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PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,780) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,920 251,567 30
Proteins 45,772 178,928 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000002337 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000000001477 Least Informative Direct
Biological Process (BP) developmental process 0.000004517 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00003617 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002035 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01385 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7262 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002328 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8055 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3803 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1111 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproduction 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000000000001562 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000000000006029 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000001985 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000000016 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000000003614 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000003835 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000000956 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000002088 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000003141 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00007819 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0001428 Moderately Informative Direct
Biological Process (BP) gene expression 0.0001899 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0007932 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.5303 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.58 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.578 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2079 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.258 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) system process 0.7244 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3078 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9553 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6948 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01531 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5306 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02067 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.17 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2496 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9732 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) phosphorylation 0.00000000000003117 Informative Direct
Biological Process (BP) gland development 0.0000001147 Informative Direct
Biological Process (BP) embryonic organ development 0.000002241 Informative Direct
Biological Process (BP) metal ion transport 0.00001692 Informative Direct
Biological Process (BP) locomotion 0.00003454 Informative Direct
Biological Process (BP) reproductive system development 0.00007779 Informative Direct
Biological Process (BP) single organism reproductive process 0.00009953 Informative Direct
Biological Process (BP) tube development 0.000518 Informative Direct
Biological Process (BP) regulation of cell development 0.001032 Informative Inherited
Biological Process (BP) generation of neurons 0.1156 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02543 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.006396 Informative Inherited
Biological Process (BP) transmembrane transport 0.8288 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4828 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001871 Informative Inherited
Biological Process (BP) epithelium development 0.1752 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.07755 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04309 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9817 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.04227 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.5947 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01115 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001541 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) growth 0.1364 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.673 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001696 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2947 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3567 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.6039 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3849 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.006452 Informative Inherited
Biological Process (BP) chromosome organization 0.002205 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3325 Informative Inherited
Biological Process (BP) regulation of ion transport 0.001254 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.3813 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.4484 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.8682 Informative Inherited
Biological Process (BP) microtubule-based process 0.9466 Informative Inherited
Biological Process (BP) single-organism behavior 0.1896 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9609 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5723 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.002635 Informative Inherited
Biological Process (BP) proteolysis 0.1536 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of system process 0.4631 Informative Inherited
Biological Process (BP) cellular component movement 0.2833 Informative Inherited
Biological Process (BP) localization of cell 0.02136 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000000000000007318 Highly Informative Direct
Biological Process (BP) placenta development 0.00000000000001083 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0000000000006604 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000000001699 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0000000004075 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.000000000788 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.000000007656 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.00000001358 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.00000001471 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00000006827 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0.0000001883 Highly Informative Direct
Biological Process (BP) regulation of proton transport 0.000001962 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.000002556 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.000008554 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.00002487 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.00002577 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00002742 Highly Informative Direct
Biological Process (BP) protein deacylation 0.0000316 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00004606 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0001065 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0001118 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0001745 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001989 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0006116 Highly Informative Direct
Biological Process (BP) histone modification 0.0007436 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1913 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.07234 Highly Informative Inherited
Biological Process (BP) developmental growth 0.003714 Highly Informative Inherited
Biological Process (BP) cell growth 0.2162 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.5344 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.5954 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.7979 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.01822 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.0369 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04877 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.7677 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3561 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.001799 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.04997 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.03099 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.8679 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.0521 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001411 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6399 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.01129 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.00925 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.2539 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.01825 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.004753 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01401 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01084 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.4272 Highly Informative Inherited
Biological Process (BP) learning or memory 0.07444 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.01116 Highly Informative Inherited
Biological Process (BP) aging 0.04496 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.06347 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.00001598 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.00000002833 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000002511 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.003857 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.2175 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000002608 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.0000004887 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.0000005994 Informative Direct
Molecular Function (MF) chromatin binding 0.0000218 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001716 Informative Direct
Molecular Function (MF) enzyme binding 0.003066 Informative Inherited
Molecular Function (MF) receptor binding 0.002471 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1985 Informative Inherited
Molecular Function (MF) kinase activity 0.01044 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000001223 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.0000000000643 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0.000000008781 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0000001248 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.00003338 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000000001887 Least Informative Direct
Cellular Component (CC) protein complex 0.00003332 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2587 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0001904 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.2758 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.528 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.0000000001712 Informative Direct
Cellular Component (CC) integral to membrane 0.3887 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.5416 Informative Inherited
Cellular Component (CC) ion channel complex 0.02207 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.03854 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.5024 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000376Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000007319Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1386Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.373Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.000009006Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.07677Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.000253InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0008401InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.006432InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1425InformativeInherited
Mammalian Phenotype (MP)abnormal circadian period0.0000002044Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.000005525Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0001614Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001071Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.003349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01293Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.008651Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.000008312InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying defective0.0000001563Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000001584Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.04088InformativeInherited
Fly Phenotype (FP)sleep defective0.000003432Highly InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.001157Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.9409Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.2983Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3101Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0001987InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003893InformativeDirect
Xenopus ANatomical entity (XAN)tail0.9168InformativeInherited
Xenopus ANatomical entity (XAN)trunk somite0.00001498Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.00001517Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0004867Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2994Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.8478Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000000275InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000004798InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processIon transport0.000003024Moderately InformativeDirect
Biological processDifferentiation0.000004995Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis0.0000001035InformativeDirect
Biological processVirulence0.0000008205InformativeDirect
Biological processSporulation0.0002235InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis0.00000000007429Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.003936Least InformativeInherited
Cellular componentCell membrane0.0002044Moderately InformativeDirect
Cellular componentChromosome0.0002727InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionNucleotide-binding0.3313Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionATP-binding0.00000002702Moderately InformativeDirect
Molecular functionFlavoprotein0.0000001706Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionPotassium6.939e-16InformativeDirect
Molecular functionFMN0.0000000001537InformativeDirect
Molecular functionCalmodulin-binding0.0000248InformativeDirect
Post-translational modificationTransferase0.000000009902Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000002475Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000000000004795Moderately InformativeDirect
Post-translational modificationHydroxylation0.00000000001197InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000000002924Least InformativeDirect
UniPathway (UP)protein ubiquitination0.000000000004521Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]