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RNA-binding domain, RBD superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   RNA-binding domain, RBD [ 54928] (5)
Families:   Canonical RBD [ 54929] (67)
  Non-canonical RBD domain [ 54954]
  Splicing factor U2AF subunits [ 64276]
  Smg-4/UPF3 [ 102987]
  GUCT domain [ 160314]


Superfamily statistics
Genomes (1,023) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 113,351 264,992 138
Proteins 82,294 194,344 130


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00032250Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.00063360Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.00033620Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.0028640Least InformativeInherited
Biological Process (BP)multicellular organismal process0.19020.09266Least InformativeInherited
Biological Process (BP)primary metabolic process0.37140.0000002083Least InformativeInherited
Biological Process (BP)biological regulation0.67580Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0012750Least InformativeInherited
Biological Process (BP)gene expression0.00000000018520Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.0000000000044560Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.0076030.04434Moderately InformativeInherited
Biological Process (BP)regulation of localization0.010781Moderately InformativeInherited
Biological Process (BP)animal organ development0.59691Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.10330Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.24371Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.39771Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.53390.04722Moderately InformativeInherited
Biological Process (BP)single-organism transport0.088371Moderately InformativeInherited
Biological Process (BP)organic substance transport0.026690.737Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0037040.008394Moderately InformativeInherited
Biological Process (BP)cellular localization0.0079250.04914Moderately InformativeInherited
Biological Process (BP)regulation of cellular localization0.0000048440.4464InformativeInherited
Biological Process (BP)positive regulation of transport0.000044181InformativeInherited
Biological Process (BP)central nervous system development0.000041140.5124InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0071560InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.0017580InformativeInherited
Biological Process (BP)single-organism cellular localization0.000006981InformativeInherited
Biological Process (BP)intracellular transport0.0012150.001784InformativeInherited
Biological Process (BP)mRNA processing00Highly InformativeDirect
Biological Process (BP)RNA splicing0.000000073450Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport0.000000008010Highly InformativeDirect
Biological Process (BP)positive regulation of intracellular transport0.0000000015170.0002975Highly InformativeDirect
Biological Process (BP)nuclear export0.000000000061730.000000000000001925Highly InformativeDirect
Biological Process (BP)establishment of RNA localization0.000000000049560Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport0.00000000034990.003608Highly InformativeInherited
Biological Process (BP)forebrain development0.000035260.7483Highly InformativeInherited
Molecular Function (MF)binding0.043630Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.000015940Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.014950.00000000000000156Least InformativeInherited
Cellular Component (CC)nuclear part0.00000081150Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.012410Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.69550.08272InformativeInherited
Cellular Component (CC)spliceosomal complex0.000011640Highly InformativeDirect
Cellular Component (CC)nuclear body0.00056230Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.0014240Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000002083 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.09266 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00000002695 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000001661 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0001023 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0001167 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.2009 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.737 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002764 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.008394 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3704 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4735 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.005657 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2931 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.472 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.5399 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.003574 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07601 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.007864 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04722 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.003108 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.9475 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.04434 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04914 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.000000000000003734 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000363 Informative Direct
Biological Process (BP) behavior 0.0001015 Informative Direct
Biological Process (BP) response to temperature stimulus 0.000502 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) electron transport chain 0.0000000000007201 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.000000157 Informative Direct
Biological Process (BP) multicellular organism reproduction 0 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0001286 Informative Direct
Biological Process (BP) regulation of cellular amide metabolic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000000002029 Informative Direct
Biological Process (BP) multi-organism reproductive process 0 Informative Direct
Biological Process (BP) cellular respiration 0.00001021 Informative Direct
Biological Process (BP) cell development 0.00000127 Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) protein transport 0.001192 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.113 Informative Inherited
Biological Process (BP) response to acid chemical 0.03389 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.7776 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.9966 Informative Inherited
Biological Process (BP) hemopoiesis 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.09178 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) system process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.5161 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.3944 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.4464 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.9063 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.3741 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.3351 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.773 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) microtubule-based process 0.8078 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.7195 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2251 Informative Inherited
Biological Process (BP) cellular response to lipid 0.3746 Informative Inherited
Biological Process (BP) central nervous system development 0.5124 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.08489 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01032 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.9777 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.03282 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.03469 Informative Inherited
Biological Process (BP) epithelium development 0.638 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) intracellular transport 0.001784 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02356 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 0.0003567 Highly Informative Direct
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) germ cell development 0 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0000101 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0006021 Highly Informative Direct
Biological Process (BP) RNA splicing 0 Highly Informative Direct
Biological Process (BP) response to cold 0.00000124 Highly Informative Direct
Biological Process (BP) photoperiodism 0.00001271 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.00000000000621 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.00000000000001937 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) gene silencing 0.000000000000001925 Highly Informative Direct
Biological Process (BP) negative regulation of translation 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.0002975 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.00000000000004251 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.00000006322 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00004601 Highly Informative Direct
Biological Process (BP) response to amino acid 0.0000004056 Highly Informative Direct
Biological Process (BP) regulation of RNA stability 0 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.000000000000203 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.00001245 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.0000000001412 Highly Informative Direct
Biological Process (BP) response to arsenic-containing substance 0.000007094 Highly Informative Direct
Biological Process (BP) cell maturation 0.0000000000002664 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.00000267 Highly Informative Direct
Biological Process (BP) nuclear export 0.000000000000001925 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0 Highly Informative Direct
Biological Process (BP) regulation of ATP metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of catabolic process 0.5713 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.1048 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.5118 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.00284 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.1259 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.003606 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.0323 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.353 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.7508 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.00874 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.4764 Highly Informative Inherited
Biological Process (BP) histone modification 0.963 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 1 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.1614 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.7778 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.001365 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.003608 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.5093 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.07635 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.8853 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.08489 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle 0.7349 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.2227 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.1776 Highly Informative Inherited
Biological Process (BP) forebrain development 0.7483 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.3623 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.9481 Highly Informative Inherited
Biological Process (BP) aging 0.0123 Highly Informative Inherited
Biological Process (BP) appendage development 0.6524 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.3171 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.9191 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.0859 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.1022 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.08853 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.04189 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.9068 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription from RNA polymerase II promoter 0.1 Highly Informative Inherited
Biological Process (BP) regulation of mitotic nuclear division 0.04393 Highly Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle phase transition 0.6242 Highly Informative Inherited
Biological Process (BP) heart development 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.3437 Highly Informative Inherited
Biological Process (BP) angiogenesis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00000000002012 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0.00000000001987 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) chromatin binding 0.02169 Highly Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00000000000000156 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) cytoplasmic region 1 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.08272 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) spliceosomal complex 0 Highly Informative Direct
Cellular Component (CC) nuclear body 0 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.0005552 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0 Highly Informative Direct
Cellular Component (CC) pole plasm 0.0000004401 Highly Informative Direct
Cellular Component (CC) chromatin 0.05918 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.00000000004189Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000002211Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.01123Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.003436Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.02837Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000009651Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000004046Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.02062Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.00000000000004272Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9875Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processTranslation regulation0InformativeDirect
Biological processBiological rhythms4.846e-16InformativeDirect
Biological processMeiosis0.000000000003123InformativeDirect
Biological processrRNA processing0.000001615InformativeDirect
Biological processProtein biosynthesis0.0001882InformativeDirect
Biological processmRNA transport0Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSpermatogenesis0.00003773Highly InformativeDirect
Biological processTranslocation0.04529Highly InformativeInherited
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentChromosome0.0000002393InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.000000000003985Moderately InformativeDirect
DomainZinc-finger0.00001146Moderately InformativeDirect
DomainWD repeat0.000002599InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationIsomerase1Moderately InformativeInherited
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationChromatin regulator0.00004442InformativeDirect
Post-translational modificationRotamase0.0000002232Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 98 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNA-binding domain, RBD domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 98 hidden Markov models representing the RNA-binding domain, RBD superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]