SUPERFAMILY 1.75 HMM library and genome assignments server

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Enolase N-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Enolase N-terminal domain-like [ 54825]
Superfamily:   Enolase N-terminal domain-like [ 54826]
Families:   Enolase N-terminal domain-like [ 54827] (14)


Superfamily statistics
Genomes (3,180) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 10,545 63,416 50
Proteins 10,537 63,396 50


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular nitrogen compound metabolic process 0.0001217 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6936 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2055 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.004725 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000000001254 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00000000000003926 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000004102 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000006475 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.00001042 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0003933 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.3134 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01055 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5466 Moderately Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000000002287 Informative Direct
Biological Process (BP) phosphorylation 0.0000000013 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000003421 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.000007918 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.001513 Informative Inherited
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0000000003708 Highly Informative Direct
Biological Process (BP) hexose biosynthetic process 0.000262 Highly Informative Direct
Biological Process (BP) monosaccharide catabolic process 0.0005909 Highly Informative Direct
Biological Process (BP) NAD metabolic process 0.8152 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000004966 Least Informative Direct
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.0000000000003859 Moderately Informative Direct
Molecular Function (MF) magnesium ion binding 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.0000000000007513 Informative Direct
Molecular Function (MF) enzyme binding 0.006315 Informative Inherited
Molecular Function (MF) protease binding 0.0000009588 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0.00004526 Moderately Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000002562 Informative Direct
Cellular Component (CC) cell surface 0.00007602 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processGlycolysis0InformativeDirect
Biological processAromatic hydrocarbons catabolism0.0003654InformativeDirect
Biological processMenaquinone biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DiseaseAllergen0.00001571Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Post-translational modificationLyase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Enolase N-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 27 hidden Markov models representing the Enolase N-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]