SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.008153Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05884Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.09659Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.1561Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1566Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1928Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2158Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2951Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6152Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6208Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.01396Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01434Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.02761Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.09163Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.0929Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1274Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.1593Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1596Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2252Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.2588Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4029Moderately InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4062Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.5545Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.00004378InformativeDirect
Phenotypic Abnormality (PA)Constitutional symptom0.001817InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.0024InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.005381InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.00567InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hypothalamus-pituitary axis0.0117InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.01332InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.0151InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.02295InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.02713InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.04033InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.04817InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.05684InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06075InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.0855InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1732InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.1944InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.4592InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000001944Highly InformativeDirect
Phenotypic Abnormality (PA)Glioblastoma multiforme0.000000003099Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.00000003548Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.00000005964Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0000001352Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0000003649Highly InformativeDirect
Phenotypic Abnormality (PA)Peripheral primitive neuroectodermal neoplasm0.0000003649Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.0000004303Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000001523Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000001931Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.000002412Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000002651Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.000006515Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.000006515Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.0000125Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.00001284Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.0000214Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.0000231Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002398Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00003028Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.00005075Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.00007736Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of creatine metabolism0.0001274Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0002572Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0004421Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.0006581Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.0006945Highly InformativeDirect
Phenotypic Abnormality (PA)Anxiety0.0009545Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0009545Highly InformativeDirect
Phenotypic Abnormality (PA)Limb muscle weakness0.002222Highly InformativeInherited
Phenotypic Abnormality (PA)Short attention span0.00353Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.004306Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.03415Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.1308Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04403Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01772InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01838InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0002132Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0002195Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004415Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004887Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0005616InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001171Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0007305Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]