SUPERFAMILY 1.75 HMM library and genome assignments server


PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,780) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,864 251,567 30
Proteins 45,736 178,928 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 7.817e-12 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1.588e-10 Least Informative Direct
Biological Process (BP) developmental process 2.313e-06 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.616e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002025 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01732 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6658 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001898 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.7474 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3136 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.0976 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) reproduction 1.944e-15 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 7.696e-14 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 3.1e-13 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 9.997e-13 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 9.109e-12 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 2.026e-11 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 6.398e-11 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 9.983e-09 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.286e-06 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 8.656e-06 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 7.95e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0001417 Moderately Informative Direct
Biological Process (BP) gene expression 0.000194 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0006646 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.5178 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5728 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2359 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2246 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.05039 Moderately Informative Inherited
Biological Process (BP) system process 0.7254 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2834 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.9111 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.6342 Moderately Informative Inherited
Biological Process (BP) ion transport 0.01397 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4945 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02103 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.1601 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.2205 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.9461 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) gland development 1.248e-07 Informative Direct
Biological Process (BP) embryonic organ development 2.201e-06 Informative Direct
Biological Process (BP) metal ion transport 1.505e-05 Informative Direct
Biological Process (BP) locomotion 2.595e-05 Informative Direct
Biological Process (BP) reproductive system development 7.54e-05 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001068 Informative Direct
Biological Process (BP) tube development 0.0005381 Informative Direct
Biological Process (BP) regulation of cell development 0.001068 Informative Inherited
Biological Process (BP) generation of neurons 0.1163 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.02402 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.006445 Informative Inherited
Biological Process (BP) transmembrane transport 0.8238 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.4892 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001934 Informative Inherited
Biological Process (BP) epithelium development 0.175 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.0729 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04156 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.9859 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.03754 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.5882 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01148 Informative Inherited
Biological Process (BP) response to oxidative stress 0.001498 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) growth 0.1129 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.6544 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001743 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2857 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3457 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3967 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.005917 Informative Inherited
Biological Process (BP) chromosome organization 0.001954 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3346 Informative Inherited
Biological Process (BP) regulation of ion transport 0.00126 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.3813 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.443 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.8489 Informative Inherited
Biological Process (BP) microtubule-based process 0.9507 Informative Inherited
Biological Process (BP) single-organism behavior 0.1612 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.9551 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5732 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.002459 Informative Inherited
Biological Process (BP) proteolysis 0.149 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of system process 0.447 Informative Inherited
Biological Process (BP) cellular component movement 0.278 Informative Inherited
Biological Process (BP) localization of cell 0.01945 Informative Inherited
Biological Process (BP) defense response 1 Informative Inherited
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 3.77e-15 Highly Informative Direct
Biological Process (BP) placenta development 1.091e-14 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 5.114e-13 Highly Informative Direct
Biological Process (BP) circadian rhythm 1.07e-12 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 3.139e-10 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 9.631e-10 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 7.584e-09 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 1.174e-08 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 1.26e-08 Highly Informative Direct
Biological Process (BP) lactate metabolic process 4.26e-08 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 5.58e-08 Highly Informative Direct
Biological Process (BP) regulation of proton transport 2.143e-06 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 2.504e-06 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 7.171e-06 Highly Informative Direct
Biological Process (BP) spermatogenesis 2.346e-05 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 2.539e-05 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 2.641e-05 Highly Informative Direct
Biological Process (BP) protein deacylation 3.224e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0001139 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0001147 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001713 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.0001912 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0002937 Highly Informative Direct
Biological Process (BP) histone modification 0.000691 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.0008484 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.2538 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.0736 Highly Informative Inherited
Biological Process (BP) developmental growth 0.00357 Highly Informative Inherited
Biological Process (BP) cell growth 0.2131 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.5527 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.778 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.01432 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.03373 Highly Informative Inherited
Biological Process (BP) ion transmembrane transport 0.2658 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.04681 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.7395 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.2638 Highly Informative Inherited
Biological Process (BP) axon development 0.4541 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 0.001701 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.05428 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.03137 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.7435 Highly Informative Inherited
Biological Process (BP) regulation of behavior 0.04863 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6238 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.01182 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.009695 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.238 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.01839 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.004748 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.01979 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.01095 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.4204 Highly Informative Inherited
Biological Process (BP) learning or memory 0.1166 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.01142 Highly Informative Inherited
Biological Process (BP) aging 0.04437 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.06181 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 1.934e-05 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 3.881e-09 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 4.679e-06 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.01233 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.2063 Moderately Informative Inherited
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 2.159e-09 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 4.147e-07 Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 5.198e-06 Informative Direct
Molecular Function (MF) chromatin binding 2.361e-05 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0002582 Informative Direct
Molecular Function (MF) enzyme binding 0.002712 Informative Inherited
Molecular Function (MF) receptor binding 0.002444 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1755 Informative Inherited
Molecular Function (MF) kinase activity 0.01295 Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.202e-12 Highly Informative Direct
Molecular Function (MF) cation channel activity 5.488e-11 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 8.792e-09 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 1.008e-08 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 2.857e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1.926e-12 Least Informative Direct
Cellular Component (CC) protein complex 3.378e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2387 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0001774 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 0.2714 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 0.5345 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 2.344e-10 Informative Direct
Cellular Component (CC) integral to membrane 0.3956 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.5382 Informative Inherited
Cellular Component (CC) ion channel complex 0.022 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.03907 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.4904 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases3.76e-08Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups7.319e-06Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2286Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3729Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level9.047e-06Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.07692Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1154Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.125Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.2202Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.247Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5703Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0001112InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0008566InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.006262InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.04772InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1431InformativeInherited
Mammalian Phenotype (MP)abnormal circadian period2.076e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level5.634e-06Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0001488Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001082Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.003349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01293Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.008651Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant8.312e-06InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying defective1.563e-07Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant1.584e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.03888InformativeInherited
Fly Phenotype (FP)sleep defective3.475e-06Highly InformativeDirect
Fly Phenotype (FP)gravitaxis defective0.0005111Highly InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.000688Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.9395Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.2977Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.307Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0001922InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003722InformativeDirect
Xenopus ANatomical entity (XAN)tail0.9163InformativeInherited
Xenopus ANatomical entity (XAN)trunk somite1.499e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens1.521e-05Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0004773Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2997Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.8477Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases2.765e-09InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase4.758e-07InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processIon transport3.024e-06Moderately InformativeDirect
Biological processDifferentiation4.995e-06Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis1.035e-07InformativeDirect
Biological processVirulence8.205e-07InformativeDirect
Biological processSporulation0.0002235InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis7.429e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.003936Least InformativeInherited
Cellular componentCell membrane0.0002044Moderately InformativeDirect
Cellular componentChromosome0.0002727InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionNucleotide-binding0.3313Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionATP-binding2.702e-08Moderately InformativeDirect
Molecular functionFlavoprotein1.706e-07Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionPotassium6.939e-16InformativeDirect
Molecular functionFMN1.537e-10InformativeDirect
Molecular functionCalmodulin-binding2.48e-05InformativeDirect
Post-translational modificationTransferase9.902e-09Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein2.475e-07Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond4.795e-13Moderately InformativeDirect
Post-translational modificationHydroxylation1.197e-11InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism5.037e-07Least InformativeDirect
UniPathway (UP)protein ubiquitination5.863e-12Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]