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DNA repair protein MutS, domain I superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MutS N-terminal domain-like [ 55266] (2)
Superfamily:   DNA repair protein MutS, domain I [ 55271]
Families:   DNA repair protein MutS, domain I [ 55272]


Superfamily statistics
Genomes (2,600) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,514 19,209 7
Proteins 3,512 19,200 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000000000001079 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000001844 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000002952 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00002758 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biological regulation 0.8423 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000001162 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.00000000003361 Moderately Informative Direct
Biological Process (BP) reproduction 0.001247 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.02623 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.003946 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.001689 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) cell cycle process 0.00007213 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002562 Informative Direct
Biological Process (BP) chromosome organization 0.01968 Informative Inherited
Biological Process (BP) nuclear division 0.00000001333 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0000000005819 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.000002316 Highly Informative Direct
Molecular Function (MF) binding 0.00001408 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.04929 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0002379 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0005261 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.009839 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.002366 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.005917 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) ATPase activity 0.00002046 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000005966 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000006833 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000002653 Informative Direct
Molecular Function (MF) double-stranded DNA binding 0.0003018 Highly Informative Direct
Molecular Function (MF) ATP binding 0.0000003428 Highly Informative Direct
Cellular Component (CC) protein complex 0.00003992 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001355 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1203 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0007139 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA repair0.00000002718InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain I domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain I superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]