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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03154Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.06594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1202Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2374Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2465Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3328Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3618Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4373Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4924Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5266Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6041Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.002289Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02536Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.02882Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.05189Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.07714Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.11Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1781Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2116Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2176Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2528Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the glial cells0.00008667InformativeDirect
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.00009737InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.0003987InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002179InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.002192InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pituitary gland0.002348InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004591InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0105InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.01208InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.02338InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03734InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.05701InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06724InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.08282InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.09103InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1033InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.2154InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4158InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the gastrointestinal tract0.4174InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000003666Highly InformativeDirect
Phenotypic Abnormality (PA)Glioblastoma multiforme0.000000005875Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.00000006726Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000001125Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0000001187Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0000006743Highly InformativeDirect
Phenotypic Abnormality (PA)Peripheral primitive neuroectodermal neoplasm0.0000006743Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.0000007929Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000002059Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000002763Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.00000351Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.000004405Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.00001162Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001166Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001166Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.00002206Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002423Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00004112Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00005638Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0001149Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of creatine metabolism0.0001199Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.0001258Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0001323Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0004483Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0006228Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.003195Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.009758Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.03591Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.1281Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04399Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03822Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01771InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01838InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.000213Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0002193Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004414Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004886Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005616InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001171Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0007622Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]