SUPERFAMILY 1.75 HMM library and genome assignments server


Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (10)
Families:   N-acetyl transferase, NAT [ 55730] (57)
  N-myristoyl transferase, NMT [ 55748]
  Autoinducer synthetase [ 75508] (2)
  FemXAB nonribosomal peptidyltransferases [ 82749] (3)
  Hypothetical protein cg14615-pa [ 103179]
  LFTR-like [ 143711]
  Ornithine decarboxylase antizyme-like [ 143714]
  AstA-like [ 143717]
  Aq 1966-like [ 143720]
  EF1021-like [ 160644] (3)


Superfamily statistics
Genomes (3,136) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 89,403 213,696 112
Proteins 86,460 206,769 104


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process1.053e-050Least InformativeDirect
Biological Process (BP)cellular aromatic compound metabolic process0.60711Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.84721Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.50691Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.51541Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.010124.044e-06Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular protein modification process3.118e-100Moderately InformativeDirect
Biological Process (BP)cellular nitrogen compound biosynthetic process1.672e-060.0004722Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.093391Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0029340.3639Moderately InformativeInherited
Biological Process (BP)response to organic substance0.21331Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00010830.1845Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.90551Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis11Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0062750.001656Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process4.612e-050.0174Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process1.904e-050.05906Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.00052420.09454Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process11Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.8671Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.20661Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.80291Moderately InformativeInherited
Biological Process (BP)organelle organization0.26361.311e-07Moderately InformativeInherited
Biological Process (BP)cellular biogenic amine metabolic process1.245e-081.004e-12InformativeDirect
Biological Process (BP)regulation of hormone levels5.987e-116.024e-08InformativeDirect
Biological Process (BP)peptidyl-amino acid modification3.575e-050InformativeDirect
Biological Process (BP)cellular amide metabolic process2.292e-101.229e-12InformativeDirect
Biological Process (BP)chromosome organization7.48e-100InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.487e-126.59e-06InformativeDirect
Biological Process (BP)response to organic cyclic compound1.957e-070.007732InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus5.89e-050.01516InformativeInherited
Biological Process (BP)response to organonitrogen compound1.2e-080.001852InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound1.224e-060.004843InformativeInherited
Biological Process (BP)cellular macromolecular complex assembly0.28150.569InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.022730.3001InformativeInherited
Biological Process (BP)cell cycle process0.19520.9324InformativeInherited
Biological Process (BP)DNA metabolic process0.79080.8161InformativeInherited
Biological Process (BP)embryonic morphogenesis4.467e-070.01337InformativeInherited
Biological Process (BP)amino sugar metabolic process8.832e-111.246e-08Highly InformativeDirect
Biological Process (BP)polyamine metabolic process1.851e-101.604e-12Highly InformativeDirect
Biological Process (BP)chromosome segregation6.789e-097.008e-06Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process2.561e-089.451e-06Highly InformativeDirect
Biological Process (BP)response to toxic substance5.428e-079.513e-07Highly InformativeDirect
Biological Process (BP)response to purine-containing compound07.333e-15Highly InformativeDirect
Biological Process (BP)histone modification6.32e-070Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification3.687e-060Highly InformativeDirect
Biological Process (BP)chromatin assembly1.971e-067.967e-06Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process6.167e-152.667e-13Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process00Highly InformativeDirect
Biological Process (BP)amide biosynthetic process9.123e-130Highly InformativeDirect
Biological Process (BP)protein-DNA complex assembly8.936e-062.366e-05Highly InformativeDirect
Biological Process (BP)cellular response to organic cyclic compound6.503e-145.038e-07Highly InformativeDirect
Biological Process (BP)internal protein amino acid acetylation11Highly InformativeInherited
Biological Process (BP)mitosis0.00015170.006029Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity0.17490.0009742Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.0018257.08e-06InformativeInherited
Molecular Function (MF)acetyltransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)protein complex10.491Least InformativeInherited
Cellular Component (CC)N-terminal protein acetyltransferase complex1.288e-140Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm1.137e-121.271e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.044e-06 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 1.311e-07 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0004722 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.3639 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1845 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001656 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.0174 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05906 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.09454 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.7901 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 1.004e-12 Informative Direct
Biological Process (BP) regulation of hormone levels 6.024e-08 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) cellular amide metabolic process 1.229e-12 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 6.59e-06 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.007732 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01516 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001852 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.004843 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.569 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.01337 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.3001 Informative Inherited
Biological Process (BP) cell cycle process 0.9324 Informative Inherited
Biological Process (BP) DNA metabolic process 0.8161 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) amino sugar metabolic process 1.246e-08 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 1.604e-12 Highly Informative Direct
Biological Process (BP) chromosome segregation 7.008e-06 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 9.451e-06 Highly Informative Direct
Biological Process (BP) response to toxic substance 9.513e-07 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 7.333e-15 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) chromatin assembly 7.967e-06 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 2.667e-13 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.0002651 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) amide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) artery morphogenesis 0.000771 Highly Informative Direct
Biological Process (BP) protein-DNA complex assembly 2.366e-05 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 5.038e-07 Highly Informative Direct
Biological Process (BP) mitosis 0.006029 Highly Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.1539 Highly Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 1 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.18 Highly Informative Inherited
Biological Process (BP) tube formation 0.02555 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.1605 Highly Informative Inherited
Biological Process (BP) neural tube development 0.04033 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.8099 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.7878 Highly Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.0009742 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 7.08e-06 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 8.699e-07 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring amino-acyl groups 1 Highly Informative Inherited
Molecular Function (MF) transcription factor binding transcription factor activity 0.02707 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.491 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0004536 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 2.971e-05 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0 Informative Direct
Cellular Component (CC) chromosome 0.0104 Informative Inherited
Cellular Component (CC) transcription elongation factor complex 1.589e-10 Highly Informative Direct
Cellular Component (CC) N-terminal protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 1.271e-06 Highly Informative Direct
Cellular Component (CC) chromatin 0.2329 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.1025 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Amino-acid N-acetyltransferase1.704e-07Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.1178Least InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.02395Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.634InformativeInherited
Mammalian Phenotype (MP)complete embryonic lethality between implantation and somite formation0.0005411Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.72Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.08071Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.3523Moderately InformativeInherited
Worm Phenotype (WP)somatic gonad development variant2.698e-06InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00051Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0.1565Least InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.001889Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spleen0.0007217InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0Highly InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processBiological rhythms4.685e-08Highly InformativeDirect
Biological processDetoxification0.0001654Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus5.705e-05Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
DomainBromodomain2.138e-15Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationActivator3.321e-06Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcetylation1.758e-09Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0Least InformativeDirect
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis0Moderately InformativeDirect
UniPathway (UP)L-arginine metabolism0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism3.413e-12Moderately InformativeDirect
UniPathway (UP)amino-acid degradation2.367e-08Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0.0004641Moderately InformativeDirect
UniPathway (UP)L-arginine biosynthesis1.187e-06InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis1.509e-06InformativeDirect
UniPathway (UP)L-arginine degradation1.768e-05InformativeDirect
UniPathway (UP)ectoine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis5.368e-08Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 81 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA N-acyltransferases (Nat) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 81 hidden Markov models representing the Acyl-CoA N-acyltransferases (Nat) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]