SUPERFAMILY 1.75 HMM library and genome assignments server


POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (449) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 33,294 27,485 24
Proteins 31,595 26,063 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.00019640.4799Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00011110.02362Least InformativeInherited
Biological Process (BP)protein metabolic process0.65790.0007646Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.70180.3876Least InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process3.79e-124.393e-11Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process1.733e-118.515e-12Moderately InformativeDirect
Biological Process (BP)regulation of gene expression3.916e-118.917e-06Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process4.327e-112.078e-06Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0014861.305e-09Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.023820.0005654Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.070271Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.17521Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.19220.05656Moderately InformativeInherited
Biological Process (BP)macromolecule catabolic process0.033660Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.17862.775e-07Moderately InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.00038546.786e-10InformativeDirect
Biological Process (BP)negative regulation of gene expression0.00077118.016e-08InformativeDirect
Biological Process (BP)protein catabolic process0.0032020InformativeInherited
Biological Process (BP)cellular macromolecule catabolic process0.010650InformativeInherited
Biological Process (BP)proteolysis0.014810InformativeInherited
Biological Process (BP)regulation of leukocyte differentiation1.095e-057.61e-06Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.00016870Highly InformativeDirect
Biological Process (BP)ubiquitin-dependent protein catabolic process0.00094980Highly InformativeDirect
Biological Process (BP)regulation of T cell activation4.868e-050.002034Highly InformativeInherited
Molecular Function (MF)binding0.0010972.966e-05Least InformativeInherited
Molecular Function (MF)nucleic acid binding1.891e-104.106e-08Moderately InformativeDirect
Molecular Function (MF)DNA binding5.005e-140InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity3.474e-132.173e-07InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.00056141.192e-12InformativeDirect
Molecular Function (MF)protein dimerization activity0.0079510.07546InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity2.098e-137.159e-09Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity8.673e-057.251e-06Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity0.00018150Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.077710.9815Least InformativeInherited
Cellular Component (CC)protein complex0.18833.379e-09Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex3.485e-050InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex8.449e-061.04e-10Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0007646 Least Informative Direct
Biological Process (BP) developmental process 0.4496 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.001557 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02362 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.3876 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4799 Least Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 4.393e-11 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 8.515e-12 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 8.917e-06 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 2.078e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.305e-09 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0005654 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.775e-07 Moderately Informative Direct
Biological Process (BP) ion transport 0.000253 Moderately Informative Direct
Biological Process (BP) regulation of programmed cell death 0.3226 Moderately Informative Inherited
Biological Process (BP) organ development 0.07572 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05656 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4878 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.04785 Moderately Informative Inherited
Biological Process (BP) system process 0.00765 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5468 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.6053 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2079 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9802 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8969 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.007502 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3918 Moderately Informative Inherited
Biological Process (BP) reproduction 0.005175 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.01269 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 6.786e-10 Informative Direct
Biological Process (BP) negative regulation of gene expression 8.016e-08 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 6.925e-07 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) metal ion transport 3.944e-13 Informative Direct
Biological Process (BP) transmission of nerve impulse 1.317e-09 Informative Direct
Biological Process (BP) cell-cell signaling 5.154e-08 Informative Direct
Biological Process (BP) reproductive structure development 2.893e-06 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002849 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.1919 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.7048 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.4817 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1534 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.004891 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.04315 Informative Inherited
Biological Process (BP) regulation of system process 0.1108 Informative Inherited
Biological Process (BP) central nervous system development 0.1527 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.1834 Informative Inherited
Biological Process (BP) protein complex assembly 0.03648 Informative Inherited
Biological Process (BP) regulation of secretion 0.312 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2894 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3896 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3114 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1262 Informative Inherited
Biological Process (BP) cell death 0.3996 Informative Inherited
Biological Process (BP) generation of neurons 0.7362 Informative Inherited
Biological Process (BP) DNA metabolic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2725 Informative Inherited
Biological Process (BP) regulation of immune response 0.7728 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.8547 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.4229 Informative Inherited
Biological Process (BP) single-organism behavior 0.00143 Informative Inherited
Biological Process (BP) locomotion 0.3985 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.5356 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cell projection organization 0.46 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1338 Informative Inherited
Biological Process (BP) cellular component movement 0.6689 Informative Inherited
Biological Process (BP) growth 0.6781 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9051 Informative Inherited
Biological Process (BP) sexual reproduction 0.008019 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.06523 Informative Inherited
Biological Process (BP) cell cycle process 0.3822 Informative Inherited
Biological Process (BP) organelle localization 0.5224 Informative Inherited
Biological Process (BP) membrane organization 0.9372 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) immune response 0.0133 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 7.61e-06 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 1.55e-07 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 4.702e-07 Highly Informative Direct
Biological Process (BP) gonad development 0.000233 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0002851 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0003035 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0003157 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0003942 Highly Informative Direct
Biological Process (BP) cell growth 0.0004517 Highly Informative Direct
Biological Process (BP) DNA replication 0.0006188 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0006769 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0008574 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0008825 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 0.7972 Highly Informative Inherited
Biological Process (BP) renal system development 0.08925 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.01401 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.4053 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.5181 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.002419 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.01798 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5286 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.001341 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.007239 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.01881 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 0.09207 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.07425 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.002034 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2387 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.4232 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.06607 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.1233 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1333 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9298 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1301 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.192 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.04632 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.1371 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.4039 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.05055 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3435 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.6653 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.01529 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02615 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.001023 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.3312 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.4275 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.04628 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.6366 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.02892 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.01165 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.144 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.0541 Highly Informative Inherited
Molecular Function (MF) binding 2.966e-05 Least Informative Direct
Molecular Function (MF) nucleic acid binding 4.106e-08 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.03152 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 2.173e-07 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.192e-12 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 6.152e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0003663 Informative Direct
Molecular Function (MF) protein dimerization activity 0.07546 Informative Inherited
Molecular Function (MF) enzyme binding 0.8075 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 7.159e-09 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 7.251e-06 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 2.584e-05 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.005584 Highly Informative Inherited
Cellular Component (CC) protein complex 3.379e-09 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9815 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.7205 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.8051 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.9469 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.8534 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.00411 Informative Inherited
Cellular Component (CC) cell leading edge 0.1371 Informative Inherited
Cellular Component (CC) coated vesicle 0.4388 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.1326 Informative Inherited
Cellular Component (CC) integral to membrane 0.8726 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.04373 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.8844 Informative Inherited
Cellular Component (CC) chromosome 0.04509 Informative Inherited
Cellular Component (CC) cullin-RING ubiquitin ligase complex 1.04e-10 Highly Informative Direct
Cellular Component (CC) ion channel complex 3.118e-09 Highly Informative Direct
Cellular Component (CC) nuclear body 5.709e-08 Highly Informative Direct
Cellular Component (CC) leading edge membrane 9.838e-06 Highly Informative Direct
Cellular Component (CC) axon part 1.855e-05 Highly Informative Direct
Cellular Component (CC) cell body 5.048e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.00266 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.01347 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.01792 Highly Informative Inherited
Cellular Component (CC) spindle 0.1277 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.295Moderately InformativeInherited
Mammalian Phenotype (MP)muscle spasm9.501e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.006686Least InformativeInherited
Worm Phenotype (WP)growth variant0.05464Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6189Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0001783Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.007269Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.008189Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0182Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation variant1Moderately InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant5.589e-07InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant3.188e-06InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.0005186InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.01015InformativeInherited
Worm Phenotype (WP)excessive blebbing early emb2.238e-14Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased3.866e-12Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest2.711e-09Highly InformativeDirect
Worm Phenotype (WP)early larval arrest2.74e-09Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb6.627e-09Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001111Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3213Moderately InformativeInherited
Fly Phenotype (FP)body color defective1.507e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.1308Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3109Least InformativeInherited
Fly Anatomy (FA)anatomical group0.6547Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)reproductive system0.05899Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.5007Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.1708InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.2546InformativeInherited
Fly Anatomy (FA)embryonic/larval sense organ0.03999Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.08936Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.09344Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.09854Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.1226Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.2414Highly InformativeInherited
Fly Anatomy (FA)segmental subdivision of integument0.2802Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.3119Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.4436Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.569Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6712Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8959Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit1.433e-10InformativeDirect
Plant ANatomical entity (PAN)rosette leaf1.089e-08InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2071InformativeInherited
Plant ANatomical entity (PAN)vascular system0.4695InformativeInherited
Plant ANatomical entity (PAN)cortex0.007822Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport2.281e-06Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation1.322e-11Moderately InformativeDirect
Biological processHost-virus interaction0.005987Moderately InformativeInherited
Biological processCell cycle0.04875Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis6.322e-14InformativeDirect
Biological processWnt signaling pathway2.004e-08InformativeDirect
Biological processNeurogenesis1.201e-06InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway8.513e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection2.454e-10Moderately InformativeDirect
Cellular componentCell junction0.02854Moderately InformativeInherited
Cellular componentHost cytoplasm2.567e-05InformativeDirect
Cellular componentSynapse0.0003577InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat5.56e-09InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation5.444e-09Moderately InformativeDirect
Post-translational modificationPalmitate6.8e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]