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POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 39,057 105,779 24
Proteins 36,844 100,007 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.3334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.1334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.1263InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.1889InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.0006719Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.01027Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle physiology0.1378Moderately InformativeInherited
Mammalian Phenotype (MP)muscle twitch0.000425Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval growth variant0.004746Least InformativeInherited
Worm Phenotype (WP)larval development variant0.0308Least InformativeInherited
Worm Phenotype (WP)cell development variant0.08516Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.806Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.8968Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)germ cell development variant0.0004639Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.006236Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.006491Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.02727Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.1027Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.3014Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.3078Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.4419Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.9581Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.9735Moderately InformativeInherited
Worm Phenotype (WP)protein interaction variant0.9956Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant1Moderately InformativeInherited
Worm Phenotype (WP)early larval arrest0.000001514InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000004818InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00001196InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00002719InformativeDirect
Worm Phenotype (WP)neuron migration variant0.0001647InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0001679InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.01234InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.0568InformativeInherited
Worm Phenotype (WP)body axis morphology variant0Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic streaming defective0.0000000000003279Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased0.00000000005881Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance variant0.000000001009Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.000000002117Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.00000002735Highly InformativeDirect
Worm Phenotype (WP)apoptosis increased0.0000001203Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.000001078Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.00002853Highly InformativeDirect
Worm Phenotype (WP)X chromosome nondisjunction0.0007462Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3422InformativeInherited
Fly Phenotype (FP)sleep defective0.0007964Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.4621Least InformativeInherited
Fly Anatomy (FA)gonad0.2438Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.3377InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.8069Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.9608Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye1InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.03626Highly InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.148Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000218Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 100.0005288Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.57Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6723Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8973Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit0.0000000001496InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.00000001428InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2076InformativeInherited
Plant ANatomical entity (PAN)cortex0.007866Highly InformativeInherited

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 36 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 36 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]