SUPERFAMILY 1.75 HMM library and genome assignments server


Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FwdE/GAPDH domain-like [ 55346] (4)
Superfamily:   Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [ 55347] (5)
Families:   GAPDH-like [ 55348] (6)
  Homoserine dehydrogenase-like [ 55363] (2)
  Dihydrodipicolinate reductase-like [ 55368] (6)
  Biliverdin reductase [ 55373]
  Glucose 6-phosphate dehydrogenase-like [ 55376] (7)


Superfamily statistics
Genomes (3,201) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 38,430 98,504 92
Proteins 38,379 98,471 92


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 3.244e-09 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0361 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.08624 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5892 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5164 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 2.947e-11 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 1.63e-09 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 4.736e-08 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 4.933e-05 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 5.039e-06 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.5797 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2603 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.002309 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01485 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01603 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.3626 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002262 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 7.853e-05 Informative Direct
Biological Process (BP) cytoskeleton organization 5.016e-08 Informative Direct
Biological Process (BP) microtubule-based process 2.696e-13 Informative Direct
Biological Process (BP) cell death 8.627e-13 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 1.327e-07 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 1.431e-14 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 4.79e-09 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 9.377e-13 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0002548 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) alcohol metabolic process 0.9425 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.003916 Informative Inherited
Biological Process (BP) hexose metabolic process 0.2771 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.02055 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.4738 Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 3.515e-10 Highly Informative Direct
Biological Process (BP) glycolysis 6.345e-06 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0005448 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.607 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.002281 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.07911 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.01301 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 7.549e-13 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.0009468 Informative Direct
Molecular Function (MF) cofactor binding 3.52e-05 Informative Direct
Molecular Function (MF) nucleotide binding 0.0404 Informative Inherited
Molecular Function (MF) kinase activity 0.1315 Informative Inherited
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3.88e-13 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) NADP binding 4.62e-06 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.134e-05 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.6514 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0174 Least Informative Inherited
Cellular Component (CC) cytosol 1.306e-11 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 6.121e-07 Moderately Informative Direct
Cellular Component (CC) plastid 1.231e-07 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 3.564e-12 Informative Direct
Cellular Component (CC) external encapsulating structure 0.01046 Informative Inherited
Cellular Component (CC) lipid particle 0.0007841 Highly Informative Direct
Cellular Component (CC) chloroplast stroma 2.64e-08 Highly Informative Direct
Cellular Component (CC) cell wall 0.002205 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9413InformativeInherited
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase6.098e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.02435Least InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.002185InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)nutrient utilization0.1013Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0004188InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0.000287Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.00112Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.002227Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.002321Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01258Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.02205Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.02424Least InformativeInherited
Plant ANatomical entity (PAN)flower0.04188Least InformativeInherited
Plant ANatomical entity (PAN)rosette leaf0.0002799InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0003247Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0003553Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0005948Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage3.734e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorous-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.1261Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.2069InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.003118Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism1.727e-06Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1Highly InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect
Post-translational modificationADP-ribosylation3.608e-11InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.0002275Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis1.774e-08Moderately InformativeDirect
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)heterocycle metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)isoprenoid metabolism0InformativeDirect
UniPathway (UP)pentose phosphate pathway7.502e-14InformativeDirect
UniPathway (UP)L-methionine biosynthesis3.776e-12InformativeDirect
UniPathway (UP)glycolysis0.000568InformativeDirect
UniPathway (UP)carbohydrate biosynthesis1InformativeInherited
UniPathway (UP)L-threonine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via de novo pathway0Highly InformativeDirect
UniPathway (UP)isopentenyl diphosphate biosynthesis via DXP pathway0Highly InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0Highly InformativeDirect
UniPathway (UP)Calvin cycle1.494e-07Highly InformativeDirect
UniPathway (UP)L-lysine degradation8.309e-06Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation0.0008533Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]