SUPERFAMILY 1.75 HMM library and genome assignments server

Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (10)
Families:   N-acetyl transferase, NAT [ 55730] (57)
  N-myristoyl transferase, NMT [ 55748]
  Autoinducer synthetase [ 75508] (2)
  FemXAB nonribosomal peptidyltransferases [ 82749] (3)
  Hypothetical protein cg14615-pa [ 103179]
  LFTR-like [ 143711]
  Ornithine decarboxylase antizyme-like [ 143714]
  AstA-like [ 143717]
  Aq 1966-like [ 143720]
  EF1021-like [ 160644] (3)


Superfamily statistics
Genomes (3,178) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 91,077 529,159 112
Proteins 88,039 498,894 104


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.00000046140Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.66471Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.961Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.64431Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.24041Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0017570.000002553Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular protein modification process0.000000000018940Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.10281Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0040760.4537Moderately InformativeInherited
Biological Process (BP)response to organic substance0.22241Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00017380.2853Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.92771Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.74580.8376Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.35881Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.013080.00181Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0000014560.001672Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.000047860.02258Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.000018320.06974Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.00051020.1108Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.93081Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.32661Moderately InformativeInherited
Biological Process (BP)organelle organization0.29860.00000003129Moderately InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process0.0000000026450.0000000000001979InformativeDirect
Biological Process (BP)regulation of hormone levels0.0000000000071520.00000001805InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.000000076520InformativeDirect
Biological Process (BP)amide biosynthetic process0.0000000000066130InformativeDirect
Biological Process (BP)chromosome organization0.00000000098720InformativeDirect
Biological Process (BP)cellular response to nitrogen compound0.0000000000020540.00001346InformativeDirect
Biological Process (BP)response to organic cyclic compound0.00000024250.01244InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.000044260.02503InformativeInherited
Biological Process (BP)response to organonitrogen compound0.000000011050.003058InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0000023150.008048InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.28770.6338InformativeInherited
Biological Process (BP)peptide metabolic process0.0090560.03753InformativeInherited
Biological Process (BP)positive regulation of protein metabolic process0.64661InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.033650.3587InformativeInherited
Biological Process (BP)cell cycle process0.1930.9276InformativeInherited
Biological Process (BP)DNA metabolic process0.84760.8898InformativeInherited
Biological Process (BP)embryonic morphogenesis0.000003310.03136InformativeInherited
Biological Process (BP)mitotic cell cycle0.026090.3191InformativeInherited
Biological Process (BP)amino sugar metabolic process0.000000000089590.000000001552Highly InformativeDirect
Biological Process (BP)polyamine metabolic process0.000000000050550.0000000000008337Highly InformativeDirect
Biological Process (BP)chromosome segregation0.0000000069370.000009103Highly InformativeDirect
Biological Process (BP)circadian rhythm00.0000000000004365Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000000067510.00001349Highly InformativeDirect
Biological Process (BP)response to toxic substance0.00000090740.000002058Highly InformativeDirect
Biological Process (BP)response to purine-containing compound00.00000000000002793Highly InformativeDirect
Biological Process (BP)histone modification0.0000093970Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification0.00000020270Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process00.000000000000124Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process00Highly InformativeDirect
Biological Process (BP)positive regulation of catabolic process0.0018580.002135Highly InformativeInherited
Biological Process (BP)regulation of protein catabolic process0.012320.003425Highly InformativeInherited
Biological Process (BP)internal protein amino acid acetylation11Highly InformativeInherited
Biological Process (BP)mitosis0.00028630.009364Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)enzyme regulator activity0.18540.000337Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.0022810.000001157InformativeInherited
Molecular Function (MF)acetyltransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)protein complex10.6099Least InformativeInherited
Cellular Component (CC)organelle membrane0.81551Moderately InformativeInherited
Cellular Component (CC)perinuclear region of cytoplasm0.0000000000017520.000004848Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000002553 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000003129 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.966 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8105 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4537 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.2853 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.00181 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02258 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.06974 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.1108 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.001672 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.8376 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.6237 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9425 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0000000000001979 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000001805 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) amide biosynthetic process 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00001346 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.854 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.5506 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.6685 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.3335 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.6326 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.3191 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01244 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.02503 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.003058 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.008048 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.6338 Informative Inherited
Biological Process (BP) regulation of protein localization 0.09933 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of transport 0.2594 Informative Inherited
Biological Process (BP) regulation of intracellular transport 0.006529 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptide metabolic process 0.03753 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.3587 Informative Inherited
Biological Process (BP) cell cycle process 0.9276 Informative Inherited
Biological Process (BP) DNA metabolic process 0.8898 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tube development 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.03136 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.000000001552 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0000000000008337 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.000009103 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000000004365 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.00001349 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000002058 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000000000002793 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.000009803 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0005011 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.000000000000124 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0004936 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.0008168 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.00419 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.581 Highly Informative Inherited
Biological Process (BP) mitosis 0.009364 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.002135 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.003425 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.001315 Highly Informative Inherited
Biological Process (BP) peptide biosynthetic process 0.0265 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.1777 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.1781 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.1256 Highly Informative Inherited
Biological Process (BP) neural tube development 0.04374 Highly Informative Inherited
Biological Process (BP) epithelial tube formation 0.01129 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.7027 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) enzyme regulator activity 0.000337 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.000001157 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.000001039 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.01577 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.6099 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.01156 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.001029 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.02924 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.000004848 Highly Informative Direct
Cellular Component (CC) chromatin 0.3079 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.06445 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Amino-acid N-acetyltransferase0.0000001704Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.09283Least InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.01586Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.5876InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.06019Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.72Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.08071Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.3523Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.000002698InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00051Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains