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PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,786) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 71,039 251,567 30
Proteins 45,855 178,928 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7733 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0.0000000006887 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.000000001258 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000352 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0001045 Moderately Informative Direct
Biological Process (BP) ion transport 0.0002342 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0002763 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9784 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.05186 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.002826 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.01374 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.7011 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5089 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.0318 Moderately Informative Inherited
Biological Process (BP) system development 0.1324 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9688 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1782 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.005072 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01862 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3759 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7578 Moderately Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00000000000003137 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000006677 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000001745 Informative Direct
Biological Process (BP) behavior 0.000002397 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000004534 Informative Direct
Biological Process (BP) single organism reproductive process 0.00001301 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00003771 Informative Direct
Biological Process (BP) metal ion transport 0.00007702 Informative Direct
Biological Process (BP) response to radiation 0.00008168 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.0006567 Informative Direct
Biological Process (BP) response to oxidative stress 0.0008703 Informative Direct
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.4992 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.5711 Informative Inherited
Biological Process (BP) regulation of system process 0.04421 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) regulation of ion transport 0.008216 Informative Inherited
Biological Process (BP) cell-cell signaling 0.8884 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.2641 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.005651 Informative Inherited
Biological Process (BP) transmembrane transport 0.09536 Informative Inherited
Biological Process (BP) generation of neurons 0.486 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.01236 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) organelle localization 0.04254 Informative Inherited
Biological Process (BP) cell death 0.1156 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2494 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.003696 Informative Inherited
Biological Process (BP) phosphorylation 0.1963 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.006131 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.8498 Informative Inherited
Biological Process (BP) post-embryonic development 0.8392 Informative Inherited
Biological Process (BP) microtubule-based process 0.5661 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.6259 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4048 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.05702 Informative Inherited
Biological Process (BP) central nervous system development 0.1671 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5264 Informative Inherited
Biological Process (BP) chromosome organization 0.708 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.6016 Informative Inherited
Biological Process (BP) proteolysis 0.09842 Informative Inherited
Biological Process (BP) system process 0.05729 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) tissue development 0.9644 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.0148 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.003542 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) reproductive system development 0.01538 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05478 Informative Inherited
Biological Process (BP) embryo development 0.9158 Informative Inherited
Biological Process (BP) locomotion 0.001973 Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0000000000000109 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000001908 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.000000001061 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0.0000003395 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00002216 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00003052 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00003972 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00006396 Highly Informative Direct
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.00008252 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0003664 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0007894 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1919 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.04387 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.01491 Highly Informative Inherited
Biological Process (BP) response to red or far red light 0.09769 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6414 Highly Informative Inherited
Biological Process (BP) histone modification 0.0153 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.8442 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.02985 Highly Informative Inherited
Biological Process (BP) trans-synaptic signaling 0.1838 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.01412 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.06098 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1423 Highly Informative Inherited
Biological Process (BP) regulation of DNA-templated transcription in response to stress 0.001995 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) appendage development 0.04326 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.453 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.004733 Highly Informative Inherited
Biological Process (BP) brain development 0.02988 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.09402 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1565 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2277 Highly Informative Inherited
Biological Process (BP) neurological system process 0.5086 Highly Informative Inherited
Biological Process (BP) aging 0.1093 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.7414 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.169 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.01433 Highly Informative Inherited
Biological Process (BP) germ cell development 0.8167 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.9737 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.06256 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0002845 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000004346 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.000000000678 Moderately Informative Direct
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.2058 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.313 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000005592 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.0000000000048 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.00000000006596 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.00006107 Informative Direct
Molecular Function (MF) kinase activity 0.0003476 Informative Direct
Molecular Function (MF) receptor binding 0.0007827 Informative Direct
Molecular Function (MF) enzyme binding 0.02513 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.3148 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000000000004173 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000000003651 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000002884 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.0000815 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0002754 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0002952 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.001077 Highly Informative Inherited
Molecular Function (MF) double-stranded DNA binding 0.3566 Highly Informative Inherited
Cellular Component (CC) macromolecular complex 0.00000002174 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000068 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.009177 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.3227 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.005519 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.0000003769 Informative Direct
Cellular Component (CC) nucleoplasm part 0.1462 Informative Inherited
Cellular Component (CC) transporter complex 0.07974 Informative Inherited
Cellular Component (CC) receptor complex 0.000000000000001616 Highly Informative Direct
Cellular Component (CC) nuclear body 0.00000000003556 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.3417 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000376Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000007319Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1252Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1891Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6421Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00001907Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.06176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1206Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.1921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5058Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0007288InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0008187InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.009146InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.04565InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1021InformativeInherited
Mammalian Phenotype (MP)decreased heart rate0.0002501Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.0003486Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0005873Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001699Highly InformativeInherited
Mammalian Phenotype (MP)abnormal osteoblast cell number0.002858Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000004729Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0002946Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00825Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01311Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01409Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02826Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0008827Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0009283Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.01683Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.2344Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00001597InformativeDirect
Worm Phenotype (WP)oxygen response variant0.0001922InformativeDirect
Worm Phenotype (WP)body length variant0.00378InformativeInherited
Worm Phenotype (WP)body width variant0.004949InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.1986InformativeInherited
Worm Phenotype (WP)egg laying defective0.0000002188Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000001219Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.00000345Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.00001359Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002107Highly InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0003004Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0004512Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.05848Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.000008509Highly InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.001208Highly InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.4614Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.2088Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.41Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5386Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8792Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9557Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.08739Moderately InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.1371Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.3083Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0000271InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.001743InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.9206InformativeInherited
Xenopus ANatomical entity (XAN)tail1InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.000002184Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.00002341Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00003571Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.8099Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.943Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000001823InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000001009InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.00000000145Moderately InformativeDirect
Biological processVirulence0.000002988Moderately InformativeDirect
Biological processIon transport0.000003887Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis0.000000000005214InformativeDirect
Biological processAngiogenesis0.00001055InformativeDirect
Biological processSporulation0.0003839InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis0.000000001239Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.01344Least InformativeInherited
Cellular componentCell membrane0.000001651Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionNucleotide-binding0.01783Least InformativeInherited
Molecular functionFlavoprotein0.00000003942Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionPotassium9.917e-16InformativeDirect
Molecular functionFMN0.000000004811InformativeDirect
Molecular functioncAMP0.000002239Highly InformativeDirect
Post-translational modificationTransferase0.00000003372Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000002704Moderately InformativeDirect
Post-translational modificationRepressor0.0000005293Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalmodulin-binding0.000008019InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000006547Moderately InformativeDirect
Post-translational modificationHydroxylation0.000000000001351InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000005539Least InformativeDirect
UniPathway (UP)protein ubiquitination0.000000000008075Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]