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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04838Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1756Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2856Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3387Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5041Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5408Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.635Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.03578Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.03593Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.06633Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.09828Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1636Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1792Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1923Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2505Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2709Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.6573Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0001692InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.0003713InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.001684InformativeInherited
Phenotypic Abnormality (PA)Anorectal anomaly0.002009InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.002164InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002381InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.004011InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004743InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.02213InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.02569InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03249InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.04799InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.05796InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.05946InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.07738InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1561InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000008379Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.00000007008Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.0000001394Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000001715Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.0000005907Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastoma0.0000009226Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000001058Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000001662Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000003488Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.00000386Highly InformativeDirect
Phenotypic Abnormality (PA)Endometrial carcinoma0.000005641Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000007517Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001333Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001656Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.0000365Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.00003661Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00007139Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00007898Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.000143Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0006111Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pyramidal sign0.0006884Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.0009825Highly InformativeDirect
Phenotypic Abnormality (PA)Headache0.006959Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02743Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.06763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.2224Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.002302InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.002896InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.004834InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.005082InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.0291InformativeInherited
Mammalian Phenotype (MP)abnormal male meiosis0.000007344Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0002686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.0008074Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.0009184Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)dauer development variant0.0004608Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.001342Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases altering macromolecular conformation0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Adenosinetriphosphatase0.0001845Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]