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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,600 55,628 19
Proteins 9,574 55,434 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001246Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.209Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.05717Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.09597Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.000004935Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00001526Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0000001605Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000002103Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00006525Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001188Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00033Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002327Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000002303Moderately InformativeDirect
Worm Phenotype (WP)protein interaction variant0.00008619Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.008871Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.01015Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01314Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.05351Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.08004Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.08201Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1419Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1838Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9203Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9753Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000000219InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000002278InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001578InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000004673InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.00002115InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001195InformativeDirect
Worm Phenotype (WP)male mating variant0.0001495InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0002637InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0004507InformativeDirect
Worm Phenotype (WP)mitosis variant0.0006027InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0006586InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0009951InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.004859InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.008473InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.02295InformativeInherited
Worm Phenotype (WP)RNA expression variant0.124InformativeInherited
Worm Phenotype (WP)locomotion reduced0.663InformativeInherited
Worm Phenotype (WP)egg laying variant0.6972InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0000000000002984Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000007671Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000002992Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000002584Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000007558Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000009001Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.000001306Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.000001397Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000008493Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.0000183Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002889Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003026Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005143Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.008813Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.1107Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000006748Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)gonad0.0006321Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.0678Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2929Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0007222InformativeDirect
Fly Anatomy (FA)male-specific anatomical entity0.003391InformativeInherited
Fly Anatomy (FA)fat body0.02474InformativeInherited
Fly Anatomy (FA)neuroblast0.077InformativeInherited
Fly Anatomy (FA)fat cell0.000003265Highly InformativeDirect
Fly Anatomy (FA)type I neuroblast0.000004457Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001561Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001622Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.005563Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.07151Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.128Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1385Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7957Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001577Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.004005Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.03105Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001176InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008618InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006239InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.07834InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.1059InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.141InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1691InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000004636Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001045Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002385Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001596Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001214Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001738Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.009132Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2609Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0003934InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]