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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,218) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 41,094 130,592 143
Proteins 40,195 129,516 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation10.9572Least InformativeInherited
Biological Process (BP)single-organism cellular process10.6851Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.020680Least InformativeInherited
Biological Process (BP)primary metabolic process0.75270.08784Least InformativeInherited
Biological Process (BP)negative regulation of cellular process0.72881Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.099491Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.29371Moderately InformativeInherited
Biological Process (BP)reproduction0.25670.00000042Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.095571Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.31431Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.81571Moderately InformativeInherited
Biological Process (BP)multi-organism process0.40960.0000004812Moderately InformativeInherited
Biological Process (BP)proteolysis0.000000000000650InformativeDirect
Biological Process (BP)regulation of proteolysis0.010670.01927InformativeInherited
Biological Process (BP)multi-organism reproductive process0.10160.00000868InformativeInherited
Biological Process (BP)positive regulation of gene expression0.22421InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.025460.9454InformativeInherited
Biological Process (BP)single organism reproductive process0.22060.00001119InformativeInherited
Biological Process (BP)regulation of protein processing0.0000011990.000135Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.0011590.123Highly InformativeInherited
Biological Process (BP)negative regulation of multi-organism process0.00080240.08716Highly InformativeInherited
Biological Process (BP)positive regulation of proteolysis0.0061450.005638Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.000065950Least InformativeDirect
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)metal ion binding0.00046710Moderately InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides00.03337InformativeInherited
Molecular Function (MF)metallopeptidase activity0.00000000000038040Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.12650.000000000001048Moderately InformativeInherited
Cellular Component (CC)secretory vesicle0.012750.000001642InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.2963 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.9572 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6851 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.08791 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.08784 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00000042 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000004812 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00002114 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000009815 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.2104 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2338 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.1207 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.7508 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2609 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3289 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.5908 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7331 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.03227 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.005628 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5146 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.0269 Moderately Informative Inherited
Biological Process (BP) system development 0.4436 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9028 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) signaling 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.02644 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.00000868 Informative Direct
Biological Process (BP) single organism reproductive process 0.00001119 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.0000000000004264 Informative Direct
Biological Process (BP) locomotion 0.000000000003417 Informative Direct
Biological Process (BP) response to cytokine 0.000000003023 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0002468 Informative Direct
Biological Process (BP) system process 0.0007284 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.431 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.04943 Informative Inherited
Biological Process (BP) response to radiation 0.06891 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.01927 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.0708 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.512 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9897 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1777 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5785 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.7594 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.4324 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.04029 Informative Inherited
Biological Process (BP) behavior 0.07058 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4137 Informative Inherited
Biological Process (BP) regulation of locomotion 0.001059 Informative Inherited
Biological Process (BP) response to temperature stimulus 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.9454 Informative Inherited
Biological Process (BP) circulatory system development 0.003729 Informative Inherited
Biological Process (BP) epithelium development 0.01599 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) reproductive system development 0.3366 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.777 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.1811 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.269 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.04504 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.01005 Informative Inherited
Biological Process (BP) regulation of protein processing 0.000135 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) multicellular organism metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) protein maturation 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0.0000001331 Highly Informative Direct
Biological Process (BP) response to UV 0.0000002011 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0.0000007765 Highly Informative Direct
Biological Process (BP) chemotaxis 0.00001437 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 0.00002328 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0.00008031 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0.00009065 Highly Informative Direct
Biological Process (BP) gastrulation 0.0001606 Highly Informative Direct
Biological Process (BP) aging 0.0002128 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0004028 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.0004288 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0004795 Highly Informative Direct
Biological Process (BP) cell migration 0.1199 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.123 Highly Informative Inherited
Biological Process (BP) negative regulation of multi-organism process 0.08716 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.009887 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1947 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5044 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001165 Highly Informative Inherited
Biological Process (BP) detection of stimulus 0.4335 Highly Informative Inherited
Biological Process (BP) positive regulation of proteolysis 0.005638 Highly Informative Inherited
Biological Process (BP) appendage development 0.009087 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.04588 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.08652 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4384 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.4449 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.239 Highly Informative Inherited
Biological Process (BP) neuron development 0.1384 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.03046 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) metal ion binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) zinc ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0.000000000007765 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.002976 Informative Inherited
Molecular Function (MF) receptor binding 0.01024 Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.03337 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 0.00001349 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0.0000001893 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0.0001306 Highly Informative Direct
Cellular Component (CC) membrane 0.000000188 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000000001048 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.000000708 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00001205 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.00133 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.5093 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.01583 Moderately Informative Inherited
Cellular Component (CC) secretory vesicle 0.000001642 Informative Direct
Cellular Component (CC) extracellular organelle 0.0007837 Informative Direct
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) lytic vacuole 0.0000000001692 Informative Direct
Cellular Component (CC) vacuolar part 0.0000001003 Informative Direct
Cellular Component (CC) transport vesicle 0.0002593 Informative Direct
Cellular Component (CC) synapse 0.01927 Informative Inherited
Cellular Component (CC) neuron projection 0.002674 Informative Inherited
Cellular Component (CC) cell projection part 0.09928 Informative Inherited
Cellular Component (CC) lytic vacuole membrane 0.00000000000008752 Highly Informative Direct
Cellular Component (CC) synaptic vesicle 0.0000000001722 Highly Informative Direct
Cellular Component (CC) dendrite 0.00000467 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02459Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5904Least InformativeInherited
Disease Ontology (DO)immune system disease0.8303Least InformativeInherited
Disease Ontology (DO)artery disease0.0000001416Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.001025Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.07661Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2894Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.00000001005InformativeDirect
Disease Ontology (DO)myopia0.000002309InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00002427InformativeDirect
Disease Ontology (DO)integumentary system cancer0.00008295InformativeDirect
Disease Ontology (DO)endometrial cancer0.0001188InformativeDirect
Disease Ontology (DO)prostate cancer0.0007214InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0007783InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0009468InformativeDirect
Disease Ontology (DO)connective tissue cancer0.1347InformativeInherited
Disease Ontology (DO)malignant glioma0.1708InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.000001571Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.00005285Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0000633Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001181Highly InformativeDirect
Disease Ontology (DO)otitis media0.0006113Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.01796Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.672Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.01084Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.02636Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1406Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the foot0.8782Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.01884InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.1128InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb bone0.1613InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the femur0.3398InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip bone0.4677InformativeInherited
Phenotypic Abnormality (PA)Reduced bone mineral density0.003027Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the acetabulum0.006351Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of bones of the lower limbs0.04006Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the radius0.07558Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.01976Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.04208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2365Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.002372InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.00321InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.00352InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.01754InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.02501InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.03694InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.05382InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.05585InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.384InformativeInherited
Mammalian Phenotype (MP)double outlet right ventricle0.00002355Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium and ventricle connection0.0000323Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone hypertrophic chondrocyte zone0.00009337Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001561Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0002327Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart valve morphology0.0004413Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.0007546Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.001001Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.02112Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.1021Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.1608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2214Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.5438Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000002966InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)cell1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1769InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.000003326Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0001137Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.01094Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.0000005915Least InformativeDirect
Drugbank ATC_code (DB)ace inhibitors, plain0.00000000000202Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0Moderately InformativeDirect
Biological processDifferentiation0.00003322Moderately InformativeDirect
Biological processApoptosis0.0003013Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processAngiogenesis0.000000000000648InformativeDirect
Biological processCell adhesion0.00000004662InformativeDirect
Biological processNotch signaling pathway0.000000001239Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor0.00000000006924InformativeDirect
Coding sequence diversityPolymorphism0.0001373Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding0.0000000005212InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationReceptor1Moderately InformativeInherited
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.000001285Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]