SUPERFAMILY 1.75 HMM library and genome assignments server

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FAD-linked oxidases, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Ferredoxin-like [ 54861] (59)
Superfamily:   FAD-linked oxidases, C-terminal domain [ 55103] (4)
Families:   Vanillyl-alcohol oxidase-like [ 55104] (2)
  D-lactate dehydrogenase [ 55109]
  Cholesterol oxidase [ 64284]
  Cytokinin dehydrogenase 1 [ 110990]


Superfamily statistics
Genomes (2,318) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,638 48,952 15
Proteins 8,545 48,521 15


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000476 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.3913 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.457 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0.003047 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.386 Moderately Informative Inherited
Biological Process (BP) amine metabolic process 0.00000003822 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00003531 Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.0000006681 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000001468 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00000001507 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) transferase activity, transferring alkyl or aryl (other than methyl) groups 0.00000000000004879 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.00000005409 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01095 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.05714 Least Informative Inherited
Cellular Component (CC) microbody 0.0000002535 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0.000000000000002328Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.00003817Moderately InformativeDirect
Biological processLipid biosynthesis0.000002617InformativeDirect
Cellular componentMitochondrion0.0000000003667Moderately InformativeDirect
Cellular componentSecreted0.0000000517Moderately InformativeDirect
Cellular componentPeroxisome0.000000000000003882InformativeDirect
DomainTransit peptide0.0000000000001644Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationGlycoprotein0.000008208Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD-linked oxidases, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the FAD-linked oxidases, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]