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Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   FwdE/GAPDH domain-like [ 55346] (4)
Superfamily:   Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain [ 55347] (5)
Families:   GAPDH-like [ 55348] (6)
  Homoserine dehydrogenase-like [ 55363] (2)
  Dihydrodipicolinate reductase-like [ 55368] (6)
  Biliverdin reductase [ 55373]
  Glucose 6-phosphate dehydrogenase-like [ 55376] (7)


Superfamily statistics
Genomes (3,249) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 39,154 245,614 92
Proteins 39,088 245,493 92


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00000000004693 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000002603 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0001162 Least Informative Direct
Biological Process (BP) biosynthetic process 0.05588 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1108 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.4984 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1551 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.464 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0.0000000000006128 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000004815 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.000000000828 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000001105 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000509 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.02243 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.4651 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3208 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.01364 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5916 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6872 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) ATP metabolic process 0 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.0000000000001248 Informative Direct
Biological Process (BP) aspartate family amino acid metabolic process 0.0000000002264 Informative Direct
Biological Process (BP) microtubule-based process 0.0000000004986 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000000001214 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.000000004134 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.000000006304 Informative Direct
Biological Process (BP) cell death 0.0000002094 Informative Direct
Biological Process (BP) nucleoside diphosphate metabolic process 0.0000004725 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0000004865 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00001377 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00001478 Informative Direct
Biological Process (BP) sulfur amino acid metabolic process 0.0007451 Informative Direct
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) dicarboxylic acid metabolic process 0.02097 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.001438 Informative Inherited
Biological Process (BP) glutamine family amino acid metabolic process 0.5683 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.997 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.3868 Informative Inherited
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000000000000446 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0000000000001075 Highly Informative Direct
Biological Process (BP) arginine metabolic process 0.000000000004387 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.0000064 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0.0003896 Highly Informative Direct
Biological Process (BP) glycolytic process 0.0007429 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.661 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 1 Highly Informative Inherited
Biological Process (BP) NADP metabolic process 0.002114 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.05176 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.01367 Highly Informative Inherited
Molecular Function (MF) binding 0.00001292 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.1033 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000006955 Informative Direct
Molecular Function (MF) kinase activity 0.5599 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.8884 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 1 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0232 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.4842 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0005159 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.00000004331 Informative Direct
Cellular Component (CC) plastid 0.0000005004 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0008974 Informative Direct
Cellular Component (CC) chloroplast stroma 0.0000002834 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.9413InformativeInherited
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0Highly InformativeDirect
Enzyme Commission (EC)Homoserine dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.00000000000006098Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)general pace of development variant0Least InformativeDirect
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.03501Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.06463Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0003459InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0.0002876Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.001128Least InformativeInherited
Plant ANatomical entity (PAN)leaf0.002243Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.002338Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.01265Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.02217Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.02436Least InformativeInherited
Plant ANatomical entity (PAN)flower0.04199Least InformativeInherited
Plant ANatomical entity (PAN)rosette leaf0.0003142InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0003259Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0.0003554Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0.0005951Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000374InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.01258Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.2087InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor0.945Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0.002239Moderately InformativeInherited
Biological processLipid metabolism1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processPyridine nucleotide biosynthesis0Highly InformativeDirect
Biological processPhospholipid metabolism0.000001766Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis1Highly InformativeInherited
Cellular componentCytoplasm0Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationS-nitrosylation0InformativeDirect
Post-translational modificationADP-ribosylation0.0000000002722InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.0000007406Least InformativeDirect
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)lipid biosynthesis0Moderately InformativeDirect
UniPathway (UP)alcohol metabolism0.01519Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)porphyrin-containing compound metabolism1Moderately InformativeInherited
UniPathway (UP)macrocycle metabolism1Moderately InformativeInherited
UniPathway (UP)L-methionine biosynthesis via de novo pathway0InformativeDirect
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)glycolysis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)NAD(+) biosynthesis0.000004743InformativeDirect
UniPathway (UP)polyol biosynthesis0Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism0Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis9.148e-16Highly InformativeDirect
UniPathway (UP)Calvin cycle0.000000000009186Highly InformativeDirect
UniPathway (UP)porphyrin-containing compound degradation0.00005168Highly InformativeDirect
UniPathway (UP)L-lysine degradation via saccharopine pathway0.0004817Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]