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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (454) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,250 33,607 94
Proteins 12,801 30,054 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00075910Least InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00051350Moderately InformativeDirect
Biological Process (BP)regulation of defense response0.00000032280.01014InformativeInherited
Biological Process (BP)positive regulation of immune response0.0035720.2701InformativeInherited
Biological Process (BP)regulation of cell killing0.0000017610.0001626Highly InformativeDirect
Biological Process (BP)positive regulation of lymphocyte mediated immunity0.0000000000012771Highly InformativeInherited
Molecular Function (MF)binding0.048860Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002309 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0002621 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0003611 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.05309 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.102 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000000000003764 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000002702 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000000002508 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000003005 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.000000003801 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000007987 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0000002727 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000004238 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00001283 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00003428 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001411 Moderately Informative Direct
Biological Process (BP) system development 0.0003131 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0003432 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.8348 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01702 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2414 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.00399 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.008495 Moderately Informative Inherited
Biological Process (BP) reproduction 0.001248 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.9467 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8655 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9212 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9472 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9184 Moderately Informative Inherited
Biological Process (BP) immune response 0.0000000000007172 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001584 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.00000000000002636 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000000000001716 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0000000000003179 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000000008871 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000000000009065 Informative Direct
Biological Process (BP) phosphorylation 0.00000000004319 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.0000000007809 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000003494 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000004315 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00001433 Informative Direct
Biological Process (BP) cell death 0.00007212 Informative Direct
Biological Process (BP) behavior 0.0001039 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0004372 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0004841 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0007894 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0009058 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.4965 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.008851 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4179 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01891 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.04624 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2484 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) transmembrane transport 0.5461 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.4497 Informative Inherited
Biological Process (BP) cell development 0.9892 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.1801 Informative Inherited
Biological Process (BP) ion homeostasis 1 Informative Inherited
Biological Process (BP) metal ion transport 0.64 Informative Inherited
Biological Process (BP) regulation of defense response 0.01014 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) embryo development 0.9306 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.003354 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.006725 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.07266 Informative Inherited
Biological Process (BP) tissue development 0.959 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.652 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.178 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01393 Informative Inherited
Biological Process (BP) system process 0.3519 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.008764 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 0.007709 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.3204 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.8199 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001374 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.03105 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2553 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1359 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.002248 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.01048 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.4419 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.08327 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.2054 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1479 Informative Inherited
Biological Process (BP) sensory organ development 0.4479 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5881 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.07822 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.2918 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001155 Informative Inherited
Biological Process (BP) actin filament-based process 0.003755 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.6498 Informative Inherited
Biological Process (BP) lipid localization 0.0226 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.4486 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01088 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.004175 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.1751 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6781 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01061 Informative Inherited
Biological Process (BP) intracellular protein transport 0.08218 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01664 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5396 Informative Inherited
Biological Process (BP) growth 0.05598 Informative Inherited
Biological Process (BP) positive regulation of immune response 0.2701 Informative Inherited
Biological Process (BP) regulation of locomotion 0.003063 Informative Inherited
Biological Process (BP) secretion by cell 0.2038 Informative Inherited
Biological Process (BP) immune effector process 0.3489 Informative Inherited
Biological Process (BP) circulatory system development 0.4378 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.468 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7919 Informative Inherited
Biological Process (BP) regulation of cell killing 0.0001626 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000006556 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000001975 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000000000002869 Highly Informative Direct
Biological Process (BP) apoptotic process 0.000000000002897 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.00000000153 Highly Informative Direct
Biological Process (BP) coagulation 0.000000003207 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.000000007434 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000002268 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000003586 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000001004 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000003365 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000003441 Highly Informative Direct
Biological Process (BP) divalent metal ion transport 0.0000007562 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.00000125 Highly Informative Direct
Biological Process (BP) innate immune response 0.00000162 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000001862 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.000001929 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.000004006 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000004791 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00001115 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00001664 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.00001987 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0000308 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00003519 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00003683 Highly Informative Direct
Biological Process (BP) regeneration 0.00005362 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001914 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0002241 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0002992 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0003132 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000363 Highly Informative Direct
Biological Process (BP) neutrophil activation 0.0004235 Highly Informative Direct
Biological Process (BP) ammonium transport 0.0007372 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0008005 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.02545 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.316 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.001335 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.6144 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01998 Highly Informative Inherited
Biological Process (BP) positive regulation of angiogenesis 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.00506 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.6438 Highly Informative Inherited
Biological Process (BP) kidney development 0.02483 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.7647 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.807 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.8699 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01955 Highly Informative Inherited
Biological Process (BP) gastrulation 0.005946 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.7786 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.001944 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02935 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.4342 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) neurological system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.005093 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.04703 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.1832 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.001674 Highly Informative Inherited
Biological Process (BP) lipid modification 0.03063 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.8784 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1639 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.03102 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.1849 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.07253 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.01894 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.3602 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.01629 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.4764 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.575 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.6079 Highly Informative Inherited
Biological Process (BP) wound healing 0.003773 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.07669 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1478 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.4718 Highly Informative Inherited
Biological Process (BP) neuron development 0.07481 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.4213 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.5865 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.03407 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 1 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.02133 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.02497 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.009392 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.04391 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.3649 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02562 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.03702 Highly Informative Inherited
Biological Process (BP) hemostasis 0.0282 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.06323 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1708 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.4763 Highly Informative Inherited
Biological Process (BP) muscle structure development 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.09566 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.007544 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.001702 Highly Informative Inherited
Biological Process (BP) protein import 0.004823 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.4907 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.7908 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.8407 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.2133 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.5961 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.9129 Highly Informative Inherited
Biological Process (BP) response to fungus 0.03873 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.04105 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.03116 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000000004295 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.000000000005998 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00003284 Moderately Informative Direct
Molecular Function (MF) anion binding 0.6907 Moderately Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00001755 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00003137 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0001663 Informative Direct
Molecular Function (MF) phospholipid binding 0.0006404 Informative Direct
Molecular Function (MF) enzyme activator activity 0.814 Informative Inherited
Molecular Function (MF) signal transducer activity 0.006252 Informative Inherited
Molecular Function (MF) kinase binding 0.00000000000003033 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000000009473 Highly Informative Direct
Molecular Function (MF) phospholipase activity 0.00000005698 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000003682 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.000008336 Highly Informative Direct
Molecular Function (MF) heme binding 0.00001109 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00007912 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.9017 Highly Informative Inherited
Molecular Function (MF) G-protein coupled receptor binding 0.8588 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.07557 Highly Informative Inherited
Cellular Component (CC) membrane 0.00003309 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.09097 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.02494 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.00000002055 Moderately Informative Direct
Cellular Component (CC) cell projection 0.003856 Moderately Informative Inherited
Cellular Component (CC) whole membrane 0.02364 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.002246 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4318 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.7868 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1035 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.00000000000007855 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000000001095 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000156 Informative Direct
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.006974 Informative Inherited
Cellular Component (CC) plasma membrane region 0.5801 Informative Inherited
Cellular Component (CC) side of membrane 0.02817 Informative Inherited
Cellular Component (CC) synapse 0.03641 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.127 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ruffle 0.000000000000003141 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000001446 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.000318 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.3833 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.6124 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00002752Least InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0001711Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.03896Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.874Moderately InformativeInherited
Disease Ontology (DO)myeloid leukemia0.3044InformativeInherited
Disease Ontology (DO)myeloid neoplasm1InformativeInherited
Disease Ontology (DO)bone marrow disease0.0000003408Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.0003614Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0001118InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.001071Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07696Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7134Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.00002703Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0001328Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of humoral immunity0.0003084Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.075Moderately InformativeInherited
Phenotypic Abnormality (PA)CNS infection0.00005583InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lymphocytes0.1497InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00002059Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000000007741Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.000000001368Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.1238Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1971Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.5134Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000001065Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000002132Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0002041Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0006328Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.02235Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.02744Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.03383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.03605Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.066Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.07053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.08736Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2523Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000002717InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.000001666InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005569InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.000112InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0002422InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.0009576InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.0009729InformativeDirect
Mammalian Phenotype (MP)abnormal interferon level0.03335InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.0488InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.05806InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.06274InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.06622InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1473InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1526InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2426InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.276InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.357InformativeInherited
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0000005583Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating interleukin-17 level0.0001606Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0003441Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.0003901Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.0004487Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005195Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.0007072Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pre-B cell morphology0.0008807Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.01147Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.02272Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2251Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2347Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.5506Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000006187Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.009503Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.1207Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.0000000000000776InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000002857InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000003853InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0007135InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.003678InformativeInherited
Worm Phenotype (WP)drug resistant0.3011InformativeInherited
Worm Phenotype (WP)mitochondria alignment variant0.00000000000007028Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.0000000005382Highly InformativeDirect
Worm Phenotype (WP)aldicarb resistant0.0007815Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00055Moderately InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0004073Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.00909Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.01214Least InformativeInherited
Fly Anatomy (FA)adult0.01236Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.0228Least InformativeInherited
Fly Anatomy (FA)nervous system0.1376Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5487Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.0002361Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.0026Moderately InformativeInherited
Fly Anatomy (FA)gonad0.01651Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.01795Moderately InformativeInherited
Fly Anatomy (FA)adult head0.02707Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05863Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0748Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0799Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.09702Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.8433Moderately InformativeInherited
Fly Anatomy (FA)ovariole0.001566InformativeInherited
Fly Anatomy (FA)eye photoreceptor cell0.01344InformativeInherited
Fly Anatomy (FA)germline cyst0.04068InformativeInherited
Fly Anatomy (FA)male organism0.2341InformativeInherited
Fly Anatomy (FA)photoreceptor cell R70.0001089Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.6804Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.2871Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5477Moderately InformativeInherited
Zebrafish Anatomy (ZA)circulating cell0.02184InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.02575InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.05709InformativeInherited
Zebrafish Anatomy (ZA)immune system0.08013InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0009721Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.008239Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.004655Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.3328Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage0.4399Least InformativeInherited
Xenopus DEvelopment stage (XDE)late tailbud stage0.3745InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 310.0001642Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002284Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000004858InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00001768InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00004458InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processTranscription regulation0.00000000000007061Moderately InformativeDirect
Biological processApoptosis0.0000000001785Moderately InformativeDirect
Biological processHost-virus interaction0.00003633Moderately InformativeDirect
Biological processLipid metabolism0.9777Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.0000000002092InformativeDirect
Biological processEndocytosis0.00000002598InformativeDirect
Biological processInflammatory response0.000002701InformativeDirect
Biological processLipid degradation0.0004129InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.00000000000001495Highly InformativeDirect
Biological processPhagocytosis0.00000000009218Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000000119Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.00000000545Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000968Moderately InformativeDirect
Cellular componentCell membrane0.00002235Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0003995Highly InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.000006535Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000000001748InformativeDirect
Molecular functionNucleotide-binding0.000004066Least InformativeDirect
Molecular functionLipid-binding0.0000000002136Moderately InformativeDirect
Molecular functionCalcium0.00003747Moderately InformativeDirect
Molecular functionManganese0.0001671Moderately InformativeDirect
Post-translational modificationTransferase0.0000000000007803Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator0.000000000000003048Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.00000000000003097Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation4.405e-16InformativeDirect
Post-translational modificationProtein phosphatase0.000000003253InformativeDirect
Post-translational modificationActin-binding0.0000001801InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000002932Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]