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CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,238) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 35,450 173,023 31
Proteins 32,278 164,747 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8746 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.5143 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00005105 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.4669 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.01071 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.661 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.08565 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.621 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1004 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02308 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.04181 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.53 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1005 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003951 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.01042 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.722 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.3128 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003275 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.04564 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02056 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000000004711 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0000001419 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00001589 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001175 Informative Direct
Biological Process (BP) transmembrane transport 0.0002603 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0003365 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000452 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0007504 Informative Direct
Biological Process (BP) anion transport 0.1309 Informative Inherited
Biological Process (BP) metal ion transport 0.9076 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.111 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.7769 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.003613 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.00167 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.007075 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.004231 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.01818 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1034 Informative Inherited
Biological Process (BP) cation homeostasis 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1148 Informative Inherited
Biological Process (BP) autophagy 0.00000000004587 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.000000003511 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00000001668 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00000007265 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.00000008672 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000002421 Highly Informative Direct
Biological Process (BP) pH reduction 0.0000004389 Highly Informative Direct
Biological Process (BP) organic cation transport 0.000001385 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000002919 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.000008141 Highly Informative Direct
Biological Process (BP) ammonium transport 0.00004295 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00008591 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.007438 Highly Informative Inherited
Biological Process (BP) anion transmembrane transport 0.001405 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.01731 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.1529 Highly Informative Inherited
Biological Process (BP) aging 0.007753 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00005885 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002922 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.7221 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.02833 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.003395 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.4889 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2505 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.0000000000002572 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.000002325 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00001246 Informative Direct
Molecular Function (MF) enzyme binding 0.00006282 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.05021 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.00351 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.162 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1228 Informative Inherited
Molecular Function (MF) kinase activity 0.2205 Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.000000000001221 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00000001596 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.000000282 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000002873 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0003946 Highly Informative Direct
Molecular Function (MF) amine transmembrane transporter activity 0.0005503 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.01068 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.006066 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.02217 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.01806 Highly Informative Inherited
Cellular Component (CC) protein complex 0.9344 Least Informative Inherited
Cellular Component (CC) membrane 0.004769 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9251 Least Informative Inherited
Cellular Component (CC) transferase complex 0.01144 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.02444 Moderately Informative Inherited
Cellular Component (CC) vacuole 0.003413 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.4224 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.6735 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02739 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.1137 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000003453 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.0000008496 Informative Direct
Cellular Component (CC) plasma membrane region 0.1186 Informative Inherited
Cellular Component (CC) vacuolar part 0.001649 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.000025 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.02509Moderately InformativeInherited
Biological processAmino-acid biosynthesis0.5719Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism0.0000008673InformativeDirect
Biological processLipid biosynthesis0.001221InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis0.000000002989Highly InformativeDirect
Biological processMethionine biosynthesis0.000002629Highly InformativeDirect
Biological processAmino-acid transport0.000244Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0006813Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0.000000000000001304Moderately InformativeDirect
Cellular componentGolgi apparatus0.00023Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00002871Least InformativeDirect
DiseaseDisease mutation0.0000004843Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.01449Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionCobalt0.00001237InformativeDirect
Post-translational modificationOxidoreductase0.00000008918Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000005856Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000309Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]