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MHC antigen-recognition domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MHC antigen-recognition domain [ 54451]
Superfamily:   MHC antigen-recognition domain [ 54452]
Families:   MHC antigen-recognition domain [ 54453] (12)


Superfamily statistics
Genomes (93) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,661 62,409 190
Proteins 3,650 62,349 190


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.11870Least InformativeInherited
Biological Process (BP)immune system process0.000029320Moderately InformativeDirect
Biological Process (BP)immune response0.00017320InformativeDirect
Cellular Component (CC)membrane0.0034430Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane0.00027250Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.015490Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01262 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) response to stress 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00004994 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0006008 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001102 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.006747 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) regulation of defense response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000000000004882 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000003271 Informative Direct
Biological Process (BP) response to bacterium 0.0000005259 Informative Direct
Biological Process (BP) regulation of secretion 0.000001973 Informative Direct
Biological Process (BP) regulation of cellular localization 0.00002134 Informative Direct
Biological Process (BP) regulation of protein localization 0.00002351 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00004396 Informative Direct
Biological Process (BP) cell adhesion 0.000431 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2902 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9405 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2927 Informative Inherited
Biological Process (BP) protein oligomerization 0.03427 Informative Inherited
Biological Process (BP) positive regulation of transport 0.1489 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1339 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1129 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.003466 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.0018 Informative Inherited
Biological Process (BP) generation of neurons 0.6722 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8683 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) innate immune response 0 Highly Informative Direct
Biological Process (BP) protein folding 0.000000000000007239 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00000000000002741 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00000000000005657 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.000000000000848 Highly Informative Direct
Biological Process (BP) cell killing 0.0000000000009211 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00000000003285 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0000000002909 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.000000007286 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 0.00000002267 Highly Informative Direct
Biological Process (BP) leukocyte cell-cell adhesion 0.0000002098 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000003595 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.0000003936 Highly Informative Direct
Biological Process (BP) negative regulation of cell development 0.000002388 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00001403 Highly Informative Direct
Biological Process (BP) detection of stimulus 0.00003988 Highly Informative Direct
Biological Process (BP) antigen processing and presentation of exogenous peptide antigen 0.0000408 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00006048 Highly Informative Direct
Biological Process (BP) inner ear development 0.00008638 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.00009935 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.0001443 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00564 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.006247 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.1121 Highly Informative Inherited
Biological Process (BP) humoral immune response 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.000001601 Informative Direct
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) signal transducer activity 0.00787 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.001034 Informative Inherited
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0.000002923 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000006507 Least Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.003619 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) lytic vacuole 0 Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) transport vesicle 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) organelle subcompartment 0.000000000002066 Informative Direct
Cellular Component (CC) extracellular organelle 0.0003378 Informative Direct
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0 Highly Informative Direct
Cellular Component (CC) lytic vacuole membrane 0 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0 Highly Informative Direct
Cellular Component (CC) endosome membrane 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) early endosome 0.000000000003731 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0000002987 Highly Informative Direct
Cellular Component (CC) late endosome 0.00007506 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.04258 Highly Informative Inherited
Cellular Component (CC) anchored component of membrane 0.08402 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.0002602Least InformativeDirect
Disease Ontology (DO)nervous system disease0.01731Least InformativeInherited
Disease Ontology (DO)organ system cancer0.07725Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001705Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000003393Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.000001298Moderately InformativeDirect
Disease Ontology (DO)skin disease0.00001496Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.0000224Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0001742Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.003294Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.007214Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03916Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.04039Moderately InformativeInherited
Disease Ontology (DO)blood coagulation disease0.08807Moderately InformativeInherited
Disease Ontology (DO)syndrome0.2894Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.7205Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006488InformativeDirect
Disease Ontology (DO)liver disease0.00000001989InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001305InformativeDirect
Disease Ontology (DO)alopecia0.00003175InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0000743InformativeDirect
Disease Ontology (DO)anemia0.0001939InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003332InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0005875InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0007745InformativeDirect
Disease Ontology (DO)peripheral nervous system disease0.00707InformativeInherited
Disease Ontology (DO)arthropathy0.007529InformativeInherited
Disease Ontology (DO)bullous skin disease0.01483InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.03127InformativeInherited
Disease Ontology (DO)myeloid leukemia0.09233InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000004791Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00000004611Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.000001781Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000008274Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001576Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002706Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00006211Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001212Highly InformativeDirect
Disease Ontology (DO)metal metabolism disorder0.00107Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.03193Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.005687Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.108Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1197Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1833Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1947Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.3624Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6414Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8352Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.00006408Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.007952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.01036Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.02478Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.03816Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.07394Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.07538Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.08161Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1089Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1109Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3192Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior segment of the globe0.634Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.0003282InformativeDirect
Phenotypic Abnormality (PA)Vascular skin abnormality0.0005388InformativeDirect
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.0006367InformativeDirect
Phenotypic Abnormality (PA)CNS infection0.0009754InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cornea0.0799InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.1387InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uvea0.18InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.5032InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.000001136Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.00007733Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of salivation0.00008231Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.00009058Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0001615Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.0001777Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.0386Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000001493Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000007042Least InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.000003373Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0003696Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.002661Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3687Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.4312Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0001342InformativeDirect
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.0003105InformativeDirect
Mammalian Phenotype (MP)abnormal interferon secretion0.001132InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.1377InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.2102InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.3723InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.8259InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0008432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.1076Highly InformativeInherited
Mammalian Phenotype (MP)decreased alpha-beta T cell number0.2338Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0002654InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000000008899Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentGPI-anchor0.0002329InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
Molecular functionIron1Moderately InformativeInherited
Molecular functionIron transport0.0000000004248Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011162 SSF54452 Protein matches
Abstract

This entry represents MHC class I and II-like antigen-recognition domains from:

  • MHC class II, N-terminal domains of alpha and beta chains [PubMed9768757]
  • MHC class I, alpha-1 and alpha-2 domains [PubMed15454423]
  • MHC class I related proteins, such as gammadelta T-cell ligand [PubMed17291278], Ulbp3 [PubMed12857997], Fc (IgG) receptor (alpha-1 and -2 domains) [PubMed7969498], CD1 (alpha-1 and -2 domains) [PubMed11677624], zinc-alpha-2-glycoprotein ZAG (fat depleting factor) [PubMed16475792]
  • Immunomodulatory protein m144, alpha-1 and alpha-2 domains [PubMed16500675]
  • Haemochromatosis protein Hfe, alpha-1 and alpha-2 domains [PubMed12667138]
  • NK cell ligand RAE-1 beta [PubMed12594837]
  • Endothelial protein C receptor (phospholipid-binding protein) [PubMed17327234]

More information about these proteins can be found at Protein of the Month: MHC.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 72 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MHC antigen-recognition domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 72 hidden Markov models representing the MHC antigen-recognition domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]