SUPERFAMILY 1.75 HMM library and genome assignments server


Thioesterase/thiol ester dehydrase-isomerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Thioesterase/thiol ester dehydrase-isomerase [ 54636]
Superfamily:   Thioesterase/thiol ester dehydrase-isomerase [ 54637] (8)
Families:   4HBT-like [ 54638] (18)
  beta-Hydroxydecanol thiol ester dehydrase [ 54641]
  Acyl-CoA thioesterase [ 54644] (2)
  MaoC-like [ 82636] (6)
  PaaI/YdiI-like [ 89902] (14)
  FabZ-like [ 110902]
  TTHA0967-like [ 143187] (2)
  Acyl-ACP thioesterase-like [ 143190] (2)


Superfamily statistics
Genomes (3,114) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 40,003 199,072 72
Proteins 33,548 178,519 62


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.45980.5511Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.5772.342e-05Least InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process5.96e-050Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process0.00044025.133e-09Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process0.044866.495e-09Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.0021045.822e-06Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.0013670Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process4.207e-070InformativeDirect
Biological Process (BP)cellular ketone metabolic process0.0036010.0005105InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.2631InformativeInherited
Biological Process (BP)monocarboxylic acid biosynthetic process0.0030110.01335InformativeInherited
Biological Process (BP)quinone biosynthetic process5.867e-063.721e-07Highly InformativeDirect
Biological Process (BP)quinone cofactor metabolic process0.00038060.005239Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.20890.0008735Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds3.453e-050Moderately InformativeDirect
Molecular Function (MF)lyase activity9.337e-070Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity3.037e-130InformativeDirect
Molecular Function (MF)thiolester hydrolase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 2.342e-05 Least Informative Direct
Biological Process (BP) biosynthetic process 0.5511 Least Informative Inherited
Biological Process (BP) lipid biosynthetic process 5.822e-06 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 5.133e-09 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 6.495e-09 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.1862 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0 Informative Direct
Biological Process (BP) lipid catabolic process 2.833e-07 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.0005105 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.01475 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.01335 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) quinone biosynthetic process 3.721e-07 Highly Informative Direct
Biological Process (BP) quinone cofactor metabolic process 0.005239 Highly Informative Inherited
Biological Process (BP) lipid modification 0.0975 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.0008735 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.3443 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0003366 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.001341 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0001208 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.0001158 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.1789 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.5271Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.02507Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase6.46e-15InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat2.002e-07InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase9.18e-12Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.02852Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1702Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis5.732e-05Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.0739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fatty acid level2.267e-08Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.1461InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Transposing C==C bonds0Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase4.916e-12Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase1.932e-09Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase6.405e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processLipid A biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPeroxisome1.148e-07InformativeDirect
Post-translational modificationHydrolase0.2585Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationRepressor0.0004494Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor biosynthesis2.081e-16Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.03781Moderately InformativeInherited
UniPathway (UP)carbohydrate metabolism0.2166Moderately InformativeInherited
UniPathway (UP)quinone cofactor biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation2.03e-08InformativeDirect
UniPathway (UP)organic acid metabolism5.477e-06InformativeDirect
UniPathway (UP)pyruvate metabolism1.76e-10Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Thioesterase/thiol ester dehydrase-isomerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 57 hidden Markov models representing the Thioesterase/thiol ester dehydrase-isomerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]