SUPERFAMILY 1.75 HMM library and genome assignments server

DNA repair protein MutS, domain I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MutS N-terminal domain-like [ 55266] (2)
Superfamily:   DNA repair protein MutS, domain I [ 55271]
Families:   DNA repair protein MutS, domain I [ 55272]


Superfamily statistics
Genomes (2,595) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,511 18,364 7
Proteins 3,509 18,360 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000000000000001913 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000000008518 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000000007624 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004237 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000001945 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001269 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.04603 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.2332 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2036 Least Informative Inherited
Biological Process (BP) developmental process 0.01064 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000002146 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.003 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1914 Moderately Informative Inherited
Biological Process (BP) immune system process 0.001052 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1217 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1788 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.143 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.009603 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.5251 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.01545 Moderately Informative Inherited
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000003985 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00001599 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00003761 Informative Direct
Biological Process (BP) cell cycle process 0.0001033 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00002766 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0006685 Informative Direct
Biological Process (BP) organelle fission 0.00005924 Informative Direct
Biological Process (BP) cell division 0.00000474 Informative Direct
Biological Process (BP) chromosome organization 0.002266 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.0011 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.1589 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.002756 Informative Inherited
Biological Process (BP) nuclear division 0.0000000001645 Highly Informative Direct
Biological Process (BP) DNA recombination 0.000312 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000007124 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.000005054 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000006704 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.000004774 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000006169 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000008097 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000007441 Highly Informative Direct
Molecular Function (MF) binding 0.000003151 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.0443 Least Informative Inherited
Molecular Function (MF) anion binding 0.0003285 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.003613 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.006007 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.006739 Moderately Informative Inherited
Molecular Function (MF) nucleotide binding 0.00002483 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0001146 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000003314 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000002448 Informative Direct
Molecular Function (MF) ATP binding 0.0000002722 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.00000007211 Highly Informative Direct
Cellular Component (CC) protein complex 0.0001843 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001022 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.05063 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0001117 Moderately Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]