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PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 71,199 577,810 30
Proteins 45,948 381,012 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000376Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000007319Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1229Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1885Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6399Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0000191Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.06176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.08527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1197Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0007047InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0008187InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.009144InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.04531InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1031InformativeInherited
Mammalian Phenotype (MP)decreased heart rate0.0002512Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.0003494Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0005871Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.00171Highly InformativeInherited
Mammalian Phenotype (MP)abnormal osteoblast cell number0.002849Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000007068Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0003696Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.001983Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02124Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02268Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.06176Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.001508Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01862Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.01883Moderately InformativeInherited
Worm Phenotype (WP)protein interaction variant0.03925Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.2519Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00002223InformativeDirect
Worm Phenotype (WP)oxygen response variant0.0001108InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0004191InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.001265InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.03139InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.1926InformativeInherited
Worm Phenotype (WP)egg laying defective0.0000003048Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.00000137Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000004679Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00001696Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002219Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004845Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.04261Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.0000256Highly InformativeDirect
Fly Phenotype (FP)circadian behavior defective0.004609Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.0721Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1418Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.1521Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4077Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4947Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.9793Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0008531Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.2785Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.00006636InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0001261InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.003993InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.1326InformativeInherited
Xenopus ANatomical entity (XAN)somite0.0003502Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.0001634Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.9138Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000000008428InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000002161InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]