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POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (502) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,043 38,955 24
Proteins 35,897 37,060 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)anatomical structure morphogenesis0.014590.09774Moderately InformativeInherited
Biological Process (BP)system development0.26040.2857Moderately InformativeInherited
Biological Process (BP)post-embryonic development0.000090790.0006427InformativeDirect
Biological Process (BP)animal organ morphogenesis0.000062570.02067InformativeInherited
Biological Process (BP)epithelium development0.00019020.2419InformativeInherited
Biological Process (BP)tube morphogenesis0.0000024340.000001302Highly InformativeDirect
Biological Process (BP)appendage development0.0000053270.00000129Highly InformativeDirect
Biological Process (BP)metamorphosis0.000014120.0000000005189Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium0.000040810.0004301Highly InformativeDirect
Biological Process (BP)instar larval or pupal morphogenesis0.00000011420.01722Highly InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.053310.7212Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.032410.2731Least InformativeInherited
Cellular Component (CC)transferase complex0.0000026330Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.000000014750InformativeDirect
Cellular Component (CC)chromosome0.000054110.03933InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.000000000000001902 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.2866 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.1778 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000002895 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000004659 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0.000002358 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.00001747 Moderately Informative Direct
Biological Process (BP) reproduction 0.0002123 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0002517 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0008743 Moderately Informative Direct
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.871 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.4258 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7847 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9461 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.9944 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09774 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2231 Moderately Informative Inherited
Biological Process (BP) system development 0.2857 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.003107 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.6058 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02541 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05926 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.3783 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2409 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.09809 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1184 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7152 Moderately Informative Inherited
Biological Process (BP) post-embryonic development 0.0006427 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00000000005754 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000000422 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.000000166 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000001065 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.000004505 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.000004542 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000006479 Informative Direct
Biological Process (BP) behavior 0.00002439 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.00004408 Informative Direct
Biological Process (BP) single organism reproductive process 0.00007037 Informative Direct
Biological Process (BP) actin filament-based process 0.0002395 Informative Direct
Biological Process (BP) immune response 0.0002457 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000976 Informative Direct
Biological Process (BP) protein oligomerization 0.000983 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.1247 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.8074 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.1122 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06459 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 0.968 Informative Inherited
Biological Process (BP) system process 0.08075 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5765 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.008563 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.7919 Informative Inherited
Biological Process (BP) central nervous system development 0.002674 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.004099 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) cell death 0.09146 Informative Inherited
Biological Process (BP) cell development 0.06039 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.02067 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4608 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8509 Informative Inherited
Biological Process (BP) generation of neurons 0.6346 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) reproductive system development 0.005155 Informative Inherited
Biological Process (BP) locomotion 0.1872 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.3616 Informative Inherited
Biological Process (BP) growth 0.7075 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.05893 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.07526 Informative Inherited
Biological Process (BP) response to acid chemical 0.04729 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) embryo development 0.7435 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) cell cycle process 0.3096 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) protein targeting 0.001512 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6268 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.2419 Informative Inherited
Biological Process (BP) tube morphogenesis 0.000001302 Highly Informative Direct
Biological Process (BP) appendage development 0.00000129 Highly Informative Direct
Biological Process (BP) metamorphosis 0.0000000005189 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0004301 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0000000000004796 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0000001092 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0000001868 Highly Informative Direct
Biological Process (BP) vesicle-mediated transport to the plasma membrane 0.0000005812 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000001912 Highly Informative Direct
Biological Process (BP) establishment of protein localization to membrane 0.00002412 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0000387 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00004871 Highly Informative Direct
Biological Process (BP) muscle structure development 0.0001413 Highly Informative Direct
Biological Process (BP) brain development 0.0002158 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0004568 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0005152 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0005959 Highly Informative Direct
Biological Process (BP) cell growth 0.000707 Highly Informative Direct
Biological Process (BP) negative regulation of chromosome segregation 0.0009259 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.1012 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.6509 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.1201 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.01368 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.06281 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.05876 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.03873 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01897 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.1919 Highly Informative Inherited
Biological Process (BP) renal system process 0.1225 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.04279 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02406 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0617 Highly Informative Inherited
Biological Process (BP) neuron development 0.2158 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.02618 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.003118 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.03155 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.04327 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9639 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.1269 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.1184 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.02542 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.6521 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.3294 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.01722 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.00565 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.5035 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.4613 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.07216 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.2639 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.03727 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.4344 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.04991 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.6982 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01246 Highly Informative Inherited
Biological Process (BP) cell maturation 0.1028 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.6619 Highly Informative Inherited
Biological Process (BP) germ cell development 0.01129 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.0137 Highly Informative Inherited
Biological Process (BP) endosomal transport 0.3258 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.384 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000008709 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0.0000000000008254 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.000004361 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.7041 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.000000000000002458 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.000000006542 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.8362 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0000000000002069 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00001683 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.0003484 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.0129 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.008381 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2731 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.7212 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.04519 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.002184 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.01666 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4203 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.2134 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.00000000000921 Informative Direct
Cellular Component (CC) synapse 0.001634 Informative Inherited
Cellular Component (CC) membrane region 0.0734 Informative Inherited
Cellular Component (CC) cell projection part 0.08714 Informative Inherited
Cellular Component (CC) plasma membrane region 0.01055 Informative Inherited
Cellular Component (CC) transport vesicle 0.153 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.4005 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.3918 Informative Inherited
Cellular Component (CC) chromosome 0.03933 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000000000379 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0002288 Highly Informative Direct
Cellular Component (CC) spindle 0.0003125 Highly Informative Direct
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.07926 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.011 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.197Moderately InformativeInherited
Mammalian Phenotype (MP)muscle twitch0.0002282Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval growth variant0.004978Least InformativeInherited
Worm Phenotype (WP)larval development variant0.03746Least InformativeInherited
Worm Phenotype (WP)cell development variant0.09777Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6926Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.7737Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.8095Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0007236Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.009898Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.03458Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.09337Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1024Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2908Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4094Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.9681Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant1Moderately InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000004974InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00001182InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00002047InformativeDirect
Worm Phenotype (WP)cell migration variant0.00563InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.007425InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.05755InformativeInherited
Worm Phenotype (WP)body axis morphology variant0Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased0.00000000004491Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.0000000006227Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.000000004941Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.0000000563Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.00000006406Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0000002521Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.0000008299Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.00002463Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.0006336Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.1581Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.0001583Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)integumentary system0.2248Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2415Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3344Least InformativeInherited
Fly Anatomy (FA)anatomical group0.5052Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)gonad0.1132Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.4839Moderately InformativeInherited
Fly Anatomy (FA)abdominal segment0.02204InformativeInherited
Fly Anatomy (FA)mechanosensory system0.1356InformativeInherited
Fly Anatomy (FA)larval abdomen0.1997InformativeInherited
Fly Anatomy (FA)ovariole0.2104InformativeInherited
Fly Anatomy (FA)larval segment0.7431InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.02978Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.03215Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.03972Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval sense organ0.04074Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.107Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.1413Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.1948Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.3017Highly InformativeInherited
Fly Anatomy (FA)segmental subdivision of integument0.4979Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.3913Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6423Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.9221Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.08382Highly InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.2179Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.5697Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6718Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8975Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.000000000149InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00000001422InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2071InformativeInherited
Plant ANatomical entity (PAN)cortex0.00783Highly InformativeInherited

Document: AP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0Least InformativeDirect
Drugbank ATC_code (DB)other nervous system drugs0Moderately InformativeDirect
Drugbank ATC_code (DB)other nervous system drugs0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000002427Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000002279Moderately InformativeDirect
Biological processHost-virus interaction0.01015Moderately InformativeInherited
Biological processCell cycle0.02455Moderately InformativeInherited
Biological processMitosis0.0000000000001659InformativeDirect
Biological processWnt signaling pathway0.00000003038InformativeDirect
Biological processNeurogenesis0.0000001457InformativeDirect
Biological processPlant defense0.0004366InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway0.00001355Highly InformativeDirect
Biological processExocytosis0.00005862Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.2478Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell junction9.774e-16Moderately InformativeDirect
Cellular componentCell membrane0.0000002609Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentHost cytoplasm0.00008431InformativeDirect
Cellular componentSarcoplasmic reticulum0.00000273Highly InformativeDirect
DiseaseEpilepsy0.0002743InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0.0000000000001295InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationPalmitate0.000001757Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]