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POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,057 105,779 24
Proteins 36,844 100,007 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.356Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7716Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1144Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.5857Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.04057InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0879InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1108InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.0006595Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.01144Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.1379Moderately InformativeInherited
Mammalian Phenotype (MP)muscle twitch0.0004258Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval growth variant0.002493Least InformativeInherited
Worm Phenotype (WP)larval development variant0.03174Least InformativeInherited
Worm Phenotype (WP)cell development variant0.1421Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.8006Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.861Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.001168Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.01568Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.02803Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.0936Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.147Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.295Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4786Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant1Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant1Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.000001228InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0000041InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00001085InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00001572InformativeDirect
Worm Phenotype (WP)neuron migration variant0.000142InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.006091InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.05534InformativeInherited
Worm Phenotype (WP)body axis morphology variant0Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.000000000000393Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased0.00000000004095Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.0000000006338Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00000002117Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.00000004733Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.00000009684Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0000008862Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.00002792Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.0006469Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3003Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.0005907Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.3743Least InformativeInherited
Fly Anatomy (FA)gonad0.213Moderately InformativeInherited
Fly Anatomy (FA)germarium0.1114InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.9895Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.9832Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye1InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.08589Highly InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.2704Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0002766Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 100.0004379Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.57Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6723Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8973Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000000001496InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00000001428InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2076InformativeInherited
Plant ANatomical entity (PAN)cortex0.007866Highly InformativeInherited

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]