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FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,091) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,908 75,370 38
Proteins 13,894 75,361 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0002002 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01672 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9922 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.001294 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3918 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.06927 Least Informative Inherited
Biological Process (BP) peptide metabolic process 0.0007546 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.00000000000002971 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00003841 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000009631 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.1265 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.02202 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6022 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0074 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.0069 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.363 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.07919 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.02774 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8283 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.0000001504 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000000000001201 Informative Direct
Biological Process (BP) cell death 0.00000819 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000001782 Informative Direct
Biological Process (BP) response to metal ion 0.996 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.04169 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.002159 Informative Inherited
Biological Process (BP) glutathione metabolic process 0.000001397 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00008348 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00000000000005932 Highly Informative Direct
Biological Process (BP) apoptotic process 0.2652 Highly Informative Inherited
Molecular Function (MF) binding 0.9848 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000001192 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00005566 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0.02153 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00004476 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000008261 Least Informative Direct
Cellular Component (CC) macromolecular complex 0.3482 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2123 Least Informative Inherited
Cellular Component (CC) membrane 0.5037 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.000009348 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.00000001082 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00000000000002918 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000003857InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.0000007596InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3429Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.08967Moderately InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.009341Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.04267Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.0006797Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.04982Moderately InformativeInherited
Worm Phenotype (WP)pesticide response variant0.000003148InformativeDirect
Worm Phenotype (WP)cell stress response variant0.00008832InformativeDirect
Worm Phenotype (WP)life span variant0.0001542InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000004486InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.0000000008656Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.000000005685Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000005887Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001493Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0.0000000000001617Least InformativeDirect
Cellular componentMitochondrion0.00000000000006818Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00002537Moderately InformativeDirect
Cellular componentCell projection0.00006827Moderately InformativeDirect
Cellular componentCilium0.00000000006992InformativeDirect
Cellular componentFlagellum0Highly InformativeDirect
Coding sequence diversityAlternative initiation0.0004015Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide0.000000000001223Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation0.000002855InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.0000002115Least InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)hydrocarbon degradation0.00001652Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]