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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,223) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 41,529 201,082 143
Proteins 40,599 197,870 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process10.642Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.020660Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)primary metabolic process0.7630.2904Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process0.14560Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.73670.9843Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.15181Moderately InformativeInherited
Biological Process (BP)multi-organism process0.45610.000001025Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.32521Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.17121Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.82781Moderately InformativeInherited
Biological Process (BP)reproduction0.24740.0000003388Moderately InformativeInherited
Biological Process (BP)proteolysis0.0000000000003320InformativeDirect
Biological Process (BP)cell activation0.025760.01085InformativeInherited
Biological Process (BP)positive regulation of gene expression0.17451InformativeInherited
Biological Process (BP)regulation of proteolysis0.016470.04225InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.026040.9896InformativeInherited
Biological Process (BP)single organism reproductive process0.220.00002038InformativeInherited
Biological Process (BP)multi-organism reproductive process0.093340.00002242InformativeInherited
Biological Process (BP)fertilization0.000040730.000005423Highly InformativeDirect
Biological Process (BP)biological adhesion0.00030990.0003966Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.0013730.009875Highly InformativeInherited
Biological Process (BP)negative regulation of multi-organism process0.00076590.05842Highly InformativeInherited
Biological Process (BP)positive regulation of proteolysis0.0044560.007289Highly InformativeInherited
Biological Process (BP)regulation of protein processing0.00012920.001749Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000050880Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)metal ion binding0.00049710Moderately InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides00.05303InformativeInherited
Molecular Function (MF)metallopeptidase activity0.0000000000003930Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.13110.0000000000001401Moderately InformativeInherited
Cellular Component (CC)secretory granule0.017340.00002699InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.642 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.2904 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0000003388 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0006247 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000001025 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0003361 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2322 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9843 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.4032 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.08041 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5434 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.06522 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.5217 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1411 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.01858 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.4819 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9464 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.5389 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.1632 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9175 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02591 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.06095 Moderately Informative Inherited
Biological Process (BP) system development 0.5661 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000000006575 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.0005995 Informative Direct
Biological Process (BP) response to cytokine 0.000000009203 Informative Direct
Biological Process (BP) locomotion 0.00000000004046 Informative Direct
Biological Process (BP) regulation of locomotion 0.0002016 Informative Direct
Biological Process (BP) single organism reproductive process 0.00002038 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00002242 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0001976 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.5164 Informative Inherited
Biological Process (BP) response to radiation 0.07594 Informative Inherited
Biological Process (BP) cell activation 0.01085 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.8099 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5032 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6664 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1774 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3619 Informative Inherited
Biological Process (BP) behavior 0.07892 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04311 Informative Inherited
Biological Process (BP) circulatory system development 0.005957 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.2418 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5032 Informative Inherited
Biological Process (BP) fatty acid derivative metabolic process 0.03286 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.002902 Informative Inherited
Biological Process (BP) response to temperature stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.04225 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9896 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.2397 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.05412 Informative Inherited
Biological Process (BP) reproductive system development 0.4173 Informative Inherited
Biological Process (BP) system process 0.005292 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) central nervous system development 0.9838 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8477 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.2219 Informative Inherited
Biological Process (BP) immune effector process 0.5533 Informative Inherited
Biological Process (BP) response to hypoxia 0.0007478 Highly Informative Direct
Biological Process (BP) kidney development 0.0000004961 Highly Informative Direct
Biological Process (BP) neutrophil mediated immunity 0.00001994 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.0004923 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00002944 Highly Informative Direct
Biological Process (BP) gastrulation 0.0001886 Highly Informative Direct
Biological Process (BP) sex differentiation 0.00000006158 Highly Informative Direct
Biological Process (BP) aging 0.0002248 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) response to UV 0.0000002639 Highly Informative Direct
Biological Process (BP) fertilization 0.000005423 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0005846 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0003966 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0 Highly Informative Direct
Biological Process (BP) appendage development 0.0002374 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.0000371 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0001425 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.009875 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.0829 Highly Informative Inherited
Biological Process (BP) neuron development 0.1874 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.05842 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.001488 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.01166 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1543 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.559 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.007289 Highly Informative Inherited
Biological Process (BP) regulation of protein processing 0.001749 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.04147 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.001106 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.3871 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.323 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.04601 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0.00000000002265 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000001021 Informative Direct
Molecular Function (MF) receptor binding 0.01531 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.05303 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.000004821 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.0001982 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.0000001911 Highly Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0.00006771 Highly Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000007029 Highly Informative Direct
Cellular Component (CC) membrane 0.00000009511 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.000001279 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000000000001401 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.01067 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5358 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.09624 Moderately Informative Inherited
Cellular Component (CC) lytic vacuole 0.0000009308 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) secretory granule 0.00002699 Informative Direct
Cellular Component (CC) extracellular organelle 0.0005565 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.000132 Informative Direct
Cellular Component (CC) vacuolar part 0.0000008757 Informative Direct
Cellular Component (CC) synapse 0.02917 Informative Inherited
Cellular Component (CC) neuron projection 0.01069 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.1359 Informative Inherited
Cellular Component (CC) Golgi apparatus 0.04287 Informative Inherited
Cellular Component (CC) lysosomal membrane 0.0000006445 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 0.0005538 Highly Informative Direct
Cellular Component (CC) synaptic vesicle 0.000000000368 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000004731 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01367Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5695Least InformativeInherited
Disease Ontology (DO)artery disease0.00000008278Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0005188Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.0735Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.285Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.000000006577InformativeDirect
Disease Ontology (DO)myopia0.000001941InformativeDirect
Disease Ontology (DO)prostate cancer0.0006274InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0006634InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0008571InformativeDirect
Disease Ontology (DO)connective tissue cancer0.1274InformativeInherited
Disease Ontology (DO)malignant glioma0.1702InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.8347InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.000001498Highly InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00002366Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.00004524Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.00006371Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.00008823Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001042Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005575Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.01838Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6746Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.009418Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.02656Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.14Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.8727Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.01912InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1158InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.1613InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.335InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip bone0.4731InformativeInherited
Phenotypic Abnormality (PA)Reduced bone mineral density0.002967Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the acetabulum0.006176Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of bones of the lower limbs0.04013Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the radius0.07473Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0278Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1713Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.224Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.25Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2581Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2893Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7746Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.001691InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.002715InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.00319InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.01421InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.0291InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.04311InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04343InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.05773InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.387InformativeInherited
Mammalian Phenotype (MP)double outlet right ventricle0.00002032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone hypertrophic chondrocyte zone0.00008213Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001469Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0002121Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.00069Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.001046Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.02734Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.1176Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.1624Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2123Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.5418Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000003751InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2594InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.000003536Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0001181Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.01389Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0Moderately InformativeDirect
Biological processDifferentiation0.00005225Moderately InformativeDirect
Biological processApoptosis0.0003271Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processAngiogenesis0.0000000000007875InformativeDirect
Biological processCell adhesion0.00000005156InformativeDirect
Biological processNotch signaling pathway0.000000001271Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000000009049InformativeDirect
Coding sequence diversityPolymorphism0.0001799Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding0.0000000005867InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]