SUPERFAMILY 1.75 HMM library and genome assignments server

Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,217) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 41,229 130,592 143
Proteins 40,317 129,516 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.91311Least InformativeInherited
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.0067480Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.20870.7641Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.86511Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.2911Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.32391Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.73721Moderately InformativeInherited
Biological Process (BP)multi-organism process0.16590.000000002717Moderately InformativeInherited
Biological Process (BP)reproductive process0.45020.000001002Moderately InformativeInherited
Biological Process (BP)proteolysis0.000000000037250InformativeDirect
Biological Process (BP)positive regulation of gene expression0.15531InformativeInherited
Biological Process (BP)sexual reproduction0.35670.05501InformativeInherited
Biological Process (BP)single organism reproductive process0.26260.0000000399InformativeInherited
Biological Process (BP)fertilization0.00027330.0000002643Highly InformativeDirect
Biological Process (BP)regulation of multi-organism process0.0067740.526Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.00089840.133Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000020720Least InformativeDirect
Molecular Function (MF)binding10.5505Least InformativeInherited
Molecular Function (MF)cation binding0.000088030Moderately InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)metallopeptidase activity0.000000000000011470Highly InformativeDirect
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.50010.000000000000003071Moderately InformativeInherited
Cellular Component (CC)secretory granule0.0056230.00793InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000004833 Least Informative Direct
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multi-organism process 0.000000002717 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000001002 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000401 Moderately Informative Direct
Biological Process (BP) organ development 0.00008022 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2504 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9975 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6545 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7065 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002731 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.005521 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7641 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6096 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4141 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.7335 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4763 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) biological adhesion 0.000001986 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000000399 Informative Direct
Biological Process (BP) protein maturation 0 Informative Direct
Biological Process (BP) peptide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0.000000000000001913 Informative Direct
Biological Process (BP) regulation of hormone levels 0.000000001041 Informative Direct
Biological Process (BP) localization of cell 0.000000004424 Informative Direct
Biological Process (BP) response to cytokine 0.0000003051 Informative Direct
Biological Process (BP) locomotion 0.0000004422 Informative Direct
Biological Process (BP) cellular component movement 0.000001623 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00000191 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001052 Informative Direct
Biological Process (BP) organ morphogenesis 0.0003079 Informative Direct
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.02423 Informative Inherited
Biological Process (BP) cardiovascular system development 0.004583 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.01675 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.9269 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6781 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.7602 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.618 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) gland development 0.831 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) cell proliferation 0.005764 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.001824 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3601 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.2365 Informative Inherited
Biological Process (BP) sexual reproduction 0.05501 Informative Inherited
Biological Process (BP) reproductive structure development 0.8717 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.4132 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001004 Informative Inherited
Biological Process (BP) immune effector process 0.8647 Informative Inherited
Biological Process (BP) fertilization 0.0000002643 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) kidney development 0.0000000000004301 Highly Informative Direct
Biological Process (BP) cell recognition 0.0000000006967 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0000000008996 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.000000001377 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 0.0000003107 Highly Informative Direct
Biological Process (BP) response to UV 0.0000009678 Highly Informative Direct
Biological Process (BP) ossification 0.000001139 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0.000001808 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.000002386 Highly Informative Direct
Biological Process (BP) negative regulation of hemostasis 0.00001083 Highly Informative Direct
Biological Process (BP) gonad development 0.00001489 Highly Informative Direct
Biological Process (BP) negative regulation of coagulation 0.00002013 Highly Informative Direct
Biological Process (BP) aging 0.00008538 Highly Informative Direct
Biological Process (BP) skeletal system development 0.00009469 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000131 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0001658 Highly Informative Direct
Biological Process (BP) sensory perception 0.0006507 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0008107 Highly Informative Direct
Biological Process (BP) cell adhesion 0.4135 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.04042 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 0.007728 Highly Informative Inherited
Biological Process (BP) negative regulation of response to wounding 0.0173 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.526 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.133 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2104 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4494 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.7964 Highly Informative Inherited
Biological Process (BP) collagen metabolic process 0.2142 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.09436 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.07708 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1742 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.6132 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.4477 Highly Informative Inherited
Biological Process (BP) regulation of chemotaxis 0.2475 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.03256 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5452 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.003429 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.5505 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0.0000004649 Informative Direct
Molecular Function (MF) receptor binding 0.0007277 Informative Direct
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000001058 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.0000000000001221 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.000005333 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000000003071 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.3786 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.4277 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.000000009383 Informative Direct
Cellular Component (CC) lytic vacuole 0.0000000166 Informative Direct
Cellular Component (CC) vacuolar part 0.00000005735 Informative Direct
Cellular Component (CC) secretory granule 0.00793 Informative Inherited
Cellular Component (CC) neuron projection 0.0117 Informative Inherited
Cellular Component (CC) synapse 0.009955 Informative Inherited
Cellular Component (CC) brush border 0 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.00000003041 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000005232 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0004488 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01456Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5634Least InformativeInherited
Disease Ontology (DO)immune system disease0.5893Least InformativeInherited
Disease Ontology (DO)artery disease0.0000007765Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.0005915Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.001538Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.06373Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3951Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.00000006607InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00001427InformativeDirect
Disease Ontology (DO)endometrial cancer0.00005561InformativeDirect
Disease Ontology (DO)integumentary system cancer0.000266InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004138InformativeDirect
Disease Ontology (DO)eye disease0.01777InformativeInherited
Disease Ontology (DO)connective tissue cancer0.09222InformativeInherited
Disease Ontology (DO)auditory system disease0.2911InformativeInherited
Disease Ontology (DO)heart disease0.2978InformativeInherited
Disease Ontology (DO)malignant glioma0.42InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.0000002093Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.00006557Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005256Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.03091Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.1995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4014Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4088Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.5887Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.8911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01414InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.02719InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1161InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1397InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.0000006265Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0002259Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0003485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2461Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.000004937InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.00003141Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0.00007748Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.01021Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.000006678Least InformativeDirect
Drugbank ATC_code (DB)ace inhibitors, plain0.00000000001192Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.00003234Moderately InformativeDirect
Biological processApoptosis0.000224Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processAngiogenesis0.0000000000004568InformativeDirect
Biological processCell adhesion0.00000003099InformativeDirect
Biological processNotch signaling pathway0.000000001196Highly InformativeDirect
Biological processAdaptive immunity0.0007653Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.0000003139InformativeDirect
Coding sequence diversityPolymorphism0.0002109Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding0.0000000006225InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.000000000003523InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]