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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,600 55,628 19
Proteins 9,574 55,434 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001252Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2088Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.05723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.09606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.000004942Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00001529Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000155Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000000199Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0002128Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0003954Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0004984Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002153Least InformativeInherited
Worm Phenotype (WP)movement variant0.0000000135Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000003772Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0000289Moderately InformativeDirect
Worm Phenotype (WP)protein interaction variant0.0001007Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.01018Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01341Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07836Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1161Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1316Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1539Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9207Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9736Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000002928InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00000002249InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001559InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000004619InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.00002089InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001181InformativeDirect
Worm Phenotype (WP)male mating variant0.0001457InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001827InformativeDirect
Worm Phenotype (WP)male gonad development variant0.0004468InformativeDirect
Worm Phenotype (WP)mitosis variant0.0006221InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000654InformativeDirect
Worm Phenotype (WP)cell component localization variant0.001008InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.004458InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.004895InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.02291InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.02856InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1293InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4521InformativeInherited
Worm Phenotype (WP)egg laying variant0.5901InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6655InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.000000000007187Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.000000000007187Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.000000000007187Highly InformativeDirect
Worm Phenotype (WP)pronuclear morphology defective early emb0.000000000007187Highly InformativeDirect
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.00000000000892Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.0000000000116Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000007578Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000002694Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000002553Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.0000003704Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000006625Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000008912Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.000001382Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000008143Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001711Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002861Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005112Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.00099Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.008533Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.1128Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000006651Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9718Least InformativeInherited
Fly Anatomy (FA)gonad0.0007324Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.07371Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2939Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.000719InformativeDirect
Fly Anatomy (FA)male organism0.004754InformativeInherited
Fly Anatomy (FA)germline cyst0.006029InformativeInherited
Fly Anatomy (FA)neuroblast0.08139InformativeInherited
Fly Anatomy (FA)type I neuroblast0.000004868Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001528Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001812Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.005363Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.07234Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1263Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1396Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7932Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000006116Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.004082Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.02486Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.00000112InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008732InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006357InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.07807InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.105InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.139InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1673InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000005351Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001053Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002448Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001605Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001323Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001619Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.009053Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2609Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0003934InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]