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ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55873]
Superfamily:   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [ 55874] (4)
Families:   Heat shock protein 90, HSP90, N-terminal domain [ 55875]
  DNA gyrase/MutL, N-terminal domain [ 55879] (6)
  Histidine kinase [ 55884] (7)
  alpha-ketoacid dehydrogenase kinase, C-terminal domain [ 69804] (2)


Superfamily statistics
Genomes (3,251) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 98,487 0 56
Proteins 97,410 0 56


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00001265Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect
Enzyme Commission (EC)Sole sub-subclass for isomerases that do not belon1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.007693Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.05762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.149Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2918Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.323Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.3912Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.4123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6194Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01368Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.04796Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.05546Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.06413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.08799Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1232Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.1288Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1359Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.1363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.1539Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1655Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1719Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3188Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.5429Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of amino acid metabolism0.00004264InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0.0008375InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.001122InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.001421InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002465InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.01115InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hypothalamus-pituitary axis0.012InformativeInherited
Phenotypic Abnormality (PA)Upper motor neuron dysfunction0.01247InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.01516InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.02719InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.03319InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.03971InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.05543InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.06007InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.08404InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1432InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.1519InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.1805InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.1884InformativeInherited
Phenotypic Abnormality (PA)Cardiac diverticulum0.000000001957Highly InformativeDirect
Phenotypic Abnormality (PA)Glioblastoma multiforme0.000000003121Highly InformativeDirect
Phenotypic Abnormality (PA)Pancreatic adenocarcinoma0.00000003566Highly InformativeDirect
Phenotypic Abnormality (PA)Pituitary adenoma0.00000006011Highly InformativeDirect
Phenotypic Abnormality (PA)Agnosia0.0000000776Highly InformativeDirect
Phenotypic Abnormality (PA)Neuroblastic tumors0.0000003672Highly InformativeDirect
Phenotypic Abnormality (PA)Peripheral primitive neuroectodermal neoplasm0.0000003672Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.000000433Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.000001533Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatocellular carcinoma0.000001939Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.000002418Highly InformativeDirect
Phenotypic Abnormality (PA)Amaurosis fugax0.000002755Highly InformativeDirect
Phenotypic Abnormality (PA)Benign neoplasm of the central nervous system0.000005445Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.000006518Highly InformativeDirect
Phenotypic Abnormality (PA)Dysgraphia0.00001054Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.00001252Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of intracranial pressure0.00002174Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment0.00002211Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skeletal system0.00002269Highly InformativeDirect
Phenotypic Abnormality (PA)Dyskinesia0.00003378Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.00004548Highly InformativeDirect
Phenotypic Abnormality (PA)Irritability0.00006652Highly InformativeDirect
Phenotypic Abnormality (PA)Urinary tract neoplasm0.00007734Highly InformativeDirect
Phenotypic Abnormality (PA)Hallucinations0.0001007Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.0001215Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of creatine metabolism0.0001282Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.0002569Highly InformativeDirect
Phenotypic Abnormality (PA)Malabsorption0.0006572Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.0006757Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0007682Highly InformativeDirect
Phenotypic Abnormality (PA)Anxiety0.0008605Highly InformativeDirect
Phenotypic Abnormality (PA)Dysarthria0.0008842Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0008842Highly InformativeDirect
Phenotypic Abnormality (PA)Depressivity0.000928Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.009316Highly InformativeInherited
Phenotypic Abnormality (PA)Weakness due to upper motor neuron dysfunction0.06141Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.04408Least InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.03825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.3308Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.01772InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.01839InformativeInherited
Mammalian Phenotype (MP)abnormal meiosis0.0002133Highly InformativeDirect
Mammalian Phenotype (MP)absent gametes0.0002197Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sperm number0.004417Highly InformativeInherited
Mammalian Phenotype (MP)decreased male germ cell number0.004889Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)retarded heterochronic variations0Least InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001195Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0007085Moderately InformativeDirect
Enzyme Commission (EC)Protein-histidine kinases0Highly InformativeDirect
Enzyme Commission (EC)DNA topoisomerase (ATP-hydrolyzing)0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processVirulence0Moderately InformativeDirect
Biological processCarbohydrate metabolism1Moderately InformativeInherited
Biological processBiological rhythms0InformativeDirect
Biological processStress response0InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processSporulation0InformativeDirect
Biological processNitrogen fixation0.000000000436InformativeDirect
Biological processDNA repair0.000002602InformativeDirect
Biological processAntibiotic resistance0.000007648InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Biological processGlucose metabolism0.000000000000004302Highly InformativeDirect
Cellular componentMembrane0.000000001968Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0003869Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionChromophore0InformativeDirect
Molecular functionCopper0.000004058InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0.000000000002508Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationProtein phosphatase4.464e-16InformativeDirect
Post-translational modificationPhotoreceptor protein0Highly InformativeDirect
Post-translational modificationTopoisomerase0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationS-nitrosylation0.00000002306InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003594 SSF55874 Protein matches
Abstract

This domain is found in several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases [PubMed15105144], heat shock protein HSP90 [PubMed15292259, PubMed14718169, PubMed15217611], phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]