SUPERFAMILY 1.75 HMM library and genome assignments server

ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,027) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 43,714 245,097 43
Proteins 32,484 191,922 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.0008350Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.0015870Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.0058130Least InformativeInherited
Biological Process (BP)single-organism cellular process0.02730.000885Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.000010080Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.000014570.000000000023Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.00002320Moderately InformativeDirect
Molecular Function (MF)transferase activity0.019720.8068Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000885 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7923 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6929 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000023 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0005563 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0007526 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.3536 Moderately Informative Inherited
Biological Process (BP) organ development 0.4492 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2221 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4801 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.003088 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0001075 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0001318 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) gland development 0.03941 Informative Inherited
Biological Process (BP) neurological system process 0.08408 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) reproductive structure development 0.06225 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2998 Informative Inherited
Biological Process (BP) response to light stimulus 0.00183 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.008815 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.009913 Informative Inherited
Biological Process (BP) single-organism behavior 0.1038 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0000000002 Highly Informative Direct
Biological Process (BP) mammary gland alveolus development 0.00000001391 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.0000002428 Highly Informative Direct
Biological Process (BP) response to cold 0.00005958 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0001792 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0008437 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.09668 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.008253 Highly Informative Inherited
Biological Process (BP) response to UV 0.00596 Highly Informative Inherited
Biological Process (BP) learning or memory 0.07377 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.8068 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.000000001384 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0000009342 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000002083 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0001797 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00839 Moderately Informative Inherited
Molecular Function (MF) hydro-lyase activity 0.0000000000009762 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000001172 Informative Direct
Molecular Function (MF) kinase activity 0.5149 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.02831 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0.000000000000003138 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0.0000000000001818 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.000000000002918 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7781 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plastid 0.00000001702 Informative Direct
Cellular Component (CC) chloroplast stroma 0.000002103 Highly Informative Direct
Cellular Component (CC) cell body 0.01361 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.03481Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.006915Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01129Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.0000392InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0007277InformativeDirect
Mammalian Phenotype (MP)abnormal touch/ nociception0.005973InformativeInherited
Mammalian Phenotype (MP)abnormal serotonin level0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thermal nociception0.000007515Highly InformativeDirect

Document: MP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)behavior defective0InformativeDirect
Fly Phenotype (FP)feeding behavior defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0.00006776Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0001663Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0001833Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0003187Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Lyases0.001421Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005672Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0.000005224Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.09261Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen0.00000000000003264InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000002524InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000002356InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00007909InformativeDirect
Enzyme Commission (EC)In linear amides0.09923InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)0.3062InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Ammonia-lyases0Highly InformativeDirect
Enzyme Commission (EC)Diphosphoric monoester hydrolases9.63e-16Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor0.0000000009422Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)other alimentary tract and metabolism products1InformativeInherited
Drugbank ATC_code (DB)sapropterin0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0.000000000000001859Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0.000000000007494Highly InformativeDirect
Biological processPhenylalanine catabolism0.000000004599Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1118Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0.000001445InformativeDirect
Coding sequence diversityAlternative initiation0.000000009225Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.0000263Moderately InformativeDirect
Molecular functionNucleotide-binding0.00000008323Least InformativeDirect
Molecular functionDNA-binding0.000002168Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.00000000000001454Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationOxidoreductase0.268Moderately InformativeInherited
Post-translational modificationMonooxygenase0.00000000001024Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)aromatic compound metabolism0.000000000003683Least InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0002758Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0.04962Moderately InformativeInherited
UniPathway (UP)purine metabolism0.4517Moderately InformativeInherited
UniPathway (UP)amino-acid degradation0.6659Moderately InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0.00000000000003308InformativeDirect
UniPathway (UP)aromatic amino-acid biosynthesis0.0000001988InformativeDirect
UniPathway (UP)L-lysine biosynthesis0.000003127InformativeDirect
UniPathway (UP)amine and polyamine biosynthesis0.0001292InformativeDirect
UniPathway (UP)tryptophan metabolism0.9769InformativeInherited
UniPathway (UP)L-lysine biosynthesis via DAP pathway0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)prephenate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-phenylalanine biosynthesis0Highly InformativeDirect
UniPathway (UP)ppGpp biosynthesis0Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.00000000000005367Highly InformativeDirect
UniPathway (UP)L-tryptophan degradation0.000000000001745Highly InformativeDirect
UniPathway (UP)L-serine biosynthesis0.00000000001347Highly InformativeDirect
UniPathway (UP)catecholamine biosynthesis0.000000001327Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0.0000001606Highly InformativeDirect
UniPathway (UP)L-phenylalanine degradation0.000008081Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]