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Glutamine synthetase/guanido kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Glutamine synthetase/guanido kinase [ 55930]
Superfamily:   Glutamine synthetase/guanido kinase [ 55931] (5)
Families:   Glutamine synthetase catalytic domain [ 55932]
  Guanido kinase catalytic domain [ 55935] (2)
  Glutamate-cysteine ligase family 2 (GCS2) [ 111160]
  Glutamate-cysteine ligase [ 118090]
  GatB/GatE catalytic domain-like [ 143812] (2)


Superfamily statistics
Genomes (3,225) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 14,311 93,365 24
Proteins 14,212 93,056 24


Functional annotation
General category Metabolism
Detailed category Amino acids metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity0.2320.00009448Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.00084950Moderately InformativeDirect
Molecular Function (MF)ligase activity0.00000047490InformativeDirect
Molecular Function (MF)acid-amino acid ligase activity0.069990.8885Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00005638 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00007092 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9359 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01319 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.08954 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.007963 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.0000000000001047 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.00000000005784 Moderately Informative Direct
Biological Process (BP) amide biosynthetic process 0.0000000001245 Moderately Informative Direct
Biological Process (BP) sulfur compound metabolic process 0.0000000003055 Moderately Informative Direct
Biological Process (BP) peptide metabolic process 0.000000001191 Moderately Informative Direct
Biological Process (BP) tissue development 0.9635 Moderately Informative Inherited
Biological Process (BP) reproduction 0.7523 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9727 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9153 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.3527 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) response to temperature stimulus 0.00000000000001079 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.0000000000001248 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00000001614 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.000004675 Informative Direct
Biological Process (BP) amine metabolic process 0.0005875 Informative Direct
Biological Process (BP) multicellular organism reproduction 0.3727 Informative Inherited
Biological Process (BP) growth 0.1208 Informative Inherited
Biological Process (BP) cell development 0.9973 Informative Inherited
Biological Process (BP) reproductive system development 0.01747 Informative Inherited
Biological Process (BP) post-embryonic development 0.02745 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.3181 Informative Inherited
Biological Process (BP) single organism reproductive process 0.7867 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.03637 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.4606 Informative Inherited
Biological Process (BP) alpha-amino acid biosynthetic process 0.4134 Informative Inherited
Biological Process (BP) system process 0.3995 Informative Inherited
Biological Process (BP) cellular modified amino acid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to heat 0 Highly Informative Direct
Biological Process (BP) glutathione metabolic process 0 Highly Informative Direct
Biological Process (BP) nonribosomal peptide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) polyamine metabolic process 0.0000001767 Highly Informative Direct
Biological Process (BP) cellular biogenic amine catabolic process 0.000002929 Highly Informative Direct
Biological Process (BP) trichome differentiation 0.000004309 Highly Informative Direct
Biological Process (BP) glutamate metabolic process 0.00006536 Highly Informative Direct
Biological Process (BP) seed development 0.0003989 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.004584 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1198 Highly Informative Inherited
Biological Process (BP) cell growth 0.007382 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 0.174 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.00009448 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.1305 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.2033 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.4069 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.000002208 Informative Direct
Molecular Function (MF) kinase activity 0.000005318 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.02849 Informative Inherited
Molecular Function (MF) ribonucleotide binding 0.03192 Informative Inherited
Molecular Function (MF) amino acid binding 0.000000000856 Highly Informative Direct
Molecular Function (MF) acid-amino acid ligase activity 0.8885 Highly Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) extracellular space 0 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxy-lyases0.0952Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as ac0InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.03504InformativeInherited
Enzyme Commission (EC)Acid--ammonia (or amide) ligases (amide synthases)0Highly InformativeDirect
Enzyme Commission (EC)Glutamate decarboxylase0Highly InformativeDirect
Enzyme Commission (EC)Glutathione synthase0.0000003637Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processNitrogen fixation0InformativeDirect
Biological processProtein biosynthesis0InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0.000000000000004283Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationKinase0.000000000002447Moderately InformativeDirect
Post-translational modificationNitration0.00001897InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glutamine synthetase/guanido kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 15 hidden Markov models representing the Glutamine synthetase/guanido kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]