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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03212Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.06747Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1215Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1418Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2359Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2576Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3185Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4504Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.482Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6245Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.02622Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.02916Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.05169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.07494Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1113Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1999Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2109Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2321Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2703Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.2977Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.0001027InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.0001201InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pancreas0.001991InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002202InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.002357InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pituitary gland0.002812InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004472InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.0112InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.01498InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03669InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.03895InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.04362InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06398InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.08066InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.184InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4117InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000003309Highly InformativeDirect
Phenotypic Abnormality (PA)Glioblastoma multiforme0.000000005276Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.00000006016Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.00000007686Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000001009Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the rectum0.000000161Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0000006062Highly InformativeDirect
Phenotypic Abnormality (PA)Peripheral primitive neuroectodermal neoplasm0.0000006062Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.0000007131Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000001756Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000002493Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000003165Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.000003971Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000005991Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001143Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001143Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002369Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00003606Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00004814Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00005102Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.000109Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of creatine metabolism0.0001104Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0001324Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.0003418Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0004089Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0005553Highly InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.0006433Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.003816Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperactivity0.01053Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.1076Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04399Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03822Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01771InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01839InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0002131Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0002194Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004415Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004887Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.2641Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.009483Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0.0009438InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001143Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00079Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]