SUPERFAMILY 1.73 HMM library and genome assignments server


Acyl-CoA N-acyltransferases (Nat) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (334)
  Mainly antiparallel beta sheets (segregated alpha and beta regions)
Fold:   Acyl-CoA N-acyltransferases (Nat) [ 55728]
  3 layers: a/b/a; contains mixed beta-sheet
Superfamily:   Acyl-CoA N-acyltransferases (Nat) [ 55729] (9)
Families:   N-acetyl transferase, NAT [ 55730] (56)
  N-myristoyl transferase, NMT [ 55748]
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  Autoinducer synthetase [ 75508] (2)
  Pfam 00765
  FemXAB nonribosomal peptidyltransferases [ 82749] (2)
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  Hypothetical protein cg14615-pa [ 103179]
  duplication: consists of two NAT-like domains swapped with the C-terminal strands
  LFTR-like [ 143711]
  Pfam 03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
  Ornithine decarboxylase antizyme-like [ 143714]
  Pfam 02100; may have evolved different function; putative active site maps to the same location in the common fold
  AstA-like [ 143717]
  Pfam 04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops
  Aq 1966-like [ 143720]
  Pfam 06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold


Superfamily statistics
Genomes (1,213) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 35,791 39,201 104
Proteins 34,920 38,400 97


Functional annotation
General category Metabolism
Detailed category Transferases

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Acyl-CoA N-acyltransferases (Nat) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 75 hidden Markov models representing the Acyl-CoA N-acyltransferases (Nat) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]