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DNA repair protein MutS, domain I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MutS N-terminal domain-like [ 55266] (2)
Superfamily:   DNA repair protein MutS, domain I [ 55271]
Families:   DNA repair protein MutS, domain I [ 55272]


Superfamily statistics
Genomes (2,599) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,513 18,364 7
Proteins 3,511 18,360 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000000008994 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000001203 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000001127 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00008518 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.7747 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000008279 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000004102 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.003328 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02252 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001499 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001006 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.00005743 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002266 Informative Direct
Biological Process (BP) chromosome organization 0.03934 Informative Inherited
Biological Process (BP) nuclear division 0.00000001248 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000000000597 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.000002562 Highly Informative Direct
Molecular Function (MF) binding 0.00002799 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.04695 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0002246 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0004923 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002865 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.006943 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.009076 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.00001894 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.00000596 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000006815 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000002691 Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.0004454 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000003433 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0009755 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.002142 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1217 Least Informative Inherited
Cellular Component (CC) nuclear part 0.000688 Moderately Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]