SUPERFAMILY 1.75 HMM library and genome assignments server

FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
Superfamily:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
Families:   FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)


Superfamily statistics
Genomes (3,086) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 13,879 75,370 38
Proteins 13,865 75,361 38


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00000000007748 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01772 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.0212 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02364 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000000001752 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0006174 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0007494 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00002315 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00006264 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.2772 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.2823 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.06391 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.03194 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cofactor metabolic process 0.003693 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 0.00000000000007887 Informative Direct
Biological Process (BP) cellular modified amino acid metabolic process 0.000001192 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000000000007248 Informative Direct
Biological Process (BP) response to inorganic substance 0.000000002041 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0007644 Informative Direct
Biological Process (BP) carboxylic acid catabolic process 0.6621 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.7264 Informative Inherited
Biological Process (BP) apoptotic process 0.2113 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.02691 Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.001904 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1594 Informative Inherited
Biological Process (BP) acyl-CoA metabolic process 0.00000002486 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0.000000000001411 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.0001373 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0.0000000000475 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0003 Highly Informative Direct
Biological Process (BP) hydrogen peroxide metabolic process 0.0000000000001023 Highly Informative Direct
Biological Process (BP) cell redox homeostasis 0.00000000000005193 Highly Informative Direct
Biological Process (BP) execution phase of apoptosis 0.0000000007072 Highly Informative Direct
Molecular Function (MF) binding 0.4504 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000002251 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0001154 Moderately Informative Direct
Molecular Function (MF) nucleotide binding 0.0000000000003041 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on NAD(P)H 0 Informative Direct
Molecular Function (MF) cofactor binding 0 Informative Direct
Molecular Function (MF) antioxidant activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0007823 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000788 Least Informative Direct
Cellular Component (CC) protein complex 0.17 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1903 Least Informative Inherited
Cellular Component (CC) membrane 0.02808 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.0000143 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.0000001163 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.6898 Moderately Informative Inherited
Cellular Component (CC) side of membrane 0.00002183 Informative Direct
Cellular Component (CC) oxidoreductase complex 0.000000000001069 Informative Direct
Cellular Component (CC) cell surface 0.00745 Informative Inherited
Cellular Component (CC) external side of plasma membrane 0.0000003489 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000003857InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.0000007596InformativeDirect
Enzyme Commission (EC)With other acceptors1InformativeInherited
Enzyme Commission (EC)Mercury(II) reductase0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.0000004479InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)NADH dehydrogenase0.000000001091Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.000000004699Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0.00000003053Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00001239Moderately InformativeDirect
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Cellular componentCytoplasm0.00000000000003408Least InformativeDirect
Cellular componentMitochondrion0.0000000000002622Moderately InformativeDirect
Coding sequence diversitySelenocysteine0InformativeDirect
DomainTransit peptide0.000000000008502Moderately InformativeDirect
DomainRedox-active center0InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular functionNADP0InformativeDirect
Molecular functionMercury0Highly InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationOxidation0.000008533Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0.000000145Least InformativeDirect
UniPathway (UP)aromatic compound degradation0Moderately InformativeDirect
UniPathway (UP)phenylpropanoid degradation0InformativeDirect
UniPathway (UP)hydrocarbon degradation0.00001707Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 21 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FAD/NAD-linked reductases, dimerisation (C-terminal) domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 21 hidden Markov models representing the FAD/NAD-linked reductases, dimerisation (C-terminal) domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]