SUPERFAMILY 1.75 HMM library and genome assignments server


PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,739) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 69,705 143,070 30
Proteins 45,019 97,530 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1.461e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.538e-08 Least Informative Direct
Biological Process (BP) developmental process 2.927e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 8.152e-05 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0001329 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.7249 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.02608 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2545 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.02614 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.3245 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1816 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.03222 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.931e-15 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 7.333e-15 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 2.285e-14 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 3.114e-14 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 7.539e-13 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 1.277e-11 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 5.768e-10 Moderately Informative Direct
Biological Process (BP) reproduction 5.819e-10 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 2.95e-09 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 7.082e-07 Moderately Informative Direct
Biological Process (BP) gene expression 1.403e-06 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 3.867e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001118 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.03545 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.1185 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001147 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.6799 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1968 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4739 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.9866 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6414 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.9867 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9303 Moderately Informative Inherited
Biological Process (BP) macromolecule catabolic process 0.06981 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.1489 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6358 Moderately Informative Inherited
Biological Process (BP) ion transport 0.009446 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4108 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.09509 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9725 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1.359e-13 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 9.319e-12 Informative Direct
Biological Process (BP) gland development 7.971e-08 Informative Direct
Biological Process (BP) embryonic organ development 8.856e-07 Informative Direct
Biological Process (BP) metal ion transport 7.827e-06 Informative Direct
Biological Process (BP) reproductive structure development 5.561e-05 Informative Direct
Biological Process (BP) locomotion 0.0001447 Informative Direct
Biological Process (BP) response to oxidative stress 0.0001915 Informative Direct
Biological Process (BP) protein catabolic process 0.0004582 Informative Direct
Biological Process (BP) regulation of cell development 0.001046 Informative Inherited
Biological Process (BP) regulation of secretion 0.02723 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.4579 Informative Inherited
Biological Process (BP) transmembrane transport 0.7287 Informative Inherited
Biological Process (BP) generation of neurons 0.1721 Informative Inherited
Biological Process (BP) epithelium development 0.2246 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4084 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001055 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.757 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.9826 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01631 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.3965 Informative Inherited
Biological Process (BP) single-organism behavior 0.6338 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.02187 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) growth 0.1821 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.02828 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.003011 Informative Inherited
Biological Process (BP) chromosome organization 0.2362 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.9797 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.9059 Informative Inherited
Biological Process (BP) regulation of ion transport 0.06391 Informative Inherited
Biological Process (BP) microtubule-based process 0.8699 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.4622 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01731 Informative Inherited
Biological Process (BP) sexual reproduction 0.9801 Informative Inherited
Biological Process (BP) proteolysis 0.0486 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of system process 0.9186 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.0484 Informative Inherited
Biological Process (BP) cellular component movement 0.4403 Informative Inherited
Biological Process (BP) localization of cell 0.09955 Informative Inherited
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) placenta development 5.586e-15 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 2.042e-11 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 3.553e-11 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1.377e-10 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 1.298e-09 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 5.513e-09 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 7.752e-09 Highly Informative Direct
Biological Process (BP) regulation of proton transport 1.348e-08 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 3.938e-08 Highly Informative Direct
Biological Process (BP) epithelial tube morphogenesis 1.333e-07 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 7.609e-07 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 2.261e-06 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 4.508e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 4.66e-06 Highly Informative Direct
Biological Process (BP) cellular response to radiation 1.128e-05 Highly Informative Direct
Biological Process (BP) spermatogenesis 1.488e-05 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 2.104e-05 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001007 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0003544 Highly Informative Direct
Biological Process (BP) morphogenesis of a branching epithelium 0.0004877 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0005116 Highly Informative Direct
Biological Process (BP) positive regulation of cell differentiation 0.5079 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.003704 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.02499 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.2378 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.02371 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.7003 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.007414 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.036 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.01942 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.003424 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.3978 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.2148 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.02263 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.01622 Highly Informative Inherited
Biological Process (BP) histone modification 0.1331 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01241 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.002054 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.00407 Highly Informative Inherited
Biological Process (BP) aging 0.03841 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.04877 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 1.592e-07 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 4.407e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.0092 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.1554 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 9.833e-10 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 2.125e-07 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002682 Informative Direct
Molecular Function (MF) enzyme binding 0.01366 Informative Inherited
Molecular Function (MF) receptor binding 0.02041 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1753 Informative Inherited
Molecular Function (MF) kinase activity 0.01321 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.623e-11 Highly Informative Direct
Molecular Function (MF) ion channel activity 2.437e-09 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 7.818e-09 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 9.568e-09 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 2.359e-05 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 8.069e-11 Least Informative Direct
Cellular Component (CC) protein complex 4.614e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5291 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0002392 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.2065 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.4394 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 6.474e-10 Informative Direct
Cellular Component (CC) integral to membrane 0.316 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.4569 Informative Inherited
Cellular Component (CC) transcription factor complex 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.01801 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.4725 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases3.76e-08Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups7.319e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2235Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4137Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level8.555e-06Moderately InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.07653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1036Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1304Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2135Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0002498InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0007919InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.007666InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02525InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1292InformativeInherited
Mammalian Phenotype (MP)abnormal circadian period2.216e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level5.005e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0001669Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001137Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.003349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01293Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.008651Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant8.312e-06InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying defective1.563e-07Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant1.584e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)circadian rhythm defective0.0005208InformativeDirect
Fly Phenotype (FP)behavior defective0.02393InformativeInherited
Fly Phenotype (FP)eclosion rhythm defective7.474e-07Highly InformativeDirect
Fly Phenotype (FP)semi-sterile2.342e-05Highly InformativeDirect
Fly Phenotype (FP)locomotor rhythm defective0.0001568Highly InformativeDirect
Fly Phenotype (FP)gravitaxis defective0.0003192Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.9385Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.2934Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.2945Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0001516InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003462InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000724InformativeDirect
Xenopus ANatomical entity (XAN)tail0.915InformativeInherited
Xenopus ANatomical entity (XAN)lens1.096e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk somite1.492e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0003526Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.3209Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.8377Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases5.139e-08InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase4.519e-07InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processIon transport2.664e-06Moderately InformativeDirect
Biological processDifferentiation4.291e-06Moderately InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis8.323e-08InformativeDirect
Biological processVirulence5.867e-07InformativeDirect
Biological processSporulation0.0002187InformativeDirect
Biological processBiological rhythms0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis7.111e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.004602Least InformativeInherited
Cellular componentCell membrane0.0002489Moderately InformativeDirect
Cellular componentChromosome0.0002375InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.3496Least InformativeInherited
Molecular functionFlavoprotein1.483e-07Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionPotassium6.914e-16InformativeDirect
Molecular functionFMN1.48e-10InformativeDirect
Molecular functionCalmodulin-binding2.422e-05InformativeDirect
Post-translational modificationTransferase5.315e-09Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.818e-07Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation5.681e-09Moderately InformativeDirect
Post-translational modificationIsopeptide bond3.767e-06Moderately InformativeDirect
Post-translational modificationHydroxylation5.396e-12InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism2.951e-08Least InformativeDirect
UniPathway (UP)protein ubiquitination2.392e-12Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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