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POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (507) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 38,484 87,732 24
Proteins 36,321 83,003 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0056570.00002772Least InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.015720.02076Moderately InformativeInherited
Biological Process (BP)tissue development0.062150.001972Moderately InformativeInherited
Biological Process (BP)animal organ development0.0330.00001739Moderately InformativeInherited
Biological Process (BP)post-embryonic development0.000080170.004761InformativeInherited
Biological Process (BP)animal organ morphogenesis0.000066550.06014InformativeInherited
Biological Process (BP)epithelium development0.00027620.9263InformativeInherited
Biological Process (BP)morphogenesis of an epithelium0.000058130.0002135Highly InformativeDirect
Biological Process (BP)post-embryonic animal morphogenesis0.000014670.0000000009774Highly InformativeDirect
Biological Process (BP)tube morphogenesis0.0000019310.000002885Highly InformativeDirect
Biological Process (BP)appendage development0.0000028770.00001739Highly InformativeDirect
Molecular Function (MF)binding0.012650.0000000000001611Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.046350.3007Least InformativeInherited
Cellular Component (CC)transferase complex0.0000032870Moderately InformativeDirect
Cellular Component (CC)ubiquitin ligase complex0.000000011570InformativeDirect
Cellular Component (CC)chromosome0.000015850.00602InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00002772 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0004212 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01192 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1333 Least Informative Inherited
Biological Process (BP) reproduction 0.0001819 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0007764 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00000005499 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0002495 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0006689 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000004875 Moderately Informative Direct
Biological Process (BP) animal organ development 0.00001739 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000004387 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.8775 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.4227 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.2013 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.812 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9104 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8503 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02621 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5405 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.696 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01863 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.001597 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.6289 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001972 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02076 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.01929 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.007517 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01234 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3688 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0002658 Informative Direct
Biological Process (BP) proteolysis 0.00000000000001763 Informative Direct
Biological Process (BP) behavior 0.00001443 Informative Direct
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00001712 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0001792 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.00006796 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000675 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.00000000005285 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000001976 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.000005975 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000003001 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.3626 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7931 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) cell death 0.1909 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.172 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.08296 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.05431 Informative Inherited
Biological Process (BP) response to acid chemical 0.03793 Informative Inherited
Biological Process (BP) epithelium development 0.9263 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1141 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.003894 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.001896 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.9229 Informative Inherited
Biological Process (BP) cell development 0.001046 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.6869 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.06014 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.004761 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4267 Informative Inherited
Biological Process (BP) protein localization to organelle 0.617 Informative Inherited
Biological Process (BP) hemopoiesis 0.2799 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.1708 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.5133 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.9258 Informative Inherited
Biological Process (BP) system process 0.8759 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.01406 Informative Inherited
Biological Process (BP) generation of neurons 0.6217 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.6029 Informative Inherited
Biological Process (BP) locomotion 0.217 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.4784 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.675 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) reproductive system development 0.009663 Informative Inherited
Biological Process (BP) embryo development 0.1045 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) cell cycle process 0.14 Informative Inherited
Biological Process (BP) organelle localization 0.1719 Informative Inherited
Biological Process (BP) secretion by cell 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) immune response 0.003456 Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.0002135 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0000248 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.0000000009774 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.000004579 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.000003009 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0.0000000004163 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.00000000754 Highly Informative Direct
Biological Process (BP) tube morphogenesis 0.000002885 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000000000004801 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.000000008149 Highly Informative Direct
Biological Process (BP) post-translational protein modification 0.0000000007906 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.00001295 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0009715 Highly Informative Direct
Biological Process (BP) appendage development 0.00001739 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.0000007808 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000003182 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.0003567 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0008725 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00002414 Highly Informative Direct
Biological Process (BP) regulation of protein modification by small protein conjugation or removal 0.00006554 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.02745 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.08781 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.6243 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.1248 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.05283 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.05423 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.09615 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.5056 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.202 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.0112 Highly Informative Inherited
Biological Process (BP) kidney development 0.1836 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.00605 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.2677 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.05539 Highly Informative Inherited
Biological Process (BP) sodium ion transport 1 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.09101 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.02505 Highly Informative Inherited
Biological Process (BP) neuron development 0.9114 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3122 Highly Informative Inherited
Biological Process (BP) positive regulation of secretion by cell 0.7876 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.0014 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.01332 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.4877 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.3524 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.4677 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.006587 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.4409 Highly Informative Inherited
Biological Process (BP) muscle tissue development 0.152 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.197 Highly Informative Inherited
Biological Process (BP) regulation of chromosome segregation 0.05142 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.09037 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.02954 Highly Informative Inherited
Biological Process (BP) nervous system process 0.1121 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.006616 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.06108 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.06609 Highly Informative Inherited
Biological Process (BP) germ cell development 0.02174 Highly Informative Inherited
Biological Process (BP) cell maturation 0.05879 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle phase transition 0.1628 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.06753 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.03932 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.2195 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 0.08449 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.07096 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000001611 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0000004442 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.8109 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.000000005401 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.00000000003534 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0000278 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00007032 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01412 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.004962 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.08386 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3007 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.00000000000002829 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.01419 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.1583 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.9337 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005415 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) membrane protein complex 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.218 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.171 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.00000001028 Informative Direct
Cellular Component (CC) transporter complex 0 Informative Direct
Cellular Component (CC) plasma membrane region 0.02204 Informative Inherited
Cellular Component (CC) membrane region 0.1023 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.8806 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.7111 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle part 0.967 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.868 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.2836 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.01989 Informative Inherited
Cellular Component (CC) chromosome 0.00602 Informative Inherited
Cellular Component (CC) dendrite 0.0001255 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000000001045 Highly Informative Direct
Cellular Component (CC) main axon 0.000000000007653 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.0002441 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000008925 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0.03054 Highly Informative Inherited
Cellular Component (CC) cytoplasmic vesicle membrane 0.4374 Highly Informative Inherited
Cellular Component (CC) membrane coat 0.003597 Highly Informative Inherited
Cellular Component (CC) nuclear body 0.001037 Highly Informative Inherited
Cellular Component (CC) coated vesicle 0.1006 Highly Informative Inherited
Cellular Component (CC) spindle 0.003322 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0000008552Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processDifferentiation0.00000000007931Moderately InformativeDirect
Biological processHost-virus interaction0.01171Moderately InformativeInherited
Biological processCell cycle0.0354Moderately InformativeInherited
Biological processMitosis0.0000000000003452InformativeDirect
Biological processNeurogenesis0.000000006407InformativeDirect
Biological processWnt signaling pathway0.00000004072InformativeDirect
Biological processPlant defense0.0009329InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway0.00001651Highly InformativeDirect
Biological processExocytosis0.00007177Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.35Least InformativeInherited
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell membrane0.0000003658Moderately InformativeDirect
Cellular componentSynapse0.0000003219InformativeDirect
Cellular componentHost cytoplasm0.0001914InformativeDirect
Cellular componentSarcoplasmic reticulum0.000003612Highly InformativeDirect
DiseaseEpilepsy0.00013InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat0.0000000000001652InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationPalmitate0.000001684Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]