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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 9,600 45,773 19
Proteins 9,574 45,602 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.0006040.0007753Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000790.000002768Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.00039770Least InformativeDirect
Biological Process (BP)reproduction0.0000068650.00000000000002102Moderately InformativeDirect
Biological Process (BP)tissue development0.0000057380.001961Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000022380.3957Moderately InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.00000076710.0000000001228InformativeDirect
Biological Process (BP)post-embryonic development0.00000013130.00000000000001079InformativeDirect
Biological Process (BP)multicellular organism reproduction0.00000067670.000000000006129InformativeDirect
Biological Process (BP)single organism reproductive process0.000053270.0000000000003866InformativeDirect
Biological Process (BP)reproductive system development0.00000008210.00000000000002606InformativeDirect
Biological Process (BP)trichome differentiation0.00000000055190Highly InformativeDirect
Biological Process (BP)seed development0.0000000025290Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0007753 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000002768 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00000000000002102 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00003393 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.6811 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001961 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.006966 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.2261 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.239 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.8085 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.3957 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.4189 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8428 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0000000001228 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) post-embryonic development 0.00000000000001079 Informative Direct
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000000000006129 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000347 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) cellular protein complex assembly 0.00000001552 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000000003866 Informative Direct
Biological Process (BP) cell development 0.0000001529 Informative Direct
Biological Process (BP) organelle localization 0.00000007352 Informative Direct
Biological Process (BP) reproductive system development 0.00000000000002606 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.00001808 Informative Direct
Biological Process (BP) single-organism cellular localization 0.0006869 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.4502 Informative Inherited
Biological Process (BP) organelle assembly 0.02048 Informative Inherited
Biological Process (BP) intracellular transport 0.003077 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.1716 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.00004472 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0000001114 Highly Informative Direct
Biological Process (BP) trichome differentiation 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) seed development 0 Highly Informative Direct
Biological Process (BP) protein polymerization 0.000000000000001925 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000000009329 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.1373 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.4235 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1527 Highly Informative Inherited
Molecular Function (MF) binding 0.8905 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.884 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0008459 Moderately Informative Direct
Molecular Function (MF) anion binding 0.02519 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.007743 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.003304 Moderately Informative Inherited
Molecular Function (MF) purine nucleotide binding 0.00004022 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.00004995 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.00001096 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.0000000006003 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.000000000002654 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01493 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000000000001172 Informative Direct
Cellular Component (CC) supramolecular polymer 0 Informative Direct
Cellular Component (CC) plastid 0.02018 Informative Inherited
Cellular Component (CC) spindle 0.0000000006964 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0.000000000000003036 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 0.0002171 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processAntibiotic resistance0.0001595InformativeDirect
Biological processSeptation0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationNitration0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]