SUPERFAMILY 1.75 HMM library and genome assignments server

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SH2 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   SH2-like [ 55549]
Superfamily:   SH2 domain [ 55550]
Families:   SH2 domain [ 55551] (34)


Superfamily statistics
Genomes (456) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,438 33,607 94
Proteins 12,967 30,054 90


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00074070Least InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00048480Moderately InformativeDirect
Biological Process (BP)regulation of immune response0.00080660.000003381InformativeDirect
Biological Process (BP)regulation of leukocyte mediated immunity0.000000000060940.0000002627Highly InformativeDirect
Biological Process (BP)regulation of cell killing0.0000016240.000226Highly InformativeDirect
Molecular Function (MF)binding0.026590Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002368 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0005282 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.0006231 Least Informative Direct
Biological Process (BP) primary metabolic process 0.08551 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07793 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000000000002362 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000001921 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.00000000005068 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0000000008112 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000002362 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000000036 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000000279 Moderately Informative Direct
Biological Process (BP) defense response 0.0000002931 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000003152 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000003995 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001315 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.0004477 Moderately Informative Direct
Biological Process (BP) reproduction 0.0005838 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9249 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.007194 Moderately Informative Inherited
Biological Process (BP) ion transport 0.8412 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.0107 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8049 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02086 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.935 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.8665 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8927 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 1 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.005855 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2486 Moderately Informative Inherited
Biological Process (BP) regulation of immune response 0.000003381 Informative Direct
Biological Process (BP) immune response 0.00000000000008102 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.000000000000001925 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00001464 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) localization of cell 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000000000001254 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00000000000001763 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0000000000002919 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.0000000000003719 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000000000004525 Informative Direct
Biological Process (BP) phosphorylation 0.00000000002142 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0.000000001748 Informative Direct
Biological Process (BP) intracellular signal transduction 0.000000005538 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.000001734 Informative Direct
Biological Process (BP) response to wounding 0.000002182 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000004366 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00001168 Informative Direct
Biological Process (BP) behavior 0.00002203 Informative Direct
Biological Process (BP) cell death 0.00005078 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00006519 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.0003543 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0004656 Informative Direct
Biological Process (BP) regulation of locomotion 0.0006595 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0007174 Informative Direct
Biological Process (BP) regulation of cell differentiation 0.0009903 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.105 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.1492 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1847 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.04996 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) secretion by cell 0.08627 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.5788 Informative Inherited
Biological Process (BP) transmembrane transport 0.6181 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.7036 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.0154 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.4128 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.5184 Informative Inherited
Biological Process (BP) metal ion transport 0.9064 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.1355 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) embryo development 0.9325 Informative Inherited
Biological Process (BP) system process 0.3208 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.01836 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.004217 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 1 Informative Inherited
Biological Process (BP) generation of neurons 0.06884 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.01375 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01643 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2666 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2177 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04333 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.2763 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.2111 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.1283 Informative Inherited
Biological Process (BP) regulation of secretion 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.4526 Informative Inherited
Biological Process (BP) organelle localization 1 Informative Inherited
Biological Process (BP) immune effector process 0.2848 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.3469 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.3714 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03065 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.2077 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.001259 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00747 Informative Inherited
Biological Process (BP) chromosome organization 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01905 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6782 Informative Inherited
Biological Process (BP) hemopoiesis 0.007759 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.1013 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.3692 Informative Inherited
Biological Process (BP) lipid localization 0.02579 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.006932 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.4167 Informative Inherited
Biological Process (BP) epithelium development 0.3711 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.4928 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6817 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.6823 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.2122 Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.01241 Informative Inherited
Biological Process (BP) intracellular transport 1 Informative Inherited
Biological Process (BP) protein transport 0.1104 Informative Inherited
Biological Process (BP) growth 0.03595 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of defense response 0.002709 Informative Inherited
Biological Process (BP) circulatory system development 0.3256 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.8339 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) regulation of leukocyte mediated immunity 0.0000002627 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0.000226 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000008338 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000000000000341 Highly Informative Direct
Biological Process (BP) apoptotic process 0.0000000000014 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.000000000001658 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.0000000008645 Highly Informative Direct
Biological Process (BP) coagulation 0.000000004046 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00000002454 Highly Informative Direct
Biological Process (BP) cell proliferation 0.00000003016 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00000007283 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.000000116 Highly Informative Direct
Biological Process (BP) regulation of hemopoiesis 0.0000001553 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.0000001914 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.0000004998 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0.0000005271 Highly Informative Direct
Biological Process (BP) innate immune response 0.000001683 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000001801 Highly Informative Direct
Biological Process (BP) female gamete generation 0.000001911 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.000002238 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.000004642 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000004995 Highly Informative Direct
Biological Process (BP) regeneration 0.000005177 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00000602 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.000009573 Highly Informative Direct
Biological Process (BP) vasculogenesis 0.00001407 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.00002884 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.00003178 Highly Informative Direct
Biological Process (BP) single-organism nuclear import 0.00004336 Highly Informative Direct
Biological Process (BP) ammonium transport 0.00004372 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00005024 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0001594 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0002533 Highly Informative Direct
Biological Process (BP) glycerophospholipid biosynthetic process 0.0002821 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.0002872 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0003435 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0003786 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0003937 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0005586 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000561 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.0007923 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0009394 Highly Informative Direct
Biological Process (BP) positive regulation of apoptotic process 0.02157 Highly Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.3362 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.5531 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.5736 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.3633 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.7179 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 1 Highly Informative Inherited
Biological Process (BP) divalent inorganic cation transport 0.002054 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02461 Highly Informative Inherited
Biological Process (BP) regulation of response to wounding 0.09691 Highly Informative Inherited
Biological Process (BP) regulation of lipid localization 1 Highly Informative Inherited
Biological Process (BP) positive regulation of angiogenesis 0.9786 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.04069 Highly Informative Inherited
Biological Process (BP) kidney development 0.01439 Highly Informative Inherited
Biological Process (BP) response to fungus 0.009683 Highly Informative Inherited
Biological Process (BP) response to growth factor 0.02018 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.006416 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.7836 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.01745 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002675 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.5043 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.8483 Highly Informative Inherited
Biological Process (BP) negative regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) nervous system process 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.01854 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.6287 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.2136 Highly Informative Inherited
Biological Process (BP) lipid modification 0.03064 Highly Informative Inherited
Biological Process (BP) negative regulation of defense response 0.2019 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1954 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 0.03371 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.02486 Highly Informative Inherited
Biological Process (BP) leukocyte degranulation 0.9499 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.9758 Highly Informative Inherited
Biological Process (BP) regulation of cysteine-type endopeptidase activity 0.07015 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01649 Highly Informative Inherited
Biological Process (BP) regulation of protein import 0.001688 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 1 Highly Informative Inherited
Biological Process (BP) regulation of intracellular protein transport 0.002539 Highly Informative Inherited
Biological Process (BP) regulation of nucleocytoplasmic transport 0.07186 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.002314 Highly Informative Inherited
Biological Process (BP) granulocyte activation 0.9194 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.09636 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.1529 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 1 Highly Informative Inherited
Biological Process (BP) neuron development 0.05979 Highly Informative Inherited
Biological Process (BP) histone modification 1 Highly Informative Inherited
Biological Process (BP) myeloid cell homeostasis 0.04769 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.06038 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.8078 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 1 Highly Informative Inherited
Biological Process (BP) germ cell development 0.022 Highly Informative Inherited
Biological Process (BP) cell chemotaxis 0.1843 Highly Informative Inherited
Biological Process (BP) protein polymerization 0.007493 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.03629 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.4499 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.02498 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.03795 Highly Informative Inherited
Biological Process (BP) hemostasis 0.03368 Highly Informative Inherited
Biological Process (BP) response to nutrient levels 0.06155 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.1878 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.5352 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.3287 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.003764 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.07151 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.002403 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.8012 Highly Informative Inherited
Biological Process (BP) protein import 0.005587 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.4193 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular component movement 0.8953 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) organic hydroxy compound transport 0.2392 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.4241 Highly Informative Inherited
Biological Process (BP) myeloid cell activation involved in immune response 0.7569 Highly Informative Inherited
Biological Process (BP) activation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.04855 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Biological Process (BP) multicellular organismal homeostasis 0.004562 Highly Informative Inherited
Biological Process (BP) sex differentiation 0.02868 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00000000008838 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.00000000002772 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00006701 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0 Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00001984 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.00003665 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.0001022 Informative Direct
Molecular Function (MF) enzyme activator activity 0.8273 Informative Inherited
Molecular Function (MF) signal transducer activity 0.002722 Informative Inherited
Molecular Function (MF) kinase binding 0.00000000000001606 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000000006549 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.0000006847 Highly Informative Direct
Molecular Function (MF) heme binding 0.00001254 Highly Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00001469 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.0000153 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000104 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.7634 Highly Informative Inherited
Molecular Function (MF) cytokine receptor binding 0.8435 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.006161 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.08897 Highly Informative Inherited
Cellular Component (CC) membrane 0.00004655 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.008732 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.1421 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.00000002022 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.02931 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1518 Moderately Informative Inherited
Cellular Component (CC) vesicle 0.003775 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2893 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.8309 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.007596 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.0000000000001236 Informative Direct
Cellular Component (CC) extrinsic component of membrane 0.00000000001561 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0002669 Informative Direct
Cellular Component (CC) side of membrane 0.03061 Informative Inherited
Cellular Component (CC) plasma membrane region 0.6466 Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.008454 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.1859 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 1 Informative Inherited
Cellular Component (CC) ruffle 0.00000000000000156 Highly Informative Direct
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.000001539 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.0001544 Highly Informative Direct
Cellular Component (CC) plasma membrane raft 0.0002444 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0.3577 Highly Informative Inherited
Cellular Component (CC) microtubule organizing center 0.5748 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000006817Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000002804Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00007356Moderately InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.0000000000000101InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0001895InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-3,4,5-trisphosphate 5-phospha0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processTranscription regulation0.00000000000008937Moderately InformativeDirect
Biological processApoptosis0.0000000001915Moderately InformativeDirect
Biological processHost-virus interaction0.00003704Moderately InformativeDirect
Biological processLipid metabolism0.982Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0.000000000231InformativeDirect
Biological processEndocytosis0.00000002627InformativeDirect
Biological processInflammatory response0.000002728InformativeDirect
Biological processLipid degradation0.000444InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0.000000000001509Highly InformativeDirect
Biological processPhagocytosis0.0000000001002Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0.00000000001272Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000005833Moderately InformativeDirect
Cellular componentGolgi apparatus0.000008799Moderately InformativeDirect
Cellular componentCell membrane0.00002719Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0.0004061Highly InformativeDirect
DiseaseProto-oncogene0Moderately InformativeDirect
DiseaseOncogene0.00000595Moderately InformativeDirect
DomainSH2 domain0InformativeDirect
DomainSH3 domain0InformativeDirect
DomainSH3-binding0.0000000000001796InformativeDirect
Molecular functionNucleotide-binding0.000006291Least InformativeDirect
Molecular functionLipid-binding0.000000000237Moderately InformativeDirect
Molecular functionCalcium0.00004163Moderately InformativeDirect
Molecular functionManganese0.000218Moderately InformativeDirect
Post-translational modificationTransferase0.00000000000105Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationActivator0.000000000000003271Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000000000000349Moderately InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0InformativeDirect
Post-translational modificationGTPase activation4.413e-16InformativeDirect
Post-translational modificationProtein phosphatase0.000000003372InformativeDirect
Post-translational modificationActin-binding0.0000001864InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000006954Moderately InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SH2 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 38 hidden Markov models representing the SH2 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]