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Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (18)
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  Acyl-CoA thioesterase [ 54644] (2)
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (14)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187] (2)
  Acyl-ACP thioesterase-like [ 143190] (2)


Superfamily statistics
Genomes (3,123) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 40,072 237,524 72
Proteins 33,610 204,301 62


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)biosynthetic process0.17030.1175Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.2460.00002225Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.00000017550Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00015620.00004232Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.00021590Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.05670.5377Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.18681Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.44431Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.000000020950InformativeDirect
Biological Process (BP)protein oligomerization0.0053030.05849InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0010840.00006681InformativeInherited
Biological Process (BP)protein homotetramerization0.00026320.0001342Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.065960.000002748Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00000044580Moderately InformativeDirect
Molecular Function (MF)lyase activity0.0000033830Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity0.0000000000012720InformativeDirect
Molecular Function (MF)thiolester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00002225 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1175 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00004232 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000001664 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000000008211 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.5377 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.03159 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3569 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0312 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.06557 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.00006681 Informative Direct
Biological Process (BP) lipid catabolic process 0.0008634 Informative Direct
Biological Process (BP) protein oligomerization 0.05849 Informative Inherited
Biological Process (BP) protein homotetramerization 0.0001342 Highly Informative Direct
Biological Process (BP) lipid modification 0.1424 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.000002748 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00003848 Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.7901 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5271Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.02507Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000000000646InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.0000002002InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000000000918Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.000000003571InformativeDirect
Post-translational modificationHydrolase0.05341Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationRepressor0.0003926Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]