SUPERFAMILY 1.75 HMM library and genome assignments server


Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)


Superfamily statistics
Genomes (3,175) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 39,370 68,973 143
Proteins 38,586 68,266 141


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.85591Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.010870Least InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.21050.9252Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.7691Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.13511Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.15551Moderately InformativeInherited
Biological Process (BP)reproduction0.20195.466e-08Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.43841Moderately InformativeInherited
Biological Process (BP)proteolysis2.713e-100InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.054820.003587InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.055961InformativeInherited
Biological Process (BP)single organism reproductive process0.09219.23e-14InformativeInherited
Biological Process (BP)sexual reproduction0.13227.124e-05InformativeInherited
Biological Process (BP)cell activation0.017120.2781InformativeInherited
Biological Process (BP)biological adhesion0.0011911.072e-05InformativeInherited
Biological Process (BP)regulation of protein processing6.345e-073.947e-06Highly InformativeDirect
Biological Process (BP)fertilization0.00022481.813e-05Highly InformativeDirect
Biological Process (BP)cell adhesion0.00069649.299e-06Highly InformativeDirect
Biological Process (BP)regulation of reproductive process0.0012580.205Highly InformativeInherited
Molecular Function (MF)hydrolase activity0.00011710Least InformativeDirect
Molecular Function (MF)binding0.98410.3111Least InformativeInherited
Molecular Function (MF)cation binding5.085e-050Moderately InformativeDirect
Molecular Function (MF)peptidase activity00InformativeDirect
Molecular Function (MF)metallopeptidase activity4.191e-140Highly InformativeDirect
Molecular Function (MF)endopeptidase activity11Highly InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)vesicle0.27070Moderately InformativeInherited
Cellular Component (CC)secretory granule0.0056590.5082InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.931e-15 Least Informative Direct
Biological Process (BP) developmental process 0.0001095 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 5.466e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0001772 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 3.705e-10 Moderately Informative Direct
Biological Process (BP) organ development 3.178e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.9252 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3498 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.9139 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.8553 Moderately Informative Inherited
Biological Process (BP) system process 0.05539 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.007346 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001669 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.9056 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.6419 Moderately Informative Inherited
Biological Process (BP) proteolysis 0 Informative Direct
Biological Process (BP) biological adhesion 1.072e-05 Informative Direct
Biological Process (BP) single organism reproductive process 9.23e-14 Informative Direct
Biological Process (BP) sexual reproduction 7.124e-05 Informative Direct
Biological Process (BP) cellular amide metabolic process 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) localization of cell 4e-09 Informative Direct
Biological Process (BP) regulation of hormone levels 5.391e-09 Informative Direct
Biological Process (BP) response to cytokine stimulus 1.848e-07 Informative Direct
Biological Process (BP) locomotion 7.688e-07 Informative Direct
Biological Process (BP) cellular component movement 2.612e-06 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0008788 Informative Direct
Biological Process (BP) response to light stimulus 0.02619 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.003587 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8813 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.6785 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) gland development 0.446 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.6269 Informative Inherited
Biological Process (BP) monocarboxylic acid biosynthetic process 0.32 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001925 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.008801 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell activation 0.2781 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.5345 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.0105 Informative Inherited
Biological Process (BP) regulation of locomotion 0.006094 Informative Inherited
Biological Process (BP) immune effector process 0.772 Informative Inherited
Biological Process (BP) reproductive structure development 0.3369 Informative Inherited
Biological Process (BP) regulation of protein processing 3.947e-06 Highly Informative Direct
Biological Process (BP) fertilization 1.813e-05 Highly Informative Direct
Biological Process (BP) cell adhesion 9.299e-06 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0 Highly Informative Direct
Biological Process (BP) protein processing 0 Highly Informative Direct
Biological Process (BP) multicellular organismal catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Biological Process (BP) renal system development 1.575e-12 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.308e-10 Highly Informative Direct
Biological Process (BP) ovulation cycle process 2.21e-09 Highly Informative Direct
Biological Process (BP) cardiocyte differentiation 2.486e-07 Highly Informative Direct
Biological Process (BP) gonad development 7.828e-07 Highly Informative Direct
Biological Process (BP) response to UV 1.141e-06 Highly Informative Direct
Biological Process (BP) ossification 1.871e-06 Highly Informative Direct
Biological Process (BP) aging 0.0001671 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid metabolic process 0.0007947 Highly Informative Direct
Biological Process (BP) regulation of reproductive process 0.205 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1435 Highly Informative Inherited
Biological Process (BP) cell fate commitment 0.4234 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.00306 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.9926 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.09817 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.01007 Highly Informative Inherited
Biological Process (BP) collagen metabolic process 0.3417 Highly Informative Inherited
Biological Process (BP) sensory perception 0.006861 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.1735 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2727 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.7926 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.03739 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.601 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.008837 Highly Informative Inherited
Biological Process (BP) fatty acid derivative metabolic process 0.001364 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.1008 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.0315 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.5119 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.00904 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.3111 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) peptidase activity 0 Informative Direct
Molecular Function (MF) transition metal ion binding 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.001047 Informative Inherited
Molecular Function (MF) receptor activity 1 Informative Inherited
Molecular Function (MF) metallopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) exopeptidase activity 1.246e-06 Highly Informative Direct
Molecular Function (MF) protein complex binding 4.812e-09 Highly Informative Direct
Molecular Function (MF) endopeptidase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 2.176e-07 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.06095 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.05453 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular matrix 1.689e-14 Informative Direct
Cellular Component (CC) vacuolar part 7.883e-08 Informative Direct
Cellular Component (CC) lytic vacuole 1.436e-07 Informative Direct
Cellular Component (CC) synapse part 1.831e-06 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0008073 Informative Direct
Cellular Component (CC) secretory granule 0.5082 Informative Inherited
Cellular Component (CC) neuron projection 0.01397 Informative Inherited
Cellular Component (CC) coated vesicle 0.4072 Informative Inherited
Cellular Component (CC) brush border 0 Highly Informative Direct
Cellular Component (CC) lysosome 4.668e-09 Highly Informative Direct
Cellular Component (CC) clathrin-coated vesicle 1.394e-08 Highly Informative Direct
Cellular Component (CC) vacuolar membrane 1.879e-08 Highly Informative Direct
Cellular Component (CC) dendrite 3.147e-08 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 2.315e-06 Highly Informative Direct
Cellular Component (CC) extracellular matrix part 0.0006851 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01369Least InformativeInherited
Disease Ontology (DO)nervous system disease0.686Least InformativeInherited
Disease Ontology (DO)immune system disease0.7039Least InformativeInherited
Disease Ontology (DO)artery disease7.127e-07Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.001948Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.09931Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.3057Moderately InformativeInherited
Disease Ontology (DO)myopia8.804e-07InformativeDirect
Disease Ontology (DO)Kawasaki disease1.56e-05InformativeDirect
Disease Ontology (DO)integumentary system cancer4.595e-05InformativeDirect
Disease Ontology (DO)cardiomyopathy0.04819InformativeInherited
Disease Ontology (DO)connective tissue cancer0.1068InformativeInherited
Disease Ontology (DO)auditory system disease0.2029InformativeInherited
Disease Ontology (DO)malignant glioma0.2731InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.7139InformativeInherited
Disease Ontology (DO)adult astrocytic tumour4.886e-07Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma1.762e-05Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm7.353e-05Highly InformativeDirect
Disease Ontology (DO)otitis media0.0005071Highly InformativeDirect
Disease Ontology (DO)adenoid cystic carcinoma0.0006944Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.05115Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2701Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3056Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.3796Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.602Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.6479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7502Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.02251InformativeInherited
Mammalian Phenotype (MP)pathological neovascularization0.04773InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1117InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.148InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1737InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology2.917e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle outflow tract morphology0.0002018Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.000214Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0003687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2464Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant4.937e-06InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage3.145e-05Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage7.746e-05Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1123Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation2.027e-05Moderately InformativeDirect
Biological processApoptosis0.0001867Moderately InformativeDirect
Biological processRibosome biogenesis0InformativeDirect
Biological processrRNA processing0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processAngiogenesis3.896e-13InformativeDirect
Biological processCell adhesion1.013e-06InformativeDirect
Biological processNotch signaling pathway1.113e-09Highly InformativeDirect
Biological processAdaptive immunity0.0006323Highly InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentExtracellular matrix0InformativeDirect
Cellular componentGPI-anchor2.305e-07InformativeDirect
Coding sequence diversityPolymorphism0.0002095Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainEGF-like domain0InformativeDirect
DomainSignal-anchor0InformativeDirect
DomainSH3-binding6.123e-10InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationNuclease0Moderately InformativeDirect
Post-translational modificationProtease0Moderately InformativeDirect
Post-translational modificationEndonuclease0InformativeDirect
Post-translational modificationMetalloprotease0InformativeDirect
Post-translational modificationToxin0InformativeDirect
Post-translational modificationHemostasis impairing toxin0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationZymogen0InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid1.555e-10InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]