.007413InformativeInherited
Disease Ontology (DO)arthropathy0.007735InformativeInherited
Disease Ontology (DO)bullous skin disease0.01636InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03061InformativeInherited
Disease Ontology (DO)myeloid leukemia0.0918InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000004946Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00000004712Highly InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001377Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.000001877Highly InformativeDirect
Disease Ontology (DO)spondylitis0.00000855Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001949Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002771Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00005977Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001174Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.001062Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.03256Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.005781Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.07278Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1206Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1835Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.185Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.3642Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6023Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8384Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.00006544Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vasculature0.005664Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.03847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.0479Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0679Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.07409Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.07526Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.08337Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.112Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3213Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.439Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.6186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.0000229InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system electrophysiology0.0003429InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.0009809InformativeDirect
Phenotypic Abnormality (PA)Decreased body weight0.07609InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.08069InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uvea0.1713InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.4965InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.000001297Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of salivation0.00007939Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.0000883Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.00009101Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0001608Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.0001726Highly InformativeDirect
Phenotypic Abnormality (PA)Arthritis0.0006474Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.03841Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature of the eye0.04504Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000002999Least InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.000002806Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0006276Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte cell number0.1803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.4369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.702Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.8241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0001324InformativeDirect
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.0003109InformativeDirect
Mammalian Phenotype (MP)abnormal interferon secretion0.001055InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.002686InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.1342InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.203InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.3793InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8227InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.000798Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.000995Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1102Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.2534Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0002635InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000009714Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentGPI-anchor0.0002498InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0.0000000005168Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011162 SSF54452 Protein matches
Abstract

This entry represents MHC class I and II-like antigen-recognition domains from:

  • MHC class II, N-terminal domains of alpha and beta chains [PubMed9768757]
  • MHC class I, alpha-1 and alpha-2 domains [PubMed15454423]
  • MHC class I related proteins, such as gammadelta T-cell ligand [PubMed17291278], Ulbp3 [PubMed12857997], Fc (IgG) receptor (alpha-1 and -2 domains) [PubMed7969498], CD1 (alpha-1 and -2 domains) [PubMed11677624], zinc-alpha-2-glycoprotein ZAG (fat depleting factor) [PubMed16475792]
  • Immunomodulatory protein m144, alpha-1 and alpha-2 domains [PubMed16500675]
  • Haemochromatosis protein Hfe, alpha-1 and alpha-2 domains [PubMed12667138]
  • NK cell ligand RAE-1 beta [PubMed12594837]
  • Endothelial protein C receptor (phospholipid-binding protein) [PubMed17327234]

More information about these proteins can be found at Protein of the Month: MHC.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MHC antigen-recognition domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the MHC antigen-recognition domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]