SUPERFAMILY 1.75 HMM library and genome assignments server

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UBC-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   UBC-like [ 54494]
Superfamily:   UBC-like [ 54495] (4)
Families:   UBC-related [ 54496] (6)
  UEV domain [ 75383] (2)
  RWD domain [ 110843] (4)
  UFC1-like [ 143072]

Superfamily statistics
Genomes (545) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 21,162 0 68
Proteins 20,812 0 68

Functional annotation
General category Processes_IC
Detailed category Protein modification

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.04852Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.002263InformativeInherited
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0003768Highly InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000001204Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000001429Least InformativeDirect
Worm Phenotype (WP)larval growth variant0.6816Least InformativeInherited
Worm Phenotype (WP)larval development variant0.9589Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0006663Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.172Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)sick0.0006637InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0.002095Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.004704Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.02903Least InformativeInherited
Xenopus ANatomical entity (XAN)egg0.00006393Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.002311Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.00003528InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0.007716InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.01696InformativeInherited
Xenopus ANatomical entity (XAN)bone tissue0.0009731Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.0005228Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0.00009948Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660.00001498InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003759Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.0165Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.07332Least InformativeInherited
Plant ANatomical entity (PAN)pollen tube cell0.00002326InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00000001192Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processCell cycle0.00000000000002504Moderately InformativeDirect
Biological processApoptosis0.000000000004333Moderately InformativeDirect
Biological processProtein transport0.0000003183Moderately InformativeDirect
Biological processDNA damage0.00001623Moderately InformativeDirect
Biological processDifferentiation0.0004873Moderately InformativeDirect
Biological processSporulation0.000000000000001691InformativeDirect
Biological processTranslation regulation0.0000000001299InformativeDirect
Biological processNeurogenesis0.000000003073InformativeDirect
Biological processStress response0.000001145InformativeDirect
Biological processGrowth regulation0.00001567Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndosome0.00000005722Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0006788Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationChromatin regulator0.0000000001794InformativeDirect
Post-translational modificationActin-binding0.0003129InformativeDirect
Post-translational modificationAcetylation0.0000000000000114Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 42 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a UBC-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 42 hidden Markov models representing the UBC-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]