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POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (507) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 38,484 87,732 24
Proteins 36,321 83,003 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)system development0.25180.1256Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.014640.02513Moderately InformativeInherited
Biological Process (BP)animal organ morphogenesis0.000060880.08627InformativeInherited
Biological Process (BP)tissue development0.058240.002983InformativeInherited
Biological Process (BP)post-embryonic development0.000089820.01358InformativeInherited
Biological Process (BP)tube morphogenesis0.0000018440.00001807Highly InformativeDirect
Biological Process (BP)appendage development0.0000028790.00007352Highly InformativeDirect
Biological Process (BP)post-embryonic animal morphogenesis0.000018420.000000007613Highly InformativeDirect
Biological Process (BP)morphogenesis of an epithelium0.000034560.0005454Highly InformativeDirect
Cellular Component (CC)macromolecular complex0.0041280Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.044690.2097Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.038220.4702Least InformativeInherited
Cellular Component (CC)transferase complex0.000002770Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.000000013060InformativeDirect
Cellular Component (CC)chromosome0.00001370.006447InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0007522 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.1811 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01277 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000002033 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000001888 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000008879 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0009136 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.007327 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.05461 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8984 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1577 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.7995 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02513 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.01615 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2881 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01181 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6598 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7172 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2752 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.02795 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001145 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.9829 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.004505 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5629 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.001358 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.02894 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4733 Moderately Informative Inherited
Biological Process (BP) system development 0.1256 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) proteolysis 0.000000000000342 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0000000001867 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000005559 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.00000003327 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000002644 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00002487 Informative Direct
Biological Process (BP) behavior 0.00003063 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.00008676 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001046 Informative Direct
Biological Process (BP) actin filament-based process 0.000154 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000205 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.783 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.2537 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.8773 Informative Inherited
Biological Process (BP) cell death 0.165 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1995 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.3843 Informative Inherited
Biological Process (BP) intracellular protein transport 0.3874 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.8796 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.04211 Informative Inherited
Biological Process (BP) cell cycle process 0.2485 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.4828 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1382 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.9101 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.08627 Informative Inherited
Biological Process (BP) central nervous system development 0.02083 Informative Inherited
Biological Process (BP) reproductive system development 0.01846 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.00101 Informative Inherited
Biological Process (BP) organelle localization 0.6937 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.7884 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) cell development 0.001538 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.5105 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.002271 Informative Inherited
Biological Process (BP) generation of neurons 0.353 Informative Inherited
Biological Process (BP) tissue development 0.002983 Informative Inherited
Biological Process (BP) protein localization to organelle 0.6236 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.2357 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.003955 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.007969 Informative Inherited
Biological Process (BP) locomotion 0.2879 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.5956 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5165 Informative Inherited
Biological Process (BP) response to acid chemical 0.03388 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9958 Informative Inherited
Biological Process (BP) system process 0.1812 Informative Inherited
Biological Process (BP) embryo development 0.209 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.003744 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) membrane organization 0.09881 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) immune response 0.002368 Informative Inherited
Biological Process (BP) post-embryonic development 0.01358 Informative Inherited
Biological Process (BP) sensory organ development 0.9777 Informative Inherited
Biological Process (BP) tube morphogenesis 0.00001807 Highly Informative Direct
Biological Process (BP) appendage development 0.00007352 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000000007613 Highly Informative Direct
Biological Process (BP) morphogenesis of an epithelium 0.0005454 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000000000005865 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000000004262 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.0000000009655 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00000002652 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000004992 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.0000003306 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000132 Highly Informative Direct
Biological Process (BP) muscle structure development 0.00001379 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00002115 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00002806 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.00004617 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00005893 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0001892 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000488 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0007212 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0009302 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.08768 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.6402 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.1889 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.5035 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.02949 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.09136 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.2055 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.5102 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.0779 Highly Informative Inherited
Biological Process (BP) kidney development 0.1626 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.005216 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2268 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.04555 Highly Informative Inherited
Biological Process (BP) renal system process 0.1533 Highly Informative Inherited
Biological Process (BP) neurological system process 0.01088 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.01932 Highly Informative Inherited
Biological Process (BP) brain development 0.001281 Highly Informative Inherited
Biological Process (BP) neuron development 0.8536 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2914 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.05839 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.3433 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.9896 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.04782 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.07002 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 0.1952 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.01119 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.3193 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.003953 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.09135 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.2243 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.04888 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.002734 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.04319 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.5077 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.07733 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.7539 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0168 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.7657 Highly Informative Inherited
Biological Process (BP) germ cell development 0.03216 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.6448 Highly Informative Inherited
Biological Process (BP) cell maturation 0.172 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.05231 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.2281 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.05812 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.01041 Highly Informative Inherited
Biological Process (BP) sodium ion transport 1 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000003229 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00000559 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.7455 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.000000000000001646 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00000006956 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.000000000005168 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.00002016 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.03044 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.02525 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.002301 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 1 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2097 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4702 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00000000000002918 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.1366 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.006347 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.0145 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.2851 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9353 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1704 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.000000004736 Informative Direct
Cellular Component (CC) plasma membrane region 0.0189 Informative Inherited
Cellular Component (CC) membrane region 0.1031 Informative Inherited
Cellular Component (CC) synapse 0.001446 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.9137 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.9315 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.7476 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.01197 Informative Inherited
Cellular Component (CC) chromosome 0.006447 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.2647 Informative Inherited
Cellular Component (CC) cell body membrane 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.000000000004484 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000005141 Highly Informative Direct
Cellular Component (CC) dendrite 0.00006283 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.0003049 Highly Informative Direct
Cellular Component (CC) nuclear body 0.000862 Highly Informative Direct
Cellular Component (CC) coated vesicle 0.09659 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.4198 Highly Informative Inherited
Cellular Component (CC) spindle 0.003156 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.1381Moderately InformativeInherited
Mammalian Phenotype (MP)muscle twitch0.0004227Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval growth variant0.005229Least InformativeInherited
Worm Phenotype (WP)larval development variant0.03696Least InformativeInherited
Worm Phenotype (WP)cell development variant0.1008Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.7428Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.84Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.8602Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.000648Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.015Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0315Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.09798Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1287Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.2978Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.4815Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant1Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant1Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.000001342InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000004538InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00001095InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0000168InformativeDirect
Worm Phenotype (WP)neuron migration variant0.0001285InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.00634InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.05472InformativeInherited
Worm Phenotype (WP)body axis morphology variant0Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.0000000000004237Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased0.00000000002894Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance defective early emb0.0000000004972Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00000000717Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.00000005341Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.00000007783Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0000005507Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.00002499Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.0005701Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.2129Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.0001792Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.3633Least InformativeInherited
Fly Anatomy (FA)gonad0.2123Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.3494InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.4093Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6609Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.9915Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.1243Highly InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.2339Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.5697Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6718Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8975Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.000000000149InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00000001422InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2071InformativeInherited
Plant ANatomical entity (PAN)cortex0.00783Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.000001082Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000007175Moderately InformativeDirect
Biological processHost-virus interaction0.01151Moderately InformativeInherited
Biological processCell cycle0.03335Moderately InformativeInherited
Biological processMitosis0.0000000000001972InformativeDirect
Biological processNeurogenesis0.000000005945InformativeDirect
Biological processWnt signaling pathway0.00000003938InformativeDirect
Biological processPlant defense0.0006575InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway0.00001592Highly InformativeDirect
Biological processExocytosis0.00006821Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.35Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.0000003897Moderately InformativeDirect
Cellular componentSynapse0.0000003413InformativeDirect
Cellular componentHost cytoplasm0.0001884InformativeDirect
Cellular componentSarcoplasmic reticulum0.000003595Highly InformativeDirect
DiseaseEpilepsy0.0007382InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0.0000000000001567InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationPalmitate0.000001635Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]