SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (500) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,623 38,955 24
Proteins 36,437 37,060 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.00015510.432Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00022440.01166Least InformativeInherited
Biological Process (BP)protein metabolic process0.68160.001707Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.73250.4196Least InformativeInherited
Biological Process (BP)regulation of gene expression0.000000000092550.000001875Moderately InformativeDirect
Biological Process (BP)regulation of macromolecule biosynthetic process0.0000000000069160.000000000001397Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.000000000068070.00003622Moderately InformativeDirect
Biological Process (BP)regulation of cellular biosynthetic process0.000000000031150.0000000007576Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0015270.000000002377Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.023020.001071Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.070321Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18851Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.20260.04954Moderately InformativeInherited
Biological Process (BP)negative regulation of gene expression0.00075880.00000001333InformativeDirect
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.00047810.0000000001506InformativeDirect
Biological Process (BP)regulation of cell activation0.0054990.1893InformativeInherited
Biological Process (BP)protein modification by small protein conjugation or removal0.001970InformativeInherited
Biological Process (BP)protein ubiquitination0.00023270Highly InformativeDirect
Biological Process (BP)regulation of T cell activation0.000054660.0008321Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.0000089350.000002356Highly InformativeDirect
Molecular Function (MF)binding0.0012780.0001578Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000000037140.0000001077Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity0.00000000000056940.0000000155InformativeDirect
Molecular Function (MF)DNA binding0.00000000000011790InformativeDirect
Molecular Function (MF)protein dimerization activity0.010750.08962InformativeInherited
Molecular Function (MF)ligase activity0.002360.00000005075InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity0.00000000000024450.0000000005508Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity0.0002020Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity0.00010250.000006936Highly InformativeDirect
Cellular Component (CC)protein complex0.043740.000000003451Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex0.0000014890InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex0.00000019750.00000000004487Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.5638 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.004515 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01166 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.4196 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.432 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001707 Least Informative Inherited
Biological Process (BP) ion transport 0.0002537 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000002377 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000001875 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000000001397 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00003622 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000007576 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000002433 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000135 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.04954 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4539 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.08716 Moderately Informative Inherited
Biological Process (BP) system process 0.008767 Moderately Informative Inherited
Biological Process (BP) immune system process 0.5183 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.2205 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.969 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001071 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8881 Moderately Informative Inherited
Biological Process (BP) reproduction 0.01386 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.05489 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01086 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.5385 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0000006795 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) synaptic transmission 0.0000002049 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0000001238 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.00000001333 Informative Direct
Biological Process (BP) metal ion transport 0.0000000000003954 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0000000001506 Informative Direct
Biological Process (BP) reproductive system development 0.000003035 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.2247 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1351 Informative Inherited
Biological Process (BP) tube development 0.8131 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5529 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1194 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.1498 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.002209 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.03091 Informative Inherited
Biological Process (BP) central nervous system development 0.07021 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2316 Informative Inherited
Biological Process (BP) regulation of system process 0.1355 Informative Inherited
Biological Process (BP) regulation of secretion 0.436 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5479 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4251 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.4513 Informative Inherited
Biological Process (BP) regulation of cell activation 0.1893 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2122 Informative Inherited
Biological Process (BP) sexual reproduction 0.01268 Informative Inherited
Biological Process (BP) single organism reproductive process 0.001259 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08585 Informative Inherited
Biological Process (BP) apoptotic process 0.7552 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.195 Informative Inherited
Biological Process (BP) generation of neurons 0.6568 Informative Inherited
Biological Process (BP) DNA metabolic process 0.9759 Informative Inherited
Biological Process (BP) protein localization to organelle 0.3023 Informative Inherited
Biological Process (BP) regulation of immune response 0.7892 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.8746 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.4307 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9721 Informative Inherited
Biological Process (BP) single-organism behavior 0.001464 Informative Inherited
Biological Process (BP) locomotion 0.5017 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.4509 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cell projection organization 0.5761 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.1104 Informative Inherited
Biological Process (BP) cellular component movement 0.775 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9648 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.4003 Informative Inherited
Biological Process (BP) cell cycle process 0.4702 Informative Inherited
Biological Process (BP) organelle localization 0.4333 Informative Inherited
Biological Process (BP) cellular membrane organization 0.8846 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8578 Informative Inherited
Biological Process (BP) immune response 0.008135 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) DNA replication 0.000397 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) gonad development 0.0003176 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.000009498 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) cell growth 0.0008468 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) spindle checkpoint 0.0006559 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0001627 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00000003296 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0003718 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0000000001145 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0008321 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0008324 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000002356 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.0007276 Highly Informative Direct
Biological Process (BP) renal system development 0.09788 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.2081 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.2946 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.02198 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.002495 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.0788 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.54 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.001789 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.02522 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.02729 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.001994 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2157 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.002489 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.003064 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.01458 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.01366 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.4985 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.07964 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.1472 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1574 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1253 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.2154 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.0767 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.05507 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.4594 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.07533 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.345 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.8627 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.009961 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02527 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.04004 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.04682 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.6777 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.004937 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.07107 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1703 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.06934 Highly Informative Inherited
Molecular Function (MF) binding 0.0001578 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000001077 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.02828 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0000000155 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ligase activity 0.00000005075 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0003417 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000005074 Informative Direct
Molecular Function (MF) protein dimerization activity 0.08962 Informative Inherited
Molecular Function (MF) enzyme binding 0.8591 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.0000000005508 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.000000000000001562 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00001341 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.000006936 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.009844 Highly Informative Inherited
Molecular Function (MF) channel regulator activity 0.008741 Highly Informative Inherited
Cellular Component (CC) protein complex 0.000000003451 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5105 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.586 Least Informative Inherited
Cellular Component (CC) cell projection 0.7256 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.6672 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.156 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7998 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.006018 Informative Inherited
Cellular Component (CC) cell leading edge 0.1557 Informative Inherited
Cellular Component (CC) coated vesicle 0.4994 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.421 Informative Inherited
Cellular Component (CC) integral to membrane 0.9309 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.06288 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.5079 Informative Inherited
Cellular Component (CC) chromosome 0.07078 Informative Inherited
Cellular Component (CC) nuclear body 0.00000007324 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.00000000004487 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.000000005287 Highly Informative Direct
Cellular Component (CC) cell body 0.000001215 Highly Informative Direct
Cellular Component (CC) main axon 0.00000008124 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.005479 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.01617 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.02669 Highly Informative Inherited
Cellular Component (CC) spindle 0.1483 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.3482Moderately InformativeInherited
Mammalian Phenotype (MP)muscle spasm0.00001026Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.006686Least InformativeInherited
Worm Phenotype (WP)growth variant0.05464Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6189Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0001783Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.007269Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.008189Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0182Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation variant1Moderately InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant0.0000005589InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000003188InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.0005186InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.01015InformativeInherited
Worm Phenotype (WP)excessive blebbing early emb0.00000000000002238Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased0.000000000003866Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.000000002711Highly InformativeDirect
Worm Phenotype (WP)early larval arrest0.00000000274Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.000000006627Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001111Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.2482InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.06501Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1512Least InformativeInherited
Fly Anatomy (FA)adult0.5369Least InformativeInherited
Fly Anatomy (FA)anatomical group0.601Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)reproductive system0.03208Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1798Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.06692InformativeInherited
Fly Anatomy (FA)mechanosensory sensory organ0.0945InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.2318InformativeInherited
Fly Anatomy (FA)adult abdominal segment0.0005054Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval sense organ0.02702Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.09041Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.09114Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.09616Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.1175Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.2374Highly InformativeInherited
Fly Anatomy (FA)segmental subdivision of integument0.269Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.3083Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.4417Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.569Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6712Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8959Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000000001433InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00000001089InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2071InformativeInherited
Plant ANatomical entity (PAN)vascular system0.4695InformativeInherited
Plant ANatomical entity (PAN)cortex0.007822Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000001849Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.00000000002Moderately InformativeDirect
Biological processHost-virus interaction0.006136Moderately InformativeInherited
Biological processCell cycle0.04408Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis0.00000000000004899InformativeDirect
Biological processWnt signaling pathway0.00000001957InformativeDirect
Biological processNeurogenesis0.000001535InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway0.000009516Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.000000000001906Moderately InformativeDirect
Cellular componentCell junction0.03188Moderately InformativeInherited
Cellular componentHost cytoplasm0.00003318InformativeDirect
Cellular componentSynapse0.0004501InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0.000000004995InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000009053Moderately InformativeDirect
Post-translational modificationPalmitate0.000007545Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]