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Tubulin C-terminal domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Bacillus chorismate mutase-like [ 55297] (9)
Superfamily:   Tubulin C-terminal domain-like [ 55307]
Families:   Tubulin, C-terminal domain [ 55308] (3)


Superfamily statistics
Genomes (3,000) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 9,600 55,628 19
Proteins 9,574 55,434 19


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.01649Moderately InformativeInherited
Disease Ontology (DO)schizophrenia0.0008665InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.000538Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2919Least InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.04639Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.06948Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the brainstem0.0000008478Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cortical gyration0.000003326Highly InformativeDirect
Phenotypic Abnormality (PA)Cortical dysplasia0.0006158Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00000009627Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000008005Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00002701Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0001195Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002186Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001939Least InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.0000000003104Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00000217Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00991Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.05945Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.08076Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1528Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2143Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.2356Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.3782Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.964Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9948Moderately InformativeInherited
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.00000000203InformativeDirect
Worm Phenotype (WP)nicotine response variant0.0000001442InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.000002813InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001085InformativeDirect
Worm Phenotype (WP)mitosis variant0.0003529InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.0005887InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.0005936InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.004747InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.0237InformativeInherited
Worm Phenotype (WP)RNA expression variant0.1424InformativeInherited
Worm Phenotype (WP)organelle organization biogenesis variant0.3579InformativeInherited
Worm Phenotype (WP)locomotion reduced0.7203InformativeInherited
Worm Phenotype (WP)egg laying variant0.7424InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.0000000000003293Highly InformativeDirect
Worm Phenotype (WP)distal tip cell migration variant0.00000000006392Highly InformativeDirect
Worm Phenotype (WP)touch resistant0.000000001851Highly InformativeDirect
Worm Phenotype (WP)recycling endosome localization variant0.00000002325Highly InformativeDirect
Worm Phenotype (WP)miRNA expression variant0.0000007008Highly InformativeDirect
Worm Phenotype (WP)post hermaphrodite contact variant0.0000008353Highly InformativeDirect
Worm Phenotype (WP)mitotic spindle defective early emb0.000001315Highly InformativeDirect
Worm Phenotype (WP)alae morphology variant0.000001436Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.000007465Highly InformativeDirect
Worm Phenotype (WP)presynaptic region morphology variant0.000008507Highly InformativeDirect
Worm Phenotype (WP)dead eggs laid0.00001589Highly InformativeDirect
Worm Phenotype (WP)sluggish0.00002416Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0003161Highly InformativeDirect
Worm Phenotype (WP)nose touch variant0.0003748Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0005421Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.006814Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)fertile0.05476Moderately InformativeInherited
Fly Phenotype (FP)wild-type0.0005302InformativeDirect
Fly Phenotype (FP)sterile0.0006037InformativeDirect
Fly Phenotype (FP)cell cycle defective0.0009782InformativeDirect
Fly Phenotype (FP)male fertile0.0000005205Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.9687Least InformativeInherited
Fly Anatomy (FA)gonad0.000756Moderately InformativeDirect
Fly Anatomy (FA)somatic precursor cell0.07616Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.2936Moderately InformativeInherited
Fly Anatomy (FA)germline cell0.0007834InformativeDirect
Fly Anatomy (FA)male organism0.004786InformativeInherited
Fly Anatomy (FA)germline cyst0.006637InformativeInherited
Fly Anatomy (FA)neuroblast0.08265InformativeInherited
Fly Anatomy (FA)type I neuroblast0.000003814Highly InformativeDirect
Fly Anatomy (FA)type II neuroblast0.00001474Highly InformativeDirect
Fly Anatomy (FA)spermatid0.00001638Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.01278Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.05672Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.06207Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.1027Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2654Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.779Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002558Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.003069Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.08187Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2243Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.6018Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.0000005581InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00001396InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.00008805InformativeDirect
Xenopus ANatomical entity (XAN)pancreas0.0005215InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.04841InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.06184InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0000000001014Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000001627Highly InformativeDirect
Xenopus ANatomical entity (XAN)vegetal hemisphere0.0001475Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.0008633Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.003677Highly InformativeInherited
Xenopus ANatomical entity (XAN)intersomitic region0.00649Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.03367Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.03708Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.000377InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.2609Least InformativeInherited
Plant ANatomical entity (PAN)portion of vascular tissue0.0003934InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008280 SSF55307 Protein matches
Abstract

This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tubulin C-terminal domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Tubulin C-terminal domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]