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ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,032) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 43,742 231,824 43
Proteins 32,506 177,065 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00020690.00000000000002124Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.0006410Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00078160Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0036120.002276Least InformativeInherited
Biological Process (BP)primary metabolic process0.0023320.4425Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.00000130Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000035220.000000000000009171Moderately InformativeDirect
Molecular Function (MF)transferase activity0.0001260.5035Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000000000002124 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6968 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6748 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.4425 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.002276 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000000009171 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00009586 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0008687 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.9288 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.02718 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9868 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1861 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3269 Moderately Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.00000003396 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000001023 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0001063 Informative Direct
Biological Process (BP) response to nitrogen compound 0.0002315 Informative Direct
Biological Process (BP) behavior 0.000721 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.05151 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4071 Informative Inherited
Biological Process (BP) response to acid chemical 0.01935 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.04206 Informative Inherited
Biological Process (BP) amine metabolic process 0.03093 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.05133 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.218 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.172 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002316 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1463 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1523 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000002829 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.00000159 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.00001064 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00007876 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0001547 Highly Informative Direct
Biological Process (BP) response to amino acid 0.0003809 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.008361 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.002652 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.003412 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.001007 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.5035 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000000004634 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000012 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000001327 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0001163 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0008635 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.4123 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.9271 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.00000000000009488 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000000003255 Informative Direct
Molecular Function (MF) identical protein binding 0.00003473 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.1098 Informative Inherited
Molecular Function (MF) ATPase activity 0.07745 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0.0071 Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.299 Informative Inherited
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000000000000006357 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.147 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6118 Least Informative Inherited
Cellular Component (CC) plastid 0.00000007694 Informative Direct
Cellular Component (CC) chloroplast stroma 0.000003578 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01743Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)brain disease0.0002201Moderately InformativeDirect
Disease Ontology (DO)schizophrenia0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.06964Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.09143Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0003962Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.004537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02912Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0001855InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.004087InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0.000000003045Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.00002099Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0Moderately InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0.00006802Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001669Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001834Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003189Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.002262Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.006063Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000004905Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.07472Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.9233Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000000002088InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.0000000001471InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000002239InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001043InformativeDirect
Enzyme Commission (EC)In linear amides0.2056InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.3439InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.829e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0.00000000009254Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0.000000000000001439Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0.000000000005887Highly InformativeDirect
Biological processPhenylalanine catabolism0.000000004223Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1354Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0.0000002348InformativeDirect
Coding sequence diversityAlternative initiation0.00000002062Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.00002327Moderately InformativeDirect
Molecular functionMagnesium0.000000604Least InformativeDirect
Molecular functionNucleotide-binding0.08536Least InformativeInherited
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.000000000143Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000003454Moderately InformativeDirect
Post-translational modificationOxidoreductase0.6212Moderately InformativeInherited
Post-translational modificationMonooxygenase0.00000000003851Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.00000000000837Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0002923Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0529Moderately InformativeInherited
UniPathway (UP)purine metabolism0.4478Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.6979Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0.000000304InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.000004889InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0001364InformativeDirect
UniPathway (UP)tryptophan metabolism0.9909InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)prephenate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.00000000000009406Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.0000000000004371Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.000000000001853Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.000000001436Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0.0000002592Highly InformativeDirect
UniPathway (UP)L-phenylalanine degradation0.000009881Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]