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Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FwdE/GAPDH domain-like [ 55346] (4)
Superfamily:   Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [ 55347] (5)
Families:   GAPDH-like [ 55348] (6)
  Homoserine dehydrogenase-like [ 55363] (2)
  Dihydrodipicolinate reductase-like [ 55368] (6)
  Biliverdin reductase [ 55373]
  Glucose 6-phosphate dehydrogenase-like [ 55376] (7)


Superfamily statistics
Genomes (3,249) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,154 245,614 92
Proteins 39,088 245,493 92


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000000002767 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000001208 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00009694 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.4725 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.05095 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1386 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.09749 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4437 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000000000002091 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.00000000000116 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0000000002329 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000745 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0002838 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.009082 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3144 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.484 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6973 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5613 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.02278 Moderately Informative Inherited
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) oxidoreduction coenzyme metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.00000000000003101 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.00000000066 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000008094 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000000001115 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000007182 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.0000000082 Informative Direct
Biological Process (BP) cell death 0.0000002287 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000002638 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00001712 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.02348 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.4556 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001639 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.4013 Informative Inherited
Biological Process (BP) alcohol metabolic process 1 Informative Inherited
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000000000000376 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.0000000000001264 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0000000000001878 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0002863 Highly Informative Direct
Biological Process (BP) glycolytic process 0.000356 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.06377 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.6962 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 1 Highly Informative Inherited
Biological Process (BP) NADP metabolic process 0.002302 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01293 Highly Informative Inherited
Molecular Function (MF) binding 0.000006214 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.1042 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000009959 Informative Direct
Molecular Function (MF) kinase activity 0.5443 Informative Inherited
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.8966 Highly Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.5003 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01597 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0007028 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00000004403 Informative Direct
Cellular Component (CC) plastid 0.0000003342 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0007682 Informative Direct
Cellular Component (CC) chloroplast stroma 0.0000002296 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9413InformativeInherited
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.00000000000006098Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.002592Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processGlycolysis0InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism0.0000005795Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1Highly InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect
Post-translational modificationADP-ribosylation0.0000000003118InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]