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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,600 55,628 19
Proteins 9,574 55,434 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01652Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008675InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00005376Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1915Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.05736Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.08998Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000004051Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.00003342Highly InformativeDirect
Phenotypic Abnormality (PA)Cortical dysplasia0.0004534Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00000009499Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000008488Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00002652Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000143Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002126Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001793Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000002776Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000001848Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.009756Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07127Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.07857Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1493Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2129Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2134Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.3876Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9479Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9957Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000001732InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001176InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000003536InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.00001793InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001096InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001687InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0003463InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003547InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0005434InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.0006837InformativeDirect
Worm Phenotype (WP)copulation variant0.003523InformativeInherited
Worm Phenotype (WP)sexually dimorphic behavior variant0.003605InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.004461InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.02382InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1379InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.3756InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.5073InformativeInherited
Worm Phenotype (WP)locomotion reduced0.7112InformativeInherited
Worm Phenotype (WP)egg laying variant0.7424InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0000000000002759Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000006275Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000002223Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.0000000211Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000006526Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000007799Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.000001179Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.00000128Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000006886Highly InformativeDirect
Worm Phenotype (WP)presynaptic region morphology variant0.000009019Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001581Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002523Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0002983Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0004071Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005053Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.0009375Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.00661Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.1136Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000006283Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9692Least InformativeInherited
Fly Anatomy (FA)gonad0.0007519Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.0721Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2897Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0007785InformativeDirect
Fly Anatomy (FA)male organism0.004773InformativeInherited
Fly Anatomy (FA)germline cyst0.006209InformativeInherited
Fly Anatomy (FA)neuroblast0.08001InformativeInherited
Fly Anatomy (FA)type I neuroblast0.000003621Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001557Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001853Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02814Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.08809Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.08867Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7961Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000002052Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.001118Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.02544Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.0000006817InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00008833InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0004272InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.07112InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.07582InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.1146InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1464InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000001553Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00000000009274Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002435Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001231Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.001393Highly InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.001446Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.004617Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.007613Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2609Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0003934InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]