SUPERFAMILY 1.75 HMM library and genome assignments server


ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,026) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 43,695 245,097 43
Proteins 32,470 191,922 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00076487.377e-15Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.0013840Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0024760Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process9.63e-060Moderately InformativeDirect
Biological Process (BP)single-organism biosynthetic process1.808e-053.77e-15Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process1.996e-050Moderately InformativeDirect
Molecular Function (MF)transferase activity0.015940.5239Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 7.377e-15 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6694 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7576 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 3.77e-15 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0003823 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3114 Moderately Informative Inherited
Biological Process (BP) organ development 0.6127 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2189 Moderately Informative Inherited
Biological Process (BP) system process 0.6176 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.01311 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.002236 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0001198 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) gland development 0.01345 Informative Inherited
Biological Process (BP) reproductive system development 0.03473 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.326 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.004405 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2275 Informative Inherited
Biological Process (BP) response to light stimulus 0.001932 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.02075 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.007489 Informative Inherited
Biological Process (BP) single-organism behavior 0.004847 Informative Inherited
Biological Process (BP) mammary gland alveolus development 1.554e-08 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 3.263e-08 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 1.046e-06 Highly Informative Direct
Biological Process (BP) response to cold 6.354e-05 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 8.704e-05 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0002036 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.1034 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.008982 Highly Informative Inherited
Biological Process (BP) response to UV 0.005231 Highly Informative Inherited
Biological Process (BP) learning or memory 0.07166 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.5239 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 1.039e-09 Moderately Informative Direct
Molecular Function (MF) lyase activity 1.498e-06 Moderately Informative Direct
Molecular Function (MF) anion binding 0.003712 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.003984 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 1.238e-11 Informative Direct
Molecular Function (MF) carboxylic acid binding 5.412e-08 Informative Direct
Molecular Function (MF) kinase activity 0.3558 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.04884 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 9.93e-14 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 5.406e-13 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.793e-11 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7329 Least Informative Inherited
Cellular Component (CC) plastid 2.186e-08 Informative Direct
Cellular Component (CC) chloroplast stroma 2.394e-06 Highly Informative Direct
Cellular Component (CC) cell body 0.01402 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red3.708e-15Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.371e-07Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases2.527e-06Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases2.328e-15InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases2.234e-14InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep8.021e-08InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.03399Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat3.906e-05InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007056InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.006152InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception7.733e-06Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage6.776e-05Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001663Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001833Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003187Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.001169Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.01049Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors2.71e-05Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.09835Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1.545e-14InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases2.633e-11InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1.931e-07InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor7.522e-05InformativeDirect
Enzyme Commission (EC)In linear amides0.07202InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.2996InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.586e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor9.733e-10Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1.858e-15Highly InformativeDirect
Biological processDiaminopimelate biosynthesis7.55e-12Highly InformativeDirect
Biological processPhenylalanine catabolism4.611e-09Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1118Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane1.25e-06InformativeDirect
Coding sequence diversityAlternative initiation8.651e-09Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.0001246Moderately InformativeDirect
Molecular functionNucleotide-binding7.273e-08Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionDNA-binding2.067e-06Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase9.585e-15Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0.3561Moderately InformativeInherited
Post-translational modificationMonooxygenase4.508e-12Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism1.908e-12Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0002317Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.04696Moderately InformativeInherited
UniPathway (UP)purine metabolism0.4498Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.6391Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis1.919e-14InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis1.438e-07InformativeDirect
UniPathway (UP)L-lysine biosynthesis2.208e-06InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0001193InformativeDirect
UniPathway (UP)tryptophan metabolism0.9673InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)prephenate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis4.758e-14Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation1.754e-12Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis6.517e-10Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis1.345e-09Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis1.213e-07Highly InformativeDirect
UniPathway (UP)L-phenylalanine degradation8.142e-06Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]