SUPERFAMILY 1.75 HMM library and genome assignments server

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ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,034) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 43,765 0 43
Proteins 32,528 0 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.01763Least InformativeInherited
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)brain disease0.0002216Moderately InformativeDirect
Disease Ontology (DO)schizophrenia0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.06938Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0909Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0003939Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.004505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.0001836InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.004115InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0.000000003059Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.00002105Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0Moderately InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.1815Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2428Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.3832Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.13Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.2235Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk0.6585Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.003504InformativeInherited
Zebrafish Anatomy (ZA)trunk vasculature0.006482InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.009596InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.01058InformativeInherited
Zebrafish Anatomy (ZA)blood vessel0.01251InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic multipotent progenitor cell0.000004334Highly InformativeDirect
Zebrafish Anatomy (ZA)axial blood vessel0.000493Highly InformativeDirect
Zebrafish Anatomy (ZA)artery0.000866Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0.00006802Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001669Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001834Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003189Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.002688Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005687Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000007028Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.07541Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.923Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000000000006024InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.000000000155InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000002905InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001074InformativeDirect
Enzyme Commission (EC)In linear amides0.2114InformativeInherited
Enzyme Commission (EC)Intramolecular transferases0.3486InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.896e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0.00000000003573Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0.00000000000000145Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0.000000000005536Highly InformativeDirect
Biological processPhenylalanine catabolism0.00000000462Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1355Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0.0000001206InformativeDirect
Coding sequence diversityAlternative initiation0.00000002072Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.0000127Moderately InformativeDirect
Molecular functionMagnesium0.000001033Least InformativeDirect
Molecular functionNucleotide-binding0.05702Least InformativeInherited
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.00000000006956Least InformativeDirect
Post-translational modificationMultifunctional enzyme0Moderately InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationDNA-binding0.000000004174Moderately InformativeDirect
Post-translational modificationOxidoreductase0.6075Moderately InformativeInherited
Post-translational modificationAllosteric enzyme0.000000000009623InformativeDirect
Post-translational modificationMonooxygenase0.00000000001715Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]