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Profilin (actin-binding protein) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   Profilin (actin-binding protein) [ 55770]
Families:   Profilin (actin-binding protein) [ 55771]


Superfamily statistics
Genomes (487) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,362 3,178 12
Proteins 1,345 3,157 12


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000004540.000004508Least InformativeDirect
Biological Process (BP)biological regulation0.0001290.07937Least InformativeInherited
Biological Process (BP)multicellular organismal process0.010170.42Least InformativeInherited
Biological Process (BP)regulation of cellular component organization00.000000000008746Moderately InformativeDirect
Biological Process (BP)reproduction0.00000014690.00003752Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000024050.00001242Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.067180.1125Moderately InformativeInherited
Biological Process (BP)organelle organization0.13750.1025Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.0041440.02118Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0016520.02326Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0086360.01736Moderately InformativeInherited
Biological Process (BP)cellular localization0.000025780.003079Moderately InformativeInherited
Biological Process (BP)regulation of anatomical structure size00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00.000000000000005563InformativeDirect
Biological Process (BP)supramolecular fiber organization0.00000000000016820.0000000001346InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.000000058460.0000001917InformativeDirect
Biological Process (BP)actin cytoskeleton organization0.00000010290.00000005406InformativeDirect
Biological Process (BP)post-embryonic development0.0000099560.00001296InformativeDirect
Biological Process (BP)regulation of organelle organization0.000028480.00002147InformativeDirect
Biological Process (BP)reproductive system development0.00002860.0000336InformativeDirect
Biological Process (BP)positive regulation of cellular component organization0.000091580.0001477InformativeDirect
Biological Process (BP)growth0.00011080.0006888InformativeDirect
Biological Process (BP)locomotion0.00029130.0001935InformativeDirect
Biological Process (BP)developmental process involved in reproduction0.00077160.0008848InformativeDirect
Biological Process (BP)organelle localization0.0067750.02659InformativeInherited
Biological Process (BP)intracellular transport0.0034920.005979InformativeInherited
Biological Process (BP)regulation of protein polymerization00Highly InformativeDirect
Biological Process (BP)maintenance of location0.000000000054120.000000002911Highly InformativeDirect
Biological Process (BP)positive regulation of cellular component biogenesis0.00000000044410.000000003066Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex assembly0.0000000024850.0000000001668Highly InformativeDirect
Biological Process (BP)negative regulation of supramolecular fiber organization0.0000001190.0000001472Highly InformativeDirect
Biological Process (BP)establishment of organelle localization0.000014970.0002008Highly InformativeDirect
Biological Process (BP)positive regulation of supramolecular fiber organization0.000019820.000006009Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization0.000026190.00004824Highly InformativeDirect
Biological Process (BP)cell growth0.000030470.0002166Highly InformativeDirect
Biological Process (BP)developmental growth involved in morphogenesis0.00052070.00006935Highly InformativeDirect
Biological Process (BP)regulation of actin polymerization or depolymerization0.031450.001007Highly InformativeInherited
Molecular Function (MF)binding0.0000000020450.0000001828Least InformativeDirect
Molecular Function (MF)anion binding0.000000048190.0000000009951Moderately InformativeDirect
Molecular Function (MF)phospholipid binding00InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)phosphatidylinositol phosphate binding00.0000000000004262Highly InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle0.0020750.001174Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00092440.0003655Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000004508 Least Informative Direct
Biological Process (BP) biological regulation 0.07937 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.42 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.000000000008746 Moderately Informative Direct
Biological Process (BP) reproduction 0.00003752 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00001242 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.1125 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1025 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02118 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.02326 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.01736 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.003079 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000000000005563 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.0000000001346 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000001917 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00000005406 Informative Direct
Biological Process (BP) post-embryonic development 0.00001296 Informative Direct
Biological Process (BP) regulation of organelle organization 0.00002147 Informative Direct
Biological Process (BP) reproductive system development 0.0000336 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0001477 Informative Direct
Biological Process (BP) growth 0.0006888 Informative Direct
Biological Process (BP) locomotion 0.0001935 Informative Direct
Biological Process (BP) developmental process involved in reproduction 0.0008848 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.04326 Informative Inherited
Biological Process (BP) organelle localization 0.02659 Informative Inherited
Biological Process (BP) intracellular transport 0.005979 Informative Inherited
Biological Process (BP) regulation of protein polymerization 0 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000000002911 Highly Informative Direct
Biological Process (BP) positive regulation of cellular component biogenesis 0.000000003066 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex assembly 0.0000000001668 Highly Informative Direct
Biological Process (BP) negative regulation of supramolecular fiber organization 0.0000001472 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0002008 Highly Informative Direct
Biological Process (BP) positive regulation of supramolecular fiber organization 0.000006009 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0.00004824 Highly Informative Direct
Biological Process (BP) cell growth 0.0002166 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.00006935 Highly Informative Direct
Biological Process (BP) regulation of actin polymerization or depolymerization 0.001007 Highly Informative Inherited
Molecular Function (MF) binding 0.0000001828 Least Informative Direct
Molecular Function (MF) anion binding 0.0000000009951 Moderately Informative Direct
Molecular Function (MF) phospholipid binding 0 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) phosphatidylinositol phosphate binding 0.0000000000004262 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.001174 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0003655 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.0001684 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
Molecular functionLipid-binding0.0000000006372Moderately InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002097 SSF55770 Protein matches
Abstract Profilin is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerization of actin into filaments (F-actin). It can also in certain circumstance promote actin polymerization. Profilin also binds to polyphosphoinositides such as PIP2. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin.

A protein structurally similar to profilin is present in the genome of Variola virus and Vaccinia virus (gene A42R).

Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen, stings, drugs, or food) that, in most people, result in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P., Hoffmann D., Loewenstein H., Marsh D.G., Platts-Mills T.A.E., Thomas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed of the first three letters of the genus; a space; the first letter of the species name; a space and an arabic number. In the event that two species names have identical designations, they are discriminated from one another by adding one or more letters (as necessary) to each species designation.

The allergens in this family include allergens with the following designations: Ara t 8, Bet v 2, Cyn d 12, Hel a 2, Mer a 1 and Phl p 11.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Profilin (actin-binding protein) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Profilin (actin-binding protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]