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RNA-binding domain, RBD superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   RNA-binding domain, RBD [ 54928] (5)
Families:   Canonical RBD [ 54929] (67)
  Non-canonical RBD domain [ 54954]
  Splicing factor U2AF subunits [ 64276]
  Smg-4/UPF3 [ 102987]
  GUCT domain [ 160314]


Superfamily statistics
Genomes (1,022) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 113,124 114,064 138
Proteins 82,132 84,156 130


Functional annotation
General category Regulation
Detailed category RNA binding, metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.00018830Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.0001960Least InformativeDirect
Biological Process (BP)cellular nitrogen compound metabolic process0.0003590Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00075010Least InformativeDirect
Biological Process (BP)biological regulation0.45880Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.0015030Least InformativeInherited
Biological Process (BP)primary metabolic process0.28960.00000003619Least InformativeInherited
Biological Process (BP)RNA metabolic process0.0000000000052370Moderately InformativeDirect
Biological Process (BP)gene expression0.00000000014690Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0028180.006891Moderately InformativeInherited
Biological Process (BP)organic substance transport0.02310.7485Moderately InformativeInherited
Biological Process (BP)nitrogen compound transport0.0066390.05571Moderately InformativeInherited
Biological Process (BP)regulation of localization0.017531Moderately InformativeInherited
Biological Process (BP)system development0.72261Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.21430.3656Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.072010Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.15881Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.29541Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.39440.2181Moderately InformativeInherited
Biological Process (BP)single-organism transport0.075941Moderately InformativeInherited
Biological Process (BP)regulation of cellular amide metabolic process0.00035930InformativeDirect
Biological Process (BP)positive regulation of transport0.000034141InformativeInherited
Biological Process (BP)central nervous system development0.00002470.5989InformativeInherited
Biological Process (BP)response to temperature stimulus0.014520.002449InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0021510InformativeInherited
Biological Process (BP)mRNA processing00Highly InformativeDirect
Biological Process (BP)establishment of RNA localization0.00000000003050Highly InformativeDirect
Biological Process (BP)nuclear export0.00000000004290Highly InformativeDirect
Biological Process (BP)nucleobase-containing compound transport0.0000000053090Highly InformativeDirect
Biological Process (BP)RNA splicing0.000000081910Highly InformativeDirect
Biological Process (BP)response to cold0.00052240.000002825Highly InformativeDirect
Biological Process (BP)brain development0.00033231Highly InformativeInherited
Molecular Function (MF)binding0.024790Least InformativeInherited
Molecular Function (MF)nucleic acid binding00Moderately InformativeDirect
Molecular Function (MF)RNA binding00InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.000012070Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.01080.0000000000004716Least InformativeInherited
Cellular Component (CC)macromolecular complex0.022010Least InformativeInherited
Cellular Component (CC)nuclear part0.00000065930Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.0096970Moderately InformativeInherited
Cellular Component (CC)nucleoplasm part0.71440.05163InformativeInherited
Cellular Component (CC)spliceosomal complex0.000013640Highly InformativeDirect
Cellular Component (CC)nuclear body0.00045780Highly InformativeDirect
Cellular Component (CC)small nuclear ribonucleoprotein complex0.0015860Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000003619 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000004359 Moderately Informative Direct
Biological Process (BP) reproduction 0.000002596 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0005533 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000641 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.9911 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.05008 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3656 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.7485 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2373 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.08835 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.2181 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3027 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.1377 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.005013 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.503 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.006891 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) amide biosynthetic process 0.002494 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.003494 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.8549 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.05571 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.001088 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2295 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 0 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.000000000000028 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.00000000000144 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000006832 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.000000000002356 Informative Direct
Biological Process (BP) ribonucleoprotein complex subunit organization 0 Informative Direct
Biological Process (BP) electron transport chain 0.0000000000004699 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.0000003212 Informative Direct
Biological Process (BP) intracellular protein transport 0.000002441 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00000287 Informative Direct
Biological Process (BP) cellular respiration 0.000007293 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000125 Informative Direct
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.01393 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.5716 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.636 Informative Inherited
Biological Process (BP) response to acid chemical 0.04707 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.5704 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.9359 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.3618 Informative Inherited
Biological Process (BP) cellular response to lipid 0.2489 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.04725 Informative Inherited
Biological Process (BP) positive regulation of transport 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5775 Informative Inherited
Biological Process (BP) ncRNA processing 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.2505 Informative Inherited
Biological Process (BP) central nervous system development 0.5989 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.01425 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.01 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.01842 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.002449 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) post-embryonic development 0.9349 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) behavior 0.008189 Informative Inherited
Biological Process (BP) microtubule-based process 1 Informative Inherited
Biological Process (BP) cell development 0.001476 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3046 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.6748 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) mRNA processing 0 Highly Informative Direct
Biological Process (BP) establishment of RNA localization 0 Highly Informative Direct
Biological Process (BP) nuclear export 0 Highly Informative Direct
Biological Process (BP) nucleobase-containing compound transport 0 Highly Informative Direct
Biological Process (BP) RNA splicing 0 Highly Informative Direct
Biological Process (BP) response to cold 0.000002825 Highly Informative Direct
Biological Process (BP) germ cell development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular amide metabolic process 0 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) gene silencing 0 Highly Informative Direct
Biological Process (BP) ribonucleoprotein complex localization 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.00000000000001267 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.00000000000002463 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00000000000008994 Highly Informative Direct
Biological Process (BP) nucleocytoplasmic transport 0.00000000002807 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.0000000001504 Highly Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000001273 Highly Informative Direct
Biological Process (BP) cell maturation 0.000000003812 Highly Informative Direct
Biological Process (BP) response to amino acid 0.000000256 Highly Informative Direct
Biological Process (BP) cellular response to decreased oxygen levels 0.000001402 Highly Informative Direct
Biological Process (BP) photoperiodism 0.000007644 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00002511 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00003317 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.00003978 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0004904 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.5234 Highly Informative Inherited
Biological Process (BP) regulation of cytoplasmic translation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.3048 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7251 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.002412 Highly Informative Inherited
Biological Process (BP) response to hypoxia 0.272 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.00159 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.02797 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.6379 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.9646 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 1 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.4546 Highly Informative Inherited
Biological Process (BP) histone modification 0.9231 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.4816 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.2043 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0563 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.9297 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.07615 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.1676 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.7837 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.9069 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.5894 Highly Informative Inherited
Biological Process (BP) positive regulation of mitotic cell cycle phase transition 0.009608 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.2015 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.2984 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.2695 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1821 Highly Informative Inherited
Biological Process (BP) appendage development 0.7136 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.0204 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.7798 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.00152 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.003801 Highly Informative Inherited
Biological Process (BP) locomotory behavior 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.206 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.003912 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.005661 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1859 Highly Informative Inherited
Biological Process (BP) angiogenesis 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 1 Informative Inherited
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 1 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.000000000004172 Highly Informative Direct
Molecular Function (MF) single-stranded DNA binding 0.0000000001732 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) S-adenosylmethionine-dependent methyltransferase activity 1 Highly Informative Inherited
Molecular Function (MF) chromatin binding 0.0337 Highly Informative Inherited
Molecular Function (MF) translation factor activity, RNA binding 1 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000000000004716 Least Informative Direct
Cellular Component (CC) macromolecular complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0 Informative Direct
Cellular Component (CC) synapse 0.9927 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) cytoplasmic region 1 Informative Inherited
Cellular Component (CC) neuron projection 0.9127 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.05163 Informative Inherited
Cellular Component (CC) chromosome 1 Informative Inherited
Cellular Component (CC) spliceosomal complex 0 Highly Informative Direct
Cellular Component (CC) nuclear body 0 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0 Highly Informative Direct
Cellular Component (CC) pole plasm 0.0000004301 Highly Informative Direct
Cellular Component (CC) CCR4-NOT complex 0.0004327 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 1 Highly Informative Inherited
Cellular Component (CC) chromatin 0.05904 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.00000000004189Least InformativeDirect
Enzyme Commission (EC)Isomerases0.000002211Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.01123Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.003436Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.02837Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000009651Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.00000004046Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.02062Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.00000000000004272Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.01939InformativeInherited
Disease Ontology (DO)ischemia0.2817Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Pace of progression0.003008Moderately InformativeInherited
Rapidly progressive0.0008826InformativeDirect
Mode of Inheritance (MI)Y-linked inheritance0.000004732InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.107Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2108Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.262Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.3367Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.3471Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6514Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.6958Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.8633Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.9883Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.02487Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1724Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.3391Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4498Moderately InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5019Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.5421Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.6199Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.6693Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.7747Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.9452Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscular dystrophy0.0001447InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating enzyme level0.0003273InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0003661InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0008907InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.01473InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.01611InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.04486InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.04512InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06785InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.06851InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.09436InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.1719InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.18InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.2896InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.4291InformativeInherited
Phenotypic Abnormality (PA)Rimmed vacuoles0.000000001065Highly InformativeDirect
Phenotypic Abnormality (PA)Frontotemporal dementia0.0000002426Highly InformativeDirect
Phenotypic Abnormality (PA)Amyotrophic lateral sclerosis0.0000004876Highly InformativeDirect
Phenotypic Abnormality (PA)Bowing of the vocal cords0.000003648Highly InformativeDirect
Phenotypic Abnormality (PA)Brisk reflexes0.000007042Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar signs0.000007042Highly InformativeDirect
Phenotypic Abnormality (PA)Perseveration0.000007042Highly InformativeDirect
Phenotypic Abnormality (PA)Disinhibition0.000008604Highly InformativeDirect
Phenotypic Abnormality (PA)Mutism0.00001241Highly InformativeDirect
Phenotypic Abnormality (PA)Aspiration0.00001757Highly InformativeDirect
Phenotypic Abnormality (PA)Loss of ability to walk0.00002437Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lower motor neuron morphology0.00002449Highly InformativeDirect
Phenotypic Abnormality (PA)Limb-girdle muscle weakness0.00002598Highly InformativeDirect
Phenotypic Abnormality (PA)Pseudobulbar paralysis0.00002646Highly InformativeDirect
Phenotypic Abnormality (PA)Apathy0.00002814Highly InformativeDirect
Phenotypic Abnormality (PA)Tongue fasciculations0.00002814Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated alkaline phosphatase0.00003935Highly InformativeDirect
Phenotypic Abnormality (PA)Personality changes0.00004958Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior horn cell morphology0.00005523Highly InformativeDirect
Phenotypic Abnormality (PA)Sleep apnea0.00006367Highly InformativeDirect
Phenotypic Abnormality (PA)Postural tremor0.0000813Highly InformativeDirect
Phenotypic Abnormality (PA)Language impairment0.0000832Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration involving the corticospinal tracts0.0001226Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0.0002104Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.0002735Highly InformativeDirect
Phenotypic Abnormality (PA)Progressive muscle weakness0.0003705Highly InformativeDirect
Phenotypic Abnormality (PA)Hoarse voice0.0006569Highly InformativeDirect
Phenotypic Abnormality (PA)Azoospermia0.0008679Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.3827Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2897Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.8267Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.8905Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.7812InformativeInherited
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.000629Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000000000000002601Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000004252Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0006016Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0007951Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001144Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.005056Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.0005598Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.09788Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.1111Moderately InformativeInherited
Worm Phenotype (WP)apoptosis variant0.2088Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.4775Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.5114Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.634Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant1Moderately InformativeInherited
Worm Phenotype (WP)sterile progeny1Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.00000000006525InformativeDirect
Worm Phenotype (WP)sick0.0000009587InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.00002819InformativeDirect
Worm Phenotype (WP)brood size variant0.0001158InformativeDirect
Worm Phenotype (WP)alimentary system development variant0.0003513InformativeDirect
Worm Phenotype (WP)cell number increased0.001518InformativeInherited
Worm Phenotype (WP)egg laying variant0.05569InformativeInherited
Worm Phenotype (WP)germ cell cytoplasmic morphology variant0.1713InformativeInherited
Worm Phenotype (WP)vulva cell fate specification variant0.2401InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.383InformativeInherited
Worm Phenotype (WP)cell proliferation increased0Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.0000001186Highly InformativeDirect
Worm Phenotype (WP)dendrite development variant0.000000396Highly InformativeDirect
Worm Phenotype (WP)embryonic lethal late emb0.000001393Highly InformativeDirect
Worm Phenotype (WP)RNA processing variant0.00001964Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00008272Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0002175Highly InformativeDirect
Worm Phenotype (WP)P granule defective0.07581Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.000000000000007149Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0.0000002028Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0.0000002042Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0000007275Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0.00001223Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.0001182Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.004718Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.01277Least InformativeInherited
Xenopus ANatomical entity (XAN)egg0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000000000005539Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.000000001995Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.00000002842Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.0000004233Moderately InformativeDirect
Xenopus ANatomical entity (XAN)female genitalia0.000007581Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0005571Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0.002378Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.002382Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.09425Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.00000000001214InformativeDirect
Xenopus ANatomical entity (XAN)heart0.0000000000565InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0.0000001168InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0000008311InformativeDirect
Xenopus ANatomical entity (XAN)spleen0.000001071InformativeDirect
Xenopus ANatomical entity (XAN)lung0.000001314InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000001783InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0.000004424InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00009388InformativeDirect
Xenopus ANatomical entity (XAN)limb0.0002656InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0003769InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0.0005911InformativeDirect
Xenopus ANatomical entity (XAN)oocyte0.00000005527Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomach0.000000138Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastopore lip0.00002504Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.002634Highly InformativeInherited
Xenopus DEvelopment stage (XDE)oocyte stage III0.00004248Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0.00000008502Least InformativeDirect
Plant ANatomical entity (PAN)seed0.000006117Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0.0001148Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.002602Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.005038Least InformativeInherited
Plant ANatomical entity (PAN)inflorescence0.009955Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.02104Least InformativeInherited
Plant ANatomical entity (PAN)flower0.1691Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.2Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.2113Least InformativeInherited
Plant ANatomical entity (PAN)gamete0.00005279InformativeDirect
Plant ANatomical entity (PAN)cultured plant cell0.0001433Highly InformativeDirect
Plant ANatomical entity (PAN)bud0.03185Highly InformativeInherited
Plant structure DEvelopment stage (PDE)D bilateral stage0.00001301Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004974Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0001061Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0.000115Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.03507Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.0000000001215Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.0000001013Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.002055Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0188Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.04721Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.7489Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.000000000000009885InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.00000003387InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0004352InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.486e-16Highly InformativeDirect
Enzyme Commission (EC)Poly(A)-specific ribonuclease0.0000000000004168Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.9614Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processProtein transport1Moderately InformativeInherited
Biological processmRNA processing0InformativeDirect
Biological processTranslation regulation0InformativeDirect
Biological processBiological rhythms4.844e-16InformativeDirect
Biological processMeiosis0.000000000002902InformativeDirect
Biological processrRNA processing0.000001715InformativeDirect
Biological processProtein biosynthesis0.0002053InformativeDirect
Biological processmRNA transport0Highly InformativeDirect
Biological processNonsense-mediated mRNA decay0Highly InformativeDirect
Biological processRNA-mediated gene silencing0Highly InformativeDirect
Biological processSpermatogenesis0.00003852Highly InformativeDirect
Biological processTranslocation0.04604Highly InformativeInherited
Cellular componentNucleus0Least InformativeDirect
Cellular componentSpliceosome0InformativeDirect
Cellular componentChromosome0.0000002388InformativeDirect
Coding sequence diversityAlternative splicing0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0.000000000004653Moderately InformativeDirect
DomainZinc-finger0.00001286Moderately InformativeDirect
DomainWD repeat0.000002727InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationIsomerase1Moderately InformativeInherited
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationChromatin regulator0.00004561InformativeDirect
Post-translational modificationRotamase0.0000002275Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 98 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNA-binding domain, RBD domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 98 hidden Markov models representing the RNA-binding domain, RBD superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]