SUPERFAMILY 1.75 HMM library and genome assignments server


POZ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   POZ domain [ 54694]
Superfamily:   POZ domain [ 54695] (2)
Families:   BTB/POZ domain [ 54696] (5)
  Tetramerization domain of potassium channels [ 54701] (6)


Superfamily statistics
Genomes (489) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 36,890 38,955 24
Proteins 34,786 37,060 24


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.00017270.4546Least InformativeInherited
Biological Process (BP)regulation of cellular process0.00029820.02233Least InformativeInherited
Biological Process (BP)protein metabolic process0.71140.0007752Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.76080.2894Least InformativeInherited
Biological Process (BP)regulation of biosynthetic process7.442e-114.431e-13Moderately InformativeDirect
Biological Process (BP)regulation of gene expression1.067e-107.167e-06Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process1.101e-101.477e-06Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.0014821.956e-10Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.022820.0004291Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.072331Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.18651Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.22150.05975Moderately InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process0.00042229.183e-11InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal0.0020730InformativeInherited
Biological Process (BP)protein ubiquitination0.00024640Highly InformativeDirect
Biological Process (BP)regulation of T cell activation5.923e-050.0006188Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation1.039e-051.645e-06Highly InformativeDirect
Molecular Function (MF)binding0.0023311.514e-05Least InformativeInherited
Molecular Function (MF)nucleic acid binding4.773e-103.962e-08Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding transcription factor activity9.598e-135.268e-08InformativeDirect
Molecular Function (MF)DNA binding1.575e-130InformativeDirect
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.00077629.803e-13InformativeDirect
Molecular Function (MF)protein dimerization activity0.01110.08225InformativeInherited
Molecular Function (MF)sequence-specific DNA binding transcription factor activity3.465e-131.843e-09Highly InformativeDirect
Molecular Function (MF)small conjugating protein ligase activity0.0002640Highly InformativeDirect
Molecular Function (MF)protein homodimerization activity0.00011977.329e-06Highly InformativeDirect
Cellular Component (CC)protein complex0.11543.309e-09Least InformativeInherited
Cellular Component (CC)ubiquitin ligase complex3.67e-050InformativeDirect
Cellular Component (CC)cullin-RING ubiquitin ligase complex9.3e-066.395e-11Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0007752 Least Informative Direct
Biological Process (BP) developmental process 0.3679 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.00102 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02233 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.2894 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.9751 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.4546 Least Informative Inherited
Biological Process (BP) ion transport 0.000137 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 4.431e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 1.956e-10 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 7.167e-06 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1.477e-06 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 8.655e-08 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0004291 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 5.917e-05 Moderately Informative Direct
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.05975 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4381 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05195 Moderately Informative Inherited
Biological Process (BP) system process 0.01174 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4244 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8276 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1204 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9913 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.8208 Moderately Informative Inherited
Biological Process (BP) organ development 0.05411 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01039 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3769 Moderately Informative Inherited
Biological Process (BP) reproduction 0.007046 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.006304 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 5.043e-07 Informative Direct
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) cell-cell signaling 6.697e-08 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 1.468e-07 Informative Direct
Biological Process (BP) transmission of nerve impulse 1.778e-09 Informative Direct
Biological Process (BP) metal ion transport 1.29e-13 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.0006014 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 9.183e-11 Informative Direct
Biological Process (BP) reproductive system development 2.237e-06 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.9382 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.1159 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1593 Informative Inherited
Biological Process (BP) tube development 0.8273 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5469 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1261 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) actin filament-based process 0.001208 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01868 Informative Inherited
Biological Process (BP) regulation of system process 0.1087 Informative Inherited
Biological Process (BP) central nervous system development 0.1889 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.226 Informative Inherited
Biological Process (BP) protein complex assembly 0.03212 Informative Inherited
Biological Process (BP) regulation of secretion 0.3329 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4438 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3349 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.357 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.1687 Informative Inherited
Biological Process (BP) programmed cell death 0.5064 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1768 Informative Inherited
Biological Process (BP) generation of neurons 0.6612 Informative Inherited
Biological Process (BP) DNA metabolic process 0.9734 Informative Inherited
Biological Process (BP) protein localization to organelle 0.2622 Informative Inherited
Biological Process (BP) regulation of immune response 0.739 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.8616 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.442 Informative Inherited
Biological Process (BP) single-organism behavior 0.001359 Informative Inherited
Biological Process (BP) locomotion 0.4287 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.3884 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) response to other organism 1 Informative Inherited
Biological Process (BP) cell projection organization 0.4897 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.09109 Informative Inherited
Biological Process (BP) cellular component movement 0.703 Informative Inherited
Biological Process (BP) growth 0.6929 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8995 Informative Inherited
Biological Process (BP) sexual reproduction 0.01213 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.08807 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.3483 Informative Inherited
Biological Process (BP) cell cycle process 0.3292 Informative Inherited
Biological Process (BP) organelle localization 0.5266 Informative Inherited
Biological Process (BP) cellular membrane organization 0.9505 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.8549 Informative Inherited
Biological Process (BP) immune response 0.004882 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) DNA replication 0.0006663 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0009583 Highly Informative Direct
Biological Process (BP) gonad development 0.0002974 Highly Informative Direct
Biological Process (BP) post-embryonic development 7.332e-06 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0 Highly Informative Direct
Biological Process (BP) cell growth 0.0005142 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) spindle checkpoint 0.000649 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 3.416e-08 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.0007299 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0007597 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 1.316e-10 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.0009881 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.0006188 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0003248 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.645e-06 Highly Informative Direct
Biological Process (BP) regulation of intrinsic apoptotic signaling pathway 0.000302 Highly Informative Direct
Biological Process (BP) renal system development 0.1005 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.1917 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.5139 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.4348 Highly Informative Inherited
Biological Process (BP) erythrocyte differentiation 0.01674 Highly Informative Inherited
Biological Process (BP) myeloid cell development 0.002193 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5407 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 0.007311 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.001261 Highly Informative Inherited
Biological Process (BP) regulation of production of molecular mediator of immune response 0.01965 Highly Informative Inherited
Biological Process (BP) establishment of vesicle localization 0.07372 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2006 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.001942 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.002398 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.009233 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.009009 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.4986 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.06415 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.1331 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1362 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.9444 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1174 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 0.1978 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 0.06543 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.0502 Highly Informative Inherited
Biological Process (BP) humoral immune response 0.4699 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.1499 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.4063 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) axon development 1 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 1 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.007106 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.02806 Highly Informative Inherited
Biological Process (BP) developmental maturation 0.332 Highly Informative Inherited
Biological Process (BP) regulation of mitosis 0.04551 Highly Informative Inherited
Biological Process (BP) negative regulation of cell cycle 0.6465 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.03114 Highly Informative Inherited
Biological Process (BP) vesicle organization 0.01238 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.1483 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.07187 Highly Informative Inherited
Molecular Function (MF) binding 1.514e-05 Least Informative Direct
Molecular Function (MF) nucleic acid binding 3.962e-08 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.02096 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 5.268e-08 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 9.803e-13 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0003339 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 4.824e-10 Informative Direct
Molecular Function (MF) protein dimerization activity 0.08225 Informative Inherited
Molecular Function (MF) enzyme binding 0.8559 Informative Inherited
Molecular Function (MF) nucleotide binding 1 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1.843e-09 Highly Informative Direct
Molecular Function (MF) cation channel activity 1.558e-15 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 2.802e-05 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 7.329e-06 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.008702 Highly Informative Inherited
Molecular Function (MF) channel regulator activity 0.00794 Highly Informative Inherited
Cellular Component (CC) protein complex 3.309e-09 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3761 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5871 Least Informative Inherited
Cellular Component (CC) cell projection 0.6368 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) vesicle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.7257 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.1231 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.7784 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) neuron projection 0.002471 Informative Inherited
Cellular Component (CC) cell leading edge 0.1435 Informative Inherited
Cellular Component (CC) coated vesicle 0.4455 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.3965 Informative Inherited
Cellular Component (CC) integral to membrane 0.8813 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.04547 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.4535 Informative Inherited
Cellular Component (CC) chromosome 0.05256 Informative Inherited
Cellular Component (CC) nuclear body 4.936e-08 Highly Informative Direct
Cellular Component (CC) leading edge membrane 9.778e-06 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 6.395e-11 Highly Informative Direct
Cellular Component (CC) ion channel complex 3.779e-09 Highly Informative Direct
Cellular Component (CC) cell body 7.848e-05 Highly Informative Direct
Cellular Component (CC) main axon 2.129e-07 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.003444 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.0141 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.01813 Highly Informative Inherited
Cellular Component (CC) spindle 0.1385 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.3174Moderately InformativeInherited
Mammalian Phenotype (MP)muscle spasm1.036e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0.006686Least InformativeInherited
Worm Phenotype (WP)growth variant0.05464Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6189Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.0001783Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.007269Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.008189Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0182Moderately InformativeInherited
Worm Phenotype (WP)protein aggregation variant1Moderately InformativeInherited
Worm Phenotype (WP)pachytene progression during oogenesis variant5.589e-07InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant3.188e-06InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.0005186InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.01015InformativeInherited
Worm Phenotype (WP)excessive blebbing early emb2.238e-14Highly InformativeDirect
Worm Phenotype (WP)cell proliferation increased3.866e-12Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest2.711e-09Highly InformativeDirect
Worm Phenotype (WP)early larval arrest2.74e-09Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb6.627e-09Highly InformativeDirect
Worm Phenotype (WP)resistant to protein aggregation induced paralysis0.0001111Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.3422InformativeInherited
Fly Phenotype (FP)body color defective1.312e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0.1348Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3201Least InformativeInherited
Fly Anatomy (FA)anatomical group0.664Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)reproductive system0.05733Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.5006Moderately InformativeInherited
Fly Anatomy (FA)abdominal segment0.004582InformativeInherited
Fly Anatomy (FA)larval abdomen0.1051InformativeInherited
Fly Anatomy (FA)ovariole0.1139InformativeInherited
Fly Anatomy (FA)mechanosensory system0.169InformativeInherited
Fly Anatomy (FA)larval segment0.5505InformativeInherited
Fly Anatomy (FA)embryonic/larval sense organ0.04053Highly InformativeInherited
Fly Anatomy (FA)chordotonal organ0.08799Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 30.09609Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 20.1012Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 40.126Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 70.2474Highly InformativeInherited
Fly Anatomy (FA)segmental subdivision of integument0.2829Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 60.3188Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment 50.4496Highly InformativeInherited

Document: FA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.569Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.6712Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.8959Least InformativeInherited
Plant ANatomical entity (PAN)whole plant1Least InformativeInherited
Plant ANatomical entity (PAN)seed1Least InformativeInherited
Plant ANatomical entity (PAN)fruit1.433e-10InformativeDirect
Plant ANatomical entity (PAN)rosette leaf1.089e-08InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.2071InformativeInherited
Plant ANatomical entity (PAN)vascular system0.4695InformativeInherited
Plant ANatomical entity (PAN)cortex0.007822Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1.413e-07Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation1.573e-11Moderately InformativeDirect
Biological processHost-virus interaction0.00591Moderately InformativeInherited
Biological processCell cycle0.04774Moderately InformativeInherited
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis6.224e-14InformativeDirect
Biological processWnt signaling pathway1.912e-08InformativeDirect
Biological processNeurogenesis1.434e-06InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processEthylene signaling pathway9.395e-06Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection1.447e-12Moderately InformativeDirect
Cellular componentCell junction0.03056Moderately InformativeInherited
Cellular componentHost cytoplasm3.059e-05InformativeDirect
Cellular componentSynapse0.0004318InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainZinc-finger0Moderately InformativeDirect
DomainANK repeat5.17e-09InformativeDirect
DomainKelch repeat0Highly InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation6.262e-09Moderately InformativeDirect
Post-translational modificationPalmitate7.44e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR011333 SSF54695 Protein matches
Abstract

The BTB (for BR-C, ttk and bab) [PubMed7938017] or POZ (for Pox virus and Zinc finger) [PubMed7958847, PubMed17384421] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination [PubMed16207353]. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [PubMed9917379], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets [PubMed9770450]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [PubMed9019154, PubMed9824158, PubMed9765306]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

This entry differs from IPR000210 in including POZ-containing Skp1 proteins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a POZ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 12 hidden Markov models representing the POZ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]