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FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,094) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 13,940 77,446 38
Proteins 13,926 77,415 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.0001328 Least Informative Direct
Biological Process (BP) biosynthetic process 0.9954 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01569 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.3988 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.003071 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.06706 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.00000000000002436 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000009564 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00003331 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.0007201 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.02036 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.6101 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1536 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.007333 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.006666 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.07582 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.3525 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.02646 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.8134 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.00000000000009834 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.0000001315 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000001628 Informative Direct
Biological Process (BP) cell death 0.000007423 Informative Direct
Biological Process (BP) response to metal ion 0.9998 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.04033 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.00209 Informative Inherited
Biological Process (BP) acyl-CoA biosynthetic process 0.00000000000006184 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.00000131 Highly Informative Direct
Biological Process (BP) serine family amino acid metabolic process 0.00008339 Highly Informative Direct
Biological Process (BP) apoptotic process 0.2554 Highly Informative Inherited
Molecular Function (MF) binding 0.8942 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000001528 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00004776 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0.02306 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000004209 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00002556 Least Informative Direct
Cellular Component (CC) protein complex 0.7898 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1106 Least Informative Inherited
Cellular Component (CC) membrane 0.5748 Least Informative Inherited
Cellular Component (CC) mitochondrial protein complex 0.00002888 Moderately Informative Direct
Cellular Component (CC) organelle inner membrane 0.00004262 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.01532 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.00000000000005256 Informative Direct
Cellular Component (CC) nucleolar part 0.00000181 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000003857InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.0000007596InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001492Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0.0000000000001242Least InformativeDirect
Cellular componentMitochondrion0.0000000000000693Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000264Moderately InformativeDirect
Cellular componentCell projection0.00007323Moderately InformativeDirect
Cellular componentCilium0.00000000007242InformativeDirect
Cellular componentFlagellum0Highly InformativeDirect
Coding sequence diversityAlternative initiation0.0004236Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide0.000000000001269Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation0.000003709InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]