SUPERFAMILY 1.75 HMM library and genome assignments server

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ACT-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   ACT-like [ 55021] (14)
Families:   Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [ 55022]
  Allosteric threonine deaminase C-terminal domain [ 55025]
  Phenylalanine metabolism regulatory domain [ 55028] (2)
  Nickel responsive regulator NikR, C-terminal domain [ 102999]
  Glycine cleavage system transcriptional repressor [ 110980]
  IlvH-like [ 143376]
  SP0238-like [ 143381]
  Atu0741-like [ 143384]
  VC0802-like [ 143387]
  Aspartokinase allosteric domain-like [ 143390]
  BT0572-like [ 143395]
  AF1403 N-terminal domain-like [ 143398]
  NIL domain-like [ 160322] (2)
  TM1266-like [ 160329]


Superfamily statistics
Genomes (3,034) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 43,765 231,824 43
Proteins 32,528 177,065 32


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00019070.00000000000001079Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.00060730Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.00071680Least InformativeDirect
Biological Process (BP)primary metabolic process0.0021880.5488Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0034750.2835Least InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.0000011780Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.0000032290.000000000000007296Moderately InformativeDirect
Molecular Function (MF)transferase activity0.000121Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00000000000001079 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.5488 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6032 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9613 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6044 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6366 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2835 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000000002606 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000000005908 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000001278 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000005774 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.00004394 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0004609 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0005497 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.9575 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) behavior 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.00000000002558 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00000000003467 Informative Direct
Biological Process (BP) ammonium ion metabolic process 0.000000005052 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.0000000224 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0001129 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.2317 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to acid chemical 0.1677 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.03833 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.08451 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.08477 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3007 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.002366 Informative Inherited
Biological Process (BP) amine metabolic process 0.03061 Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0 Highly Informative Direct
Biological Process (BP) single-organism behavior 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.00000000004201 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0.000001192 Highly Informative Direct
Biological Process (BP) aromatic amino acid family biosynthetic process 0.000001695 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0001444 Highly Informative Direct
Biological Process (BP) branched-chain amino acid metabolic process 0.0009819 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.4911 Highly Informative Inherited
Biological Process (BP) response to amino acid 0.02063 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.00402 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000001224 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000004522 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000745 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0009911 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.5071 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.00000000000008414 Informative Direct
Molecular Function (MF) hydro-lyase activity 0.000000007106 Informative Direct
Molecular Function (MF) identical protein binding 0.0002011 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.0006308 Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0.0008402 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0.1208 Informative Inherited
Molecular Function (MF) ATPase activity 0.1108 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.2776 Informative Inherited
Molecular Function (MF) monooxygenase activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.1508 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9424 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) plastid 0.0000002017 Informative Direct
Cellular Component (CC) protein-DNA complex 0.000581 Informative Direct
Cellular Component (CC) chloroplast stroma 0.000006235 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)Lyases0.00038Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.005559Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000007371Moderately InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000002527Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.2547Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.05367Moderately InformativeInherited
Enzyme Commission (EC)Diphosphotransferases0.000000000000002328InformativeDirect
Enzyme Commission (EC)Carbon-nitrogen lyases0.00000000000002234InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep0.00000008021InformativeDirect
Enzyme Commission (EC)Transferring other groups0.001969InformativeInherited
Enzyme Commission (EC)Aspartate kinase0Highly InformativeDirect
Enzyme Commission (EC)Chorismate mutase0Highly InformativeDirect
Enzyme Commission (EC)[Protein-PII] uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoglycerate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)GTP diphosphokinase0Highly InformativeDirect
Enzyme Commission (EC)Prephenate dehydratase0Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processAmino-acid transport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0.000000000000001442Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0.000000000006019Highly InformativeDirect
Biological processPhenylalanine catabolism0.000000004264Highly InformativeDirect
Biological processAromatic amino acid biosynthesis0.1353Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0.0000002385InformativeDirect
Coding sequence diversityAlternative initiation0.00000002461Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransit peptide0.00001157Moderately InformativeDirect
Molecular functionMagnesium0.0000007152Least InformativeDirect
Molecular functionNucleotide-binding0.08883Least InformativeInherited
Molecular functionNickel0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0.00000000007338Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationDNA-binding0.00000000487Moderately InformativeDirect
Post-translational modificationOxidoreductase0.5887Moderately InformativeInherited
Post-translational modificationMonooxygenase0.00000000001057Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACT-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 35 hidden Markov models representing the ACT-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]