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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,223) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 41,529 201,082 143
Proteins 40,599 197,870 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000036830Least InformativeDirect
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)single-organism cellular process10.5984Least InformativeInherited
Biological Process (BP)multicellular organismal process0.810Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.0017120Least InformativeInherited
Biological Process (BP)primary metabolic process0.1160.177Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.78361Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.37561Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.17441Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.20711Moderately InformativeInherited
Biological Process (BP)multi-organism process0.57310.0000005291Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.87361Moderately InformativeInherited
Biological Process (BP)reproduction0.30670.0000000249Moderately InformativeInherited
Biological Process (BP)proteolysis00InformativeDirect
Biological Process (BP)single organism reproductive process0.25720.0000164InformativeInherited
Biological Process (BP)positive regulation of gene expression0.18051InformativeInherited
Biological Process (BP)regulation of proteolysis0.019110.05067InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.031711InformativeInherited
Biological Process (BP)behavior0.0095660.3447InformativeInherited
Biological Process (BP)cell activation0.029420.0123InformativeInherited
Biological Process (BP)multi-organism reproductive process0.1140.00001181InformativeInherited
Biological Process (BP)fertilization0.000094330.000009242Highly InformativeDirect
Biological Process (BP)biological adhesion0.00045520.00002073Highly InformativeDirect
Biological Process (BP)negative regulation of multi-organism process0.00091420.05941Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.0017560.004693Highly InformativeInherited
Biological Process (BP)regulation of protein processing0.00018270.00178Highly InformativeInherited
Biological Process (BP)positive regulation of proteolysis0.0043520.008394Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0000000056970Least InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides10.4921InformativeInherited
Molecular Function (MF)metallopeptidase activity0.0000000000003280Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.16210.000000000000003036Moderately InformativeInherited
Cellular Component (CC)endomembrane system10.0008915Moderately InformativeInherited
Cellular Component (CC)secretory granule0.022780.00006185InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.177 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5984 Least Informative Inherited
Biological Process (BP) reproduction 0.0000000249 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000005291 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003009 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000007076 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0008518 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1665 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5802 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.3132 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.2243 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.08487 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6294 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9586 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2462 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01974 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4142 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.04567 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.09964 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1798 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0005322 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00001181 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000164 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000000001129 Informative Direct
Biological Process (BP) locomotion 0.000000000008322 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001466 Informative Direct
Biological Process (BP) regulation of locomotion 0.0001525 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.4604 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.00537 Informative Inherited
Biological Process (BP) response to radiation 0.03383 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) system process 0.009152 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.7837 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1234 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5726 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7738 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.03153 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.3077 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.6071 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) behavior 0.3447 Informative Inherited
Biological Process (BP) response to wounding 0.02299 Informative Inherited
Biological Process (BP) cell death 0.8185 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.0302 Informative Inherited
Biological Process (BP) circulatory system development 0.00483 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.3053 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4615 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.004361 Informative Inherited
Biological Process (BP) response to temperature stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.05067 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.3491 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9713 Informative Inherited
Biological Process (BP) epithelium development 0.01574 Informative Inherited
Biological Process (BP) central nervous system development 0.8071 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell activation 0.0123 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2839 Informative Inherited
Biological Process (BP) immune effector process 0.595 Informative Inherited
Biological Process (BP) post-embryonic development 0.9316 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) fertilization 0.000009242 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00002073 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0.000000004538 Highly Informative Direct
Biological Process (BP) response to UV 0.00000002913 Highly Informative Direct
Biological Process (BP) kidney development 0.0000003739 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000008024 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.00001927 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00001993 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00002263 Highly Informative Direct
Biological Process (BP) appendage development 0.00003874 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.00004804 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0001487 Highly Informative Direct
Biological Process (BP) aging 0.0001609 Highly Informative Direct
Biological Process (BP) multi-multicellular organism process 0.0001679 Highly Informative Direct
Biological Process (BP) gastrulation 0.0003231 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0003722 Highly Informative Direct
Biological Process (BP) regeneration 0.0004819 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.000496 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0006186 Highly Informative Direct
Biological Process (BP) programmed cell death involved in cell development 0.0006281 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.05941 Highly Informative Inherited
Biological Process (BP) regulation of hemopoiesis 0.004257 Highly Informative Inherited
Biological Process (BP) neuron development 0.0791 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.004693 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.04387 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.01317 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1804 Highly Informative Inherited
Biological Process (BP) wound healing 0.002646 Highly Informative Inherited
Biological Process (BP) heart development 0.006814 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.7549 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.656 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.004753 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 0.00178 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.008394 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.07701 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01639 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.1762 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.1573 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0.00000000001992 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000001941 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.4921 Informative Inherited
Molecular Function (MF) receptor binding 0.02098 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000006654 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.00000001114 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.0000001885 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.00007106 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.000211 Highly Informative Direct
Cellular Component (CC) membrane 0.000000102 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000000003036 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.000001764 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00002547 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0008915 Moderately Informative Direct
Cellular Component (CC) cell projection 0.2779 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.01248 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.1418 Moderately Informative Inherited
Cellular Component (CC) secretory granule 0.00006185 Informative Direct
Cellular Component (CC) extracellular organelle 0.0005475 Informative Direct
Cellular Component (CC) cell surface 0.000000000000008837 Informative Direct
Cellular Component (CC) vacuolar part 0.0000009642 Informative Direct
Cellular Component (CC) lytic vacuole 0.000001107 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00007648 Informative Direct
Cellular Component (CC) Golgi apparatus 0.01646 Informative Inherited
Cellular Component (CC) neuron projection 0.001378 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.2285 Informative Inherited
Cellular Component (CC) dendrite 0.00000001512 Highly Informative Direct
Cellular Component (CC) lysosomal membrane 0.0000005645 Highly Informative Direct
Cellular Component (CC) presynapse 0.00009628 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.01104 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0Moderately InformativeDirect
Biological processDifferentiation0.000003817Moderately InformativeDirect
Biological processApoptosis0.000359Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processAngiogenesis0.0000000000000988InformativeDirect
Biological processCell adhesion0.00000006198InformativeDirect
Biological processNotch signaling pathway0.000000001328Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000000011InformativeDirect
Coding sequence diversityPolymorphism0.0003723Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding0.0000000006654InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.00000008626Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid4.894e-16InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]