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CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,236) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 35,369 173,023 31
Proteins 32,210 164,747 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.831 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.4585 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0007313 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.9911 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.6965 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.009367 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.009838 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2978 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.6464 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cell communication 0.6225 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01918 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.003263 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.08101 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02973 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5072 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.03806 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.08474 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.09133 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4453 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002588 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.04163 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000000002835 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0000001026 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0000002275 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00001362 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0001051 Informative Direct
Biological Process (BP) transmembrane transport 0.0001606 Informative Direct
Biological Process (BP) regulation of cell cycle 0.0003266 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0003648 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0006937 Informative Direct
Biological Process (BP) metal ion transport 0.9574 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.09327 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.00667 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.01621 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.003149 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1024 Informative Inherited
Biological Process (BP) anion transport 0.1094 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.004296 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.001439 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.1175 Informative Inherited
Biological Process (BP) autophagy 0.00000000004063 Highly Informative Direct
Biological Process (BP) cellular response to extracellular stimulus 0.000000008424 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000000008656 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00000006556 Highly Informative Direct
Biological Process (BP) modified amino acid transport 0.00000008557 Highly Informative Direct
Biological Process (BP) maintenance of location 0.0000001846 Highly Informative Direct
Biological Process (BP) pH reduction 0.0000004551 Highly Informative Direct
Biological Process (BP) organic cation transport 0.0000006999 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000002879 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.00000696 Highly Informative Direct
Biological Process (BP) ammonium transport 0.00002244 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.00002459 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00006036 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00006793 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00007582 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.0007774 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.02326 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.1482 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0001315 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00581 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.01 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.6742 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.02609 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2244 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5776 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.000000000003307 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.000005694 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00001114 Informative Direct
Molecular Function (MF) enzyme binding 0.0001282 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.07158 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.0039 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.1503 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1775 Informative Inherited
Molecular Function (MF) kinase activity 0.2961 Informative Inherited
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.000000000009511 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00000005324 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0000002061 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000006876 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0001804 Highly Informative Direct
Molecular Function (MF) amine transmembrane transporter activity 0.0005172 Highly Informative Direct
Molecular Function (MF) vitamin binding 0.007679 Highly Informative Inherited
Molecular Function (MF) protein domain specific binding 0.004143 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.02066 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.9596 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.03216 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.003043 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8076 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9982 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.02697 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.01981 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.4225 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.6724 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.02273 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000002696 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.000004783 Informative Direct
Cellular Component (CC) plasma membrane region 0.2029 Informative Inherited
Cellular Component (CC) vacuolar part 0.001526 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.0000907 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1758Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6674Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4266Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.0002798InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glomerulus0.002409InformativeInherited
Phenotypic Abnormality (PA)Tubulointerstitial fibrosis0.000002812Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulosclerosis0.00004187Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3013Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4587Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.07722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.315Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01086InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04822InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5206InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption0.0000004811Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.00162Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.009874Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant0.000000000008354InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.00000000443Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.5737Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0005976Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.03217Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.243Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.52Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.01569InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses0.006457Highly InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.03179Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.02397Moderately InformativeInherited
Biological processAmino-acid biosynthesis0.5653Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism0.0000008573InformativeDirect
Biological processLipid biosynthesis0.001208InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis0.000000002804Highly InformativeDirect
Biological processMethionine biosynthesis0.000002573Highly InformativeDirect
Biological processAmino-acid transport0.0001791Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0006656Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0.000000000000001304Moderately InformativeDirect
Cellular componentGolgi apparatus0.0002348Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00004237Least InformativeDirect
DiseaseDisease mutation0.0000004427Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.0188Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionCobalt0.00001175InformativeDirect
Post-translational modificationOxidoreductase0.00000007514Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000006053Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00002276Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.8641Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.08206Moderately InformativeInherited
UniPathway (UP)L-methionine biosynthesis via de novo pathway0.000000000001085InformativeDirect
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)L-cysteine metabolism0.0000000000001998Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]