SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00008386Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0002263Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03892Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8747Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0003953InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3018InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003423Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.000397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.0461Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6538Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00001969Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.0001309Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0002395Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1237Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4223Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.000005565InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.0008412InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cell physiology0.003439InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.003818InformativeInherited
Phenotypic Abnormality (PA)Abnormal immunoglobulin level0.0000005208Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.000007975Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000007478Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000000132Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1224Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1964Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.5094Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001076Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002045Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001991Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006424Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02182Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02433Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03447Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.0349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03561Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07145Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.08628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000002514InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001694InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00000551InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001153InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002307InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0009576InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009581InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03259InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04804InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05861InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06283InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06696InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.146InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1545InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2401InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.276InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3571InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000005648Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001612Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003441Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004017Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004608Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005241Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0007118Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008186Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.01389Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.0252Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2328Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3604Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.601Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00001032Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.009206Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1175Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000000000000735InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002713InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000003256InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0004258InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.003786InformativeInherited
Worm Phenotype (WP)drug resistant0.2969InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00000000000006647Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000005103Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0008164Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00002926InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.009041Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01421Least InformativeInherited
Fly Anatomy (FA)adult0.01521Least InformativeInherited
Fly Anatomy (FA)integumentary system0.01751Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02594Least InformativeInherited
Fly Anatomy (FA)nervous system0.1332Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5716Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002951Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.0009672Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.002756Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.005395Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01688Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01717Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01855Moderately InformativeInherited
Fly Anatomy (FA)adult head0.02672Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05682Moderately InformativeInherited
Fly Anatomy (FA)appendage0.06919Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0934Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1254Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1928Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1943Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5188Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.6534Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.7713Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.8565Moderately InformativeInherited
Fly Anatomy (FA)midline crossing tract0.0006524InformativeDirect
Fly Anatomy (FA)wing blade0.0009992InformativeDirect
Fly Anatomy (FA)ovariole0.002021InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.0115InformativeInherited
Fly Anatomy (FA)germline cyst0.04064InformativeInherited
Fly Anatomy (FA)male organism0.2422InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.0001048Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.4106Least InformativeInherited
Zebrafish Anatomy (ZA)immune system0.1371InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.007036Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000001895Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000007159InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00001823InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00003083InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]