SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (448) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,022 15,320 94
Proteins 12,605 13,787 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000012990Least InformativeDirect
Biological Process (BP)protein metabolic process0.00013650Least InformativeDirect
Biological Process (BP)regulation of cellular process0.97340.00000003076Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.78710.8539Least InformativeInherited
Biological Process (BP)multicellular organismal process0.059950Least InformativeInherited
Biological Process (BP)developmental process0.027750Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0010270.00000000002595Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0037290Least InformativeInherited
Biological Process (BP)immune system process0.000000088970Moderately InformativeDirect
Biological Process (BP)cellular protein modification process0.00000087560Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.000028260Moderately InformativeDirect
Biological Process (BP)organ development0.00018260.00003284Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00018860Moderately InformativeDirect
Biological Process (BP)cell differentiation0.00094230Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.023740.00001268Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.81150.001584Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0060310.000000000000003741Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.10570.41Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.011430.000000006794Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.08650.000000000000007318Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.069030.1128Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction10.00000004176Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.081Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process0.00000072720.0003583InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000012980InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011630InformativeDirect
Biological Process (BP)phosphorylation0.00012990InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.00018020InformativeDirect
Biological Process (BP)gland development0.00024210.0007934InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.000000034880.1954InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.01530.000004223InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.01261InformativeInherited
Biological Process (BP)positive regulation of protein modification process0.095290.9719InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0036470InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0012370.0004361InformativeInherited
Biological Process (BP)negative regulation of cell communication0.065660.00003407InformativeInherited
Biological Process (BP)negative regulation of signaling0.077550.000007791InformativeInherited
Biological Process (BP)regulation of intracellular protein kinase cascade0.095890.167InformativeInherited
Biological Process (BP)regulation of defense response0.0000000000000032580.08944InformativeInherited
Biological Process (BP)regulation of immune response0.0015420.00000001176InformativeInherited
Biological Process (BP)positive regulation of cell killing0.00000000000011770.0001326Highly InformativeDirect
Biological Process (BP)peptidyl-tyrosine modification0.00000000000029440Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process0.000034960.000009488Highly InformativeDirect
Biological Process (BP)protein phosphorylation0.000040490Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000067390.000003436Highly InformativeDirect
Biological Process (BP)positive regulation of peptidyl-tyrosine phosphorylation0.00064310.00002973Highly InformativeDirect
Biological Process (BP)negative regulation of phosphorylation0.010990.03513Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process0.013880.004108Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.000000029710.3178Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.00000099711Highly InformativeInherited
Biological Process (BP)regulation of leukocyte mediated cytotoxicity0.0012481Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte mediated immunity0.00038261Highly InformativeInherited
Biological Process (BP)regulation of lymphocyte mediated immunity01Highly InformativeInherited
Molecular Function (MF)binding0.00000014450Least InformativeDirect
Cellular Component (CC)cell junction0.0000068240InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000002595 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000003076 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.8539 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.003487 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.00003284 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.000000006794 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00001268 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.000000000000007318 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.00000003803 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00001338 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000000000001284 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000000000005916 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000003974 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.00000004176 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000004672 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000413 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0.000006826 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00002453 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0004205 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1128 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8487 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001584 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7304 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.7767 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.004104 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.004335 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.004348 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.03754 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.41 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.4907 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.003527 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0003583 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0007934 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004361 Informative Direct
Biological Process (BP) regulation of immune response 0.00000001176 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000004406 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) negative regulation of protein metabolic process 0.000004223 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00003407 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000007791 Informative Direct
Biological Process (BP) leukocyte activation 0.000000000000003741 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000000000000003741 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000000002447 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.00000000000002447 Informative Direct
Biological Process (BP) cellular component movement 0.000000000006304 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.00000000004926 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0.00000000007951 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0000000001926 Informative Direct
Biological Process (BP) blood circulation 0.0000000002527 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000002614 Informative Direct
Biological Process (BP) defense response 0.0000000004461 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000004728 Informative Direct
Biological Process (BP) response to wounding 0.000000003329 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.000000007899 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.000000008138 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000002268 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.00000008035 Informative Direct
Biological Process (BP) biological adhesion 0.0000006318 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.00000065 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000007126 Informative Direct
Biological Process (BP) cytoplasmic transport 0.000002251 Informative Direct
Biological Process (BP) generation of neurons 0.00003528 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00004237 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00006924 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00007275 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.00008017 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00008308 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0002158 Informative Direct
Biological Process (BP) regulation of locomotion 0.0003693 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0003967 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0004574 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006173 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.06969 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.136 Informative Inherited
Biological Process (BP) positive regulation of transport 0.7564 Informative Inherited
Biological Process (BP) regulation of secretion 0.1841 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.3681 Informative Inherited
Biological Process (BP) cation homeostasis 0.2248 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.2391 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.08944 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.6285 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.7844 Informative Inherited
Biological Process (BP) protein localization to organelle 0.006427 Informative Inherited
Biological Process (BP) protein transport 0.04968 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.8945 Informative Inherited
Biological Process (BP) regulation of ion transport 0.3432 Informative Inherited
Biological Process (BP) actin filament-based process 0.01373 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01015 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.2703 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.664 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1954 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.9719 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02917 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1894 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.167 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.137 Informative Inherited
Biological Process (BP) immune effector process 0.8612 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.003335 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.03442 Informative Inherited
Biological Process (BP) regulation of growth 0.001634 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6088 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) dephosphorylation 1 Informative Inherited
Biological Process (BP) response to light stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5369 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.009791 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.8512 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.004925 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.6807 Informative Inherited
Biological Process (BP) cell projection organization 0.01029 Informative Inherited
Biological Process (BP) lipid localization 0.01614 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) muscle tissue development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.9167 Informative Inherited
Biological Process (BP) response to other organism 0.00559 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) single-organism behavior 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3653 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.3742 Informative Inherited
Biological Process (BP) sexual reproduction 0.01115 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.007667 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001015 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) secretion by cell 0.1067 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.8526 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) positive regulation of cell killing 0.0001326 Highly Informative Direct
Biological Process (BP) peptidyl-tyrosine modification 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000009488 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.000003436 Highly Informative Direct
Biological Process (BP) positive regulation of peptidyl-tyrosine phosphorylation 0.00002973 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00000001622 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000000003203 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000000000009867 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0.0000000001209 Highly Informative Direct
Biological Process (BP) lactation 0.0000000001656 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000000001749 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0000000002825 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000003811 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000000004852 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000002856 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.00000005954 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000001519 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000002983 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000003076 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0000003255 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000005563 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0000005567 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000000784 Highly Informative Direct
Biological Process (BP) monoamine transport 0.000001014 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.000001121 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000001974 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00000218 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000002192 Highly Informative Direct
Biological Process (BP) negative regulation of cell activation 0.000002547 Highly Informative Direct
Biological Process (BP) nuclear import 0.000003234 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.00000436 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000005696 Highly Informative Direct
Biological Process (BP) learning or memory 0.00001522 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00003271 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.00003585 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00004062 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.00004675 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00005694 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.00006236 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00007032 Highly Informative Direct
Biological Process (BP) wound healing 0.0000988 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.0001239 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001364 Highly Informative Direct
Biological Process (BP) protein import 0.0001417 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.000155 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001671 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002793 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0005241 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0006289 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0006682 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0009606 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.2228 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.2933 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.1345 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4782 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2424 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.005849 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.1203 Highly Informative Inherited
Biological Process (BP) regulation of hemostasis 0.01282 Highly Informative Inherited
Biological Process (BP) regulation of coagulation 0.01811 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.1161 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.001444 Highly Informative Inherited
Biological Process (BP) renal system development 0.3386 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.08751 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.08135 Highly Informative Inherited
Biological Process (BP) placenta development 0.6972 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02048 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.008128 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.08553 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.008693 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.002045 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.02127 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphorylation 0.03513 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.004108 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.3178 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.07363 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.09838 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte mediated cytotoxicity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.123 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.05974 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2395 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05625 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1567 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.8944 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.002787 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.2447 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.005114 Highly Informative Inherited
Biological Process (BP) response to UV 0.08524 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.03022 Highly Informative Inherited
Biological Process (BP) cell junction organization 0.001818 Highly Informative Inherited
Biological Process (BP) regulation of Rho GTPase activity 0.04625 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.7657 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.9545 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) regulation of angiogenesis 0.01421 Highly Informative Inherited
Biological Process (BP) muscle organ development 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.9239 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.04352 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1665 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9608 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.4958 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.4385 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.002321 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9839 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.6922 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.43 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.8984 Highly Informative Inherited
Biological Process (BP) response to fungus 0.302 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.00502 Highly Informative Inherited
Biological Process (BP) gonad development 0.414 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000000000001566 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000002623 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.8403 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.00000000000006213 Informative Direct
Molecular Function (MF) DNA binding 0.00002027 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00003315 Informative Direct
Molecular Function (MF) enzyme binding 0.00006092 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.0000613 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 1 Informative Inherited
Molecular Function (MF) protein domain specific binding 0.000000000000001557 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000007667 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0.0000002359 Highly Informative Direct
Molecular Function (MF) heme binding 0.000002178 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.00002942 Highly Informative Direct
Molecular Function (MF) protein complex binding 0.00003541 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0003193 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0005715 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1713 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.3832 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.07297 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.001868 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.3346 Highly Informative Inherited
Cellular Component (CC) membrane 0.000003339 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001116 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.6248 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.000000002846 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0003885 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0031 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9168 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.0231 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000000002463 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000001469 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) membrane raft 0.000000000000006075 Highly Informative Direct
Cellular Component (CC) adherens junction 0.00000000004184 Highly Informative Direct
Cellular Component (CC) extrinsic to plasma membrane 0.0000107 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00006766 Highly Informative Direct
Cellular Component (CC) centrosome 0.4221 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0002855Least InformativeDirect
Disease Ontology (DO)immune system disease0.01277Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05682Moderately InformativeInherited
Disease Ontology (DO)leukemia0.1708Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.000293InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3151InformativeInherited
Disease Ontology (DO)polycythemia0.000000008668Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0000008429Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.0000292Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.009265InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000000008066Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0000000001767Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.07729Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1078Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.9073Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0000000001639Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.000007632Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.0001268Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0001639Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0002586Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.0002734Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.004852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.00799Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.02322Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2341Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.5757Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6164Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000001535InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000005639InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.00004042InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002739InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.007922InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.02786InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03445InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05713InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06389InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1184InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1362InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1437InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1783InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.184InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2644InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00000127Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00002496Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0004176Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0004725Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0009528Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.02661Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0002365InformativeDirect
Fly Phenotype (FP)size defective0.0005857InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0008625Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.005564Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01296Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.0274Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.03076Least InformativeInherited
Fly Anatomy (FA)organ system0.1268Least InformativeInherited
Fly Anatomy (FA)cell0.8618Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.00005406Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.00153Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.007428Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.03599Moderately InformativeInherited
Fly Anatomy (FA)adult head0.04518Moderately InformativeInherited
Fly Anatomy (FA)appendage0.05256Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05762Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07063Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1075Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1657Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.2244Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.2598Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.2713Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5529Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.7664Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.0001031InformativeDirect
Fly Anatomy (FA)optic lobe neuron0.0001465InformativeDirect
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.0002335InformativeDirect
Fly Anatomy (FA)ommatidium0.000634InformativeDirect
Fly Anatomy (FA)ovariole0.001597InformativeInherited
Fly Anatomy (FA)germline stem cell0.01505InformativeInherited
Fly Anatomy (FA)germline cyst0.03598InformativeInherited
Fly Anatomy (FA)male germline cell0.1254InformativeInherited
Fly Anatomy (FA)male reproductive system0.4286InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7827InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0007508Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.515Least InformativeInherited
Zebrafish Anatomy (ZA)lymphoid progenitor cell0.00001279InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0001344Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000003909Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00008144InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001588InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000009647Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00000000000001942Moderately InformativeDirect
Biological processApoptosis0.00000000009484Moderately InformativeDirect
Biological processHost-virus interaction0.00008772Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion0.0000000001186InformativeDirect
Biological processEndocytosis0.00000001558InformativeDirect
Biological processInflammatory response0.000001028InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.0000000000003817Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.428e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000000004328Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000001963Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000005674Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.00001059Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000000001869InformativeDirect
Molecular functionNucleotide-binding0.000007993Least InformativeDirect
Molecular functionATP-binding0.0000000001443Moderately InformativeDirect
Molecular functionCalcium0.00004548Moderately InformativeDirect
Molecular functionLipid-binding0.0000000000508InformativeDirect
Molecular functionActin-binding0.0000001307InformativeDirect
Post-translational modificationTransferase0.000000003539Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator4.442e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000005688Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationProtein phosphatase0.00000002287InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000002876Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]