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CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,238) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,450 0 31
Proteins 32,278 0 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1939Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0001944InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3013Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4581Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.0767Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.3141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01078InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04779InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5203InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption0.0000004882Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.00159Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.009806Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant0.00000000001225InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000000004542Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.5726Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0006357Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.03219Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.2436Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.5182Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.01547InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses0.006358Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.03133Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.02597Moderately InformativeInherited
Biological processAmino-acid biosynthesis0.5746Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism0.0000008956InformativeDirect
Biological processLipid biosynthesis0.001233InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis0.000000003052Highly InformativeDirect
Biological processMethionine biosynthesis0.000002621Highly InformativeDirect
Biological processAmino-acid transport0.00005713Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0006863Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0.000000000000003257Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002569Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00002429Least InformativeDirect
DiseaseDisease mutation0.0000007128Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.01652Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionCobalt0.00001264InformativeDirect
Post-translational modificationOxidoreductase0.0000001248Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000004843Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00003042Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]