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Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (18)
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  Acyl-CoA thioesterase [ 54644] (2)
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (14)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187] (2)
  Acyl-ACP thioesterase-like [ 143190] (2)

Superfamily statistics
Genomes (2,396) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 31,825 87,878 72
Proteins 26,477 76,797 62

 Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.57890.1941Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.62116.037e-07Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.00047834.362e-13Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process0.000760Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0016940.0002055Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.031835.365e-10Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.0055854.523e-05Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process3.23e-060InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.024180.001748InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.26211InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0029660.005057InformativeInherited
Biological Process (BP)quinone biosynthetic process0.00010041.436e-06Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process0.00049530.006542Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.14710.0003349Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00025633.07e-15Moderately InformativeDirect
Molecular Function (MF)lyase activity0.0013621.829e-11Moderately InformativeInherited
Molecular Function (MF)carbon-oxygen lyase activity4.798e-060InformativeDirect
Molecular Function (MF)thiolester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 6.037e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.1941 Least Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 4.362e-13 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0002055 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 4.523e-05 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 5.365e-10 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.1834 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2689 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.2324 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 1.203e-05 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 4.665e-05 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.001748 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.005057 Informative Inherited
Biological Process (BP) quinone biosynthetic process 1.436e-06 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 0.006542 Highly Informative Inherited
Biological Process (BP) lipid modification 0.0382 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0003349 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 3.07e-15 Moderately Informative Direct
Molecular Function (MF) lyase activity 1.829e-11 Moderately Informative Direct
Molecular Function (MF) carbon-oxygen lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.01446 Informative Inherited
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.6625 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) microbody 2.351e-14 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5271Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.02507Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase6.46e-15InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.002e-07InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase9.18e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04736Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid level0.0001735Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level5.512e-07InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1453InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase5.556e-12Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase2.137e-09Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase7.235e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome1.377e-07InformativeDirect
Post-translational modificationHydrolase0.3054Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0.0004986Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.5225Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis1.245e-09Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0006517Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.3938Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis8.147e-06InformativeDirect
UniPathway (UP)carnitine metabolism5.358e-05InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.