SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (456) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,438 41,145 94
Proteins 12,967 36,814 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00008386Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0002263Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03892Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8747Moderately InformativeInherited
Disease Ontology (DO)breast cancer0.0003953InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3018InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003423Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.000397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04857Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5789Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00003642Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0003027Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.131Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4241Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.000005049InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.003463InformativeInherited
Phenotypic Abnormality (PA)Abnormal immunoglobulin level0.0000007266Highly InformativeDirect
Phenotypic Abnormality (PA)Cellulitis0.000006948Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000007427Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001311Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1221Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1961Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.51Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001076Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002045Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0001985Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006422Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02182Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03489Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.0358Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.08648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1847Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000002507InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001691InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00000551InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001153InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002306InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0009561InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009578InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03259InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.04805InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0586InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06281InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06696InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.146InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1546InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.1913InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2402InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.276InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3571InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.000000564Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003438Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0004016Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005244Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0007108Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008183Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.01386Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.02532Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2347Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3646Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6031Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00001056Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.009159Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1172Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000000000006697InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000000273InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000003142InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0004196InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.003791InformativeInherited
Worm Phenotype (WP)drug resistant0.2971InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00000000000006038Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.000000000488Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0008183Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.00003314InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.008519Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01467Least InformativeInherited
Fly Anatomy (FA)adult0.01523Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02523Least InformativeInherited
Fly Anatomy (FA)nervous system0.1304Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5804Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002593Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.00089Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.002473Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01633Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01641Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01893Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05389Moderately InformativeInherited
Fly Anatomy (FA)appendage0.06579Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09456Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09592Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1238Moderately InformativeInherited
Fly Anatomy (FA)head0.1847Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1852Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1875Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5143Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.6745Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.7895Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.8707Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.0009815InformativeDirect
Fly Anatomy (FA)ovariole0.001924InformativeInherited
Fly Anatomy (FA)tract0.005599InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.0117InformativeInherited
Fly Anatomy (FA)germline cyst0.04217InformativeInherited
Fly Anatomy (FA)male organism0.2441InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.00009528Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.372Least InformativeInherited
Zebrafish Anatomy (ZA)immune system0.08565InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.00733Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000001859Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000007548InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000181InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00003087InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]