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Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (10)
Families:   N-acetyl transferase, NAT [ 55730] (57)
  N-myristoyl transferase, NMT [ 55748]
  Autoinducer synthetase [ 75508] (2)
  FemXAB nonribosomal peptidyltransferases [ 82749] (3)
  Hypothetical protein cg14615-pa [ 103179]
  LFTR-like [ 143711]
  Ornithine decarboxylase antizyme-like [ 143714]
  AstA-like [ 143717]
  Aq 1966-like [ 143720]
  EF1021-like [ 160644] (3)


Superfamily statistics
Genomes (3,184) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 91,278 569,656 112
Proteins 88,233 552,257 104


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.00005650.0003704Least InformativeDirect
Biological Process (BP)organonitrogen compound metabolic process0.000001820Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.053391Least InformativeInherited
Biological Process (BP)biosynthetic process0.83510.4466Least InformativeInherited
Biological Process (BP)primary metabolic process0.94760.6765Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.94741Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)cellular protein modification process00Moderately InformativeDirect
Biological Process (BP)heterocycle biosynthetic process0.00001360.00000982Moderately InformativeDirect
Biological Process (BP)aromatic compound biosynthetic process0.000023620.0002202Moderately InformativeDirect
Biological Process (BP)amide biosynthetic process0.000033570.00001081Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process0.00011310.0001341Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.060361Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.9641Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0023740.4353Moderately InformativeInherited
Biological Process (BP)peptide metabolic process0.88571Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.90921Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.26411Moderately InformativeInherited
Biological Process (BP)cellular component assembly11Moderately InformativeInherited
Biological Process (BP)organelle organization0.0035070.000000002469Moderately InformativeInherited
Biological Process (BP)response to organic substance0.23261Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.21471Moderately InformativeInherited
Biological Process (BP)amine metabolic process0.00018560.00004357InformativeDirect
Biological Process (BP)regulation of hormone levels0.00000000026360.0000001342InformativeDirect
Biological Process (BP)peptidyl-amino acid modification0.0000072830InformativeDirect
Biological Process (BP)chromosome organization00InformativeDirect
Biological Process (BP)response to nitrogen compound0.0000000095750.0194InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.0000001330.004054InformativeInherited
Biological Process (BP)response to organic cyclic compound0.000000032820.0123InformativeInherited
Biological Process (BP)regulation of catabolic process0.40990.08093InformativeInherited
Biological Process (BP)ammonium ion metabolic process0.0079350.1507InformativeInherited
Biological Process (BP)cell cycle process0.40631InformativeInherited
Biological Process (BP)embryo development0.00077360.381InformativeInherited
Biological Process (BP)mitotic cell cycle0.14420.9358InformativeInherited
Biological Process (BP)amino sugar metabolic process0.000000000029360.00000000034Highly InformativeDirect
Biological Process (BP)polyamine metabolic process0.00000010370.00000009073Highly InformativeDirect
Biological Process (BP)circadian rhythm00.0000000000000109Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000019470.0001854Highly InformativeDirect
Biological Process (BP)response to purine-containing compound00.000000000000003764Highly InformativeDirect
Biological Process (BP)histone modification0.00000000035910Highly InformativeDirect
Biological Process (BP)peptidyl-lysine modification0.0003490Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)indole-containing compound biosynthetic process00Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process00Highly InformativeDirect
Biological Process (BP)response to antibiotic0.000000059480.0000003977Highly InformativeDirect
Biological Process (BP)response to organophosphorus00Highly InformativeDirect
Biological Process (BP)cellular response to organonitrogen compound0.0000000000000061020.000001261Highly InformativeDirect
Biological Process (BP)protein-DNA complex subunit organization0.000021620.000002614Highly InformativeDirect
Biological Process (BP)positive regulation of catabolic process0.02350.0202Highly InformativeInherited
Biological Process (BP)chromatin assembly or disassembly0.67441Highly InformativeInherited
Biological Process (BP)nuclear division0.00082690.1007Highly InformativeInherited
Biological Process (BP)cellular biogenic amine catabolic process0.93520.8349Highly InformativeInherited
Biological Process (BP)gastrulation0.00000000015570.002563Highly InformativeInherited
Biological Process (BP)nuclear chromosome segregation0.0013620.02154Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)molecular function regulator10.2348Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)enzyme inhibitor activity0.51070.02774InformativeInherited
Molecular Function (MF)acetyltransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)macromolecular complex11Least InformativeInherited
Cellular Component (CC)transferase complex0.0035790Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.16471Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum-Golgi intermediate compartment0.0000003010.000003681Highly InformativeDirect
Cellular Component (CC)protein acetyltransferase complex0.0000000000011450Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.000000000032730.00001217Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.0003704 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.6765 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4466 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) organelle organization 0.000000002469 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.00000982 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0002202 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.00001081 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0001341 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.4353 Moderately Informative Inherited
Biological Process (BP) peptide metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.6369 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) amine metabolic process 0.00004357 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000001342 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 0 Informative Direct
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) regulation of cellular localization 0.09932 Informative Inherited
Biological Process (BP) regulation of protein modification process 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.0194 Informative Inherited
Biological Process (BP) regulation of establishment of protein localization 0.285 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.2539 Informative Inherited
Biological Process (BP) cell cycle process 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.004054 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0123 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.08093 Informative Inherited
Biological Process (BP) positive regulation of transport 0.4239 Informative Inherited
Biological Process (BP) ammonium ion metabolic process 0.1507 Informative Inherited
Biological Process (BP) embryo development 0.381 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.9358 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0.00000000034 Highly Informative Direct
Biological Process (BP) protein lipidation 0.0000001002 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.00000009073 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000000000109 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0.0001854 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.000000000000003764 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 0.00003042 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) indole-containing compound biosynthetic process 0 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to antibiotic 0.0000003977 Highly Informative Direct
Biological Process (BP) response to organophosphorus 0 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.000001261 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.000002614 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.00004031 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.005365 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.0202 Highly Informative Inherited
Biological Process (BP) chromatin assembly or disassembly 1 Highly Informative Inherited
Biological Process (BP) nuclear division 0.1007 Highly Informative Inherited
Biological Process (BP) cellular biogenic amine catabolic process 0.8349 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.1172 Highly Informative Inherited
Biological Process (BP) gastrulation 0.002563 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.02154 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) molecular function regulator 0.2348 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) enzyme inhibitor activity 0.02774 Informative Inherited
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 0.0000008248 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.03758 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.08081 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.08652 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.00000000000004875 Informative Direct
Cellular Component (CC) chromosome 0.0108 Informative Inherited
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.000003681 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0.0000000032 Highly Informative Direct
Cellular Component (CC) protein acetyltransferase complex 0 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.00001217 Highly Informative Direct
Cellular Component (CC) chromatin 0.279 Highly Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.003311 Highly Informative Inherited
Cellular Component (CC) peptidase complex 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Amino-acid N-acetyltransferase0.0000001704Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.5182Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.7821Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the orbital region0.07723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1337Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.2835Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the periorbital region0.02816InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.06277InformativeInherited
Phenotypic Abnormality (PA)Sparse and thin eyebrow0.00007357Highly InformativeDirect
Phenotypic Abnormality (PA)Prominent nasal bridge0.0004973Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)reproductive system development variant0.04116Moderately InformativeInherited
Worm Phenotype (WP)gonad development variant0.001147InformativeInherited
Worm Phenotype (WP)cell number increased0.007052InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis1Moderately InformativeInherited
Biological processAntibiotic resistance0InformativeDirect
Biological processBiological rhythms0.000002727InformativeDirect
Biological processArginine biosynthesis0Highly InformativeDirect
Biological processArginine metabolism0Highly InformativeDirect
Biological processPolyamine biosynthesis0.0000003026Highly InformativeDirect
Biological processDetoxification0.0002779Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentNucleus0.000001526Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
DomainBromodomain0.000000000000003678Highly InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationActivator0.00000104Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationChromatin regulator0InformativeDirect
Post-translational modificationAcetylation0.00000002351Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)amino-acid metabolism0.000000000000004738Least InformativeDirect
UniPathway (UP)carbohydrate metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis0.000000004204Moderately InformativeDirect
UniPathway (UP)amino-acid degradation0.00000005034Moderately InformativeDirect
UniPathway (UP)aromatic compound biosynthesis0.002072Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism0.2955Moderately InformativeInherited
UniPathway (UP)energy metabolism0.3317Moderately InformativeInherited
UniPathway (UP)L-arginine biosynthesis0InformativeDirect
UniPathway (UP)hormone biosynthesis0InformativeDirect
UniPathway (UP)siderophore metabolism0.00000003533InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0.000004667InformativeDirect
UniPathway (UP)L-arginine degradation0.000007175InformativeDirect
UniPathway (UP)putrescine metabolism0.0009936InformativeDirect
UniPathway (UP)amine and polyamine degradation0.1508InformativeInherited
UniPathway (UP)amine and polyamine biosynthesis0.4735InformativeInherited
UniPathway (UP)ectoine biosynthesis0Highly InformativeDirect
UniPathway (UP)L-arginine degradation via AST pathway0Highly InformativeDirect
UniPathway (UP)putrescine degradation0Highly InformativeDirect
UniPathway (UP)melatonin biosynthesis0Highly InformativeDirect
UniPathway (UP)UDP-N-acetyl-alpha-D-glucosamine biosynthesis0.00000000007927Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 81 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA N-acyltransferases (Nat) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 81 hidden Markov models representing the Acyl-CoA N-acyltransferases (Nat) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]