SUPERFAMILY 1.75 HMM library and genome assignments server


FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,084) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,861 75,370 38
Proteins 13,847 75,361 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 1.629e-09 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.1026 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.0205 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 3.456e-14 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 5.099e-14 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.269e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0008136 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0008847 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.582 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.003132 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.09268 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.02956 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1.085e-14 Informative Direct
Biological Process (BP) response to oxidative stress 1.776e-14 Informative Direct
Biological Process (BP) response to inorganic substance 1.863e-09 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 3.45e-06 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.592 Informative Inherited
Biological Process (BP) apoptotic process 0.2625 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02127 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1563 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.6112 Informative Inherited
Biological Process (BP) hydrogen peroxide metabolic process 1.146e-13 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 1.208e-13 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 5.612e-12 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 2.295e-11 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 4.826e-11 Highly Informative Direct
Biological Process (BP) acyl-CoA metabolic process 2.245e-08 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0001287 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0003042 Highly Informative Direct
Molecular Function (MF) binding 0.421 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001153 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 3.796e-13 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1.189e-11 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002295 Least Informative Direct
Cellular Component (CC) protein complex 0.1927 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1465 Least Informative Inherited
Cellular Component (CC) membrane 0.03461 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) mitochondrial part 1.868e-07 Moderately Informative Direct
Cellular Component (CC) organelle envelope 1.916e-05 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.05688 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4933 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) nucleolus 0.0003178 Informative Direct
Cellular Component (CC) cell surface 0.005596 Informative Inherited
Cellular Component (CC) external side of plasma membrane 4.02e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions3.857e-09InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors7.596e-07InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage4.479e-07InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase1.108e-09Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions5.309e-09Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors3.227e-08Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis1.239e-05Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm3.514e-14Least InformativeDirect
Cellular componentMitochondrion2.587e-13Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide8.129e-12Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation8.647e-06Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism1.435e-07Least InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)hydrocarbon degradation1.704e-05Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]