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Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (18)
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  Acyl-CoA thioesterase [ 54644] (2)
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (14)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187] (2)
  Acyl-ACP thioesterase-like [ 143190] (2)


Superfamily statistics
Genomes (3,116) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,995 199,072 72
Proteins 33,555 178,519 62


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.38310.0003109Least InformativeInherited
Biological Process (BP)biosynthetic process0.16560.03137Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process0.0000039630Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00013560.00002115Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.28531Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.15591Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.0016890Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.00000034020InformativeDirect
Biological Process (BP)protein oligomerization0.0024670.03377InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0015860.0001974InformativeInherited
Biological Process (BP)protein homotetramerization0.00013620.0000623Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.22580.00003961Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.000024790Moderately InformativeDirect
Molecular Function (MF)lyase activity0.000013038.405e-16Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity0.000000000010110InformativeDirect
Molecular Function (MF)thiolester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0003109 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.03137 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000001356 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.00002115 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.0000000002213 Moderately Informative Direct
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.2626 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0127 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.02066 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.05996 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 0.00043 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0001974 Informative Direct
Biological Process (BP) protein oligomerization 0.03377 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.07894 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.00328 Informative Inherited
Biological Process (BP) protein homotetramerization 0.0000623 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00774 Highly Informative Inherited
Biological Process (BP) lipid modification 0.09899 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00003961 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 8.405e-16 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00003349 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6533 Least Informative Inherited
Cellular Component (CC) microbody 0.0000000000003995 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5271Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.02507Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000000000646InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.0000002002InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000000000918Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.03452Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0000921Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal fatty acid level0.00000003866Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.07488InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transposing C=C bonds0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000000004447Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.00000000003256Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.0000000001248Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0009287Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome0.000000003489InformativeDirect
Post-translational modificationHydrolase0.196Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0.0008595Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0.2943Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0.000000001683Moderately InformativeDirect
UniPathway (UP)aromatic compound degradation0.0008436Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.4014Moderately InformativeInherited
UniPathway (UP)fatty acid biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0InformativeDirect
UniPathway (UP)quinol/quinone biosynthesis0InformativeDirect
UniPathway (UP)toxin biosynthesis0.000001215InformativeDirect
UniPathway (UP)carnitine metabolism0.00005555InformativeDirect
UniPathway (UP)siderophore biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]