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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (449) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,027 15,320 94
Proteins 12,608 13,787 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00059330Least InformativeDirect
Biological Process (BP)response to stimulus0.020140Least InformativeInherited
Biological Process (BP)regulation of response to stimulus0.00063480Moderately InformativeDirect
Biological Process (BP)immune system process0.0012010Moderately InformativeInherited
Biological Process (BP)immune response0.00071150.0000000000385InformativeDirect
Biological Process (BP)regulation of immune response0.0008940.0000132InformativeDirect
Biological Process (BP)regulation of leukocyte mediated immunity0.000000000041870.00002841Highly InformativeDirect
Biological Process (BP)regulation of cell killing0.0000019750.000704Highly InformativeDirect
Molecular Function (MF)binding0.039640Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.001559 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3812 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1007 Least Informative Inherited
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000000000008501 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000000001435 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000001783 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.00000000002318 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000000002597 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000000002805 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000004245 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000002082 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000002232 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000002033 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00009879 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0005879 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0007296 Moderately Informative Direct
Biological Process (BP) system development 0.0009887 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.991 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8445 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.06362 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.001144 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9914 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1954 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.9573 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3711 Moderately Informative Inherited
Biological Process (BP) reproduction 0.003989 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.004387 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7283 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) immune response 0.0000000000385 Informative Direct
Biological Process (BP) regulation of immune response 0.0000132 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.0000000000009238 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003008 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) cell adhesion 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000000000007596 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000000000114 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000001219 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000000001095 Informative Direct
Biological Process (BP) phosphorylation 0.0000000001177 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000000000145 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000000007077 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000002513 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00002574 Informative Direct
Biological Process (BP) nucleocytoplasmic transport 0.00007332 Informative Direct
Biological Process (BP) behavior 0.0001154 Informative Direct
Biological Process (BP) cell death 0.0004562 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0005247 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0005556 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0006737 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0007225 Informative Direct
Biological Process (BP) generation of neurons 0.0009539 Informative Direct
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.07634 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.09393 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.002753 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.01216 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.06422 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0195 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.007261 Informative Inherited
Biological Process (BP) epithelium development 0.3166 Informative Inherited
Biological Process (BP) embryo development 0.9066 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.2344 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) system process 0.5956 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.6105 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.00761 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.002167 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.0234 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.04508 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.2814 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.7544 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.195 Informative Inherited
Biological Process (BP) protein targeting 0.004711 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2581 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.09336 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8094 Informative Inherited
Biological Process (BP) regulation of locomotion 0.01171 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.01376 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1852 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.3486 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2359 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.1047 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.2569 Informative Inherited
Biological Process (BP) growth 0.08535 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.02989 Informative Inherited
Biological Process (BP) regulation of growth 0.5505 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01433 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.08466 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.5679 Informative Inherited
Biological Process (BP) actin filament-based process 0.02526 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.02877 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6743 Informative Inherited
Biological Process (BP) lipid localization 0.02658 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.481 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01319 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.788 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.02877 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001855 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.7315 Informative Inherited
Biological Process (BP) metal ion transport 0.6441 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.7065 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.003219 Informative Inherited
Biological Process (BP) secretion 0.2839 Informative Inherited
Biological Process (BP) regulation of defense response 0.003334 Informative Inherited
Biological Process (BP) circulatory system development 0.4295 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9019 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.8282 Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.00002841 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.000704 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000003323 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) cell migration 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000000422 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.0000000000008409 Highly Informative Direct
Biological Process (BP) apoptotic process 0.000000000003699 Highly Informative Direct
Biological Process (BP) coagulation 0.000000001457 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00000001052 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000003152 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000001547 Highly Informative Direct
Biological Process (BP) innate immune response 0.0000004175 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000004533 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000007453 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000008499 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.000001276 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000003172 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000003754 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00000388 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.000004567 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.000005951 Highly Informative Direct
Biological Process (BP) regeneration 0.000008923 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00001035 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00002367 Highly Informative Direct
Biological Process (BP) regulated exocytosis 0.00002845 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0001349 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001701 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001877 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0002476 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0002633 Highly Informative Direct
Biological Process (BP) endocytosis 0.0003099 Highly Informative Direct
Biological Process (BP) divalent inorganic cation transport 0.000311 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000402 Highly Informative Direct
Biological Process (BP) instar larval or pupal morphogenesis 0.0004996 Highly Informative Direct
Biological Process (BP) ammonium transport 0.0005024 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0009254 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.02197 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.3099 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.3262 Highly Informative Inherited
Biological Process (BP) positive regulation of angiogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.705 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.002048 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.1139 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.001108 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.00985 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002209 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.001269 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.1433 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.01608 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.656 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.05198 Highly Informative Inherited
Biological Process (BP) appendage development 0.7496 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.06226 Highly Informative Inherited
Biological Process (BP) lipid modification 0.02966 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.9308 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.03186 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.1549 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.08518 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01958 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.3005 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.1122 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.07237 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.6285 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.6349 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.03424 Highly Informative Inherited
Biological Process (BP) steroid metabolic process 0.1115 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.06918 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.07682 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1728 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.8739 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.4079 Highly Informative Inherited
Biological Process (BP) neuron development 0.3098 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.02739 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.05343 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3215 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.3329 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.0116 Highly Informative Inherited
Biological Process (BP) cell projection organization 0.06479 Highly Informative Inherited
Biological Process (BP) wound healing 0.00423 Highly Informative Inherited
Biological Process (BP) hemostasis 0.05016 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.3485 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.07357 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.296 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.7155 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.006842 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.003393 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.00945 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.07744 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.02117 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8247 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.2163 Highly Informative Inherited
Biological Process (BP) protein import 0.007013 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.9197 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.9363 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 0.557 Highly Informative Inherited
Biological Process (BP) response to fungus 0.06265 Highly Informative Inherited
Biological Process (BP) innate immune response-activating signal transduction 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Biological Process (BP) lymphocyte activation 0.08446 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.03763 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000000001066 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000000005416 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00003897 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6343 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.000000000001777 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00001866 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.00003673 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0004558 Informative Direct
Molecular Function (MF) phospholipid binding 0.0006045 Informative Direct
Molecular Function (MF) enzyme activator activity 0.868 Informative Inherited
Molecular Function (MF) signal transducer activity 0.009364 Informative Inherited
Molecular Function (MF) kinase binding 0.0000000000001493 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000001328 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.0000000686 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00001085 Highly Informative Direct
Molecular Function (MF) heme binding 0.00001191 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0002186 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.8429 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.9915 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.07951 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2811 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) membrane 0.001947 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2174 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.000005214 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.01656 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.6454 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.003959 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.6737 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.01417 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1184 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.0000000000002102 Informative Direct
Cellular Component (CC) membrane region 0.000000000001652 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00006216 Informative Direct
Cellular Component (CC) synapse 0.1682 Informative Inherited
Cellular Component (CC) side of membrane 0.1533 Informative Inherited
Cellular Component (CC) plasma membrane region 0.5408 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ruffle 0 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000001641 Highly Informative Direct
Cellular Component (CC) membrane raft 1 Highly Informative Inherited
Cellular Component (CC) endocytic vesicle 0.3076 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.2101 Highly Informative Inherited
Cellular Component (CC) polymeric cytoskeletal fiber 0.1737 Highly Informative Inherited
Cellular Component (CC) centrosome 0.1876 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00002945Least InformativeDirect
Disease Ontology (DO)immune system disease0.0993Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0001558Moderately InformativeDirect
Disease Ontology (DO)bone marrow disease0.09266Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.871Moderately InformativeInherited
Disease Ontology (DO)myeloid leukemia0.3076InformativeInherited
Disease Ontology (DO)polycythemia0.0000002418Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003773Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0001213InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.001053Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07901Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.706Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00002634Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0001348Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.0002909Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.07467Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.00005571InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.001569InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lymphocytes0.1439InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.0000218Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000002095Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000000002675Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.09803Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2082Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000006788Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000001861Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001536Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0009537Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.01328Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03955Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.04161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000003106InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001905InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001169InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001141InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0006052InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.001584InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.0324InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.05294InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.05549InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05846InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06475InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1437InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1535InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.233InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2777InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.346InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000006104Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.000166Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005233Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0005288Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0005496Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.183Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01118Moderately InformativeInherited
Worm Phenotype (WP)aldicarb response variant0.003212InformativeInherited
Worm Phenotype (WP)drug resistant0.3019InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0007063Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0006123Moderately InformativeDirect
Fly Phenotype (FP)size defective0.0009415InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0005057Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.009118Least InformativeInherited
Fly Anatomy (FA)integumentary system0.009152Least InformativeInherited
Fly Anatomy (FA)adult0.01199Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.03159Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.05784Least InformativeInherited
Fly Anatomy (FA)nervous system0.1543Least InformativeInherited
Fly Anatomy (FA)cell0.7395Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002492Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.0008157Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.001101Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01475Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01844Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01884Moderately InformativeInherited
Fly Anatomy (FA)adult head0.0234Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.04403Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.06121Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06607Moderately InformativeInherited
Fly Anatomy (FA)appendage0.08844Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.09916Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1554Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2348Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.7027Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.0008587InformativeDirect
Fly Anatomy (FA)ovariole0.001556InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01473InformativeInherited
Fly Anatomy (FA)germline cyst0.02843InformativeInherited
Fly Anatomy (FA)male organism0.2154InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7827InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.0001279Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.8939Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.214Moderately InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.02814InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.02877InformativeInherited
Zebrafish Anatomy (ZA)immune system0.1324InformativeInherited
Zebrafish Anatomy (ZA)thymus0.0001565Highly InformativeDirect
Zebrafish Anatomy (ZA)granulocyte0.0008738Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.003138Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.3299Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.435Least InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.01819InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 310.0001864Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002221Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00001625InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00004454InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)antineoplastic and immunomodulating agents0.00000000003047Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.6203Least InformativeInherited
Drugbank ATC_code (DB)protein kinase inhibitors0Moderately InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0.08958Moderately InformativeInherited
Drugbank ATC_code (DB)immunosuppressants0.9246Moderately InformativeInherited
Drugbank ATC_code (DB)tofacitinib0.0000007579InformativeDirect
Drugbank ATC_code (DB)adrenergic and dopaminergic agents0.002689InformativeInherited
Drugbank ATC_code (DB)drugs for obstructive airway diseases0.02074InformativeInherited
Drugbank ATC_code (DB)isoprenaline0.00002542Highly InformativeDirect
Drugbank ATC_code (DB)non-selective beta-adrenoreceptor agonists0.00002542Highly InformativeDirect
Drugbank ATC_code (DB)non-selective beta-adrenoreceptor agonists0.00002542Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processTranscription regulation0.00000000000005084Moderately InformativeDirect
Biological processApoptosis0.0000000001684Moderately InformativeDirect
Biological processHost-virus interaction0.00004072Moderately InformativeDirect
Biological processLipid metabolism0.9768Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.0000000002013InformativeDirect
Biological processEndocytosis0.00000002466InformativeDirect
Biological processInflammatory response0.000002622InformativeDirect
Biological processLipid degradation0.0004074InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.00000000000000729Highly InformativeDirect
Biological processPhagocytosis0.00000000009235Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.000000000007516Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000002998Moderately InformativeDirect
Cellular componentGolgi apparatus0.000008545Moderately InformativeDirect
Cellular componentCell membrane0.00003332Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0003711Highly InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.000006799Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000000001713InformativeDirect
Molecular functionNucleotide-binding0.000003638Least InformativeDirect
Molecular functionATP-binding0.00000000002174Moderately InformativeDirect
Molecular functionLipid-binding0.0000000001752Moderately InformativeDirect
Molecular functionCalcium0.00003318Moderately InformativeDirect
Molecular functionManganese0.0002251Moderately InformativeDirect
Molecular functionActin-binding0.0000001955InformativeDirect
Post-translational modificationTransferase0.000000000971Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator0.000000000000002231Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000000000002262Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation4.502e-16InformativeDirect
Post-translational modificationProtein phosphatase0.000000003224InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000005675Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]