SUPERFAMILY 1.75 HMM library and genome assignments server

PYP-like sensor domain (PAS domain) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Families:   PYP-like [ 55786] (2)
  Heme-binding PAS domain [ 55789] (2)
  Flavin-binding PAS domain [ 88853] (3)
  N-terminal PAS domain of Pas kinase [ 82764]
  Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]
  PAS domain of steroid receptor coactivator 1A, NCo-A1 [ 103187]
  BphP N-terminal domain-like [ 160669] (3)


Superfamily statistics
Genomes (2,781) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 70,947 251,567 30
Proteins 45,797 178,928 30


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000000008602 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000000001093 Least Informative Direct
Biological Process (BP) developmental process 0.000002988 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00001898 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.02791 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.01691 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.003403 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8678 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8123 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1337 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7346 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3369 Least Informative Inherited
Biological Process (BP) reproductive process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000000000000226 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00000000000006789 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0000000000002226 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000000000004808 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000000001819 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000005905 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000000002502 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000009493 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000000009108 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00001346 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000862 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0001798 Moderately Informative Direct
Biological Process (BP) gene expression 0.0004076 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0006605 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0009944 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.5151 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8055 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.2226 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02028 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6523 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02024 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4812 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3189 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.8879 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1613 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7205 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3619 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1002 Moderately Informative Inherited
Biological Process (BP) ion transport 0.03353 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.2058 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3682 Moderately Informative Inherited
Biological Process (BP) defense response 1 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-templated 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) response to light stimulus 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.00000000000001587 Informative Direct
Biological Process (BP) phosphorylation 0.000000000001013 Informative Direct
Biological Process (BP) reproductive structure development 0.0000000003365 Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00000005003 Informative Direct
Biological Process (BP) embryonic organ development 0.00000772 Informative Direct
Biological Process (BP) single-organism behavior 0.000007768 Informative Direct
Biological Process (BP) gland development 0.00001019 Informative Direct
Biological Process (BP) metal ion transport 0.00001699 Informative Direct
Biological Process (BP) locomotion 0.00003501 Informative Direct
Biological Process (BP) regulation of cell development 0.0003398 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.0005069 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.811 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 0.1205 Informative Inherited
Biological Process (BP) regulation of secretion 0.02851 Informative Inherited
Biological Process (BP) regulation of system process 0.03841 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) response to oxidative stress 0.00203 Informative Inherited
Biological Process (BP) ion transmembrane transport 0.6804 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.5969 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.001817 Informative Inherited
Biological Process (BP) tube development 0.007198 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.1269 Informative Inherited
Biological Process (BP) regulation of ion transport 0.001484 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.002889 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.04545 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) growth 0.1379 Informative Inherited
Biological Process (BP) positive regulation of developmental process 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.8196 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.05045 Informative Inherited
Biological Process (BP) proteolysis 0.1556 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.001559 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.37 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.7743 Informative Inherited
Biological Process (BP) microtubule-based process 0.7506 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.007009 Informative Inherited
Biological Process (BP) chromosome organization 0.002327 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.4076 Informative Inherited
Biological Process (BP) protein catabolic process 0.00271 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2978 Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.3393 Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0.435 Informative Inherited
Biological Process (BP) cellular carbohydrate metabolic process 0.8566 Informative Inherited
Biological Process (BP) neurological system process 0.02366 Informative Inherited
Biological Process (BP) cellular component movement 0.06711 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.5336 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8704 Informative Inherited
Biological Process (BP) sexual reproduction 0.02832 Informative Inherited
Biological Process (BP) cardiovascular system development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 1 Informative Inherited
Biological Process (BP) epithelium development 0.007243 Informative Inherited
Biological Process (BP) localization of cell 0.02274 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.04691 Informative Inherited
Biological Process (BP) response to hypoxia 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0.00000000000002089 Highly Informative Direct
Biological Process (BP) placenta development 0.0000000000001023 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.000000000005632 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.00000000004265 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.000000001307 Highly Informative Direct
Biological Process (BP) xenobiotic metabolic process 0.0000000129 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0.00000001307 Highly Informative Direct
Biological Process (BP) lactate metabolic process 0.00000004749 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.000000111 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.000000143 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0000005473 Highly Informative Direct
Biological Process (BP) histone modification 0.000001133 Highly Informative Direct
Biological Process (BP) regulation of proton transport 0.000001288 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.000002545 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0.00001109 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00001407 Highly Informative Direct
Biological Process (BP) negative regulation of hormone metabolic process 0.00001563 Highly Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.00002626 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.00003105 Highly Informative Direct
Biological Process (BP) protein deacylation 0.00003158 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.00005379 Highly Informative Direct
Biological Process (BP) in utero embryonic development 0.00007722 Highly Informative Direct
Biological Process (BP) columnar/cuboidal epithelial cell differentiation 0.00007728 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.0001674 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0002111 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0002391 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002656 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1495 Highly Informative Inherited
Biological Process (BP) developmental growth 0.00698 Highly Informative Inherited
Biological Process (BP) cell growth 0.1171 Highly Informative Inherited
Biological Process (BP) neuron projection development 0.5407 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.5785 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.7228 Highly Informative Inherited
Biological Process (BP) aging 0.07007 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid biosynthetic process 0.02189 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.008937 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.8675 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.08938 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3613 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.02599 Highly Informative Inherited
Biological Process (BP) positive regulation of homeostatic process 0.1124 Highly Informative Inherited
Biological Process (BP) regulation of myeloid cell differentiation 0.0301 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.001312 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.6869 Highly Informative Inherited
Biological Process (BP) respiratory system development 0.01064 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.01141 Highly Informative Inherited
Biological Process (BP) learning or memory 0.03224 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.3137 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.252 Highly Informative Inherited
Biological Process (BP) peptidyl-lysine modification 0.004353 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.01113 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.2045 Highly Informative Inherited
Biological Process (BP) cellular polysaccharide biosynthetic process 0.4216 Highly Informative Inherited
Biological Process (BP) germ cell development 0.963 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.06305 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.006515 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) transferase activity 0.000256 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000004663 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00000005171 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.004233 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.2141 Moderately Informative Inherited
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0000000003153 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000002721 Informative Direct
Molecular Function (MF) chromatin binding 0.00002976 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.0001733 Informative Direct
Molecular Function (MF) enzyme binding 0.003364 Informative Inherited
Molecular Function (MF) receptor binding 0.002368 Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0.1288 Informative Inherited
Molecular Function (MF) kinase activity 0.009701 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.000000000001006 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.00000000006783 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0000001687 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.000036 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 1 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.002723 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000723 Least Informative Direct
Cellular Component (CC) protein complex 0.00005644 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0008889 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.9428 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.5604 Moderately Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.2704 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 1 Moderately Informative Inherited
Cellular Component (CC) transporter complex 0.1591 Informative Inherited
Cellular Component (CC) integral component of membrane 0.4223 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.5409 Informative Inherited
Cellular Component (CC) cytoplasmic ribonucleoprotein granule 0.000000002041 Highly Informative Direct
Cellular Component (CC) ion channel complex 0.005947 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.0455 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.4256 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.4681Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000376Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000007319Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.7839Moderately InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)3',5'-cyclic-nucleotide phosphodiesterase0.0001609Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.1432Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3309Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6899Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.000009718Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.07586Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.09864Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1171Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5392Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0002958InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0007696InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.006106InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02503InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.04956InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.1417InformativeInherited
Mammalian Phenotype (MP)abnormal circadian period0.0000001691Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00000517Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0001624Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.001166Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.003349Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01293Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.008651Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0.000008312InformativeDirect
Worm Phenotype (WP)body length variant0.001979InformativeInherited
Worm Phenotype (WP)body width variant0.002389InformativeInherited
Worm Phenotype (WP)egg laying defective0.0000001563Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000001584Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.04082InformativeInherited
Fly Phenotype (FP)sleep defective0.000003425Highly InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.001158Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.942Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)visual system0.2998Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.3113Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0002009InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003893InformativeDirect
Xenopus ANatomical entity (XAN)tail0.9167InformativeInherited
Xenopus ANatomical entity (XAN)trunk somite0.00001499Highly InformativeDirect
Xenopus ANatomical entity (XAN)lens0.00001586Highly InformativeDirect
Xenopus ANatomical entity (XAN)retina0.0004859Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2981Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.8479Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000002712InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000004823InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)sensory organs0.000523Least InformativeDirect
Drugbank ATC_code (DB)cardiovascular system0.0005468Least InformativeDirect
Drugbank ATC_code (DB)antiinfectives for systemic use0.01772Least InformativeInherited
Drugbank ATC_code (DB)alimentary tract and metabolism0.3914Least InformativeInherited
Drugbank ATC_code (DB)stomatological preparations0.0006081Moderately InformativeDirect
Drugbank ATC_code (DB)genito urinary system and sex hormones0.003612Moderately InformativeInherited
Drugbank ATC_code (DB)cardiac therapy0.02811Moderately InformativeInherited
Drugbank ATC_code (DB)antifungals for topical use1Moderately InformativeInherited
Drugbank ATC_code (DB)alpha-adrenoreceptor antagonists0.00000007314InformativeDirect
Drugbank ATC_code (DB)miconazole0.0000006741InformativeDirect
Drugbank ATC_code (DB)imidazole derivatives0.0000006741InformativeDirect
Drugbank ATC_code (DB)miconazole0.0000006741InformativeDirect
Drugbank ATC_code (DB)miconazole0.0000006741InformativeDirect
Drugbank ATC_code (DB)miconazole0.0000006741InformativeDirect
Drugbank ATC_code (DB)miconazole0.0000006741InformativeDirect
Drugbank ATC_code (DB)antiadrenergic agents, peripherally acting0.000001618InformativeDirect
Drugbank ATC_code (DB)antiarrhythmics, class iii0.1439InformativeInherited
Drugbank ATC_code (DB)antihistamines for systemic use1InformativeInherited
Drugbank ATC_code (DB)ibutilide0.0000003302Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processTranscription regulation0Moderately InformativeDirect
Biological processIon transport0.00000306Moderately InformativeDirect
Biological processDifferentiation0.000005481Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processNeurogenesis0.0000001075InformativeDirect
Biological processVirulence0.0000008228InformativeDirect
Biological processSporulation0.0002229InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGluconeogenesis0.0000000000739Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.004569Least InformativeInherited
Cellular componentCell membrane0.0002205Moderately InformativeDirect
Cellular componentChromosome0.000281InformativeDirect
DomainRepeat0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.3186Least InformativeInherited
Molecular functionATP-binding0.00000002713Moderately InformativeDirect
Molecular functionFlavoprotein0.0000001662Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionPotassium6.918e-16InformativeDirect
Molecular functionFMN0.0000000001549InformativeDirect
Molecular functionCalmodulin-binding0.0000243InformativeDirect
Post-translational modificationTransferase0.000000009828Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.0000002416Moderately InformativeDirect
Post-translational modificationRepressor0.0001025Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000000000005765Moderately InformativeDirect
Post-translational modificationHydroxylation0.00000000001167InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.000000504Least InformativeDirect
UniPathway (UP)protein ubiquitination0.000000000005968Moderately InformativeDirect

Document: UP annotation of SCOP domains

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 16 hidden Markov models representing the PYP-like sensor domain (PAS domain) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]