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FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,087) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,879 75,370 38
Proteins 13,865 75,361 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0002678 Least Informative Direct
Biological Process (BP) response to stimulus 0.0001901 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00007085 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.06473 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1278 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00000000000003235 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00003526 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000519 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.2098 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007298 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001024 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3105 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.03423 Moderately Informative Inherited
Biological Process (BP) response to stress 0.01803 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.06891 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.0183 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5358 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.0000002237 Informative Direct
Biological Process (BP) response to oxidative stress 0.0000000000004853 Informative Direct
Biological Process (BP) cell death 0.000001409 Informative Direct
Biological Process (BP) response to inorganic substance 0.0000000005619 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000001602 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.01916 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01784 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.002463 Informative Inherited
Biological Process (BP) glutathione metabolic process 0.000002026 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00008337 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.0000000000000788 Highly Informative Direct
Biological Process (BP) apoptotic process 0.3627 Highly Informative Inherited
Molecular Function (MF) binding 0.9867 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000001722 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00005183 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0.01774 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0004673 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000003534 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1037 Least Informative Inherited
Cellular Component (CC) membrane 0.4991 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.000005523 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.00000000632 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.01487 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.0000000000000175 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000003857InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.0000007596InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3678Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.08871Moderately InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.006306Least InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000004486InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.0000000009263Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.000000005955Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000006063Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001479Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0.0000000000001504Least InformativeDirect
Cellular componentMitochondrion0.00000000000006823Moderately InformativeDirect
Coding sequence diversityAlternative initiation0.0004049Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide0.0000000000042Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation0.000001805Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.0000002177Least InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)hydrocarbon degradation0.0000183Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]