SUPERFAMILY 1.75 HMM library and genome assignments server

SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (448) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,022 15,320 94
Proteins 12,605 13,787 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.00000012770Least InformativeDirect
Biological Process (BP)positive regulation of biological process0.000011370Least InformativeDirect
Biological Process (BP)protein metabolic process0.00015290Least InformativeDirect
Biological Process (BP)regulation of metabolic process0.83920.5092Least InformativeInherited
Biological Process (BP)multicellular organismal process0.053180Least InformativeInherited
Biological Process (BP)developmental process0.028250Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0010390.0000000008805Least InformativeInherited
Biological Process (BP)regulation of cellular process10.0000001936Least InformativeInherited
Biological Process (BP)single-organism cellular process0.076280Least InformativeInherited
Biological Process (BP)immune system process0.000000085630Moderately InformativeDirect
Biological Process (BP)cellular protein modification process0.00000090420Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.00004140Moderately InformativeDirect
Biological Process (BP)organ development0.00017970.0002486Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00022840Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.016480.000001103Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.80480.001932Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.094050.0225Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.028760.0000000000003261Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.36740.0113Moderately InformativeInherited
Biological Process (BP)regulation of phosphorus metabolic process0.0081480Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.19271Moderately InformativeInherited
Biological Process (BP)regulation of immune effector process0.00000079970.0004396InformativeDirect
Biological Process (BP)negative regulation of immune system process0.0000015720.0000000005928InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000013050.0000005198InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000013670InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development0.000081860InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00011860InformativeDirect
Biological Process (BP)phosphorylation0.0003130InformativeDirect
Biological Process (BP)regulation of protein phosphorylation0.000000041190.1242InformativeInherited
Biological Process (BP)negative regulation of cellular protein metabolic process0.032150.01581InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.0036830InformativeInherited
Biological Process (BP)regulation of immune response0.0012970.000000006839InformativeInherited
Biological Process (BP)regulation of defense response0.0000000000000032510.0414InformativeInherited
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation0.0000000000025140Highly InformativeDirect
Biological Process (BP)protein phosphorylation0.000025440Highly InformativeDirect
Biological Process (BP)regulation of cell adhesion0.0009480Highly InformativeDirect
Biological Process (BP)negative regulation of protein phosphorylation0.010250.009599Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.000000029220.2812Highly InformativeInherited
Biological Process (BP)positive regulation of leukocyte mediated cytotoxicity0.00074560.4987Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte mediated immunity0.11331Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.0000012891Highly InformativeInherited
Molecular Function (MF)binding0.00000016040Least InformativeDirect
Cellular Component (CC)cell junction0.0000068740InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0 Least Informative Direct
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000000008805 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000001936 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.004151 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5092 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organ development 0.0002486 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.000001103 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000000000003261 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000001249 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00003233 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000000000000005526 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000000007887 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000002659 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000000000423 Moderately Informative Direct
Biological Process (BP) defense response 0.00000000005718 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000002467 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000002299 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0000001934 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0000001987 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.0113 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.006945 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.001932 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9982 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.004522 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6814 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.006887 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.006617 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.8183 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.667 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002196 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05133 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0225 Moderately Informative Inherited
Biological Process (BP) regulation of immune effector process 0.0004396 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000005928 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000005198 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of immune response 0.000000006839 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002509 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000008391 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0003851 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001485 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00001033 Informative Direct
Biological Process (BP) leukocyte activation 0.000000000000003707 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) cellular component movement 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.000000000000001913 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.000000000000005526 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000000000000007248 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.00000000000002422 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000000000004707 Informative Direct
Biological Process (BP) cell proliferation 0.0000000000002091 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000000000005269 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.00000000007803 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000001081 Informative Direct
Biological Process (BP) blood circulation 0.0000000002588 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000001725 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.00000007834 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000001945 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0000002922 Informative Direct
Biological Process (BP) biological adhesion 0.0000004232 Informative Direct
Biological Process (BP) regulation of intracellular transport 0.0000007207 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.000001544 Informative Direct
Biological Process (BP) protein maturation 0.000001851 Informative Direct
Biological Process (BP) cytoplasmic transport 0.000004974 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00004011 Informative Direct
Biological Process (BP) generation of neurons 0.00004042 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.00004827 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00005961 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.00006212 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00007153 Informative Direct
Biological Process (BP) response to bacterium 0.0001131 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0001288 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0004339 Informative Direct
Biological Process (BP) regulation of locomotion 0.0004743 Informative Direct
Biological Process (BP) cell projection organization 0.0006237 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0006791 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0007438 Informative Direct
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01451 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.003569 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3612 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.5225 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1603 Informative Inherited
Biological Process (BP) regulation of response to wounding 0.03005 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.1973 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.00962 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.09019 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.003137 Informative Inherited
Biological Process (BP) embryonic organ development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.2311 Informative Inherited
Biological Process (BP) metal ion transport 0.8529 Informative Inherited
Biological Process (BP) regulation of defense response 0.0414 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.1129 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.4043 Informative Inherited
Biological Process (BP) regulation of protein localization 0.8258 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.1242 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.02959 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.007246 Informative Inherited
Biological Process (BP) positive regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.09919 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02829 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.6202 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.6316 Informative Inherited
Biological Process (BP) positive regulation of transport 0.8394 Informative Inherited
Biological Process (BP) regulation of secretion 0.1618 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.2244 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00278 Informative Inherited
Biological Process (BP) regulation of growth 0.00141 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) dephosphorylation 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.7864 Informative Inherited
Biological Process (BP) protein localization to organelle 0.003953 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5777 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.06825 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.1683 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.07691 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7968 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01559 Informative Inherited
Biological Process (BP) lipid localization 0.01873 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.5314 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) regulation of peptidase activity 0.1623 Informative Inherited
Biological Process (BP) single-organism behavior 0.1163 Informative Inherited
Biological Process (BP) gland development 0.002308 Informative Inherited
Biological Process (BP) response to nutrient levels 0.3825 Informative Inherited
Biological Process (BP) sexual reproduction 0.1099 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5853 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.01581 Informative Inherited
Biological Process (BP) actin filament-based process 0.001926 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.06366 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.02872 Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.02605 Informative Inherited
Biological Process (BP) protein transport 0.01565 Informative Inherited
Biological Process (BP) immune effector process 0.8687 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Informative Inherited
Biological Process (BP) secretion by cell 0.03169 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) sensory organ development 0.6221 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00000001445 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) zymogen activation 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0 Highly Informative Direct
Biological Process (BP) phagocytosis 0 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000000003707 Highly Informative Direct
Biological Process (BP) coagulation 0.0000000000006975 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000000001266 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000000000277 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.0000000000551 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000002327 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0000000006396 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.000000001263 Highly Informative Direct
Biological Process (BP) cell adhesion 0.00000001413 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.00000001563 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0.00000004951 Highly Informative Direct
Biological Process (BP) regulation of cellular response to insulin stimulus 0.00000005886 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.0000001436 Highly Informative Direct
Biological Process (BP) female gamete generation 0.0000003239 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000003351 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000003505 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.0000003988 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0000007542 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.0000008358 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000008528 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.000001228 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.000001291 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000001423 Highly Informative Direct
Biological Process (BP) myeloid cell development 0.000001629 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.000004369 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.0000103 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.00001546 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.00003215 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.00003414 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00004327 Highly Informative Direct
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.00005107 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00008239 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.00008277 Highly Informative Direct
Biological Process (BP) protein import 0.00008659 Highly Informative Direct
Biological Process (BP) regulation of exocytosis 0.0001316 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0001387 Highly Informative Direct
Biological Process (BP) regulation of glucose import 0.0001521 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0001819 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0002279 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002386 Highly Informative Direct
Biological Process (BP) learning or memory 0.0003036 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0003303 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0003984 Highly Informative Direct
Biological Process (BP) inositol phosphate metabolic process 0.0004652 Highly Informative Direct
Biological Process (BP) innate immune response 0.000484 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0005541 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.0005628 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.0006886 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0007961 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.0009331 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.2727 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.2987 Highly Informative Inherited
Biological Process (BP) negative regulation of nervous system development 0.9012 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.4019 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.001341 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.08932 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.2425 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 0.4213 Highly Informative Inherited
Biological Process (BP) kidney development 0.05512 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.005907 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.07896 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.09185 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.003805 Highly Informative Inherited
Biological Process (BP) in utero embryonic development 0.08058 Highly Informative Inherited
Biological Process (BP) placenta development 0.5639 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02091 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9647 Highly Informative Inherited
Biological Process (BP) response to purine-containing compound 0.009333 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.02969 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.008194 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.06184 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.002145 Highly Informative Inherited
Biological Process (BP) regulation of endocytosis 0.01502 Highly Informative Inherited
Biological Process (BP) positive regulation of response to wounding 0.3231 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.07923 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 0.2812 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte mediated cytotoxicity 0.4987 Highly Informative Inherited
Biological Process (BP) regulation of adaptive immune response 0.8223 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.05583 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1017 Highly Informative Inherited
Biological Process (BP) negative regulation of leukocyte activation 0.264 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.2283 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.0835 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.002409 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.927 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) protein dephosphorylation 0.2525 Highly Informative Inherited
Biological Process (BP) post-embryonic development 1 Highly Informative Inherited
Biological Process (BP) cellular response to radiation 0.007072 Highly Informative Inherited
Biological Process (BP) response to UV 0.09338 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.007041 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.06354 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein kinase activity 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.3515 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.1042 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02272 Highly Informative Inherited
Biological Process (BP) intrinsic apoptotic signaling pathway 1 Highly Informative Inherited
Biological Process (BP) gonad development 0.3019 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.1619 Highly Informative Inherited
Biological Process (BP) wound healing 0.001318 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1654 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.9659 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.485 Highly Informative Inherited
Biological Process (BP) germ cell development 0.00826 Highly Informative Inherited
Biological Process (BP) negative regulation of protein phosphorylation 0.009599 Highly Informative Inherited
Biological Process (BP) negative regulation of immune response 0.006271 Highly Informative Inherited
Biological Process (BP) negative regulation of immune effector process 0.3055 Highly Informative Inherited
Biological Process (BP) regulation of humoral immune response 0.6777 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) exocytosis 0.4412 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Biological Process (BP) response to fungus 0.3191 Highly Informative Inherited
Biological Process (BP) alpha-beta T cell activation 0.05334 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000003107 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.002531 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.7927 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.00002536 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00002968 Informative Direct
Molecular Function (MF) enzyme binding 0.00004271 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0.00007271 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.7155 Informative Inherited
Molecular Function (MF) protein complex binding 0.1254 Informative Inherited
Molecular Function (MF) phosphatase activity 1 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000000001593 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000004653 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000228 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0004358 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0005333 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.1676 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.001745 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08343 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.3823 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.003326 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000008093 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0009389 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7428 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000436 Moderately Informative Direct
Cellular Component (CC) cell projection 0.07219 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.002948 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.6367 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.1952 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.2498 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.1729 Moderately Informative Inherited
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000000002026 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0000000004797 Informative Direct
Cellular Component (CC) plasma membrane region 0.8807 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) adherens junction 0.00000000003995 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.0000005434 Highly Informative Direct
Cellular Component (CC) receptor complex 0.00008826 Highly Informative Direct
Cellular Component (CC) microtubule organizing center 0.7583 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0003158Least InformativeDirect
Disease Ontology (DO)immune system disease0.01372Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.05628Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.8574Moderately InformativeInherited
Disease Ontology (DO)in situ carcinoma0.0002942InformativeDirect
Disease Ontology (DO)myeloid leukemia0.3129InformativeInherited
Disease Ontology (DO)polycythemia0.00000000868Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.0000008275Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.00002877Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of leukocytes0.009221InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00000000004219Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000000009903Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.09283Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1372Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.0000000002597Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00000509Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune cell physiology0.00008951Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.0001157Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0.0001987Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0003314Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0.004604Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.007786Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.0161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.604Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000001924InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.000006234InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.00007362InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.007853InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.02575InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03577InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.06144InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.06528InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1215InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.1394InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.1412InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.1719InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.2249InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2333InformativeInherited
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.0000001175Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00002762Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.000437Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005318Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0009187Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.02771Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03499Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.01539Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.3188InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0003212Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0002348InformativeDirect
Fly Phenotype (FP)size defective0.000584InformativeDirect
Fly Phenotype (FP)planar polarity defective0.000861Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.005584Least InformativeInherited
Fly Anatomy (FA)anatomical group0.01288Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.02728Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.03085Least InformativeInherited
Fly Anatomy (FA)organ system0.1271Least InformativeInherited
Fly Anatomy (FA)cell0.861Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.00005469Moderately InformativeDirect
Fly Anatomy (FA)adult nervous system0.001515Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.007488Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.03587Moderately InformativeInherited
Fly Anatomy (FA)adult head0.04481Moderately InformativeInherited
Fly Anatomy (FA)appendage0.05285Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.05725Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07047Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.1079Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1661Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.2239Moderately InformativeInherited
Fly Anatomy (FA)sensillum0.2598Moderately InformativeInherited
Fly Anatomy (FA)adult sense organ0.2703Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.5538Moderately InformativeInherited
Fly Anatomy (FA)external sensory organ0.7664Moderately InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.0001027InformativeDirect
Fly Anatomy (FA)optic lobe neuron0.000146InformativeDirect
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.0002326InformativeDirect
Fly Anatomy (FA)ommatidium0.0006333InformativeDirect
Fly Anatomy (FA)ovariole0.00159InformativeInherited
Fly Anatomy (FA)germline stem cell0.01504InformativeInherited
Fly Anatomy (FA)germline cyst0.03595InformativeInherited
Fly Anatomy (FA)male germline cell0.1254InformativeInherited
Fly Anatomy (FA)male reproductive system0.4287InformativeInherited
Fly Anatomy (FA)somatic stem cell0.7826InformativeInherited
Fly Anatomy (FA)male germline stem cell0.0007495Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5099Least InformativeInherited
Zebrafish Anatomy (ZA)lymphoid progenitor cell0.00001198InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)portion of tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0001511Highly InformativeDirect
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000003869Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00008057InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001577InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000009442Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

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DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.6395Least InformativeInherited
Drugbank ATC_code (DB)antineoplastic agents0.008227Moderately InformativeInherited
Drugbank ATC_code (DB)cardiac therapy0.1061Moderately InformativeInherited
Drugbank ATC_code (DB)protein kinase inhibitors0InformativeDirect
Drugbank ATC_code (DB)adrenergic and dopaminergic agents0.001986InformativeInherited
Drugbank ATC_code (DB)selective immunosuppressants0.002755InformativeInherited
Drugbank ATC_code (DB)isoprenaline0.00001812Highly InformativeDirect
Drugbank ATC_code (DB)isopropanol0.00001812Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

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KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.00000000000002123Moderately InformativeDirect
Biological processApoptosis0.00000000009495Moderately InformativeDirect
Biological processHost-virus interaction0.00008786Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processCell adhesion0.00000000012InformativeDirect
Biological processEndocytosis0.00000001661InformativeDirect
Biological processInflammatory response0.000001102InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.0000000000003397Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane6.436e-16Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.0000000000004925Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002131Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000006015Moderately InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.00001019Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.000000000000182InformativeDirect
Molecular functionNucleotide-binding0.000007891Least InformativeDirect
Molecular functionATP-binding0.0000000001425Moderately InformativeDirect
Molecular functionCalcium0.00005344Moderately InformativeDirect
Molecular functionLipid-binding0.00000000005104InformativeDirect
Molecular functionActin-binding0.0000001339InformativeDirect
Post-translational modificationTransferase0.000000003553Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator4.449e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000000005694Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationProtein phosphatase0.00000002265InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.0000000000355Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

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