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ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,028) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 43,725 245,097 43
Proteins 32,491 191,922 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.00012010Least InformativeDirect
Biological Process (BP)biosynthetic process0.00020860Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00073120Least InformativeDirect
Biological Process (BP)primary metabolic process0.0021420.3768Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0047760.006486Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000001260Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000030590Moderately InformativeDirect
Molecular Function (MF)transferase activity0.00012480.5931Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.3768 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6406 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6193 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.006486 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.006001 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.9862 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.05768 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.745 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7616 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.9851 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1859 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000006686 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000008199 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.00005096 Informative Direct
Biological Process (BP) behavior 0.0001675 Informative Direct
Biological Process (BP) response to acid chemical 0.01231 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1678 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1093 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4782 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.05765 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.03466 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.03549 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.04588 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.004429 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.06043 Informative Inherited
Biological Process (BP) amine metabolic process 0.4145 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.000000001666 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.0000001926 Highly Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.000004922 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.00001415 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00005388 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.00006684 Highly Informative Direct
Biological Process (BP) response to amino acid 0.0007422 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.001589 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.01216 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.001718 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.00126 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.5931 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000000002818 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000262 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000001303 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000451 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0005207 Moderately Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000000000000003237 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.00000000009337 Informative Direct
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0.112 Informative Inherited
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.000000000000001646 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1454 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1865 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plastid 0.00000006607 Informative Direct
Cellular Component (CC) chloroplast stroma 0.000009641 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.01155Least InformativeInherited
Disease Ontology (DO)nervous system disease0.0175Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)bone marrow disease0.0002851Moderately InformativeDirect
Disease Ontology (DO)schizophrenia0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.03311Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.006962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.00004268InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.004576InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.000005324Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0Moderately InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0.00006802Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001669Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001834Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003189Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.002004Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.007258Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000005285Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.09021Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.9281Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000000000957InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.0000000002056InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000002925InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001146InformativeDirect
Enzyme Commission (EC)In linear amides0.2036InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.3502InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.758e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0.0000000001311Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)sapropterin0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0.000000000000001433Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0.000000000006315Highly InformativeDirect
Biological processPhenylalanine catabolism0.000000004343Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1406Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0.000000175InformativeDirect
Coding sequence diversityAlternative initiation0.00000002053Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.00005074Moderately InformativeDirect
Molecular functionNucleotide-binding0.00000003415Least InformativeDirect
Molecular functionDNA-binding0.00000463Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0.00000000000006531Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.000000000000003111Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0.3359Moderately InformativeInherited
Post-translational modificationMonooxygenase0.00000000003513Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.000000000009341Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0003046Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.0531Moderately InformativeInherited
UniPathway (UP)purine metabolism0.4475Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.7024Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0.00000000000007618InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0.0000003321InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.000004899InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0001381InformativeDirect
UniPathway (UP)tryptophan metabolism0.9936InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)prephenate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.00000000000009718Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.0000000000004655Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.000000000001858Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.000000001438Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0.0000002693Highly InformativeDirect
UniPathway (UP)L-phenylalanine degradation0.000008088Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]