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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.0468Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.08166Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1774Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2778Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.33Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4066Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4975Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.5284Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5515Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.005327Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.03393Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.03527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.06482Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.0955Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1547Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1558Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1745Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1896Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.2478Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2605Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.656Moderately InformativeInherited
Phenotypic Abnormality (PA)Gonadal neoplasm0.00007079InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0001701InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.0003932InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.001586InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.002224InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.003614InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004679InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.02216InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.02488InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03279InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.04171InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.04651InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.05397InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.07531InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.08122InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1506InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000008716Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.00000007281Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.0000001447Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000001776Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.000000614Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000001098Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastoma0.000001098Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000001773Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000003614Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000004371Highly InformativeDirect
Phenotypic Abnormality (PA)Endometrial carcinoma0.000005791Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000007779Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001383Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001606Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002924Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.00003819Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00003903Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00006383Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00007835Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0006223Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal pyramidal sign0.0007012Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.0009776Highly InformativeDirect
Phenotypic Abnormality (PA)Headache0.006511Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.04598Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02744Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.06766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.2223Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal male reproductive gland morphology0.002302InformativeInherited
Mammalian Phenotype (MP)abnormal internal male genitalia morphology0.002898InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.004834InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.005083InformativeInherited
Mammalian Phenotype (MP)abnormal sex determination0.0291InformativeInherited
Mammalian Phenotype (MP)abnormal male meiosis0.000007347Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0002687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.000808Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.000919Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0107Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0002574Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0003913Moderately InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001867Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003113Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0009123Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases altering macromolecular conformation0InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect
Enzyme Commission (EC)Adenosinetriphosphatase0.0001793Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]