SUPERFAMILY 1.75 HMM library and genome assignments server

Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FwdE/GAPDH domain-like [ 55346] (4)
Superfamily:   Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [ 55347] (5)
Families:   GAPDH-like [ 55348] (6)
  Homoserine dehydrogenase-like [ 55363] (2)
  Dihydrodipicolinate reductase-like [ 55368] (6)
  Biliverdin reductase [ 55373]
  Glucose 6-phosphate dehydrogenase-like [ 55376] (7)


Superfamily statistics
Genomes (3,243) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 39,084 208,109 92
Proteins 39,019 208,063 92


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000006126 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.7923 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.05243 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.04652 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7456 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.000000000005986 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00000004825 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0000001502 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000001212 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000000002533 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0001123 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.00007739 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.5473 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.00518 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.4527 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01168 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.009352 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.01245 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3699 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.1976 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.00000000000002422 Informative Direct
Biological Process (BP) apoptotic process 0.00000000000002089 Informative Direct
Biological Process (BP) response to oxidative stress 0.00005304 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000002202 Informative Direct
Biological Process (BP) microtubule-based process 0.000000004063 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.00000002095 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.00000000000006471 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000001994 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000000000004382 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) localization of cell 0.5776 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.001537 Informative Inherited
Biological Process (BP) hexose metabolic process 0.5199 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01779 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.3669 Informative Inherited
Biological Process (BP) glycolytic process 0 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.00005911 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) polyol biosynthetic process 0.0000007257 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) cell-type specific apoptotic process 0 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.7074 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 0.005413 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.00658 Highly Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.01152 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.0032 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.000000000004688 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0004836 Informative Direct
Molecular Function (MF) protein complex binding 0.000000000001633 Informative Direct
Molecular Function (MF) cofactor binding 0.00000003459 Informative Direct
Molecular Function (MF) nucleotide binding 0.001466 Informative Inherited
Molecular Function (MF) kinase activity 0.2722 Informative Inherited
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 0.0000000000007834 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) NADP binding 0.0000000004185 Highly Informative Direct
Molecular Function (MF) NAD binding 0.000008509 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00002555 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8887 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.08537 Least Informative Inherited
Cellular Component (CC) cytosol 0.00000000001497 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00001188 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) lipid particle 0.000318 Informative Direct
Cellular Component (CC) plastid 0.0000001001 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00000000006785 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004174 Informative Direct
Cellular Component (CC) chloroplast stroma 0.00000003568 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9413InformativeInherited
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.00000000000006098Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.009924Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.08254Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0004089InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0.000287Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.00112Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.002227Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.002321Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01258Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.02205Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.02424Least InformativeInherited
Plant ANatomical entity (PAN)flower0.04188Least InformativeInherited
Plant ANatomical entity (PAN)rosette leaf0.0002799InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0003247Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0003553Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0005948Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.00003734InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.04171Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.2054InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.001996Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism0.000001796Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1Highly InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect
Post-translational modificationADP-ribosylation0.00000000003869InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.000001259Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.008889Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis4.527e-16InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0.000005274InformativeDirect
UniPathway (UP)L-methionine biosynthesis1InformativeInherited
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0.000000000000001345Highly InformativeDirect
UniPathway (UP)Calvin cycle0.00000000006794Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation0.00005266Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0.0004987Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]