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PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,782) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,947 251,567 30
Proteins 45,796 178,928 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.5146 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.6376 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) cell communication 0.00000000004593 Moderately Informative Direct
Biological Process (BP) signaling 0.000000008721 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000009118 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00008309 Moderately Informative Direct
Biological Process (BP) ion transport 0.00008875 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001425 Moderately Informative Direct
Biological Process (BP) nucleobase-containing compound biosynthetic process 0.0002312 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 0.2206 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8251 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8773 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.9792 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6013 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2804 Moderately Informative Inherited
Biological Process (BP) system development 0.1269 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.1927 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.844 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.04959 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.01463 Moderately Informative Inherited
Biological Process (BP) gene expression 0.3258 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.7335 Moderately Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00000000000008501 Informative Direct
Biological Process (BP) transcription, DNA-templated 0.000000003863 Informative Direct
Biological Process (BP) regulation of hormone levels 0.000000007996 Informative Direct
Biological Process (BP) behavior 0.000000741 Informative Direct
Biological Process (BP) single organism reproductive process 0.0000131 Informative Direct
Biological Process (BP) metal ion transport 0.00004157 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00004511 Informative Direct
Biological Process (BP) response to radiation 0.00006221 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.000698 Informative Direct
Biological Process (BP) locomotion 0.0009577 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.2532 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.3921 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.6633 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.7646 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.01675 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.0457 Informative Inherited
Biological Process (BP) transmembrane transport 0.04022 Informative Inherited
Biological Process (BP) generation of neurons 0.05814 Informative Inherited
Biological Process (BP) cell death 0.1302 Informative Inherited
Biological Process (BP) regulation of ion transport 0.007357 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2301 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.009548 Informative Inherited
Biological Process (BP) regulation of secretion 0.003223 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) reproductive system development 0.001604 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.2389 Informative Inherited
Biological Process (BP) phosphorylation 0.12 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.004278 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001743 Informative Inherited
Biological Process (BP) response to inorganic substance 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.7741 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3217 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.4624 Informative Inherited
Biological Process (BP) central nervous system development 0.1817 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.5925 Informative Inherited
Biological Process (BP) proteolysis 0.1214 Informative Inherited
Biological Process (BP) microtubule-based process 0.6274 Informative Inherited
Biological Process (BP) post-embryonic development 0.9143 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.7469 Informative Inherited
Biological Process (BP) system process 0.04083 Informative Inherited
Biological Process (BP) animal organ morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.1266 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.03645 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.006085 Informative Inherited
Biological Process (BP) regulation of system process 0.0715 Informative Inherited
Biological Process (BP) embryo development 0.9437 Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.00000000000006292 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0000000000001344 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000000003046 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00000001186 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.00000005027 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0.0000001179 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0.00001888 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00002263 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00002915 Highly Informative Direct
Biological Process (BP) cellular response to xenobiotic stimulus 0.0000317 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00004641 Highly Informative Direct
Biological Process (BP) single-organism behavior 0.0003977 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0005118 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.04574 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.00912 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 0.006466 Highly Informative Inherited
Biological Process (BP) response to red or far red light 0.09178 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.6467 Highly Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 1 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.02438 Highly Informative Inherited
Biological Process (BP) synaptic signaling 0.1774 Highly Informative Inherited
Biological Process (BP) apoptotic process 0.01191 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.1646 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.04848 Highly Informative Inherited
Biological Process (BP) pattern specification process 0.5056 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.8532 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.01531 Highly Informative Inherited
Biological Process (BP) appendage development 0.1038 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.001628 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2248 Highly Informative Inherited
Biological Process (BP) brain development 0.02502 Highly Informative Inherited
Biological Process (BP) histone modification 0.009677 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.2174 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.1055 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1275 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.03698 Highly Informative Inherited
Biological Process (BP) aging 0.09005 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.1245 Highly Informative Inherited
Biological Process (BP) cell migration 0.6754 Highly Informative Inherited
Biological Process (BP) germ cell development 0.8851 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.8977 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.065 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.0002652 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000009411 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.000000004792 Moderately Informative Direct
Molecular Function (MF) protein binding 0.154 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.1917 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.2758 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000000002969 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000000001995 Informative Direct
Molecular Function (MF) passive transmembrane transporter activity 0.00000000003761 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0000754 Informative Direct
Molecular Function (MF) kinase activity 0.0003722 Informative Direct
Molecular Function (MF) receptor binding 0.0007785 Informative Direct
Molecular Function (MF) enzyme binding 0.035 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.2983 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.002025 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.03148 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0.000000000002095 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.00000000649 Highly Informative Direct
Molecular Function (MF) chromatin binding 0.000004812 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 0.00001032 Highly Informative Direct
Molecular Function (MF) gated channel activity 0.0001159 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.0001836 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.001148 Highly Informative Inherited
Cellular Component (CC) protein complex 0.000000007249 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000002366 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.03525 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0437 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.2406 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein granule 0.0000001226 Informative Direct
Cellular Component (CC) transporter complex 0.05305 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.2012 Informative Inherited
Cellular Component (CC) receptor complex 0.00000000000000601 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.2595 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000376Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000007319Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.1666Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1829Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6667Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.00001718Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.427Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0004736InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.000826InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.007865InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.04763InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1251InformativeInherited
Mammalian Phenotype (MP)decreased heart rate0.0002366Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.0004294Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001972Highly InformativeInherited
Mammalian Phenotype (MP)abnormal osteoblast cell number0.003023Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000003092Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0002887Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.007834Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01046Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01195Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02388Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.001057Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.01652Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.00001565InformativeDirect
Worm Phenotype (WP)body length variant0.003704InformativeInherited
Worm Phenotype (WP)body width variant0.004915InformativeInherited
Worm Phenotype (WP)egg laying defective0.0000002086Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000001203Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000003059Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.000009406Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0002085Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.04942Moderately InformativeInherited
Fly Phenotype (FP)sleep defective0.000007002Highly InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.001145Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.01934Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.06094Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.7149Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8166Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8532Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.000664Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.166Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3167Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.3441Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0004795InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0007937InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.001147InformativeInherited
Xenopus ANatomical entity (XAN)skeletal muscle0.1319InformativeInherited
Xenopus ANatomical entity (XAN)kidney0.245InformativeInherited
Xenopus ANatomical entity (XAN)tail0.973InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.0000006908Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.000007344Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.00001117Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.0004831Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.6039Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.9346Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00000000352InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000009251InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0.0003888Least InformativeDirect
Drugbank ATC_code (DB)sensory organs0.0006072Least InformativeDirect
Drugbank ATC_code (DB)antiinfectives for systemic use0.02647Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism0.2067Least InformativeInherited
Drugbank ATC_code (DB)stomatological preparations0.0007002Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.003952Moderately InformativeInherited
Drugbank ATC_code (DB)otologicals0.02057Moderately InformativeInherited
Drugbank ATC_code (DB)cardiac therapy0.02214Moderately InformativeInherited
Drugbank ATC_code (DB)dermatologicals0.03836Moderately InformativeInherited
Drugbank ATC_code (DB)alpha-adrenoreceptor antagonists0.00000008447InformativeDirect
Drugbank ATC_code (DB)miconazole0.000000792InformativeDirect
Drugbank ATC_code (DB)imidazole derivatives0.000000792InformativeDirect
Drugbank ATC_code (DB)miconazole0.000000792InformativeDirect
Drugbank ATC_code (DB)miconazole0.000000792InformativeDirect
Drugbank ATC_code (DB)miconazole0.000000792InformativeDirect
Drugbank ATC_code (DB)miconazole0.000000792InformativeDirect
Drugbank ATC_code (DB)antiadrenergic agents, peripherally acting0.000001897InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0.3011InformativeInherited
Drugbank ATC_code (DB)antihistamines for systemic use1InformativeInherited
Drugbank ATC_code (DB)ibutilide0.0000003807Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processDifferentiation0.000000001008Moderately InformativeDirect
Biological processVirulence0.000002858Moderately InformativeDirect
Biological processIon transport0.000003723Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis0.000000000004578InformativeDirect
Biological processAngiogenesis0.0000102InformativeDirect
Biological processSporulation0.0003916InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis0.00000000132Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.01331Least InformativeInherited
Cellular componentCell membrane0.0000861Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.2536Least InformativeInherited
Molecular functionATP-binding0.0000001181Moderately InformativeDirect
Molecular functionPotassium0.00000000000000962InformativeDirect
Molecular functionFMN0.000000004513InformativeDirect
Molecular functionCalmodulin-binding0.00002454InformativeDirect
Post-translational modificationTransferase0.000000004897Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000001797Moderately InformativeDirect
Post-translational modificationRepressor0.000001547Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000000000665Moderately InformativeDirect
Post-translational modificationHydroxylation0.000000000001359InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000005535Least InformativeDirect
UniPathway (UP)protein ubiquitination0.000000000007736Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]