SUPERFAMILY 1.75 HMM library and genome assignments server


CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,188) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 33,966 68,771 31
Proteins 31,161 66,054 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 3.889e-06 Least Informative Direct
Biological Process (BP) biosynthetic process 0.4945 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.1616 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 1.315e-07 Moderately Informative Direct
Biological Process (BP) homeostatic process 9.811e-05 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.001787 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00513 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2422 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.5322 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.2365 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.04242 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.0418 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.4376 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.09495 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2774 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.4961 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5083 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.5128 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.747 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.008642 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.3121 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.6217 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.6666 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7182 Moderately Informative Inherited
Biological Process (BP) response to nutrient levels 2.653e-10 Informative Direct
Biological Process (BP) regulation of ion transport 8.628e-10 Informative Direct
Biological Process (BP) lipid localization 4.016e-09 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.047e-06 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 2.249e-05 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 2.458e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 3.84e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 5.796e-05 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0001511 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0002556 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.0003189 Informative Direct
Biological Process (BP) transmembrane transport 0.0003324 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.06966 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.01522 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.006524 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.004056 Informative Inherited
Biological Process (BP) metal ion transport 0.3361 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.4917 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.547 Informative Inherited
Biological Process (BP) anion transport 0.03396 Informative Inherited
Biological Process (BP) phosphorylation 0.05438 Informative Inherited
Biological Process (BP) autophagy 2.446e-11 Highly Informative Direct
Biological Process (BP) cellular response to starvation 2.949e-10 Highly Informative Direct
Biological Process (BP) maintenance of location 1.988e-07 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 6.629e-07 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 6.672e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 3.204e-06 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 5.121e-05 Highly Informative Direct
Biological Process (BP) inorganic anion transport 5.254e-05 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 6.712e-05 Highly Informative Direct
Biological Process (BP) guanosine-containing compound metabolic process 0.0005209 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0005606 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.001827 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 1.523e-10 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1446 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.04567 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2846 Moderately Informative Inherited
Molecular Function (MF) cation binding 0.2131 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.01541 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 4.437e-13 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 5.669e-06 Informative Direct
Molecular Function (MF) hydro-lyase activity 4.64e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0009826 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.00607 Informative Inherited
Molecular Function (MF) nucleotide binding 0.02065 Informative Inherited
Molecular Function (MF) kinase activity 0.003121 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.677e-06 Highly Informative Direct
Molecular Function (MF) protein kinase activity 3.292e-05 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.0002309 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.001488 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.5102 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0.116 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.3272 Moderately Informative Inherited
Cellular Component (CC) endosome 9.067e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1031Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.0001274InformativeDirect
Phenotypic Abnormality (PA)Abnormality of calcium homeostasis0.0002278Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2833Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5255Least InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.001286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.03857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.04821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.07451Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.09287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.005001InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.297InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption1.546e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor inner segment morphology7.614e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal photoreceptor outer segment morphology0.0001168Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.0001739Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant4.398e-12InformativeDirect
Worm Phenotype (WP)nervous system physiology variant4.204e-10Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3101Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.01168Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1351Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.3683Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.008313InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0.003393Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.0307Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.01099Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism3.474e-07InformativeDirect
Biological processLipid biosynthesis0.0005776InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis1.389e-09Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0004391Highly InformativeDirect
Biological processAmino-acid transport0.0005669Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus6.761e-05Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.000133Least InformativeDirect
DiseaseDisease mutation1.738e-07Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.01465Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionCobalt6.163e-06InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase6.448e-08Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel2.852e-15Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism2.728e-06Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis6.369e-07Moderately InformativeDirect
UniPathway (UP)L-cysteine biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]