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CBS-domain pair superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CBS-domain pair [ 54630]
Superfamily:   CBS-domain pair [ 54631]
Families:   CBS-domain pair [ 54632] (20)


Superfamily statistics
Genomes (3,231) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 35,284 147,001 31
Proteins 32,137 143,363 26


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.8036 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3645 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6872 Least Informative Inherited
Biological Process (BP) ion transport 0.000000000006577 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00001161 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative biosynthetic process 0.0008735 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.1521 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.8602 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 0.01428 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.03077 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.01613 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02222 Moderately Informative Inherited
Biological Process (BP) glycosyl compound metabolic process 0.1089 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to stress 0.4103 Moderately Informative Inherited
Biological Process (BP) cell communication 0.4899 Moderately Informative Inherited
Biological Process (BP) organophosphate biosynthetic process 0.00755 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.007828 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.002593 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.07734 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.2782 Moderately Informative Inherited
Biological Process (BP) nucleoside phosphate metabolic process 0.03012 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.533 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.000000002199 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0000000779 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00001295 Informative Direct
Biological Process (BP) transmembrane transport 0.00001928 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0000845 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000177 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0003945 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0005911 Informative Direct
Biological Process (BP) anion transport 0.1073 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.0723 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.006388 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.002393 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.001132 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.06844 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.0133 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.5589 Informative Inherited
Biological Process (BP) metal ion transport 0.6511 Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 0.003078 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.1049 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.004518 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.09133 Informative Inherited
Biological Process (BP) autophagy 0.0000000000003611 Highly Informative Direct
Biological Process (BP) cellular response to external stimulus 0.000000002845 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000000006771 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00000005167 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000003217 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.00000552 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.0000429 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.00005155 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.00006282 Highly Informative Direct
Biological Process (BP) lipid homeostasis 0.0000892 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 0.0004126 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.01637 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.5021 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.006495 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.007133 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.004459 Moderately Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 0.6163 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.02272 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.2008 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.558 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.005544 Moderately Informative Inherited
Molecular Function (MF) anion transmembrane transporter activity 0.00000000000114 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.00000124 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000008263 Informative Direct
Molecular Function (MF) enzyme binding 0.00007132 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.00009436 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.00009688 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.0781 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.00413 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.1972 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.1665 Informative Inherited
Molecular Function (MF) kinase activity 0.2791 Informative Inherited
Molecular Function (MF) kinase binding 0.00000005539 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0000001566 Highly Informative Direct
Molecular Function (MF) pyridoxal phosphate binding 0.000003543 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.00001333 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0001491 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.8519 Highly Informative Inherited
Molecular Function (MF) protein kinase activity 0.02995 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7513 Least Informative Inherited
Cellular Component (CC) membrane 0.006867 Least Informative Inherited
Cellular Component (CC) transferase complex 0.03614 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.009489 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.01361 Moderately Informative Inherited
Cellular Component (CC) endosome 0.0000001381 Informative Direct
Cellular Component (CC) plasma membrane region 0.1507 Informative Inherited
Cellular Component (CC) basolateral plasma membrane 0.0004044 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3306Least InformativeInherited
Enzyme Commission (EC)Lyases0.239Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.006567Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001371Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0.003148InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1781Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6685Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4215Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.0002467InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glomerulus0.002474InformativeInherited
Phenotypic Abnormality (PA)Tubulointerstitial fibrosis0.000002909Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulosclerosis0.00004937Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3074Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4317Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.07015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1192Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.3377Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01061InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04764InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5201InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption0.0000006279Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.001678Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.01028Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)electrophysiology variant0.000000000006422InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000000003696Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.3765Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.01438Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1513Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.3848Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.008759InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0.02758Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0.001998Least InformativeInherited
Drugbank ATC_code (DB)blood and blood forming organs0.005283Least InformativeInherited
Drugbank ATC_code (DB)nervous system0.04093Least InformativeInherited
Drugbank ATC_code (DB)analgesics0.0005069Moderately InformativeDirect
Drugbank ATC_code (DB)stomatological preparations0.008815Moderately InformativeInherited
Drugbank ATC_code (DB)antithrombotic agents1Moderately InformativeInherited
Drugbank ATC_code (DB)acetylsalicylic acid0.00000217InformativeDirect
Drugbank ATC_code (DB)salicylic acid and derivatives0.00000217InformativeDirect
Drugbank ATC_code (DB)other agents for local oral treatment0.00002697InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid metabolism0.01776Moderately InformativeInherited
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processPurine biosynthesis0InformativeDirect
Biological processFatty acid metabolism0.0000005634InformativeDirect
Biological processLipid biosynthesis0.0008545InformativeDirect
Biological processAntiport0Highly InformativeDirect
Biological processCysteine biosynthesis0.000000001721Highly InformativeDirect
Biological processAmino-acid transport0.0001809Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0.0005449Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome3.293e-16Moderately InformativeDirect
Cellular componentGolgi apparatus0.0001482Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00004104Least InformativeDirect
DiseaseDisease mutation0.000001188Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0.004259Least InformativeInherited
DomainCBS domain0Highly InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionCobalt0.000005755InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationOxidoreductase0.00000002067Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0.000000000000004857Highly InformativeDirect
Post-translational modificationPhosphoprotein0.00002145Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)XMP biosynthesis0Highly InformativeDirect
UniPathway (UP)L-cysteine metabolism0.00000000000002349Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CBS-domain pair domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the CBS-domain pair superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]