SUPERFAMILY 1.75 HMM library and genome assignments server

Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (18)
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  Acyl-CoA thioesterase [ 54644] (2)
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (14)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187] (2)
  Acyl-ACP thioesterase-like [ 143190] (2)


Superfamily statistics
Genomes (3,115) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 40,026 199,072 72
Proteins 33,567 178,519 62


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.45910.555Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.94350.0623Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.00016090.00000000000001071Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00060270.00000171Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.01970.0000000025Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0057880Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00000020630InformativeDirect
Biological Process (BP)coenzyme biosynthetic process0.19270.9909InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.0037770.000576InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0019570.005751InformativeInherited
Biological Process (BP)ketone biosynthetic process0.00003970.00001122Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.00020060.005166Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.20910.0008851Least InformativeInherited
Molecular Function (MF)lyase activity0.0000012570Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.000037390Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity0.00000000000063950InformativeDirect
Molecular Function (MF)thiolester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.0623 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.555 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.00000000000001071 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00000171 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000025 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.000004105 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.3232 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.05113 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1933 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.006744 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000576 Informative Direct
Biological Process (BP) lipid catabolic process 0.0000001603 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.9909 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.009661 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.005751 Informative Inherited
Biological Process (BP) ketone biosynthetic process 0.00001122 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone metabolic process 0.005166 Highly Informative Inherited
Biological Process (BP) lipid modification 0.09873 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0008851 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.3465 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003358 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.001394 Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001197 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0001218 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.1836 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5271Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.02507Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000000000646InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.0000002002InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000000000918Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.029Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1711Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0000566Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.07439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fatty acid level0.00000002348Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1471InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000000004919Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.000000001933Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.000000006408Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.000000117InformativeDirect
Post-translational modificationHydrolase0.2776Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0.000538Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.5283Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.000000002239Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0007566Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.3878Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis0.00001325InformativeDirect
UniPathway (UP)carnitine metabolism0.00005167InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]