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Nudix superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Information |
| Detailed category | DNA replication/repair |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR015797 SSF55811 Protein matches |
| Abstract | MutT is a small bacterial protein (~12-15Kd) involved in the GO system [ 1328155]
responsible for removing an oxidatively damaged form of guanine (8-hydroxy-
guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool.
8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A-T to G-C transversions. MutT
specifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant
release of pyrophosphate. A short conserved N-terminal region of mutT
(designated the MutT domain) is also found in a variety of other
prokaryotic, viral and eukaryotic proteins [8233837, 8170394, 8226881, 10373642].
The generic name `NUDIX hydrolases' (NUcleoside DIphosphate linked
to some other moiety X) has been coined for this domain family [8810257]. The
family can be divided into a number of subgroups, of which MutT anti-
mutagenic activity represents only one type; most of the rest hydrolyse
diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP-
mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 31 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Nudix domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 31 hidden Markov models representing the Nudix superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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