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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,600 55,628 19
Proteins 9,574 55,434 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01653Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008681InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0001308Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2047Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.05317Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.0851Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cortical gyration0.00001349Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of brainstem morphology0.00007627Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000126Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0000001682Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000151Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001738Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0003849Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0003864Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002386Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000002805Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0000000109Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000003253Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00005429Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.00518Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.007274Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.01379Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07109Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.1361Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.1599Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1861Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.9277Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9775Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000000002753InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001285InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000003653InformativeDirect
Worm Phenotype (WP)pericellular component morphology variant0.0000203InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0001032InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001109InformativeDirect
Worm Phenotype (WP)male mating variant0.0001348InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003852InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0005735InformativeDirect
Worm Phenotype (WP)cell component localization variant0.001007InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.004764InformativeInherited
Worm Phenotype (WP)nuclear appearance variant0.00477InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.02326InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.0271InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1342InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.497InformativeInherited
Worm Phenotype (WP)egg laying variant0.5959InformativeInherited
Worm Phenotype (WP)locomotion reduced0.6725InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.000000000007144Highly InformativeDirect
Worm Phenotype (WP)nucleus defective early emb0.000000000007144Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.000000000007144Highly InformativeDirect
Worm Phenotype (WP)pronuclear morphology defective early emb0.000000000007144Highly InformativeDirect
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.000000000008863Highly InformativeDirect
Worm Phenotype (WP)nuclear morphology variation early emb0.00000000001153Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000007089Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000002211Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.00000002247Highly InformativeDirect
Worm Phenotype (WP)spindle position orientation defective early emb0.0000003693Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000007022Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000008397Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.000001377Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000007613Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001618Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002709Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003001Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0004164Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005114Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.000969Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.002292Highly InformativeInherited
Worm Phenotype (WP)synapse morphology variant0.006473Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.1128Moderately InformativeInherited
Fly Phenotype (FP)male fertile0.0000006651Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9718Least InformativeInherited
Fly Anatomy (FA)gonad0.0007324Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.07371Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2939Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.000719InformativeDirect
Fly Anatomy (FA)male organism0.004754InformativeInherited
Fly Anatomy (FA)germline cyst0.006029InformativeInherited
Fly Anatomy (FA)neuroblast0.08139InformativeInherited
Fly Anatomy (FA)type I neuroblast0.000004868Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001528Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001812Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)sensory system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03017Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.08926Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.09095Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7942Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000002874Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.001233Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0275Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.000001126InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00009492InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0005794InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.07812InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.08684InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.1352InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.1661InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.000000000000001574Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001004Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000002533Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001559Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.001345Highly InformativeInherited
Xenopus ANatomical entity (XAN)archenteron0.001718Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.005305Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.009133Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2609Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0003934InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]