SUPERFAMILY 1.73 HMM library and genome assignments server


Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Zincin-like [ 55485] (2)
  contains mixed beta sheet with connection over free side of the sheet
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (15)
Families:   Zinc protease [ 55487]
  single domain
  Fungal zinc peptidase [ 64335]
  single domain with insertions in the common fold
  Thermolysin-like [ 55490] (4)
  includes alpha-helical C-terminal domain characteristic for the family
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  adopts thermolysin-like fold
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  combines M2, M3 and M32 families of metalloproteases
the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  characteristic HEXXHXXGXXH motif and Met located near C-terminus
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  Pfam 01421
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Pfam 02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site


Superfamily statistics
Genomes (1,221) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 19,419 15,242 129
Proteins 19,072 15,067 127


Functional annotation
General category Processes_IC
Detailed category Proteases

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 53 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 53 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]