SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (10)
Families:   N-acetyl transferase, NAT [ 55730] (57)
  N-myristoyl transferase, NMT [ 55748]
  Autoinducer synthetase [ 75508] (2)
  FemXAB nonribosomal peptidyltransferases [ 82749] (3)
  Hypothetical protein cg14615-pa [ 103179]
  LFTR-like [ 143711]
  Ornithine decarboxylase antizyme-like [ 143714]
  AstA-like [ 143717]
  Aq 1966-like [ 143720]
  EF1021-like [ 160644] (3)


Superfamily statistics
Genomes (3,184) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 91,278 569,656 112
Proteins 88,233 552,257 104


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)organonitrogen compound metabolic process0.0000014780Least InformativeDirect
Biological Process (BP)macromolecule metabolic process0.000024660.000316Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process0.85690.6106Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)biosynthetic process0.86820.5663Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.096761Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.96861Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.000016810.000009865Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.000028660.00001113Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.000029160.0002213Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00014780.0001388Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.97981Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.090111Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00004350.2414Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0021790.5212Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.89161Moderately InformativeInherited
Biological Process (BP)response to organic substance0.2421Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)organelle organization0.0047970.000000004203Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.29311Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.30281Moderately InformativeInherited
Biological Process (BP)chromosome organization00InformativeDirect
Biological Process (BP)regulation of hormone levels0.00000000050830.0000002104InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.000039170InformativeDirect
Biological Process (BP)amine metabolic process0.00060460.00004893InformativeDirect
Biological Process (BP)response to nitrogen compound0.000000013160.02907InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.00000017510.005422InformativeInherited
Biological Process (BP)response to organic cyclic compound0.000000067870.01911InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.0095980.1627InformativeInherited
Biological Process (BP)mitotic cell cycle0.14050.9499InformativeInherited
Biological Process (BP)embryo development0.0014870.4129InformativeInherited
Biological Process (BP)cell cycle process0.3931InformativeInherited
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)response to organophosphorus00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process00Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process00Highly InformativeDirect
Biological Process (BP)response to purine-containing compound00.000000000000003734Highly InformativeDirect
Biological Process (BP)circadian rhythm00.00000000000001763Highly InformativeDirect
Biological Process (BP)cellular response to organonitrogen compound0.0000000000000031440.000001008Highly InformativeDirect
Biological Process (BP)amino sugar metabolic process0.000000000066230.000000000509Highly InformativeDirect
Biological Process (BP)histone modification0.00000000052080Highly InformativeDirect
Biological Process (BP)response to antibiotic0.000000045290.0000009471Highly InformativeDirect
Biological Process (BP)polyamine metabolic process0.00000038980.0000001523Highly InformativeDirect
Biological Process (BP)protein-DNA complex subunit organization0.000021770.000002613Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000021770.0001905Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification0.00087090Highly InformativeDirect
Biological Process (BP)chromatin assembly or disassembly0.68031Highly InformativeInherited
Biological Process (BP)gastrulation0.00000000033550.002413Highly InformativeInherited
Biological Process (BP)nuclear division0.00096810.1039Highly InformativeInherited
Biological Process (BP)nuclear chromosome segregation0.0014530.02185Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)acetyltransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)transferase complex0.00380Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.16971Moderately InformativeInherited
Cellular Component (CC)protein acetyltransferase complex0.0000000000011820Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.000000000080790.00001891Highly InformativeDirect
Cellular Component (CC)endoplasmic reticulum-Golgi intermediate compartment0.00000030490.000003724Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.000316 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6106 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5663 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000009865 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.00001113 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0002213 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001388 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000004203 Moderately Informative Direct
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2414 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.5212 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.6855 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000002104 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) amine metabolic process 0.00004893 Informative Direct
Biological Process (BP) regulation of cellular localization 0.1144 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.02907 Informative Inherited
Biological Process (BP) regulation of protein localization 0.2406 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2546 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.005422 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01911 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.101 Informative Inherited
Biological Process (BP) hemopoiesis 0.4109 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4383 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.1627 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9499 Informative Inherited
Biological Process (BP) embryo development 0.4129 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000000003734 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.00000000000001763 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000001008 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.000000000509 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.0000009471 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0000001523 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.000002613 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.0001905 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00003873 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00003289 Highly Informative Direct
Biological Process (BP) protein lipidation 0.0000001109 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.001027 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.004927 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.01526 Highly Informative Inherited
Biological Process (BP) embryonic organ development 0.5324 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.1175 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002413 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.02185 Highly Informative Inherited
Biological Process (BP) nuclear division 0.1039 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) molecular function regulator 0.2668 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.02408 Informative Inherited
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) kinase regulator activity 0.00006718 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.04234 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.06211 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.06136 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.00000000000009487 Informative Direct
Cellular Component (CC) chromosome 0.01182 Informative Inherited
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00001891 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000003724 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.000000003223 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.004249 Highly Informative Inherited
Cellular Component (CC) chromatin 0.2911 Highly Informative Inherited
Cellular Component (CC) peptidase complex 0.9794 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Amino-acid N-acetyltransferase0.0000001704Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processBiological rhythms0.000002726InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processPolyamine biosynthesis0.0000003021Highly InformativeDirect
Biological processDetoxification0.0002817Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000001658Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
DomainBromodomain0.00000000000000367Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationActivator0.000001077Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcetylation0.00000002221Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 81 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA N-acyltransferases (Nat) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 81 hidden Markov models representing the Acyl-CoA N-acyltransferases (Nat) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]