SUPERFAMILY 1.75 HMM library and genome assignments server


ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (2,481) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 75,346 244,773 56
Proteins 74,465 243,359 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus8.493e-070Least InformativeDirect
Biological Process (BP)single-organism cellular process6.884e-051.27e-10Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process3.93e-060.08695Least InformativeInherited
Biological Process (BP)heterocycle metabolic process4.404e-051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process5.138e-051Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.00011170.3638Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00019481Least InformativeInherited
Biological Process (BP)cellular response to stress0.00016733.988e-05Moderately InformativeDirect
Biological Process (BP)DNA metabolic process5.915e-096.042e-12InformativeDirect
Biological Process (BP)response to DNA damage stimulus4.567e-140.08977InformativeInherited
Biological Process (BP)DNA repair02.423e-05Highly InformativeDirect
Molecular Function (MF)binding1.327e-051.364e-06Least InformativeDirect
Molecular Function (MF)heterocyclic compound binding0.018710.0001043Moderately InformativeInherited
Molecular Function (MF)organic cyclic compound binding0.024750.0001913Moderately InformativeInherited
Molecular Function (MF)DNA binding3.54e-092.433e-06InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.27e-10 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0008449 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001196 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3638 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.08695 Least Informative Inherited
Biological Process (BP) cellular response to stress 3.988e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.3765 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.45 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8166 Moderately Informative Inherited
Biological Process (BP) reproduction 0.008764 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8137 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9058 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.9941 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6662 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.9758 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01321 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3115 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.721 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2756 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.5555 Moderately Informative Inherited
Biological Process (BP) immune system process 0.9656 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 6.042e-12 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.215e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 3.98e-05 Informative Direct
Biological Process (BP) organophosphate catabolic process 5.147e-05 Informative Direct
Biological Process (BP) chromosome organization 7.04e-05 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 0.0001834 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 0.0002074 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0002421 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0006599 Informative Direct
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.007484 Informative Inherited
Biological Process (BP) response to lipid 0.02294 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.9359 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.9437 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) cell cycle process 0.05237 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.002 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.8082 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9979 Informative Inherited
Biological Process (BP) microtubule-based process 0.9992 Informative Inherited
Biological Process (BP) protein phosphorylation 0.00799 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.6939 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.7762 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.08489 Informative Inherited
Biological Process (BP) response to organic nitrogen 1 Informative Inherited
Biological Process (BP) response to external stimulus 0.6033 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.9153 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.9699 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.3546 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01027 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.1077 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.0286 Informative Inherited
Biological Process (BP) ribose phosphate metabolic process 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.3813 Informative Inherited
Biological Process (BP) response to DNA damage stimulus 0.08977 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.004706 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.02999 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.00317 Informative Inherited
Biological Process (BP) DNA repair 2.423e-05 Highly Informative Direct
Biological Process (BP) meiosis 5.43e-14 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 7.607e-13 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 2.225e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 9.451e-09 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 2.058e-06 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.387e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 3.25e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 5.864e-06 Highly Informative Direct
Biological Process (BP) nucleotide catabolic process 1.009e-05 Highly Informative Direct
Biological Process (BP) regulation of proton transport 0.000105 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000882 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.1668 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.008161 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.005815 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.04878 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.9006 Highly Informative Inherited
Biological Process (BP) regulation of cell projection organization 0.2119 Highly Informative Inherited
Biological Process (BP) organelle localization 0.07843 Highly Informative Inherited
Biological Process (BP) organelle assembly 0.007735 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.1486 Highly Informative Inherited
Biological Process (BP) DNA recombination 0.3976 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.005205 Highly Informative Inherited
Biological Process (BP) modification-dependent protein catabolic process 0.05491 Highly Informative Inherited
Biological Process (BP) DNA packaging 0.01373 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.6275 Highly Informative Inherited
Biological Process (BP) response to insulin stimulus 0.00199 Highly Informative Inherited
Biological Process (BP) cellular response to peptide hormone stimulus 0.153 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.08483 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.1081 Highly Informative Inherited
Molecular Function (MF) binding 1.364e-06 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) heterocyclic compound binding 0.0001043 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.0001913 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) isomerase activity 5.345e-08 Moderately Informative Direct
Molecular Function (MF) protein binding 0.6591 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.009539 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.2961 Moderately Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) DNA binding 2.433e-06 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0006208 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 6.228e-14 Informative Direct
Molecular Function (MF) nucleotide binding 6.546e-12 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 2.154e-06 Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 5.79e-07 Highly Informative Direct
Molecular Function (MF) magnesium ion binding 3.241e-06 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.079 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.7058 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5972 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7032 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.9753 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.1095 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.06718 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.02863 Moderately Informative Inherited
Cellular Component (CC) chromosome 5.61e-06 Informative Direct
Cellular Component (CC) condensed chromosome 0.000835 Highly Informative Direct
Cellular Component (CC) nuclear chromosome part 0.003371 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.265e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the abdomen0.3794Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.2413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.2444Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.0005883InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.009322InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.02007InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by anatomical site0.03357InformativeInherited
Phenotypic Abnormality (PA)Uterine neoplasm3.984e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the large intestine1.105e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm8.664e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma9.342e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1875Moderately InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.004081InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01028InformativeInherited
Mammalian Phenotype (MP)abnormal male meiosis5.99e-05Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0001169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.002208Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.00264Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)gametogenesis variant0.001002Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)portion of meristem tissue0.5126Least InformativeInherited
Plant ANatomical entity (PAN)root meristem0.000988Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1.274e-05Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processVirulence0InformativeDirect
Biological processNitrogen fixation4.81e-10InformativeDirect
Biological processAntibiotic resistance5.689e-05InformativeDirect
Biological processBiological rhythms0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processGlucose metabolism9.209e-16Highly InformativeDirect
Biological processEthylene signaling pathway1.802e-14Highly InformativeDirect
Cellular componentMembrane3.307e-06Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionDNA-binding2.206e-10Moderately InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.0001396InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor2.323e-10Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase3.211e-10InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation3.632e-12InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]