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Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)

Superfamily statistics
Genomes (2,458) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 34,664 68,973 143
Proteins 33,906 68,266 141

 Functional annotation
General category Processes_IC
Detailed category Proteases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.7511Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.18830Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.099090.8687Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.79281Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.098911Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.15041Moderately InformativeInherited
Biological Process (BP)reproduction0.12115.937e-07Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.27711Moderately InformativeInherited
Biological Process (BP)proteolysis7.616e-060InformativeDirect
Biological Process (BP)biological adhesion0.00057865.704e-06InformativeDirect
Biological Process (BP)regulation of reproductive process0.0023970.135InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.032330.01997InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.0271InformativeInherited
Biological Process (BP)single organism reproductive process0.049952.294e-13InformativeInherited
Biological Process (BP)sexual reproduction0.11638.068e-06InformativeInherited
Biological Process (BP)cell activation0.010060.203InformativeInherited
Biological Process (BP)regulation of protein processing2.141e-079.39e-06Highly InformativeDirect
Biological Process (BP)fertilization0.0001011.436e-05Highly InformativeDirect
Biological Process (BP)cell adhesion0.0003225.127e-06Highly InformativeDirect
Biological Process (BP)negative regulation of reproductive process6.766e-050.001813Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.0032170Least InformativeInherited
Molecular Function (MF)peptidase activity4.704e-140InformativeDirect
Molecular Function (MF)metallopeptidase activity6.116e-100Highly InformativeDirect
Molecular Function (MF)endopeptidase activity0.87141Highly InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)vesicle0.048220Moderately InformativeInherited
Cellular Component (CC)secretory granule0.0023280.5041InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0001973 Least Informative Direct
Biological Process (BP) multicellular organismal process 7.238e-12 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 5.937e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0004856 Moderately Informative Direct
Biological Process (BP) organ development 0.0004138 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.8687 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2108 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8558 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.6183 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5925 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.00109 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7343 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.6022 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) system process 0.0451 Moderately Informative Inherited
Biological Process (BP) immune system process 0.4547 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) biological adhesion 5.704e-06 Informative Direct
Biological Process (BP) single organism reproductive process 2.294e-13 Informative Direct
Biological Process (BP) sexual reproduction 8.068e-06 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 1.158e-14 Informative Direct
Biological Process (BP) cellular component disassembly 2.021e-12 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 5.898e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 5.749e-10 Informative Direct
Biological Process (BP) localization of cell 6.445e-08 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.919e-07 Informative Direct
Biological Process (BP) locomotion 3.801e-06 Informative Direct
Biological Process (BP) cellular component movement 5.174e-05 Informative Direct
Biological Process (BP) cardiovascular system development 0.000829 Informative Direct
Biological Process (BP) regulation of reproductive process 0.135 Informative Inherited
Biological Process (BP) response to light stimulus 0.139 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) gland development 0.6947 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.9923 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6247 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.01997 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) tube development 0.8195 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.2738 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.7265 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1372 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell activation 0.203 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.3558 Informative Inherited
Biological Process (BP) immune effector process 0.7584 Informative Inherited
Biological Process (BP) reproductive system development 0.6456 Informative Inherited
Biological Process (BP) regulation of protein processing 9.39e-06 Highly Informative Direct
Biological Process (BP) fertilization 1.436e-05 Highly Informative Direct
Biological Process (BP) cell adhesion 5.127e-06 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) multicellular organismal metabolic process 0 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) kidney development 1.905e-13 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.983e-09 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 7.123e-08 Highly Informative Direct
Biological Process (BP) response to UV 2.707e-07 Highly Informative Direct
Biological Process (BP) icosanoid biosynthetic process 1.292e-06 Highly Informative Direct
Biological Process (BP) gonad development 1.301e-06 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 6.506e-06 Highly Informative Direct
Biological Process (BP) aging 9.787e-05 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0001087 Highly Informative Direct
Biological Process (BP) ossification 0.0007434 Highly Informative Direct
Biological Process (BP) lung development 0.0008399 Highly Informative Direct
Biological Process (BP) negative regulation of reproductive process 0.001813 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.02757 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4035 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.03271 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.1116 Highly Informative Inherited
Biological Process (BP) sensory perception 0.007354 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.1168 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.09956 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.004595 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0284 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4626 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.005587 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.005531 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) zinc ion binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 1.562e-15 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.994e-09 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 3.364e-08 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.01244 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.5373 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.05925 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 1.818e-11 Informative Direct
Cellular Component (CC) synapse 0.0003483 Informative Direct
Cellular Component (CC) secretory granule 0.5041 Informative Inherited
Cellular Component (CC) cell projection part 0.001893 Informative Inherited
Cellular Component (CC) neuron part 0.001526 Informative Inherited
Cellular Component (CC) coated vesicle 0.3714 Informative Inherited
Cellular Component (CC) brush border 0 Highly Informative Direct
Cellular Component (CC) dendrite 2.776e-10 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 6.102e-09 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 1.109e-06 Highly Informative Direct
Cellular Component (CC) vesicle membrane 1.973e-05 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.0004791 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02408Least InformativeInherited
Disease Ontology (DO)nervous system disease0.6796Least InformativeInherited
Disease Ontology (DO)immune system disease0.6887Least InformativeInherited
Disease Ontology (DO)vascular disease1.708e-06Moderately InformativeDirect
Disease Ontology (DO)skin disease0.001329Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.003887Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.09898Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2843Moderately InformativeInherited
Disease Ontology (DO)heart disease0.6141Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis1.053e-07InformativeDirect
Disease Ontology (DO)myopia1.166e-06InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0002593InformativeDirect
Disease Ontology (DO)aneurysm disease0.04328InformativeInherited
Disease Ontology (DO)vascular skin disease0.08082InformativeInherited
Disease Ontology (DO)connective tissue cancer0.1153InformativeInherited
Disease Ontology (DO)auditory system disease0.2096InformativeInherited
Disease Ontology (DO)malignant glioma0.2934InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.7287InformativeInherited
Disease Ontology (DO)lymphadenitis1InformativeInherited
Disease Ontology (DO)adult astrocytic tumour5.316e-07Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm9.179e-05Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005821Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.07112Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.4135Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.1148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2182Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2436Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.4411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4598Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.5849Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7547Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.01104InformativeInherited
Mammalian Phenotype (MP)pathological neovascularization0.02581InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.03746InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1361InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1871InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.4623InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology1.812e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle outflow tract morphology0.0001718Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0002115Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0002213Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to bacterial infection0.000521Highly InformativeDirect
Mammalian Phenotype (MP)short femur0.000521Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.0006006Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2338Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart and great artery attachment1Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant4.937e-06InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage3.131e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.09715Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation8.306e-06Moderately InformativeDirect
Biological processApoptosis9.662e-05Moderately InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processAngiogenesis4.935e-14InformativeDirect
Biological processNotch signaling pathway3.494e-10Highly InformativeDirect
Biological processAdaptive immunity0.0005422Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor1.391e-07InformativeDirect
Coding sequence diversityPolymorphism0.0001605Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0Moderately InformativeDirect
DomainEGF-like domain0InformativeDirect
DomainSH3-binding8.233e-10InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid2.059e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)fatty acid metabolism0Moderately InformativeDirect
UniPathway (UP)leukotriene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.