SUPERFAMILY 1.73 HMM library and genome assignments server


Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
  core: beta-alpha-beta(4); 2 layers: alpha/beta
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (16)
  Pfam 03061
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  contains two additional beta-strands in the N-terminal extension
  Acyl-CoA thioesterase [ 54644] (2)
  duplication: consists of two domains of this fold
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (13)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187]
  contains extra C-terminal helix
  Acyl-ACP thioesterase [ 143190]
  Pfam 01643; duplication: consists of two 4HBT-like domains


Superfamily statistics
Genomes (1,194) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 16,019 17,013 64
Proteins 13,313 14,689 55


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]