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Nitrite and sulphite reductase 4Fe-4S domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Nitrite and sulphite reductase 4Fe-4S domain-like [ 56013]
Superfamily:   Nitrite and sulphite reductase 4Fe-4S domain-like [ 56014]
Families:   Nitrite and sulphite reductase 4Fe-4S domain-like [ 56015] (5)


Superfamily statistics
Genomes (2,521) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,581 57,903 10
Proteins 6,335 44,889 7


Functional annotation
General category Metabolism
Detailed category E- transfer

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.00003342 Least Informative Direct
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1101 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5651 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.000000000003335 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.172 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02982 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2096 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.08589 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.2274 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.003064 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.1417 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.1436 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0.0007161 Informative Direct
Biological Process (BP) negative regulation of cellular biosynthetic process 0.003088 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.00248 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.006225 Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.000003293 Highly Informative Direct
Biological Process (BP) negative regulation of RNA metabolic process 0.001144 Highly Informative Inherited
Molecular Function (MF) binding 0.1071 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) iron-sulfur cluster binding 0.0000000000002607 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a sulfur group of donors 0.000000001427 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.05949 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.07412 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8688 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3649 Least Informative Inherited
Cellular Component (CC) plastid 0.00000001696 Informative Direct
Cellular Component (CC) chloroplast stroma 0.00000000003023 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synth0Highly InformativeDirect
Enzyme Commission (EC)Nitrite reductase (NAD(P)H)0.000000000001128Highly InformativeDirect
Enzyme Commission (EC)With other acceptors0.000383Highly InformativeDirect
Enzyme Commission (EC)With an iron-sulfur protein as acceptor0.0004265Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCysteine biosynthesis0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processNitrate assimilation0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Molecular functionIron-sulfur0Moderately InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationThioether bond0Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nitrite and sulphite reductase 4Fe-4S domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Nitrite and sulphite reductase 4Fe-4S domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]