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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 98,487 675,695 56
Proteins 97,410 671,107 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)macromolecule metabolic process0.000011380.00000004184Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.0000025810.01137Least InformativeInherited
Biological Process (BP)primary metabolic process0.0024270.02652Least InformativeInherited
Biological Process (BP)response to stimulus0.0024580Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00000078640.01401Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0000008150.006514Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process0.0000031750.08561Least InformativeInherited
Biological Process (BP)cellular response to stress0.0000021620.05741Moderately InformativeInherited
Biological Process (BP)DNA metabolic process0.00000000046660InformativeDirect
Biological Process (BP)cellular response to DNA damage stimulus0.0000000000028960.2643InformativeInherited
Molecular Function (MF)binding0.031590.05975Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000031691Moderately InformativeInherited
Molecular Function (MF)DNA binding0.0000004210.01449InformativeInherited
Molecular Function (MF)transcription factor activity, transcription factor binding0.00000000000013690.3812Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000004184 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0.0001706 Least Informative Direct
Biological Process (BP) primary metabolic process 0.02652 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.08561 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01137 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006514 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01401 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000000001018 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.859 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3538 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.9234 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.9072 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.008363 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9229 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2895 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.05741 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) phosphorylation 0.000000000083 Informative Direct
Biological Process (BP) chromosome organization 0.0000003266 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.00002631 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.0003155 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.4252 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.6805 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.3366 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3079 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.02922 Informative Inherited
Biological Process (BP) cellular response to lipid 0.01035 Informative Inherited
Biological Process (BP) response to acid chemical 0.8034 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.1062 Informative Inherited
Biological Process (BP) organelle localization 0.4819 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) cell cycle process 0.08704 Informative Inherited
Biological Process (BP) single organism reproductive process 0.2118 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.3007 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.001405 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.05497 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.8871 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) cation homeostasis 0.4448 Informative Inherited
Biological Process (BP) inorganic ion homeostasis 0.4677 Informative Inherited
Biological Process (BP) organic acid transport 0.1325 Informative Inherited
Biological Process (BP) anion transport 0.04604 Informative Inherited
Biological Process (BP) cellular response to DNA damage stimulus 0.2643 Informative Inherited
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) response to estrogen 0 Highly Informative Direct
Biological Process (BP) response to antibiotic 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.0000000001281 Highly Informative Direct
Biological Process (BP) protein folding 0.000000006117 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0.00000009179 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.0000001264 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000002952 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000328 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000004297 Highly Informative Direct
Biological Process (BP) response to red or far red light 0.000005462 Highly Informative Direct
Biological Process (BP) response to fatty acid 0.00004798 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.00009664 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0002954 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0003259 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0.0003282 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0.0007604 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.1348 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.005069 Highly Informative Inherited
Biological Process (BP) cellular response to decreased oxygen levels 0.1441 Highly Informative Inherited
Biological Process (BP) response to hypoxia 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.007915 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.5146 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.001534 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.1121 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.3929 Highly Informative Inherited
Biological Process (BP) nuclear chromosome segregation 0.03603 Highly Informative Inherited
Biological Process (BP) cellular protein catabolic process 0.78 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.8197 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.7802 Highly Informative Inherited
Biological Process (BP) regulation of protein catabolic process 0.008178 Highly Informative Inherited
Biological Process (BP) regeneration 0.05181 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.2016 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.04024 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.8061 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.3214 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.07561 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.8977 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.05975 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.6432 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000000008098 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0.00000000004045 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000002891 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.9215 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.9639 Moderately Informative Inherited
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine nucleotide binding 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) ATPase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000003836 Informative Direct
Molecular Function (MF) magnesium ion binding 0.0008469 Informative Direct
Molecular Function (MF) enzyme binding 0.6191 Informative Inherited
Molecular Function (MF) DNA binding 0.01449 Informative Inherited
Molecular Function (MF) phosphatase activity 0.006233 Informative Inherited
Molecular Function (MF) nuclease activity 0.05802 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.000000000000001615 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0001027 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.0008105 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01903 Highly Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.3812 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000000002526 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.4664 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.00006059 Informative Direct
Cellular Component (CC) chromosome 0.009849 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.147 Highly Informative Inherited
Cellular Component (CC) receptor complex 0.006014 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processVirulence0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processNitrogen fixation0.0000000004535InformativeDirect
Biological processDNA repair0.000003022InformativeDirect
Biological processAntibiotic resistance0.000008143InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Biological processGlucose metabolism0.000000000000005203Highly InformativeDirect
Cellular componentMembrane0.000000001721Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002387Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.000003786InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000001337Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase4.413e-16InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation0.00001643InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]