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DNA repair protein MutS, domain I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MutS N-terminal domain-like [ 55266] (2)
Superfamily:   DNA repair protein MutS, domain I [ 55271]
Families:   DNA repair protein MutS, domain I [ 55272]


Superfamily statistics
Genomes (2,596) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,512 18,364 7
Proteins 3,510 18,360 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000000006612 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000007209 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000006389 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00007112 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.7239 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0009131 Moderately Informative Direct
Biological Process (BP) response to stress 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000001833 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000845 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.02039 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.004522 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.02336 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.00008161 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002076 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.001004 Informative Inherited
Biological Process (BP) organelle fission 0.00342 Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.0000000004388 Highly Informative Direct
Biological Process (BP) meiotic cell cycle process 0.000001008 Highly Informative Direct
Biological Process (BP) chromosome organization 0.001543 Highly Informative Inherited
Molecular Function (MF) binding 0.00007874 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.04432 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0002079 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003992 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.002171 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.007735 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.005364 Moderately Informative Inherited
Molecular Function (MF) purine nucleoside binding 0.000003367 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.00001662 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000005057 Informative Direct
Molecular Function (MF) ribonucleoside binding 0.000003316 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000005761 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000002298 Informative Direct
Molecular Function (MF) ATP binding 0.0000002904 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0006565 Least Informative Direct
Cellular Component (CC) protein complex 0.00002927 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1086 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0005459 Moderately Informative Direct

Document: GO annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]