SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04116Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.08599Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1653Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2684Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3264Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3764Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5016Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5378Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5445Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.0008451Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.03285Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.03447Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.06239Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.08539Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1448Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1461Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.152Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1931Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2272Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3022Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3134Moderately InformativeInherited
Phenotypic Abnormality (PA)Gonadal neoplasm0.00007226InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0001246InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.000329InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.001671InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.002406InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.003513InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004929InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.01981InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.02143InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.02464InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.04104InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.04558InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06782InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.07881InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1956InformativeInherited
Phenotypic Abnormality (PA)Agnosia0.0000001195Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000002058Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.0000003026Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000001106Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastoma0.000001106Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000002448Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00000375Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000006325Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000006808Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001251Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001575Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00003222Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.00003837Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00003837Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00006482Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00006851Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the pancreas0.0002034Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0006724Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.0009489Highly InformativeDirect
Phenotypic Abnormality (PA)Headache0.004169Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.004973Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.01855Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.04419Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.05337Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.125Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04389Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3309Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01769InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01836InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0002128Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.000219Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004409Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004884Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.2579Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.009172Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0.0009104InformativeDirect
Worm Phenotype (WP)dauer development variant0.000117Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0007859Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases altering macromolecular conformation0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]