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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 889,836 56
Proteins 97,410 883,733 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03225Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.06976Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1528Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2376Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.2607Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3229Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4634Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5069Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.514Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.0009048Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.0264Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.02938Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.05326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.07709Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1086Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1248Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.211Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2444Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2776Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.3082Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the glial cells0.00009276InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.0009502InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.001385InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.002134InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002348InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.002967InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.004256InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.01706InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01905InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03686InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.03895InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0394InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06583InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.08483InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1859InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.4308InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000003285Highly InformativeDirect
Phenotypic Abnormality (PA)Glioblastoma multiforme0.000000005247Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.00000007104Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.0000001002Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.0000001002Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0000007109Highly InformativeDirect
Phenotypic Abnormality (PA)Peripheral primitive neuroectodermal neoplasm0.0000007109Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the rectum0.0000007109Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000001126Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000001891Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000003138Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.0000044Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.0000044Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.000005544Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.00001131Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.00001336Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002315Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00003522Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.00004749Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00006747Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0001127Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0001368Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.000405Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0006703Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.000719Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.000999Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.01509Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.1188Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04399Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03822Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01771InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01839InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0002131Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0002194Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004415Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004887Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.2579Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.009141Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0.0009048InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001169Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0007828Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 50 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]